Rethinking data augmentation for adversarial robustness

Recent work has proposed novel data augmentation methods to improve the adversarial robustness of deep neural networks. In this paper, we re-evaluate such methods through the lens of different metrics that characterize the augmented manifold, finding contradictory evidence. Our extensive empirical analysis involving 5 data augmentation methods, all tested with an increasing probability of augmentation, shows that: (i) novel data augmentation methods proposed to improve adversarial robustness only improve it when combined with classical augmentations (like image flipping and rotation), and even worsen adversarial robustness if used in isolation; and (ii) adversarial robustness is significantly affected by the augmentation probability, conversely to what is claimed in recent work. We conclude by discussing how to rethink the development and evaluation of novel data augmentation methods for adversarial robustness. Our open-source code is available at https://github.com/eghbalz/rethink_da_for_a

Disulfiram for the treatment of cocaine dependence

Background: Cocaine is a psychostimulant used by approximately 0.4% of the general population worldwide. Cocaine dependence is a chronic mental disorder characterised by the inability to control cocaine use and a host of severe medical and psychosocial complications. There is current no approved pharmacological treatment for cocaine dependence. Some researchers have proposed disulfiram, a medication approved to treat alcohol use disorder. This is an update of a Cochrane review first published in 2010. Objectives: To evaluate the efficacy and safety of disulfiram for the treatment of cocaine dependence. Search methods: We updated our searches of the following databases to August 2022: the Cochrane Drugs and Alcohol Group Specialised Register, CENTRAL, MEDLINE, Embase, CINAHL, and PsycINFO. We also searched for ongoing and unpublished studies via two trials registries. We handsearched the references of topic-related systematic reviews and included studies. The searches had no language restrictions. Selection criteria: We included randomised controlled trials that evaluated disulfiram alone or associated with psychosocial interventions versus placebo, no intervention, other pharmacological interventions, or any psychosocial intervention for the treatment of cocaine dependence. Data collection and analysis: We used standard methodological procedures expected by Cochrane. Main results: Thirteen studies (1191 participants) met our inclusion criteria. Disulfiram versus placebo or no treatment Disulfiram compared to placebo may increase the number of people who are abstinent at the end of treatment (point abstinence; risk ratio (RR) 1.58, 95% confidence interval (CI) 1.05 to 2.36; 3 datasets, 142 participants; low-certainty evidence). However, compared to placebo or no pharmacological treatment, disulfiram may have little or no effect on frequency of cocaine use (standardised mean difference (SMD) -0.11 standard deviations (SDs), 95% CI -0.39 to 0.17; 13 datasets, 818 participants), amount of cocaine use (SMD -0.00 SDs, 95% CI -0.30 to 0.30; 7 datasets, 376 participants), continuous abstinence (RR 1.23, 95% CI 0.80 to 1.91; 6 datasets, 386 participants), and dropout for any reason (RR 1.20, 95% CI 0.92 to 1.55; 14 datasets, 841 participants). The certainty of the evidence was low for all these outcomes. We are unsure about the effects of disulfiram versus placebo on dropout due to adverse events (RR 12.97, 95% CI 0.77 to 218.37; 1 study, 67 participants) and on the occurrence of adverse events (RR 3.00, 95% CI 0.35 to 25.98), because the certainty of the evidence was very low for these outcomes. Disulfiram versus naltrexone Disulfiram compared with naltrexone may reduce the frequency of cocaine use (mean difference (MD) -1.90 days, 95% CI -3.37 to -0.43; 2 datasets, 123 participants; low-certainty evidence) and may have little or no effect on amount of cocaine use (SMD 0.12 SDs, 95% CI -0.27 to 0.51, 2 datasets, 123 participants; low-certainty evidence). We are unsure about the effect of disulfiram versus naltrexone on dropout for any reason (RR 0.86, 95% CI 0.56 to 1.32, 3 datasets, 131 participants) and dropout due to adverse events (RR 0.50, 95% CI 0.07 to 3.55; 1 dataset, 8 participants), because the certainty of the evidence was very low for these outcomes. Authors' conclusions: Our results show that disulfiram compared to placebo may increase point abstinence. However, disulfiram compared to placebo or no pharmacological treatment may have little or no effect on frequency of cocaine use, amount of cocaine use, continued abstinence, and dropout for any reason. We are unsure if disulfiram has any adverse effects in this population. Caution is required when transferring our results to clinical practice

Can we really solve an arch stability problem?

