Radiodermatitis as a consequence of radiation recall induced by acyclovir: case report

BACKGROUND: Radiation recall dermatitis (RRD) is an inflammatory reaction in an area of the skin previously irradiated for cancer treatment. The reaction usually occurs following the administration of a cytotoxic drug. Manifestations range from mild to severe, resulting in tissue necrosis. It is treated with removal of the probable causative agent, daily dressings and surgical debridement of the necrotic area. CASE PRESENTATION: A 54-year-old woman had a previous diagnosis of intraductal carcinoma in situ, and had been submitted to lumpectomy and adjuvant radiotherapy and hormonal therapy. One year after surgery, sores suggestive of herpes zoster infection developed, and treatment with acyclovir was started. At the same time, there was the onset of pain and fever. In the skin area previously irradiated, there was breast hardening, skin infiltration and serosanguinolent discharge. An incisional biopsy was performed to rule out radioinduced sarcoma. The patient was treated with surgical debridement. CONCLUSIONS: This case report describes acyclovir as a possible trigger of RRD, a rare condition that could have been mistaken for an eruption with other causes. In this case, the dermatitis reaction was confined to the previously irradiated area of the skin, which suggested radiation recall. A better understanding of the condition’s mechanism and about the possible joint effects of drugs and radiotherapy on the skin is necessary

INVESTIGAÇÃO DAS CAUSAS E TRATAMENTOS DA DERMATITE ATÓPICA EM CRIANÇAS

Atopic dermatitis is a chronic inflammatory skin disease, common in children, which significantly affects the quality of life of patients and their families. Its clinical management addresses a variety of challenges, including the disease's heterogeneity, associated psychosocial symptoms, and the need for effective and personalized therapies.  Objective: This study aims to conduct an integrative literature review to synthesize current knowledge about atopic dermatitis in children, exploring conventional and emerging therapeutic approaches, as well as challenges and future perspectives in clinical management of the disease. Methodology: The integrative review was conducted through systematic search of scientific articles in electronic databases, using search terms related to atopic dermatitis in children. Studies addressing clinical, therapeutic, and epidemiological aspects of the disease, published in the last 10 years, were included. Results: Analysis of the selected studies highlighted a variety of therapeutic approaches for managing atopic dermatitis in children, including topical therapies, phototherapy, systemic treatments, and new emerging therapeutic options, such as targeted biological therapies and modulation of the cutaneous microbiome. Additionally, challenges in research and clinical management of the disease were identified, including the heterogeneity of atopic dermatitis, associated comorbidities, and the psychosocial impact on quality of life. Conclusion: In conclusion, atopic dermatitis in children remains a significant clinical challenge, requiring an integrated and personalized approach for effective management of the disease. Advances in understanding underlying mechanisms, along with the development of new targeted therapies, promise to improve outcomes for pediatric patients affected by this chronic dermatological condition.A dermatite atópica é uma doença inflamatória crônica da pele, comum em crianças, que afeta significativamente a qualidade de vida dos pacientes e suas famílias. Seu manejo clínico aborda uma variedade de desafios, incluindo a heterogeneidade da doença, os sintomas psicossociais associados e a necessidade de terapias eficazes e personalizadas.Objetivo: Este estudo tem como objetivo realizar uma revisão integrativa da literatura para sintetizar o conhecimento atual sobre a dermatite atópica em crianças, explorando as abordagens terapêuticas convencionais e emergentes, bem como os desafios e perspectivas futuras no manejo clínico da doença. Metodologia: A revisão integrativa foi realizada por meio da busca sistemática de artigos científicos em bases de dados eletrônicas, utilizando termos de pesquisa relacionados à dermatite atópica em crianças. Foram incluídos estudos que abordavam aspectos clínicos, terapêuticos e epidemiológicos da doença, publicados nos últimos 10 anos. Resultados: A análise dos estudos selecionados destacou uma variedade de abordagens terapêuticas para o manejo da dermatite atópica em crianças, incluindo terapias tópicas, fototerapia, tratamentos sistêmicos e novas opções terapêuticas emergentes, como terapias biológicas direcionadas e modulação do microbioma cutâneo. Além disso, foram identificados desafios na pesquisa e no manejo clínico da doença, incluindo a heterogeneidade da dermatite atópica, comorbidades associadas e o impacto psicossocial na qualidade de vida. Conclusão: Em conclusão, a dermatite atópica em crianças continua a ser um desafio clínico significativo, exigindo uma abordagem integrada e personalizada para o manejo eficaz da doença. Avanços na compreensão dos mecanismos subjacentes, juntamente com o desenvolvimento de novas terapias direcionadas, prometem melhorar os resultados para os pacientes pediátricos afetados por essa condição dermatológica crônica

Search for the associated production of a Higgs boson with a single top quark in proton-proton collisions at root s=8 TeV

Peer reviewe

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity