History as a preparation for citizenship

Thesis (M.A.)--Boston Universit

A Cooperative Management Solution to a Fishery Commons

A common property resource with open access, such as a fishery, will be used to excess when faced with sufficient demand. This will lead to an excessive amount of effort on the part of the fishery, resulting in a depletion of the stock. This paper discusses the development of a property rights regime for the Atlantic calico scallop, Argopecten gibbus, fishery of Florida. The management solution of the Calico Scallop Conservation Association (CSCA) provides an example of the assignment of property rights to a common property resource without resorting to governmental intervention. In this particular fishery, self-regulation limited early harvesting which would be uneconomic; there may be other fisheries in which self-regulation could be economically efficient and biologically appropriate. While this solution may not be applicable to all common property resources, for those cases which may be similar; the example of the CSCA provides valuable information that may be helpful in establishing a more efficient use of the resource. Some types of government facilitation may also be useful

Assessment of treatment response in tuberculosis

Antibiotic treatment of tuberculosis has a duration of several months. There is significant variability of the host immune response and the pharmacokinetic-pharmacodynamic properties of Mycobacterium tuberculosis sub-populations at the site of disease. A limitation of sputum-based measures of treatment response may be sub-optimal detection and monitoring of Mycobacterium tuberculosis sub-populations. Potential biomarkers and surrogate endpoints should be benchmarked against hard clinical outcomes (failure/relapse/death) and may need tailoring to specific patient populations. Here, we assess the evidence supporting currently utilized and future potential host and pathogen-based models and biomarkers for monitoring treatment response in active and latent tuberculosis. Biomarkers for monitoring treatment response in extrapulmonary, pediatric and drug resistant tuberculosis are research priorities

Locke on Knowledge of Existence

The standard objection to Locke’s epistemology is that his conception of knowledge inevitably leads to skepticism about external objects. One reason for this complaint is that Locke defines knowledge as the perception of a relation between ideas, but perceiving relations between ideas does not seem like the kind of thing that can give us knowledge that tables and chairs exist. Thus Locke’s general definition of knowledge seems to be woefully inadequate for explaining knowledge of external objects. However, this interpretation and subsequent criticism ignore a special category of knowledge Locke calls “real knowledge”, which is Locke’s own account of how we can have knowledge of the real world. In in this paper I argue that real knowledge of substances requires that, in addition to the perception of a relation between ideas, there be a necessary connection between our ideas and the external objects they represent. It is because Locke thinks there is a necessary connection between these ideas and reality that he thinks the perception of ideas can give us knowledge of the actual world

Nanofluidic tuning of photonic crystal circuits

By integrating soft-lithography-based nanofluidics with silicon nanophotonics, we demonstrate dynamic, liquid-based addressing and high Delta n/n(~0.1) refractive index modulation of individual features within photonic structures at subwavelength length scales. We show ultracompact tunable spectral filtering through nanofluidic targeting of a single row of holes within a planar photonic crystal. We accomplished this with an optofluidic integration architecture comprising a nanophotonic layer, a nanofluidic delivery structure, and a microfluidic control engine. Variants of this technique could enable dynamic reconfiguration of photonic circuits, selective introduction of optical nonlinearities, or delivery of single molecules into resonant cavities for biodetection

Locke on Empirical Knowledge

This paper explores two related issues concerning Locke’s account of epistemic justification for empirical knowledge. One issue concerns the degree of justification needed for empirical knowledge. Commentators almost universally take Locke to hold a fallibilist account of justification, whereas I argue that Locke accepts infallibilism. A second issue concerns the nature of justification. Many (though not all) commentators take Locke to have a thoroughly internalist conception of justification for empirical knowledge, whereas I argue that he has a (partly) externalist conception of justification: it is the fact that sensation is caused by an external object that justifies our belief in the corresponding object. So, while most commentators take Locke to be a fallibilist with an internalist conception of justification for empirical knowledge, I argue he is actually an infallibilist with an externalist conception of justification

Can below average sixth grade pupils be made proficient in addition and multiplication, and at what expenditure of time and effort?

Thesis (Ed. M.)--Boston University, 194

Con: Can biomarkers be gold standards in Alzheimer's disease?

As Alzheimer's disease remains a clinical diagnosis, and as clinical diagnosis can be difficult, it makes sense to look for so-called biomarkers. A biomarker predicts who is likely to have the illness and who is not. Some biomarkers might even correlate with a clinically meaningful response to treatment. Developing biomarkers is often characterized as searching for a diagnostic gold standard that can seem appealing in its promise of certainty. Even so, considering both the economic history of the gold standard and the results of neuropathological studies, framing the search for measurable, biological correlates of dementia syndromes in this way is likely to be self-defeating. Instead of considering biomarkers as providing certainty through referent criterion validation, currently it makes more sense to test their construct validity and their predictive ability. This means that while biomarkers should inform, they will not dictate clinical meaningfulness. For the foreseeable future, even were they to inform diagnosis, biomarkers cannot substitute for understanding whether patients and caregivers find a given dementia treatment effective. Instead, clinicians should recognize their own determining role, both in dementia diagnosis and in the evaluation of treatment. These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment