Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.

While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variables (IV). We calculated MR estimates for each risk factor with CRC using SNP-CRC associations from 9,254 cases and 18,386 controls. Genetically predicted higher TC was associated with an elevated risk of CRC (odds ratios (OR) per unit SD increase = 1.46, 95% confidence interval [CI]: 1.20-1.79, P=1.68x10−4). The pooled ORs for LDL, HDL, and TG were 1.05 (95% CI: 0.92-1.18, P=0.49), 0.94 (95% CI: 0.84-1.05, P= 0.27), and 0.98 (95% CI: 0.85-1.12, P=0.75) respectively. A genetic risk score for 3-hydoxy-3-methylglutaryl-coenzyme A reductase (HMGCR) to mimic the effects of statin therapy was associated with a reduced CRC risk (OR=0.69, 95% CI: 0.49-0.99, P=0.046). This study supports a causal relationship between higher levels of TC with CRC risk, and a further rationale for implementing public health strategies to reduce the prevalence of hyperlipidaemia. This article is protected by copyright. All rights reserved

The relationship between schizotypal traits and hoarding symptoms: An examination of symptom specificity and the role of perceived cognitive failures

•Individuals who fell within the clinical range of hoarding symptoms endorsed significantly greater levels of schizotypal symptoms compared to those with normative saving behaviors.•Symptoms of schizotypy (in particular, odd speech, magical thinking, and social anxiety) strongly related to hoarding symptoms.•Symptoms of schizotypy shared similar cognitive vulnerability factors with hoarding symptoms.•Findings underscore the importance of assessing schizotypal traits in patients with hoarding. Hoarding disorder presents significant individual and interpersonal consequences. Because hoarding has only recently been added to the DSM, relatively little is known about associated comorbidity patterns. Several researchers have postulated a relationship between hoarding and schizotypy. To date, however, no investigations have considered which specific types of schizotypal traits relate to hoarding symptoms. We examined the association between hoarding and schizotypal symptoms using multivariate analyses in two samples—a sample of 120 young adults and a community sample of 291 individuals recruited from Mechanical Turk's online crowdsourcing system. Individuals who fell within the clinical range on the Saving Inventory Revised endorsed significantly greater levels of schizotypal symptoms compared to those with normative saving behaviors. Odd speech, magical thinking, and social anxiety were the most consistent schizotypal correlates of hoarding symptoms. Perceived cognitive dysfunction mediated the effects between odd speech and social anxiety and hoarding symptoms, suggesting that shared abnormalities in cognitive functioning may help explain the relationship between hoarding and schizotypy. This study examined the spectrum of schizotypy and hoarding symptoms via self-report in two nonclinical populations. Findings underscore the importance of assessing schizotypal traits in patients with hoarding, and suggest future avenues of research to better understand the underlying causes explaining the overlap, as well as potential treatment implications