9 research outputs found
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Acton C.
- Adam F.
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- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
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- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chawla V.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
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- Church E.
- Cianci N.
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- Clark E.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Fairbairn I.
- Fairclough A.
- Falconer E.
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- Fancois V.
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- Farzana S.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
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Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
The Use of Monitoring as a Decision-Making Tool in the Mawson’s Huts Historic Site Conservation Management Plan and the Results of Monitoring for the Period 1999-2002
- Publication venue
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The microclimate of Mawson's Hut based on snow and ice core analysis
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Dissecting George Town’s human capital challenges in built heritage
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Caught between nationalism and internationalism: replicating histories of Antarctica in Hobart
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Increasingly allergenic airborne pollen revealed in sediment of Lake Burley Griffin, Canberra
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- ACT Government
- Appleby
- AusPollen
- Australian Bureau of Meteorology
- Australian Bureau of Statistics
- Beggs
- Birks
- Caitcheon
- Canberra District and Historical Society
- Coltheart
- Commonwealth Statistician
- Commonwealth Statistician
- Commonwealth Statistician
- Conedera
- Cook
- Cooke
- Dass
- Davies
- Dawson
- Dyer
- Frei
- Godden Mackay Logan Pty. Ltd
- Green
- Haberle
- Kelso
- Lawrence
- Ling
- Maher
- Maunsell Australia Pty Ltd
- Molonglo Catchment Group
- Neil
- Pryor
- Rosich
- Ryan
- Sands
- Seppa
- Shepard
- Stevenson
- Tinner
- Verdu
- Wallbrink
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- Ziello
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- 'Oxford University Press (OUP)'
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- Field of study
Exploring the Experiences of Nineteenth-Century Colonial Children in Australia with the Application of Interpretive Reproduction Theory – An Alternative Approach in the Study of Childhood in the Past
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- Bagwell E.
- Barnes P.
- Baxter J. E.
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- Friedrich O.
- Godden Mackay Logan Pty Ltd
- Godden Mackay Logan Pty Ltd
- Greenfield P.
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- James A.
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- Mishler E. G.
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- Morphett G. C.
- Opie I.
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- Seiter E.
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- Whitmore H.
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- Wood E.
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- Biemans
- Biggs
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- Frank
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- Freeman
- Freeman
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- Garten
- Garten
- Garten
- Garten
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- Gong
