John Locke and the education of the poor

The purpose of this study was to examine John Locke\u27s views on the education of the poor and compare them with his general philosophy of man and education.;John Locke (1632-1704) is one of the best-known and respected philosophers of the Western World. For three hundred years his famous Essay Concerning Human Understanding has led many philosophers to a view of man as a free and rational being. Unburdened with innate ideas, Locke\u27s man is free to learn to be all that he can be.;Locke extended this general theory into a handbook for education. He published in great detail the training and rigors to be undergone by a child. This book, the famous Some Thoughts concerning Education, told the gentry that a disciplined study of the liberal arts untainted with useless knowledge was the basis of education. This would be augmented with the acquisition of a useful trade. Above all, the gentleman would learn how to learn. .;It seems, however, that all this concern for proper education was aimed at the gentry--the gentlemen who would need these skills to get along in a society of like men. When we look at Locke\u27s ideas on the education of the poor, we see little of the tenderness that was to be afforded the gentry.;Could these seemingly dichotomous views of education--kindness and understanding for the gentry and force and cruelty the poor--be reconciled with Locke\u27s philosophy of the rational and free man?;I hypothesized that John Locke\u27s ideas of education for the poor were consistent with his philosophy of man.;I concluded that Locke\u27s ideas for the education of the poor are indeed consistent with his views of man as put forth in the Essay Concerning Human Understanding and his views of education as shown in Some Thoughts Concerning Education

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

The Northwest Territories Thermokarst Mapping Collective: a northern-driven mapping collaborative toward understanding the effects of permafrost thaw

This paper documents the first comprehensive inventory of thermokarst and thaw-sensitive terrain indicators for a 2 million km2 region of northwestern Canada. This is accomplished through the Thermokarst Mapping Collective (TMC), a research collaborative to systematically inventory indicators of permafrost thaw sensitivity by mapping and aerial assessments across the Northwest Territories (NT), Canada. The increase in NT-based permafrost capacity has fostered science leadership and collaboration with government, academic, and community researchers to enable project implementation. Ongoing communications and outreach have informed study design and strengthened Indigenous and stakeholder relationships. Documentation of theme-based methods supported mapper training, and flexible data infrastructure facilitated progress by Canada-wide researchers throughout the COVID-19 pandemic. The TMC inventory of thermokarst and thaw-sensitive landforms agree well with fine-scale empirical mapping (69%–84% accuracy) and aerial inventory (74%–96% accuracy) datasets. National- and circumpolar-scale modelling of sensitive permafrost terrain contrasts significantly with TMC outputs, highlighting their limitations and the value of empirically based mapping approaches. We demonstrate that the multiparameter TMC outputs support a holistic understanding and refined depictions of permafrost terrain sensitivity, provide novel opportunities for regional syntheses, and inform future modelling approaches, which are urgently required to comprehend better what permafrost thaw means for Canada's North

Evolution of genes and genomes on the Drosophila phylogeny

Affiliations des auteurs : cf page 216 de l'articleInternational audienceComparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species

Evolution of genes and genomes on the Drosophila phylogeny

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species

Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema

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Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 ± 17.0 vs. 60.6 ± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35–0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis. © 2018, The Author(s)