We bring attention to the problem of solving nonlinear boundary-value problems for elastic structures such as arches and shells. Here we discuss a classical problem of a shear-deformable arch postbuckling. Considering a postbuckling behaviour of a circular arch we discuss the possibility to find numerically a solution for highly nonlinear regimes. The main attention is paid to the problem of determination of all solutions. The main conclusion that there is no guarantee to find all solutions, in general

On rotary inertia of microstuctured beams and variations thereof

We discuss the classic rotary inertia notion and extend it for microstructured beams introducing new microinertia parameters as an additional dynamic response to microstructure changes. Slender structures made of beam- or platelet-lattice metamaterials may exhibit not only large translations and rotations but also general deformations of inner structure. Here we considered a few examples of beam-like structures and derive their inertia properties which include effective mass density, rotary inertia and microinertia. Extended dynamic characteristics related to enhanced kinematics may be crucial for description of origami-like structures or other beam-lattice metamaterials

Interpreting siliciclastic sedimentation in the upper Paleozoic Mulargia-Escalaplano Basin (Sardinia, Italy): influence of tectonics on provenance

Late to post-Variscan molassic basins of Late Pennsylvanian-Permian age are exposed in Sardinia (Italy). Here, the compositional and stratigraphic evolution of the Mulargia-Escalaplano sedimentary basin (central Sardinia) has been investigated to highlight how the tectono-magmatic processes have influenced the sedimentation. Ruditic and arenitic samples were collected along well-characterized stratigraphic sections to provide a new insight into the impact of the tectono-magmatic processes on siliciclastic sedimentation. As a result, the conglomerates are mainly clast-supported, petromictic, and thus immature, with no defined maturity trend upwards. Nevertheless, pebble composition changes in times from Variscan basement pebble-rich to volcanic rock-rich, as a consequence of the basin widening and the dismantling and reworking of the coeval volcanic activity. The sandstone composition clearly changes from quartzolithic to feldspatholithic upwards, as a response to the same change of feeding and reworking of the volcanic rocks. Occasionally, interbedded quartzolithic arenites suggest exceptional floods carrying debris from the far borders of the basin. Also, the immature sandstone composition has been interpreted as being controlled by a continuous supply of fresh debris and to a rapid burial rate. In addition, the disappearance of metaradiolarite (lydite AA) Paleozoic grains in the sandstone mineral suite could represent a distinctive marker of a progressive unroofing of the Variscan chain and a clastic supply from deeper tectonic units

A flexible methodological approach to ground resilience-oriented planning policies

Following the European Environment Agency (2019), “land take” can be understood as the phenomenon wherein urban areas, with their impermeable surfaces, encroach upon agricultural or forested areas. The most severe manifestation of land take is soil sealing, an irreversible process driven by building activities and infrastructure construction where pervious land covers, characterized by the presence of soil and vegetation, are replaced by impervious artificial materials such as asphalt and concrete. Land cover dynamics, such as land take, modify soil characteristics, hydrogeological processes, and vegetation structure, and are therefore strongly connected with landslides, i.e., with the downward and outward movement of rocks and soils. Moreover, by causing the loss of natural and seminatural ecosystems, land take and soil sealing bring about the loss of multiple ecosystem services, i.e., the benefits that ecosystem supply to human beings. Some ecosystem services are relevant to the RETURN project because they contribute to reducing hazards and risks in urban and metropolitan areas; labeled “regulating ecosystem services”, these include local temperature regulation, urban flood risk mitigation, coastal protection. The relation between land cover changes and landslides has been studied by various authors (among many, Pisano et al., 2017, Hao et al., 2022), yet the relation between land take and landslide hazard is still under-researched. Therefore, such relation is here assessed to understand to what extent land-taking processes increase landslides, and it is investigated by taking as a case study the catchment basin that includes the town of Sassari, and by coupling spatial analyses and inferential models. This analytical framework is also applied within Spoke TS1 of the RETURN project to analyze, in quantitative and spatially explicit terms, the relationship between hazards related to climate change in urban and metropolitan areas, such as heat waves, and the provision of multiple ecosystem services supplied by green areas (WP3, task 5.3.4), therefore paving the way for identifying place-specific policy recommendations to improve the local environmental quality (WP4, task 5.4.3), and in turns, the quality of urban life