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- Gorham
- Gorham
- Gosselink
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- Gu
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- Harrison
- Harrison
- Harrison
- Harrison
- Harrison
- Harrison
- Harrison
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- Hartnett
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- Hedin
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- Hedin
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- Hedley
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- Hilton
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- Hobbie
- Hobbie
- Hobbie
- Hoch
- Hocking
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- Hofmann
- Hofmann
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- Hogberg
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- Howarth
- Howarth
- Howarth
- Howarth
- Howarth
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- Ingall
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- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
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- Savarino
- Savoie
- Savoie
- Savoie
- Savva
- Sayles
- Sayles
- Sayles
- Scanlon
- Scanlon
- Schaefer
- Schaefer
- Schaefer
- Schaefer
- Schaefer
- Schaefer
- Schaller
- Scheffer
- Schelske
- Schidlowski
- Schidlowski
- Schidlowski
- Schiff
- Schillawski
- Schilling
- Schilt
- Schimel
- Schimel
- Schimel
- Schimel
- Schimel
- Schimel
- Schimel
- Schindler
- Schindler
- Schindler
- Schindler
- Schindler
- Schindler
- Schindler
- Schindler
- Schipanski
- Schipper
- Schippers
- Schippers
- Schippers
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schlesinger
- Schmidt
- Schmidt
- Schmidt
- Schmidt
- Schmidt
- Schmitt
- Schmittner
- Schmitz
- Schmitz
- Schneider
- Schnell
- Schnitzer
- Schoenau
- Scholander
- Scholefield
- Schonheit
- Schopf
- Schrenk
- Schroth
- Schuffert
- Schulten
- Schulten
- Schulthess
- Schultz
- Schultz
- Schulze
- Schumann
- Schutz
- Schuur
- Schuur
- Schuur
- Schwartz
- Schwartz
- Schwartzman
- Schwertmann
- Schwintzer
- Schwintzer
- Schönbächler
- Schöttelndreier
- Scott
- Scott
- Scott
- Scott
- Scott
- Scranton
- Scriber
- Scudder
- Scurlock
- Seager
- Sears
- Seastedt
- Seastedt
- Seastedt
- Seastedt
- Seastedt
- Sebacher
- Sebacher
- Seemann
- Segura
- Sehmel
- Seiler
- Seinfeld
- Seiter
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Seitzinger
- Self
- Selin
- Selin
- Sella
- Sellers
- Selmants
- Seo
- Sequeira
- Serca
- Serrasolsas
- Serret
- Serreze
- Servant
- Servant
- Servant
- Sessions
- Severinghaus
- Sexstone
- Sexstone
- Shaffer
- Shaked
- Shakun
- Shanks
- Shannon
- Sharkey
- Sharkey
- Sharpley
- Sharpley
- Sharpley
- Shaver
- Shaver
- Shaver
- Shaver
- Shaw
- Shaw
- Shaw
- Shear
- Shearer
- Shearer
- Shearer
- Shelley
- Shen
- Shen
- Shepherd
- Shields
- Shiller
- Shimshock
- Shindell
- Shindell
- Shoji
- Sholkovitz
- Shon
- Shooter
- Shorter
- Shortle
- Shotyk
- Shugart
- Shukla
- Shukla
- Shukla
- Shuttleworth
- Siddall
- Sidle
- Siebert
- Siegel
- Siegel
- Siever
- Sigg
- Sigler
- Sigman
- Sigman
- Sillitoe
- Sillman
- Sillén
- Silver
- Silver
- Silver
- Silvester
- Silvester
- Sim
- Simas
- Simkiss
- Simmons
- Simo
- Simon
- Simon
- Simon
- Simonich
- Simonson
- Singer
- Singh
- Singh
- Singh
- Singleton
- Singleton
- Singsaas
- Sinsabaugh
- Sinsabaugh
- Sinsabaugh
- Sivan
- Sjöberg
- Sjöström
- Skiba
- Skyring
- Sleep
- Slemr
- Slemr
- Slinn
- Sloan
- Slutsky
- Smeck
- Smedley
- Smemo
- Smetacek
- Smil
- Smil
- Smirnoff
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smol
- Smolders
- Smrekar
- Snaydon
- Snider
- Snider
- Sobczak
