Tortious Toxics

In this Article we offer one small idea with potentially large implications. We propose the recognition arid development of a special tort for toxic exposures, where the exposures have not yet led to a physical illness such as cancer. We argue, in brief, that this new tort would, in one simple step, accomplish three things: it would address many of the problems with the courts\u27 current handling of toxic torts; it would consolidate the many overlapping causes of action now pressed in toxic tort cases into one single claim; and it would give expression to the real injury motivating these cases - a dignitary and autonomy-based harm, not a physical one

Dynamic bonds and polar ejection force distribution explain kinetochore oscillations in PtK1 cells

Duplicated mitotic chromosomes aligned at the metaphase plate maintain dynamic attachments to spindle microtubules via their kinetochores, and multiple motor and nonmotor proteins cooperate to regulate their behavior. Depending on the system, sister chromatids may display either of two distinct behaviors, namely (1) the presence or (2) the absence of oscillations about the metaphase plate. Significantly, in PtK1 cells, in which chromosome behavior appears to be dependent on the position along the metaphase plate, both types of behavior are observed within the same spindle, but how and why these distinct behaviors are manifested is unclear. Here, we developed a new quantitative model to describe metaphase chromosome dynamics via kinetochore–microtubule interactions mediated by nonmotor viscoelastic linkages. Our model reproduces all the key features of metaphase sister kinetochore dynamics in PtK1 cells and suggests that differences in the distribution of polar ejection forces at the periphery and in the middle of PtK1 cell spindles underlie the observed dichotomy of chromosome behavior

Procedural Pain Management for Children Receiving Physiotherapy

Purpose: This article provides an overview of literature relevant to the prevention and relief of pain and distress during physiotherapy procedures, with guidance for physiotherapists treating children

Southeast Asia, 1300-1540

The end of the thirteenth century and the early decades of the fourteenth century witnessed the end of Southeast Asia’s classical period, that age when the empires of Pagan (Burma), Angkor (Cambodia), Dai Viet (northern Vietnam), and Sri Vijaya (in the Malay Archipelago) thrived and introduced the region’s religions, political models, and cultural standards. The thirteenth-century invasions of Mongol armies coming out of Yuan China encouraged, but did not cause, the collapse of most of these states, although changes in the application of the Chinese tribute system may have played a substantial role in the fall of Sri Vijaya. On the mainland, however, Mongol intervention was merely disruptive and did not represent meaningful conquest. Instead, administrative weaknesses and trade dislocation contributed to political fragmentation followed by internecine war among the myriad successor states. This fighting would only end with the reemergence of large-scale empires from the middle to the end of the sixteenth century. The period between 1300 and 1540 thus represented a phase of near constant warfare, due both to the multiplicity of competing polities and the administrative weaknesses that worked against sustained political centralization. By the end of the period, the formation of new empires established the political terrain for warfare in the centuries to come