Prediction of severe infections in chronic lymphocytic leukemia: a simple risk score to stratify patients at diagnosis

Chronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and mortality. However, the impact of hypogammaglobulinemia on infection rates is controversial. We aimed to identify clinical and biological parameters linked to the risk of severe infectious events. Additionally, we set up a straightforward risk infection score to stratify CLL patients at diagnosis, thereby enabling the development of suitable infection prevention strategies. We retrospectively evaluated 210 unselected CLL patients diagnosed between 1988 and 2018. This evaluation encompassed demographics, Binet stage, immunoglobulin (Ig) levels, treatment history, comorbidities, and IGHV mutational status at diagnosis. The frequency and severity of infectious events were recorded. Analysis revealed that age, IGHV mutational status, Binet stage, and hypogammaglobulinemia were statistically associated with the Time to First Infection (TTFI) in univariate and multivariate analyses. Using hazard ratios from the multivariate analysis, we finally devised a risk scoring system that integrated age, IGHV mutational status, immunoglobulin levels, and Binet stage to stratify patients at diagnosis based on their specific infection risk. In our cohort, disease progression and infections were the leading cause of death. These findings pointed out the clinical need for a screening process strategic for defining infectious risk at the time of CLL diagnosis, with a significant enhancement in the clinical management of these patients

RadioLab project: knowledge of radon gas in Italy

AbstractRadioLab is an Italian project, addressed to school-age people, and designed for the dissemination of scientific culture on the theme of environmental radioactivity, with particular regards to the importance of knowledge of radon gas exposure. The project is a nationwide initiative promoted by the National Institute of Nuclear Physics- INFN. First tool used by the project, and of immediate impact to assess the public awareness on radon, is the administration of the survey “do you know the radon gas?”. In the survey, together with the knowledge of radon and of its sources, information on personal, cultural and territorial details regarding the interviewees are also taken. Reasonably, the survey invests not only young people, but also their relatives, school workers and, gradually, the public. The survey is administrated during exhibitions or outreach events devoted to schools, but also open to the public. The survey is in dual form: printed and online. The online mode clearly leads RadioLab project even outside the school environment. Based on the results of the survey, several statistical analyses have been performed and many conclusions are drawn about the knowledge of the population on the radon risk. The RadioLab benefit and the requirement to carry on the project goals, spreading awareness of environmental radioactivity from radon, emerge. The dataset involves all twenty Italian regions and consists of 28,612 entries covering the 5-year period 2018–2022

Spin-Resolved Magneto-Tunneling and Giant Anisotropic g-Factor in Broken Gap InAs-GaSb Core-Shell Nanowires

We experimentally and computationally investigate the magneto-conductance across the radial heterojunction of InAs-GaSb core-shell nanowires under a magnetic field, B, up to 30 T and at temperatures in the range 4.2-200 K. The observed double-peak negative differential conductance markedly blue-shifts with increasing B. The doublet accounts for spin-polarized currents through the Zeeman split channels of the InAs (GaSb) conduction (valence) band and exhibits strong anisotropy with respect to B orientation and marked temperature dependence. Envelope function approximation and a semiclassical (WKB) approach allow to compute the magnetic quantum states of InAs and GaSb sections of the nanowire and to estimate the B-dependent tunneling current across the broken-gap interface. Disentangling different magneto-transport channels and a thermally activated valence-to-valence band transport current, we extract the g-factor from the spin-up and spin-down dI/dV branch dispersion, revealing a giant, strongly anisotropic g-factor in excess of 60 (100) for the radial (tilted) field configurations