- Sobek
- Soden
- Sofiev
- Sollins
- Sollins
- Solomon
- Solomon
- Solomon
- Solomon
- Solomon
- Solomon
- Son
- Sorooshian
- Soule
- Sowers
- Sowers
- Sowers
- Sowers
- Spalding
- Sparks
- Sparks
- Speidel
- Spichtinger
- Spiro
- Spivack
- Spoelstra
- Sposito
- Spratt
- Springer
- Spycher
- Squyres
- Squyres
- Srinivasan
- Srivastava
- St Louis
- Staaf
- Staehr
- Staehr
- Staehr
- Staehr
- Staffelbach
- Stallard
- Stallard
- Stallard
- Stanley
- Stanley
- Stanley
- Stanley
- Stark
- Starr
- Staubes
- Steele
- Steele
- Stefels
- Stehfest
- Steinbacher
- Steinke
- Sterling
- Stern
- Sternberg
- Sterner
- Sterner
- Sterner
- Sterner
- Stetter
- Steudler
- Steudler
- Stevens
- Stevens
- Stevens
- Stevens
- Stevens
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stewart
- Still
- Stimler
- Stock
- Stockner
- Stoddard
- Stofan
- Stolt
- Stone
- Stone
- Stott
- Strahm
- Strahm
- Strand
- Strauss
- Strauss
- Strauss
- Streets
- Streets
- Striegl
- Strobel
- Stroeve
- Strojan
- Strother
- Strous
- Stuiver
- Stuiver
- Stumm
- Sturges
- Stutter
- Su
- Suarez
- Subbarao
- Suberkropp
- Subke
- Subke
- Suchet
- Suess
- Summons
- Sunda
- Sundby
- Sundquist
- Sundquist
- Sundquist
- Sunshine
- Sutherland
- Sutka
- Sutton
- Sutton
- Sutton-Grier
- Svedhem
- Svedrup
- Svensson
- Swain
- Swain
- Swan
- Swank
- Swank
- Swank
- Swank
- Swanson
- Swap
- Swap
- Sweeney
- Swetnam
- Swift
- Syakila
- Syed
- Syed
- Syvitski
- Syvitski
- Syvitski
- Szikszay
- Szilagyi
- Tabatabai
- Tabazadeh
- Tajchman
- Tajika
- Takahashi
- Takahashi
- Takahashi
- Talbot
- Talukdar
- Tamm
- Tamrazyan
- Tan
- Tan
- Tanaka
- Tanaka
- Tank
- Tanre
- Tans
- Tapia-Hernandez
- Tarafdar
- Taran
- Tarnocai
- Tarrasón
- Tavares
- Taylor
- Taylor
- Taylor
- Taylor
- Taylor
- Tegen
- Telmer
- Temple
- Templer
- Templer
- Teodoru
- Teodoru
- Terao
- Terman
- Terman
- Textor
- Tezuka
- Thamdrup
- Theobald
- Thiemens
- Thienemann
- Thomas
- Thomas
- Thomas
- Thomas
- Thomas
- Thomazo
- Thompson
- Thompson
- Thompson
- Thompson
- Thomson
- Thorneloe
- Thorpe
- Thurman
- Ti
- Tian
- Tian
- Tice
- Tice
- Tiedje
- Tiedje
- Tiedje
- Tiessen
- Tiessen
- Tiessen
- Tiessen
- Tilman
- Tilman
- Tilman
- Tilman
- Tilton
- Timmer
- Tipping
- Tischner
- Tisdall
- Tissue
- Titman
- Titus
- Titus
- Toggweiler
- Tolbert
- Toon
- Torn
- Torn
- Tornqvist
- Tortell
- Touboul
- Towe
- Townsend
- Townsend
- Townsend-Small
- Toyoda
- Trail
- Tranvik
- Travis
- Trefry
- Trefry
- Trenberth
- Trenberth
- Trenberth
- Trenberth
- Treseder
- Treseder
- Treuhaft
- Treuhaft
- Trimble
- Trimble
- Tripati
- Tripp
- Triska
- Triska
- Triska
- Trlica
- Trouwborst
- Trouwborst
- Trumbore
- Trumbore
- Trumbore
- Tukey
- Turchin
- Turco
- Turekian
- Turetsky
- Turk
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turner
- Turnipseed
- Turtle
- Turunen
- Turunen
- Turunen
- Twilley
- Tyler
- Tyler
- Uehara
- Uematsu
- Ueno
- Ugolini
- Ugolini
- Ugolini
- Uhl
- Ullah
- Umena
- Uno
- Unrau
- Updegraff
- Urban
- Urban
- Urban
- Uz
- Vadas
- Vadstein
- Vahtera
- Valentine
- Valentini
- Valett
- Vallina
- Van Bodegom
- van Breemen
- van Breemen
- van Breemen
- van Breemen
- Van Cappellen
- Van Cappellen
- Van Cappellen
- Van Cleve
- Van Cleve
- Van de Water
- van den Broeke
- van den Driessche
- van der Ent
- Van der Gon Denier
- Van der Hoven
- van der Lee
- van der Werf
- Van Devender
- Van Dijk
- Van Dijk
- Van Drecht
- van Groenigen
- van Groenigen
- van Hees
- Van Houten
- van Keken
- van Kessel
- van Kessel
- Van Mooy
- Van Oost
- van Scholl
- Van Sickle
- Van Trump
- van Zuilen
- Vance
- Vandal
- Vandenberg
- Vann
- Vanni
- Vannote
- Vasconcelos
- Vasileva
- Vazquez-Dominguez
- Velbel
- Velbel
