Diposit Digital de la Universitat de Barcelona

    Double mu(2)-(phenoxido)-bridged dinuclear and polynuclear nickel(II) complexes: Magnetic properties and DNA/protein interaction

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    One dinuclear and one 1D polymeric nickel(II) complex, namely {[Ni2(HL)2(pa)2(H2O)2]·DMF} (1) and {[Ni2(HL)2(ppda)(H2O)2]·DMF·H2O}n (2) (H2L = (E)-2-((1-hydroxybutan-2-ylimino)methyl)phenol, pa = 3-phenylacrylate, ppda = p-phenylenediacrylate) have been synthesized and characterized by X-ray single crystal structure determination. Complex 1 is double phenoxo-bridged dinuclear Ni(II) complex, whereas complex 2 is a 1D polynuclear chain where double phenoxo-bridged dinuclear units are connected through bridging ppda ligands. The variable temperature magnetic behavior of the complexes was studied using the Hamiltonian H = −JS1S2, S1 = S2 = SNi and confirms the presence of an overall antiferromagnetic interaction in both complexes. Good agreement between the experimental and simulated curves were found using the parameters: gNi = 2.15, DNi = 4.0 cm−1 and JNi-Ni = −0.60 cm−1 for 1, and gNi = 2.15, DNi = 4.8 cm−1 and JNi-Ni = −3 cm−1 for 2. The interactions of the complexes with CT-DNA were investigated using UV-Vis absorption and fluorescence spectroscopic methods and they show that both the complexes interact with CT-DNA. The intrinsic binding constants values for interaction with CT-DNA are 3.9(±0.10) × 105 and 3.43(±0.09) × 105 M−1 for 1 and 2, respectively. The interactions of the complexes with bovine serum albumins (BSA) and human serum albumins (HSA) were also studied using electronic absorption and fluorescence spectroscopic techniques and the results show that both complexes interact with the serum albumins via a ground state association process

    Classical anisotropies in models of open inflation

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    In the simplest model of open inflation there are two inflaton fields decoupled from each other. One of them, the tunneling field, produces a first stage of inflation which prepares the ground for the nucleation of a highly symmetric bubble. The other, a free field, drives a second period of slow-roll inflation inside the bubble. However, the second field also evolves during the first stage of inflation, which to some extent breaks the needed symmetry. We show that this generates large supercurvature anisotropies which, together with the results of Tanaka and Sasaki, rule out this class of simple models (unless, of course, Omega0 is sufficiently close to 1). The problem does not arise in modified models where the second field does not evolve in the first stage of inflation

    Authentication of paprika using HPLC-UV fingerprints

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    In this work we combine simple extraction and HPLC-UV methodologies with chemometric pattern-recognition strategies in order to obtain characteristic fingerprints of phenolic compounds that allow the authentication of paprika samples. To illustrate the potential of the proposed approach, two different adulteration scenarios were considered, namely adulteration of paprika based on its type (sweet, bittersweet and spicy) as well as on its region (Murcia, la Vera and Czech Republic). Upon preparation of a proper set of samples, those were analysed using a C18 reversed-phase column and registered chromatograms were then compressed employing fast Fourier transform (FFT) to reduce the large dimensionality of the data set, while preserving all relevant features. Next, data were analysed using linear discriminant analysis (LDA) for the qualitative discrimination of adulterated samples, or by partial least-squares regression (PLS) modelling to quantitatively assess the adulteration degree

    Ceci n'est pas une tit

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    Màster d'Estudis de Dones, Gènere i Ciutadania, Universitat de Barcelona, Facultat de Geografia i Història, any: 2017-2018, Tutora: Meri Torras FrancésEsto es una imagen que contesta. Esto es una copia intervenida de una pieza original, una falsificación, una respuesta artística y paródica a esa violencia, a ese panorama. Porque la imagen no agota el significado de la cosa. Y casi nunca contiene todos sus posibles significados. En lo que sigue, te invito a que te sumerjas en esos significados ocultos por las maniobras políticas de las que eres parte. Te los pongo aquí delante, a pecho descubierto. Para que los veas, para que se vean. Para que -si puedes- tomes la responsabilidad de la parte que te toca (las tetas) y, poco a poco, lleguemos -juntas- a una respuesta colectiva. (Menuda apología moralista de la ética de la vulnerabilidad de los cuerpos y de la vida, ¿verdad?

    El materialismo histórico de Benjamin: tradición, detención y destrucción

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    RESUMEN: Este artículo constituye un acercamiento 'sistemático' a las tesis Sobre el concepto de historia de Walter Benjamin; después de situar las tesis en el conjunto de la obra del autor, se propone una división de las mismas en tres grupos sucesivos, correspondientes a las tres grandes aportaciones o modificaciones que Benjamin realiza con respecto a la concepción de Marx; el objetivo es que este análisis pueda arrojar luz sobre un materialismo histórico sui generis, cuyo sorprendente método consiste en una secreta alianza con la 'teología'. ABSTRACT: This paper constitutes a systematic approach to Benjamin's thesis On the concept of history; after indicating the place of the thesis inside the life's work of the au-thor, I propose their division in three successive groups, corresponding to the three main contributions or modifications that Benjamin realizes regarding to Marx's conception; the objective is that this analysis could bring some light to an historical materialism sui generis, whose surprising methodology consists in a secret alliance with 'theology'

