(A) history of the sonnet, with special reference to England and America

Thesis (M.A.)--Boston University, 1931. This item was digitized by the Internet Archive

Dice: Blessed or Cursed?

Every year, hundreds of millions of dice are manufactured and sold. Because of the impossibility of precise dimensional control and nonuniform density, none of these dice are fair. Polyhedral dice manufactured for role-playing games like Dungeons and Dragons typically contain 4-sided, 6-sided, 8-sided, 10-sided, 12-sided, and 20-sided dice (D4, D6, D8, D10, D12, and D20). D20s are especially problematic. In 3000-roll tests of several D20s, only about one-quarter tested fair. In light of the inherent unfairness of most dice, we explored the possibility of using dice mechanics involving multiple dice to obtain fairer results. For D20s, summing three dice gave promising results. Even using dice that tested highly unfair individually, sums of three dice tested fair. We also considered Fate or Fudge dice mechanics which effectively use the sum of 4 D3s. With one exception, these dice tested fair. In our tests, three D20s tested fairer than four Fate dice

Behavioral responses around conspecific corpses in adult eastern gorillas (gorilla beringei spp.)

Humans were once considered unique in having a concept of death but a growing number of observations of animal responses to dying and dead conspecifics suggests otherwise. Complex arrays of behaviors have been described ranging from corpse removal and burial among social insects to quiet attendance and caregiving among elephants and primates. Less frequently described, however, are behavioral responses of individuals from different age/sex classes or social position toward the death of conspecifics. We describe behavioral responses of mountain gorillas (Gorilla beringei beringei) to the deaths of a dominant silverback and a dominant adult female from the same social group in Volcanoes National Park in Rwanda and the responses of Grauer's gorillas (Gorilla b. graueri) to the corpse of an extra-group silverback in Kahuzi-Biega National Park, Democratic Republic of Congo. In gorillas, interactions between groups or with a lone silverback often result in avoidance or aggression. We predicted that: (i) more individuals should interact with the corpses of same-group members than with the corpse of the extra-group silverback; (ii) adult females with infants should avoid the corpse of the extra-group silverback; and (iii) in the mountain gorilla cases, individuals that shared close social relationships with the dead individual should spend more time with the corpse than other individuals in the group. We used a combination of detailed qualitative reports, photos, and videos to describe all occurrences of affiliative/investigative and agonistic behaviors observed at the corpses. We observed similar responses toward the corpses of group and extra-group individuals. Animals in all three cases showed a variety of affiliative/investigative and agonistic behaviors directed to the corpses. Animals of all age/sex classes interacted with the corpses in affiliative/investigative ways but there was a notable absence of all adult females at the corpse of the extra-group silverback. In all three cases, we observed only silverbacks and blackbacks being agonistic around and/or toward the corpses. In the mountain gorilla cases, the individuals who spent the most time with the corpses were animals who shared close social relationships with the deceased. We emphasize the similarity in the behavioral responses around the corpses of group and extra-group individuals, and suggest that the behavioral responses were influenced in part by close social relationships between the deceased and certain group members and by a general curiosity about death. We further discuss the implications close interactions with corpses have for disease transmission within and between gorilla social groups

Repairing political trust for practical sustainability

High levels of trust in government are important in addressing complex issues, including the realization of the mainstream sustainability agenda. However, trust in government has been declining for decades across the western world, undermining legitimacy and hampering policy implementation and planning for long-term sustainability. We hypothesize that an important factor in this decline is citizen disappointment with the current types of public participation in governance and that this could be reversed through a change from informing/consulting to a relationship of partnership. Using case studies from Western Australia, the paper investigates whether an intervention targeted at establishing a partnership relationship through mini-public, deliberative, participatory budgeting would improve trust and help the implementation of sustainability. These results show evidence of improvements in trust and provide conceptual and practical tools for government administrations wishing to close the detrimental trust gap that may hamper the implementation of a sustainability agenda

Writing in Britain and Ireland, c. 400 to c. 800

No abstract available

Ebola in great apes – current knowledge, possibilities for vaccination and the implications for conservation and human health

Ebola virus disease (EVD) is a threat to human health and the survival of African great apes. The disease has led to major population declines of chimpanzees and gorillas, and infected great apes play an important role as sources of human EVD outbreaks. The threat posed by EVD raises the question whether vaccination of wild apes is a possible strategy to reduce the occurence and impact of this disease. This article reviews the current knowledge about EVD in great apes and emphasizes the link between ape and human outbreaks. It discusses the need for control strategies such as vaccination and describes aspects of primate behavior, virus biology, vaccine composition, and vaccination principles that are necessary to consider when making management decisions about great ape vaccination. Finally, it identifies gaps in the understanding of Ebola ecology and highlights surveillance and research that can aid the survival of great apes and reduce human exposure to Ebola virus. The unpredictable emergence of Ebola viruses and the severe impact of EVD call for efficient monitoring and ultimately control of Ebola. This article provides a platform for further interdiciplinary discussions to decide on optimal management solutions regarding vaccination of great apes against Ebola

Snowball Earth climate dynamics and Cryogenian geology–geobiology

Geological evidence indicates that grounded ice sheets reached sea level at all latitudes during the long‐lived Sturtian (717–659 Ma) and Marinoan (ca 645–635 Ma) glaciations. Combined U-­‐Pb and Re-­‐Os geochronology suggests that the Sturtian glacial onset and both terminations were globally synchronous. Geochemical data imply that atmospheric pCO2 was 102x modern at the Marinoan termination, consistent with Snowball Earth hysteresis. Sturtian glaciation followed the breakup of a tropical supercontinent, and its onset coincided with the equatorial emplacement of a large igneous province. Modeling shows that the small thermal inertia of a globally frozen surface reverses the annual-mean Hadley circulation, resulting in equatorial net sublimation and net deposition elsewhere. Oceanic ice thickens, forming a sea glacier that flows gravitationally toward the equator, sustained by the hydrologic cycle and by basal freeze-on and melting. Tropical ice sheets flow faster as CO2 rises, but lose mass and become sensitive to orbital forcing. Dust accumulation in the equatorial zone engenders supraglacial oligotrophic meltwater ecosystems, favorable for cyanobacteria and many eukaryotes. Meltwater flushing through moulins enables organic burial and submarine deposition of subaerially-­‐erupted volcanic ash. The subglacial ocean is turbulent and well­‐mixed, in response to geothermal heating and conductive heat loss through the ice cover, increasing with latitude. Cap carbonates, unique to Snowball Earth terminations, are products of intense weathering and ocean stratification. Whole-­ocean warming and ice-sheet forebulge collapse allow marine coastal inundations to progress long after ice-sheet disappearance. The evolutionary legacy of Snowball Earth is perceptible in fossils and living organisms

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe