15,578 research outputs found

    The oblique S parameter in higgsless electroweak models

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    We present a one-loop calculation of the oblique S parameter within Higgsless models of electroweak symmetry breaking. We have used a general effective Lagrangian with at most two derivatives, implementing the chiral symmetry breaking SU(2)_L x SU(2)_R -> SU(2)_{L+R} with Goldstones, gauge bosons and one multiplet of vector and axial-vector resonances. The estimation is based on the short-distance constraints and the dispersive approach proposed by Peskin and Takeuchi.Comment: 5 pages, 2 figures. Talk given at QCD@work 2012, International Workshop on Quantum Chromodynamics: Theory and Experiment, 18-21th June (2012), Lecce (Italy

    Monitoring fish populations in Lower Lough Erne, Northern Ireland: applicability of current methods and implications for future monitoring under the EC Water Framework Directive

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    The proposed EC Water Framework Directive (WFD) will require member states to monitor both biotic and abiotic components of lake environments. With adoption of the WFD some measurement of fish populations will also be required. This paper describes work carried out since 1971, and particularly since 1991, on the status of fish populations in Lower Lough Erne, Northern Ireland, with an emphasis on defining change over time due to human impacts on the lake. This offers a reasonable starting point from which to develop a monitoring programme suitable for the needs of the WFD in this lake. The implications for as yet unmonitored fish populations in lakes are also determined

    Quantum loops in the Resonance Chiral Theory: improving the vector form factor

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    Quantum loops in the Resonance Chiral Theory are needed to improve the implementation of non-perturbative QCD. Furthermore, the one-loop computations can predict chiral low-energy couplings at next-to-leading order, a very appealing task. We present a first calculation of the vector form factor of the pion at subleading order in the 1/N_C expansion. From the analysis of the result at large energies we justify the requirement of considering short-distance constraints from form factors with resonances in the final state. The long-distance limit of our results allows to get a next-to-leading order estimate of \ell_6.Comment: Talk given at the International Workshop e+e- Collisions from phi to J/psi, 27th February-2nd March (2006), Novosibirsk (Russia

    Twitter: A Professional Development and Community of Practice Tool for Teachers

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    This article shows how a group of language teachers use Twitter as a tool for continuous professional development through the #MFLtwitterati hashtag. Based on data collected through a survey (n=116) and interviews (n=11), it describes how this collective of teachers use the hashtag and evaluates the impact of their Twitter network on their teaching practices. The results show that most users try the suggestions and ideas that they find on this network, which have a positive impact on their teaching. Finally, the article assesses whether the hashtag users can be described as a community of practice

    Hot-spot analysis for drug discovery targeting protein-protein interactions

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    Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging. Hot-spot residues are seen as the best option to target such interactions, but their identification requires detailed structural and energetic characterization, which is only available for a tiny fraction of protein interactions. Areas covered: In this review, the authors cover a variety of computational methods that have been reported for the energetic analysis of protein-protein interfaces in search of hot-spots, and the structural modeling of protein-protein complexes by docking. This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot predictions can focus the search for inhibitors of protein-protein interactions. Expert opinion: A major difficulty for applying rational drug design methods to protein-protein interactions is that in the majority of cases the complex structure is not available. Fortunately, computational docking can complement experimental data. An interesting aspect to explore in the future is the integration of these strategies for targeting PPIs with large-scale mutational analysis.This work has been funded by grants BIO2016-79930-R and SEV-2015-0493 from the Spanish Ministry of Economy, Industry and Competitiveness, and grant EFA086/15 from EU Interreg V POCTEFA. M Rosell is supported by an FPI fellowship from the Severo Ochoa program. The authors are grateful for the support of the the Joint BSC-CRG-IRB Programme in Computational Biology.Peer ReviewedPostprint (author's final draft
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