    Blow-up algebras in Algebra, Geometry and Combinatorics

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    [eng] The primary topic of this thesis lies at the crossroads of Commutative Algebra and its interactions with Algebraic Geometry and Combinatorics. It is mainly focused around the following themes: 1) Defining equations of blow-up algebras; 2) Study of rational maps via blow-up algebras; and 3) Asymptotic properties of the powers of edge ideals of graphs. We are primarily interested in questions that arise in geometrical or combinatorial contexts and try to understand how their possible answers manifest in various algebraic structures or invariants. There is a particular algebraic object, the Rees algebra (or blow-up algebra), that appears in many constructions of Commutative Algebra, Algebraic Geometry, Geometric Modeling, Computer Aided Geometric Design and Combinatorics. The work horse and main topic of this doctoral dissertation has been the study of this algebra under various situations. The Rees algebra was introduced in the field of Commutative Algebra in the famous paper published in 1958. Since then it has become a central and fundamental object with numerous applications. The study of this algebra has been so fruitful that it is difficult to single out particular results or papers. From a geometrical point of view, the Rees algebra corresponds with the bi-homogeneous coordinate ring of two fundamental objects: the blow-up of a projective variety along a subvariety and the graph of a rational map between projective varieties. Therefore, the importance of finding the defining equations of the Rees algebra is probably beyond argument. This is a problem of tall order that has occupied commutative algebraists and algebraic geometers, and despite an extensive effort, it remains open even in the case of polynomial rings in two variables. In Chapter 2 of this dissertation, we use the theory of D-module s to describe the defining ideal of the Rees algebra in the case of a parametrization of a plane curve. In a joint work with Buse and D'Andrea, Chapter 3 of this dissertation , we introduce a new algebra that we call the saturated special fiber ring, which turns out to be an important tool to analyze the degree of a rational map. Later, in Chapter 4 of this dissertation, we compute the multiplicity of this new algebra in the case of perfect ideals of height two, which, in particular, provides an effective method to determine the degree of a rational map having those ideals as base ideal. In a joint work with Simis, Chapte r 5 of this dissertation, we consider the behavior of the degree of a rational map under specialization of the coefficients of the defining linear system. The Rees algebra of the edge ideal of a graph is a well studied object, that relates combinatorial properties of a graph with algebraic in variants of the powers of its edge ideal. For the Rees algebra of the edge ideal of a bipartite graph, Chapter 6 of this dissertation, we compute the universal Grobner basis of its defining equations and its total Castelnuovo-Mumford regularity as a bigraded algebra. It is a celeb rated result that the regularity of the powers of a homogeneous ideal is asymptotically a linear function. Considerable efforts have been put forth to understand the form of this asymptotic linear function in the case of edge ideals. In a joint work with Jafari, Picone and Nemati, Chapter 7 of this dissertation, for bicyclic graphs, i.e. graphs containing exactly two cycles, we characterize the regularity of its edge ideal in terms of the induced matching number and determine the previous asymptotic linear function in special cases

    Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

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    A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30-0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients

    De Novo PORCN and ZIC2 mutations in a highly consanguineous family

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    We present a Turkish family with two cousins (OC15 and OC15b) affected with syndromic developmental delay, microcephaly, and trigonocephaly but with some phenotypic traits distinct between them. OC15 showed asymmetrical skeletal defects and syndactyly, while OC15b presented with a more severe microcephaly and semilobal holoprosencephaly. All four progenitors were related and OC15 parents were consanguineous. Whole Exome Sequencing (WES) analysis was performed on patient OC15 as a singleton and on the OC15b trio. Selected variants were validated by Sanger sequencing. We did not identify any shared variant that could be associated with the disease. Instead, each patient presented a de novo heterozygous variant in a different gene. OC15 carried a nonsense mutation (p.Arg95*) in PORCN, which is a gene responsible for Goltz-Gorlin syndrome, while OC15b carried an indel mutation in ZIC2 leading to the substitution of three residues by a proline (p.His404_Ser406delinsPro). Autosomal dominant mutations in ZIC2 have been associated with holoprosencephaly 5. Both variants are absent in the general population and are predicted to be pathogenic. These two de novo heterozygous variants identified in the two patients seem to explain the major phenotypic alterations of each particular case, instead of a homozygous variant that would be expected by the underlying consanguinity

    WRF-LES Simulation of the Boundary Layer Turbulent Processes during the BLLAST Campaign

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    A real case long-term nested large eddy simulation (LES) of 25-day duration is performed using the WRF-LES modelling system, with a maximum horizontal grid resolution of 111 m, in order to explore the ability of the model to reproduce the turbulence magnitudes within the first tens of metres of the boundary layer. Sonic anemometer measurements from a 60-m tower installed during the Boundary Layer Late Afternoon and Sunset Turbulence (BLLAST) field campaign are used for verification, which is focused on the turbulent magnitudes in order to assess the success and limitations in resolving turbulent flow characteristics. The mesoscale and LES simulations reproduce the wind speed and direction fairly well, but only LES is able to reproduce the energy of eddies with lifetimes shorter than a few hours. The turbulent kinetic energy in LES simulation is generally underestimated during the daytime, mainly due to a vertical velocity standard deviation that is too low. The turbulent heat flux is misrepresented in the model, probably due to the inaccuracy of the sub-grid scheme

    Las narrativas del trabajo (versión 0.2)

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    Este texto recrea en forma de juego la idea de que la mujer se encuentra en un continuo de vida-trabajo. No existe "el ángel del hogar" y, por lo tanto, no hay representación de las tareas domésticas, pero éstas son un continuo que estructuran la vida de "b", ya que exigen un constante cuidado y orden. La teórica independencia de la mujer respecto a lo doméstico y el ser autónoma le han hecho adoptar el trabajo como forma de vida. Esta contribución cuestiona el concepto de trabajo y pone en evidencia las carencias de los términos "flexibilidad", "autonomía", "individualidad", etc
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