Continuous RSB mean-field solution of the Potts glass

We investigate the p-state mean-field model of the Potts glass ($2\le p \le 4$) below the continuous phase transition to a glassy phase. We find that apart from a solution with a first hierarchical level of replica-symmetry breaking (1RSB), locally stable close to the transition point, there is a continuous full replica-symmetry breaking (FRSB) solution. The latter is marginally stable and has a higher free energy than the former. We argue that the true equilibrium is reached only by FRSB, being globally thermodynamically homogeneous, whereas 1RSB is only locally homogeneous.Comment: REVTeX4.1, 4 pages, 1 figur

Evidence against a glass transition in the 10-state short range Potts glass

We present the results of Monte Carlo simulations of two different 10-state Potts glasses with random nearest neighbor interactions on a simple cubic lattice. In the first model the interactions come from a \pm J distribution and in the second model from a Gaussian one, and in both cases the first two moments of the distribution are chosen to be equal to J_0=-1 and Delta J=1. At low temperatures the spin autocorrelation function for the \pm J model relaxes in several steps whereas the one for the Gaussian model shows only one. In both systems the relaxation time increases like an Arrhenius law. Unlike the infinite range model, there are only very weak finite size effects and there is no evidence that a dynamical or a static transition exists at a finite temperature.Comment: 9 pages of Latex, 4 figure

Finite-size scaling at the dynamical transition of the mean-field 10-state Potts glass

We use Monte Carlo simulations to study the static and dynamical properties of a Potts glass with infinite range Gaussian distributed exchange interactions for a broad range of temperature and system size up to N=2560 spins. The results are compatible with a critical divergence of the relaxation time tau at the theoretically predicted dynamical transition temperature T_D, tau \propto (T-T_D)^{-\Delta} with Delta \approx 2. For finite N a further power law at T=T_D is found, tau(T=T_D) \propto N^{z^\star} with z^\star \approx 1.5 and for T>T_D dynamical finite-size scaling seems to hold. The order parameter distribution P(q) is qualitatively compatible with the scenario of a first order glass transition as predicted from one-step replica symmetry breaking schemes.Comment: 8 pages of Latex, 4 figure

The Glassy Potts Model

We introduce a Potts model with quenched, frustrated disorder, that enjoys of a gauge symmetry that forbids spontaneous magnetization, and allows the glassy phase to extend from $T_c$ down to T=0. We study numerical the 4 dimensional model with $q=4$ states. We show the existence of a glassy phase, and we characterize it by studying the probability distributions of an order parameter, the binder cumulant and the divergence of the overlap susceptibility. We show that the dynamical behavior of the system is characterized by aging.Comment: 4 pages including 4 (color) ps figures (all on page 4

Interstitial water iodine enrichments in sediments from the eastern Pacific

The vertical distribution of iodine has been examined in interstitial waters of sediment cores from the Peru Basin, Bauer Basin, Guatemala Basin and the East Pacific Rise and the sediments have been analyzed for iodine and organic carbon. Interstitial water profiles show a strong enrichment of iodine at the sediment surface relative to overlying sea water. This enrichment is much greater than would have been expected had all the iodine originated solely from the breakdown of newly sedimented plankton. This implies recycling of iodine in the region of the water-sediment interface with most of the upward diffusing iodine being rescavenged and a small fraction escaping to the deep sea. A flux equivalent to 1–5% of the diffusive flux from interstitial waters can account for an excess iodine anomaly previously described for deep Pacific waters

Synthesis of Potential Anti-Cancer Agents. XVII. Urea Nitrogen Mustards

The synthesis of nitrogen mustard ur eas from various isocyamates and the free base of NN-bis-(2-chloroe thyla mine) is described. Prelimina ry pharmacological tests show that so m e of these compounds have a cytostatic activity

Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.

BACKGROUND: Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated. Extrahepatic sources of plasma FVIII are implicated, but have remained elusive. METHODOLOGY/PRINCIPAL FINDINGS: Immunohistochemistry of normal human lung tissue, and confocal microscopy, flow cytometry, and ELISA quantification of conditioned media from normal primary endothelial cells were used to examine endothelial expression of FVIII and coexpression with von Willebrand Factor (vWF), which protects secreted FVIII heavy chain from rapid proteloysis. FVIII transcripts predicted from database mining were identified by RT-PCR and sequencing. FVIII mAb-reactive material was demonstrated in CD31+ endothelial cells in normal human lung tissue, and in primary pulmonary artery, pulmonary microvascular, and dermal microvascular endothelial cells. In pulmonary endothelial cells, this protein occasionally colocalized with vWF, centered on Weibel Palade bodies. Pulmonary artery and pulmonary microvascular endothelial cells secreted low levels of FVIII and vWF to conditioned media, and demonstrated cell surface expression of FVIII and vWF Ab-reacting proteins compared to an isotype control. Four endothelial splice isoforms were identified. Two utilize transcription start sites in alternate 5 exons within the int22h-1 repeat responsible for intron 22 inversions in 40% of severe haemophiliacs. A reciprocal relationship between the presence of short isoforms and full-length FVIII transcript suggested potential splice-switching mechanisms. CONCLUSIONS/SIGNIFICANCE: The pulmonary endothelium is confirmed as a site of FVIII secretion, with evidence of synthesis, cell surface expression, and coexpression with vWF. There is complex alternate transcription initiation from the FVIII gene. These findings provide a framework for future research on the regulation and perturbation of FVIII synthesis, and of potential relevance to haemophilia, thromboses, and pulmonary hypertensive states

Calibration of Mg/Ca thermometry in planktonic foraminifera from a sediment trap time series

Paired Mg/Ca and δ18O measurements on planktonic foraminiferal species (G. ruber white, G. ruber pink, G. sacculifer, G. conglobatus, G. aequilateralis, O. universa, N. dutertrei, P. obliquiloculata, G. inflata, G. truncatulinoides, G. hirsuta, and G. crassaformis) from a 6-year sediment trap time series in the Sargasso Sea were used to define the sensitivity of foraminiferal Mg/Ca to calcification temperature. Habitat depths and calcification temperatures were estimated from comparison of δ18O of foraminifera with equilibrium calcite, based on historical temperature and salinity data. When considered together, Mg/Ca (mmol/mol) of all species, except two, show a significant (r = 0.93) relationship with temperature (T °C) of the form Mg/Ca = 0.38 (±0.02) exp 0.090 (±0.003)T, equivalent to a 9.0 ± 0.3% change in Mg/Ca for a 1°C change in temperature. Small differences exist in calibrations between species and between different size fractions of the same species. O. universa and G. aequilateralis have higher Mg/Ca than other species, and in general, data can be best described with the same temperature sensitivity for all species and pre-exponential constants in the sequence O. universa > G. aequilateralis ≈ G. bulloides > G. ruber ≈ G. sacculifer ≈ other species. This approach gives an accuracy of ±1.2°C in the estimation of calcification temperature. The ∼9% sensitivity to temperature is similar to published studies from culture and core top calibrations, but differences exist from some literature values of pre-exponential constants. Different cleaning methodologies and artefacts of core top dissolution are probably implicated, and perhaps environmental factors yet understood. Planktonic foraminiferal Mg/Ca temperature estimates can be used for reconstructing surface temperatures and mixed and thermocline temperatures (using G. ruber pink, G. ruber white, G. sacculifer, N. dutertrei, P. obliquiloculata, etc.). The existence of a single Mg thermometry equation is valuable for extinct species, although use of species-specific equations will, where statistically significant, provide more accurate evaluation of Mg/Ca paleotemperature