8,047 research outputs found

    Learning about learning as systemic practice in the context of environmental decision-making

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    This paper has been written as the author is beginning a new phase of researching learning, investigating what supports people in their environmental decision making. This process of inquiry has arisen partly as a result of the development and teaching of the UK Open University’s Masters ’ level course Environmental decision making – a systems approach. The implications of approaching an inquiry with a view of ‘learning as systemic practice ’ is considered, drawing on insights into practice, skilled behaviour and learning systems from Lave, Wenger, Schon, Varela, Ison and Russell, among others. The relevance of various action research approaches for learning about learning as systemic practice is discussed. The paper finishes by identifying and exploring three focuses, that seem both challenging and important to the author to take account of as the research progresses. They are the needs for (i) systemic praxis (ii) an awareness of distinctions made by those who participate in the process of inquiry and (iii) using an approach with an epistemological dimension

    Activation:the point of view of clients and front line staff

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    Selecting Optimal Combinations of Transcription Factors to Promote Axon Regeneration: Why Mechanisms Matter

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    Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response. To improve outcomes, it is essential to understand and ultimately reverse these neuron-intrinsic constraints. Genetic manipulation of key transcription factors (TFs), which act to orchestrate production of multiple regeneration-associated genes, has emerged as a promising strategy. It is likely that no single TF will be sufficient to fully restore neuron-intrinsic growth potential, and that multiple, functionally interacting factors will be needed. An extensive literature, mostly from non-neural cell types, has identified potential mechanisms by which TFs can functionally synergize. Here we examine four potential mechanisms of TF/TF interaction; physical interaction, transcriptional cross-regulation, signaling-based cross regulation, and co-occupancy of regulatory DNA. For each mechanism, we consider how existing knowledge can be used to guide the discovery and effective use of TF combinations in the context of regenerative neuroscience. This mechanistic insight into TF interactions is needed to accelerate the design of effective TF-based interventions to relieve neuron-intrinsic constraints to regeneration and to foster recovery from CNS injury
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