On being a Teaching Fellow

This article was originally published in The Prophet -- a journal created by and for the students at the Boston University School of Theology (BUSTH) to amplify the voices of STH students by promoting and sharing a range of perspectives on matters of concern including, but not limited to, spiritual practices, faith communities and society, the nature of theology, and current affairs. It serves as a platform for STH students to share their academic work, theological reflections, and life experiences with one another and the wider community."One of my former discussion group students asked me to write for the Prophet about what it’s like being a Teaching Fellow at STH... " [EXCERPT

Space syntax and spatial cognition: or why the axial line?

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Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system

The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input. To prevent the culmination of pathological recurrent network excitation or debilitating periods of quiescence, adaptive alterations occur in the signaling molecules and ion channels that control membrane excitability and synaptic transmission. However, rather than encoding (and thus "hardwiring") modified gene copies, the nervous systems of metazoa have opted for expanding on post-transcriptional pre-mRNA splicing by altering key encoded amino acids using a conserved mechanism of A-to-I RNA editing: the enzymatic deamination of adenosine to inosine. Inosine exhibits similar base-pairing properties to guanosine with respect to tRNA codon recognition, replication by polymerases, and RNA secondary structure (i.e.,: forming-capacity). In addition to recoding within the open reading frame, adenosine deamination also occurs with high frequency throughout the non-coding transcriptome, where it affects multiple aspects of RNA metabolism and gene expression. Here, we describe the recoding function of key RNA editing targets in the mammalian central nervous system and their potential to be regulated. We will then discuss how interactions of A-to-I editing with gene expression and alternative splicing could play a wider role in regulating the neuronal transcriptome. Finally, we will highlight the increasing complexity of this multifaceted control hub by summarizing new findings from high-throughput studies. © 2013 Penn, Balik and Greger

THE SAEA: AFTER TWENTY YEARS

Teaching/Communication/Extension/Profession,

TOWARD AN INFORMATION SYSTEM FOR GUIDING RESEARCH IN THE SOYBEAN PRODUCTION ECONOMY

Crop Production/Industries,

CHANGES IN EUROPE AND THE USSR: AN OVERVIEW FOR SOUTHERN AGRICULTURE AND AGRIBUSINESS

Agribusiness,