Pompeu Fabra University

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    23042 research outputs found

    Determinants and functions of CAFs secretome during cancer progression and therapy

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    Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis

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    Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.This work was supported by the La Caixa-CRG International Fellowship Program to L.P., the TÁMOP 4.2.4. A/2-11-1-2012-001 “National Excellence Program” to T.N., and was supported in part by OTKA NF 84006, NN00374 (ERA-Net PathoGenomics Program), EMBO Installation Grant and by the Janos Bolyai Fellowship of the Hungarian Academy of Sciences to A.G. T.G. group research is funded in part by a grant from the Spanish Ministry of Economy and Competitiveness (BIO2012-37161), a grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC (grant agreement no. ERC-2012-StG-310325

    Zipf’s law for word frequencies: word forms versus lemmas in long texts

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    Monetary policy and bank lending in developing countries: loan applications, rates, and real effects

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    José-Luis Peydró acknowledges financialsupport from project ECO2015-68182-P (MINECO/FEDER, UE)

    Width and serialization of classical planning problems

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    We introduce a width parameter that bounds the complexity of classical planning problems and domains, along with a simple but effective blind-search procedure that runs in time that is exponential in the problem width. We show that many benchmark domains have a bounded and small width provided thatgoals are restricted to single atoms, and hence that such problems are provably solvable in low polynomial time. We then focus on the practical value of these ideas over the existing benchmarks which feature conjunctive goals. We show that the blind-search procedure can be used for both serializing the goal into subgoals and for solving the resulting problems, resulting in a ‘blind’ planner that competes well with a best-first search planner guided by state-of-the-art heuristics. In addition, ideas like helpful actions and landmarks can be integrated as well, producing a planner with state-of-the-art performance.H. Geffner is partially supported by grants TIN2009-10232,MICINN, Spain, and EC-7PM-SpaceBook

    Pasolini i Haneke contra una estètica de l’Horror

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    Treball de fi de grau d'Humanitats. Curs 2012-2013Director: Antonio Monegal BrancósDir que la violència és el problema fonamental d’Europa i del món és només constatar un fet. El cinema contemporani europeu reflecteix aquesta preocupació en cada fotograma de metratge que surt del continent i que, com la pell del nostre poble, ens recorda el nostre passat, ens presenta la conjuntura actual, i ens descriu un futur inquietant. Però l’essencial, avui en dia, no és comprovar l’indiscutible pes de la temàtica violenta en la nostra realitat factual i cinematogràfica –fet que deixaria relegada qualsevol presumpció d’originalitat en un segon pla- sinó desenredar les formes específiques, múltiples, contradictòries i profundament humanes que aquesta temàtica ens presenta actualment. Només d’aquesta forma podrem veure en quin sentit ens serveixen per explicar el nostre món

    Platform for Automatic, Normalized Annotation and Cost-Effective Acquisition of Language Resources for Human Language Technologies: PANACEA

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    El objetivo de PANACEA es engranar diferentes herramientas avanzadas para construir una fábrica de Recursos Lingüísticos (RL), una línea de producción que automatice los pasos implicados en la adquisición, producción, actualización y mantenimiento de los RL que la Traducción Automática y otras tecnologías lingüísticas, necesitan


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