6,718 research outputs found

    Death Defied: James Joyce\u27s Naturalistic Evolution

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    Death, as a thematic and narrative motif, is of particular import to the Naturalistic literary approach. This is extremely evident in the work of James Joyce, on whom the Naturalist movement had a notable influence. Throughout his career Joyce utilized the subtext surrounding death in the father-son relationship to criticize Irish culture as it appears in his works. However, Joyce was not content to simply recreate a textbook interpretation of Naturalism. Joyce developed the core principles of the Naturalistic approach, starting with a basic and purely Naturalistic approach in his early writing; Joyce eventually managed to subvert and reinterpret the literary style that inspired his career. In Joyce\u27s earliest short story “The Sisters” (1914) he recounts the death of the defrocked priest Father Flynn from the perspective of a young boy to question the effects of the judgmental and unyielding nature of religion as Flynn is allowed to slip further into ill-health due to being excommunicated from the church. Joyce\u27s work becomes all the more complex in A Portrait of the Artist as a Young Man (1916) as he presents the subtleties of Simon and Stephen Dedalus\u27s relationship, and in the process criticizes paternalism as it leads to Simon\u27s failures and spiritual demise. Finally, in Ulysses (1922) he makes light of death itself as he presents the humorous and irreverent insight of Stephen\u27s alternative father figure Leopold Bloom as he attends the funeral of Paddy Dignam. In my paper I will examine death as it appears in these works spanning Joyce\u27s career. In the process, I observe the effect of Joyce\u27s treatment of death and paternalism, and how they, like his writing and interpretation of Naturalism, evolve throughout his career

    Costs in English and Japanese legal procedure

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    The authors suggest that Japan is a non-litigious society because of high litigation costs and lengthy procedures and explain the system of costs and changes that have been made and consider what still needs to be done. Article by Sato Niiya and Sam Jarman (British Japanese Law Association) published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

    Final Human Rights Assessment of the Events of 19 December 2010 in Minsk, Belarus (CIC: December 2011)

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    N-terminal modification of proteins with o-aminophenols.

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    The synthetic modification of proteins plays an important role in chemical biology and biomaterials science. These fields provide a constant need for chemical tools that can introduce new functionality in specific locations on protein surfaces. In this work, an oxidative strategy is demonstrated for the efficient modification of N-terminal residues on peptides and N-terminal proline residues on proteins. The strategy uses o-aminophenols or o-catechols that are oxidized to active coupling species in situ using potassium ferricyanide. Peptide screening results have revealed that many N-terminal amino acids can participate in this reaction, and that proline residues are particularly reactive. When applied to protein substrates, the reaction shows a stronger requirement for the proline group. Key advantages of the reaction include its fast second-order kinetics and ability to achieve site-selective modification in a single step using low concentrations of reagent. Although free cysteines are also modified by the coupling reaction, they can be protected through disulfide formation and then liberated after N-terminal coupling is complete. This allows access to doubly functionalized bioconjugates that can be difficult to access using other methods

    Linking specification to differentiation:From proneural genes to the regulation of ciliogenesis

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    Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can acquire. One open question is how the regulators of the former process lead to attainment of the latter. “High-level” regulators of cell fate specification include the proneural factors, which drive cells to commit as precursors in the sensory nervous system. Recent research has concentrated on the gene expression events downstream of proneural factor function. Here we summarize this research and describe our own research that has provided clear links between a proneural factor, atonal and the cell biological program of ciliogenesis, which is a central aspect of sensory neuron differentiation

    The Challenge of Peace Building and Conflict Transformation: A Case Study of Northern Ireland

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    This paper provides an overview of the transition from armed conflict to peace in Northern Ireland between 1994 and 2016. It discusses the main stages of the peace process and the main elements of the peace Agreement in relation to the development of global thinking around peacebuilding as set out in the United Nations 1992 report Agenda for Peace and the 2000 Brahimi Report. The paper argues that while Northern Ireland is often highlighted as a positive example of peacebuilding, it is not without its limitations and overall the experience of the past twenty years emphasises the importance of ensuring a broadly inclusive process and the need for a sustained commitment over a long period of time.

    Austria focuses on the short term, Germany the long term, in responding to populism

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    Both the 2017 German and Austrian elections saw large vote shares go to radical right-wing populist parties in the shape of the AfD in Germany and the FPÖ in Austria. But as Alex Jarman writes, the response of Angela Merkel to the challenge posed by the AfD was notably different from how Sebastian Kurz addressed the FPÖ in Austria. He argues that by adopting a radical approach on immigration, Kurz may have found a short-term solution to stop the FPÖ from driving Austrian politics, but Merkel’s approach may ultimately prove to be more beneficial in the long-term
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