X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions

1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described. In most cases the reactions were highly regio- and stereospecific and endo-cycloadducts were obtained in good yield. However, in a few cases the initially formed cycloadducts underwent base catalysed epimerisation. The stereochemistry of the cycloadducts was assigned from NOE data and established unequivocally in several cases by X-ray crystallography

Precious Coral Fisheries of Hawaii and the U.S. Pacific Islands

The precious coral fishery in Hawaii and the Western Pacific consists of one industry but two distinct and separate fisheries. The first is the harvest of black coral by scuba divers from depths of 30-100 m. The second is a fishery for pink and gold coral at depths between 400 and 1500 m and employs either a human-operated submersible that permits selective harvest or tangle net dredges which are nonselective. The modern history of these fisheries date from 1958 until the present. In this paper the ecology, life history. and management of the dominant species that make up these fisheries are reviewed. Research needs of the fisheries and the economic and future prospects of the precious coral industry are also described. At the present, the precious coral jewelry industry in Hawaii (all species) is valued at about $25 million at the retail level

Narrative in design development

This paper describes the value of narrative used with ideation tools in aiding the rapid production of product concepts and designs for masters students of graphics, fine art, product and industrial design. The ideation tools used alongside narrative included elements of divergent and convergent thinking in combination with reverse engineering and functional analysis, and practical prototyping using a range of readily adapted artefacts. Narrative was introduced and used by the students in order to ensure the development of a context and purpose for the product, artefact or system developed or proposed and to stimulate original product concepts, ideas and thinking. The concept of narrative is familiar in design. Here however the concept was reinforced using structures associated with fictional narrative. Reverse engineering exploring the deconstruction and identification of function for each component in a product was used to aid students ensure practicality in their idea implementation. This paper describes positive experiences resulting from this activity, with a particular focus on the value of narrative in developing robust concepts. The use of physical prototyping provided tangible and instant feedback for divergent and convergent phases of idea development

Quantitative modelling of the human–Earth System a new kind of science?

The five grand challenges set out for Earth System Science by the International Council for Science in 2010 require a true fusion of social science, economics and natural science—a fusion that has not yet been achieved. In this paper we propose that constructing quantitative models of the dynamics of the human–Earth system can serve as a catalyst for this fusion. We confront well-known objections to modelling societal dynamics by drawing lessons from the development of natural science over the last four centuries and applying them to social and economic science. First, we pose three questions that require real integration of the three fields of science. They concern the coupling of physical planetary boundaries via social processes; the extension of the concept of planetary boundaries to the human–Earth System; and the possibly self-defeating nature of the United Nation’s Millennium Development Goals. Second, we ask whether there are regularities or ‘attractors’ in the human–Earth System analogous to those that prompted the search for laws of nature. We nominate some candidates and discuss why we should observe them given that human actors with foresight and intentionality play a fundamental role in the human–Earth System. We conclude that, at sufficiently large time and space scales, social processes are predictable in some sense. Third, we canvass some essential mathematical techniques that this research fusion must incorporate, and we ask what kind of data would be needed to validate or falsify our models. Finally, we briefly review the state of the art in quantitative modelling of the human–Earth System today and highlight a gap between so-called integrated assessment models applied at regional and global scale, which could be filled by a new scale of model

Sonogashira/N-acyliminium ion aromatic π-cyclisation processes: access to tetra- and pentacyclic lactams

Application of the Sonogashira reaction of N-alkynylimides with 2-iodophenol or 2-iodo-N-tosylaniline affords 2-(N-alkylimino)-benzofurans and indoles in good yield. Selective partial reduction of the latter followed by treatment with TsOH generates N-acyliminium ions, which cyclise to afford tetra- and pentacyclic lactams in good yield. The latter are reduced to the analogous cyclic amines by BH3

Is home-based, high-intensity interval training cycling feasible and safe for patients with knee osteoarthritis? Study protocol for a randomized pilot study

Background: Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups. Purpose: The primary objective of this pilot study was to examine the feasibility and safety of home-based HIIT and MICT cycling in middle-aged and older adults with knee OA. A secondary objective was to gain some insight into the relative efficacy of HIIT and MICT for improving health status (pain, stiffness, and disability), muscle function, and body composition in this population. This study protocol is being published separately to allow a detailed description of the research methods, explain the rationale for choosing the methodological details, and to stimulate consideration of the best means to simulate a research protocol that is relevant to a real-life treatment environment. Study Design: Randomized pilot study protocol. Methods: This trial sought to recruit 40 middle-aged and older adults with knee OA. Participants were randomly allocated to either continuous (MICT) or HIIT home-based cycle training programs, with both programs requiring the performance of 4 cycling sessions (approximately 25 minutes per session) each week. Participants were measured at baseline and postintervention (8 weeks). Feasibility and safety were assessed by adherence rate, dropout rate, and number of adverse events. The relative efficacy of the cycling programs was investigated by 2 knee OA health status questionnaires (Western Ontario and McMaster Universities Osteoarthritis Index scale[WOMAC] and the Lequesne Index) as well as the timed up and go, sit to stand, preferred gait speed, and body composition. Discussion: This pilot study appears to be the first study assessing the feasibility and safety of a home-based HIIT training program for middle-aged and older adults with knee OA. As HIIT has been demonstrated to be more effective than MICT for improving aspects of health status, body composition, and/or muscular function in other chronic disease groups, the current study has the potential to improve patient outcomes and inform the design of future randomized controlled trials