Never Thought It Would Be So Hard

2014 essay contest winner Robin Cone-Murakami\u27s Never Thought It Would Be So Har

Student Galapagonian Shenanigans

Postcard from Robin Cone-Murakami, during the Linfield College Semester Abroad Program at the Galapagos Academic Institute for the Arts and Sciences in Ecuado

The Regulatory Review Process in South Africa: Challenges and Opportunities for a New Improved System.

BACKGROUND: The aims of this study were to assess the regulatory review process in South Africa from 2015 to 2017, identify the key milestones and timelines; evaluate the effectiveness of measures to ensure consistency, transparency, timeliness, and predictability in the review process; and to provide recommendations for enhanced regulatory practices. METHODS: A questionnaire was completed by the Medicines Control Council (MCC) to describe the organization of the authority, record key milestones and timelines in the review process and to identify good review practices (GRevPs). RESULTS: Currently, the MCC conducts a full assessment of quality, efficacy, and safety data in the review of all applications. The overall regulatory median approval time decreased by 14% in 2017 (1411 calendar days) compared with that of 2016, despite the 27% increase in the number of applications. However, the MCC has no target for overall approval time of new active substance applications and no targets for key review milestones. Guidelines, standard operating procedures, and review templates are in place, while the formal implementation of GRevPs and the application of an electronic document management system are planned for the near future. CONCLUSIONS: As the MCC transitions to the newly established South Africa Health Products Regulatory Authority, it would be crucial for the authority to recognize the opportunities for an enhanced regulatory review and should consider models such as abridged assessment, which encompass elements of risk stratification and reliance. It is hoped that resource constraints may then be alleviated and capacity developed to meet target timelines.Peer reviewedFinal Published versio

Minimum induced drag airfoil body Patent

Electric analog for measuring induced drag on nonplanar airfoil

Process for control of cell division

A method of controlling mitosis of biological cells was developed, which involved inducing a change in the intracellular ionic hierarchy accompanying the cellular electrical transmembrane potential difference (Esubm) of the cells. The ionic hierarchy may be varied by imposing changes on the relative concentrations of Na(+), K(+) and Cl(-), or by directly imposing changes in the physical Esubm level across the cell surface

Minimum induced drag airfoil body Patent

Electric analog for measuring induced drag on nonplanar airfoil

Apery and micro-invariants of a one dimensional Cohen-Macaulay local ring and invariants of its tangent cone

Given a one-dimensional Cohen-Macaulay local ring we compare several sets of invariants (micro-invariants, Apery invariants and invariants of the tangent cone) and give explicit formulas relating them. We show that, in fact, they coincide if and only if the tangent cone of the ring is Cohen-Macaulay. Some explicit computations are also given, particularly in the case of semigroup rings.Comment: 20 page

The intrinsic normal cone

We suggest a construction of virtual fundamental classes of certain types of moduli spaces.Comment: LaTeX, Postscript file available at http://www.math.ubc.ca/people/faculty/behrend/inc.p

Land Grant Application- Cone, Elijah (Lovell)

Land grant application submitted to the Maine Land Office on behalf of Elijah Cone for service in the Revolutionary War, by their widow Judith.https://digitalmaine.com/revolutionary_war_me_land_office/1204/thumbnail.jp