- Velders
- Velicogna
- Velicogna
- Velicogna
- Venterea
- Venterea
- Venterink
- Venterink
- Verchot
- Vergutz
- Verhoeven
- Vernadsky
- Verstraten
- Viereck
- Vila-Costa
- Vile
- Villareal
- Virginia
- Virginia
- Virginia
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitousek
- Vitt
- Vo
- Vogt
- Vogt
- Vogt
- Vogt
- Vogt
- Volk
- Vollenweider
- Volz
- von Fischer
- Voroney
- Vose
- Vossbrinck
- Vrede
- Vuichard
- Vörösmarty
- Vörösmarty
- Vörösmarty
- Vörösmarty
- Vörösmarty
- Vörösmarty
- Wacey
- Wackett
- Wada
- Wada
- Wadhams
- Wagener
- Wagner
- Wagner
- Wahlen
- Waite
- Wakatsuki
- Wakefield
- Walbridge
- Walbridge
- Waldman
- Waldman
- Waldrop
- Walker
- Walker
- Walker
- Walker
- Walker
- Walker
- Walker
- Walker
- Walker
- Wallace
- Wallace
- Wallace
- Wallace
- Wallace
- Wallenstein
- Wallerstein
- Walling
- Walling
- Wallmann
- Wallmann
- Walsh
- Walsh
- Walsh
- Walter
- Walter
- Walter
- Walter
- Walter
- Walvoord
- Wan
- Wanek
- Wanek
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wanninkhof
- Wanninkhof
- Warby
- Ward
- Ward
- Ward
- Ward
- Wardle
- Wardle
- Ware
- Warembourg
- Waring
- Waring
- Waring
- Warneck
- Warren
- Watanabe
- Watkins
- Watmough
- Watson
- Watson
- Watson
- Watson
- Watson
- Watson
- Watts
- Watts
- Watwood
- Watwood
- Waugh
- Waughman
- Waughman
- Wayne
- Weand
- Weathers
- Weathers
- Webb
- Webb
- Webb
- Weber
- Weber
- Webster
- Webster
- Webster
- Webster
- Webster
- Wedepohl
- Wedin
- Weier
- Weier
- Weir
- Weiss
- Weiss
- Weiss
- Weiss
- Weiss
- Weiss-Penzias
- Weitz
- Welch
- Welch
- Wells
- Wellsbury
- Weng
- Wennberg
- Wentz
- Wenzhofer
- Wesely
- Wessman
- Wessman
- West
- West
- West
- Westheimer
- Westman
- Weston
- Weston
- Wetherill
- Wetherill
- Wetselaar
- Wetzel
- Wetzel
- Wetzel
- Weyl
- Whalen
- Whalen
- Wheat
- Whelpdale
- White
- White
- White
- White
- White
- White
- White
- White
- Whitehead
- Whiteside
- Whitfield
- Whitfield
- Whitfield
- Whiticar
- Whiticar
- Whiting
- Whitlow
- Whitman
- Whitney
- Whittaker
- Whittaker
- Whittaker
- Whittaker
- Whittaker
- Whittaker
- Whittaker
- Wickham
- Widdel
- Widmer
- Wieder
- Wieder
- Wieder
- Wiegert
- Wigley
- Wilde
- Wilhelm
- Wilkinson
- Wilkinson
- Wilkinson
- Willbold
- Willett
- Williams
- Williams
- Williams
- Williams
- Williams
- Williams
- Williams
- Williams
- Williams
- Williams
- Willison
- Wilson
- Wilson
- Wilson
- Windolf
- Winner
- Wittmann
- Wogelius
- Wohlfahrt
- Wolf
- Wolf
- Wolfe
- Wolfe
- Wolfe-Simon
- Wolin
- Wollast
- Wollast
- Wollast
- Wollheim
- Wollheim
- Wollheim
- Woltemate
- Wong
- Wong
- Wood
- Wood
- Wood
- Woodbury
- Woodmansee
- Woodmansee
- Woodmansee
- Woodward
- Woodward
- Woodward
- Woodwell
- Woolf
- Woosley
- Woosley
- Workshop
- Worm
- Worsley
- Wortmann
- Wotawa
- Wotawa
- Wrage
- Wright
- Wright
- Wright
- Wu
- Wu
- Wu
- Wu
- Wuebbles
- Wuebbles
- Wullstein
- Xia
- Xiao
- Xie
- Xiong
- Xu
- Xu
- Xu
- Yaalon
- Yagi
- Yamada
- Yamagata
- Yanagawa
- Yanai
- Yang
- Yang
- Yang
- Yang
- Yano
- Yavitt
- Yavitt
- Ye
- Ye
- Yi
- Yin
- Yin
- Yoh
- Yoh
- Yokouchi
- Yokouchi
- Yokouchi
- Yokoyama
- Yoneyama
- Yool
- Yoshida
- Yoshida
- Yoshinari
- Young
- Youngberg
- Yu
- Yu
- Yu
- Yu
- Yuan
- Yuan
- Yuan
- Yuan
- Yuji
- Yung
- Yung
- Yung
- Yung
- Yvon-Lewis
- Zachos
- Zagal
- Zak
- Zak
- Zbieranowski
- Zechmeister-Boltenstern
- Zedler
- Zeebe
- Zeebe
- Zehetner
- Zehnder
- Zehr
- Zehr
- Zektser
- Zektser
- Zender
- Zerihun
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhou
- Zhou
- Zhu
- Zhuang
- Ziebis
- Zierl
- Zimmerman
- Zimov
- Zimov
- Zobel
- Zou
- Zuber
- Zwally
- Zychowski
- Zysset
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study