Rotational Support of Giant Clumps in High-z Disc Galaxies

We address the internal support against total free-fall collapse of the giant clumps that form by violent gravitational instability in high-z disc galaxies. Guidance is provided by an analytic model, where the proto-clumps are cut from a rotating disc and collapse to equilibrium while preserving angular momentum. This model predicts prograde clump rotation. This is confirmed in hydro-AMR zoom-in simulations of galaxies in a cosmological context. In most high-z clumps, the centrifugal force dominates the support, R=Vrot^2/Vcirc^2 > 0.5, where Vrot is the rotation velocity and Vcirc is the circular velocity. The clump spin indeed tends to be in the sense of the global disc angular momentum, but substantial tilts are frequent. Most clumps are in Jeans equilibrium, with the rest of the support provided by turbulence. Simulations of isolated gas-rich discs that resolve the clump substructure reveal that the cosmological simulations may overestimate R by ~30%, but the dominance of rotational support at high-z is not a resolution artifact. In turn, isolated gas-poor disc simulations produce at z=0 smaller gaseous non-rotating transient clouds, indicating that the difference in rotational support is associated with the fraction of cold baryons in the disc. In our current cosmological simulations, the clump rotation velocity is typically Vrot~100 km/s, but when beam smearing of \geq 0.1 arcsec is imposed, the rotation signal is reduced to a small gradient of \leq 30 km/s/kpc across the clump. The velocity dispersion in the simulated clumps is comparable to the disc dispersion so it is expected to leave only a marginal signal. Retrograde minor-merging galaxies could lead to massive clumps that do not show rotation.Testable predictions of the scenario as simulated are that the mean stellar age of the clumps, and the stellar fraction, are declining linearly with distance from the disc center.Comment: accepted at MNRAS, 34 pages, 25 figures, 5 tables, movies and high-resolution version can be found at http://www.phys.huji.ac.il/~ceverino/Site/Welcome.htm

Writing in Britain and Ireland, c. 400 to c. 800

No abstract available

Self-Regulated Star Formation in Galaxies via Momentum Input from Massive Stars

Feedback from massive stars is believed to play a critical role in shaping the galaxy mass function, the structure of the interstellar medium (ISM), and the low efficiency of star formation, but the exact form of the feedback is uncertain. In this paper, the first in a series, we present and test a novel numerical implementation of stellar feedback resulting from momentum imparted to the ISM by radiation, supernovae, and stellar winds. We employ a realistic cooling function, and find that a large fraction of the gas cools to <100K, so that the ISM becomes highly inhomogeneous. Despite this, our simulated galaxies reach an approximate steady state, in which gas gravitationally collapses to form giant molecular clouds (GMCs), dense clumps, and stars; subsequently, stellar feedback disperses the GMCs, repopulating the diffuse ISM. This collapse and dispersal cycle is seen in models of SMC-like dwarfs, the Milky-Way, and z~2 clumpy disk analogues. The simulated global star formation efficiencies are consistent with the observed Kennicutt-Schmidt relation. Moreover, the star formation rates are nearly independent of the numerically imposed high-density star formation efficiency, density threshold, and density scaling. This is a consequence of the fact that, in our simulations, star formation is regulated by stellar feedback limiting the amount of very dense gas available for forming stars. In contrast, in simulations without stellar feedback, i.e. under the action of only gravity and gravitationally-induced turbulence, the ISM experiences runaway collapse to very high densities. In these simulations without feedback, the global star formation rates exceed observed galactic star formation rates by 1-2 orders of magnitude, demonstrating that stellar feedback is crucial to the regulation of star formation in galaxies.Comment: 24 pages, 13 figures, accepted to MNRAS (significantly expanded to match accepted version). Movies of the simulations here can be found at https://www.cfa.harvard.edu/~phopkins/Site/Movies_sbw.htm

The effect of formocresol on hamster connective tissue cells, a histologic and quantitative radioautographic study with proline-H3

The reaction to formocresol of connective tissue cells has been examined in sponge implants and femur wounds, by means of quantitative radioautography following proline-H3 injection. For twenty-four hamsters, a sponge implant on the dorsum of the neck and a surgical opening in the right femur were prepared. Formocresol was diluted to 1/50 of a normal concentration for the sponge implant study and the normal concentration was tested on the femur. The time intervals from application of the drug to sacrifice were 5 hr, 1 day, 3 and 10 days, and 1 month. Proline-H3 was injected 4 or 24 hr prior to sacrifice. Three animals were used for the scintillation counting of blood level of tritium from 2.5 min to 6 days. The tissues were fixed in Bouin's solution, embedded and sectioned in a routine manner. The sections were coated with Kodak NTB-3 emulsion and exposed for suitable lengths of time. Formocresol used in 1/50 concentration caused degeneration of cells in the immediate vicinity of the sponge implant as judged by histology and radioautographic grain counts. However, in all animals treated with formocresol a definite reduction in the number of infiltrating inflammatory cells was observed. By the tenth day both the experimental and control sponges showed a comparable recovery of the connective tissue ingrowth. This was also true for the repair in the femur wound area. It was concluded that formocresol does not interfere with prolonged recovery of connective tissue and might suppress initial inflammatory response, significantly.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33206/1/0000594.pd

A lexicon of DNA modifications: their roles in embryo development and the germline

5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are thought to be solely associated with DNA damage. However, growing evidence indicates that some base modifications, namely 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxylcytosine (5caC), and N6-methadenine (6mA), may be of biological relevance, particularly during early stages of embryo development. Although abundance of these DNA modifications in eukaryotic genomes can be low, there are suggestions that they cooperate with other epigenetic markers to affect DNA-protein interactions, gene expression, defense of genome stability and epigenetic inheritance. Little is still known about their distribution in different tissues and their functions during key stages of the animal lifecycle. This review discusses current knowledge and future perspectives of these novel DNA modifications in the mammalian genome with a focus on their dynamic distribution during early embryonic development and their potential function in epigenetic inheritance through the germ line

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified