Connecting String/M Theory to the Electroweak Scale and to LHC Data

The Standard Model of particle physics explains (almost) all observed non-gravitational microscopic phenomena but has many open theoretical questions. We are on the threshold of unraveling the mysteries of the Standard Model and discovering its extension. This could be achieved in the near future with the help of many experiments in particle physics and cosmology, the LHC in particular. Assuming that data confirming the existence of new physics beyond the Standard Model is obtained, one is left with the very important and challenging task of solving the "Inverse Problem", \emph{viz.} "How can one deduce the nature of the underlying (perhaps microscopic) theory from data?" This thesis explores this question in detail, and also proposes an approach to address the problem in a meaningful way which could prove crucial to the possible solution to this problem in the future. The proposed approach has three aspects - a) To systematically study classes of microscopic (string/$M$ theory) constructions to the extent that they could be connected to low energy physics (electroweak scale), b) To find patterns of experimental observables which are sensitive to the properties of the underlying theoretical constructions thereby allowing us to distinguish among different constructions, and c) To try to get insights about the qualitative features of the theoretical model from data in a bottom-up approach which complements the top-down approach and strengthens it as well. This thesis studies all the above aspects in detail. The methods used and results obtained in this thesis will hopefully be of great importance in solving the Inverse Problem.Comment: PhD Thesis, 320 pages, 63 figures References Adde

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Carolyn Gillelyn, Doris Young, Joyce Banks-Davidson, Patricia Brassel, Jackie Faye Roberts Ammons

On Feb. 25, 1970, more than 60 African American students were arrested following a nonviolent protest staged in front of Fulton Chapel during a performance of the international music revue Up with People. Many of the students were detained at the State Penitentiary at Parchman. Eight students were expelled from the University. Fifty years later, the University of Mississippi commemorated these events with two days of remembrance, including speakers, panel discussions, a staged reading, and a luncheon. The events were sponsored by the Arch Dalrymple III Department of History and the Center for the Study of Southern Culture, with support from the Division of Diversity and Community Engagement and the Office of the Provost.https://egrove.olemiss.edu/blkpower_photo/1005/thumbnail.jp

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease

'A certain minor light':Plath in Brontë country

The poet and academic Sarah Corbett reveals Plath’s profound response to Yorkshire’s powerful and often threatening natural and human landscape, as well as to the writings of Emily Brontë and Ted Hughes. In a handful of poems, Plath can be heard sounding out a Hughesian strain of voice against the ghosts and rumoured angels of her own emergent poetic imagination. These West Yorkshire interludes show Plath making use of an ambivalent energy in the landscape to mirror her self/psyche, a technique that can be seen in many of the Ariel poems, and the beginnings of a working out of the struggle between masculine and feminine voices that was to underpin much of her mature work

Plath's Whimsy

Will May returns us to Plath’s early reception, and finds there a vital but overlooked context for her work: the whimsical. Taking seriously Plath’s fascination with the unthreatening fantasy worlds of children’s stories and their attendant winsome philosophy, May rehabilitates a literary term that has often been used disparagingly by the Movement poets. Instead, he shows us how indebted Plath’s dark comedy and verbal games are to whimsy. With close attention to her children’s stories, May unveils Plath’s cultural conversation with the domestic, the miniature and the absurd, though she herself was disingenuous about her interventions with whimsy. May debunks any notion that Plath’s poetry and stories belong in separate spheres. Neither, he argues, does her children’s writing