Controlling single-photon detector ID210 with bright light

We experimentally demonstrate that a single-photon detector ID210 commercially available from ID Quantique is vulnerable to blinding and can be fully controlled by bright illumination. In quantum key distribution, this vulnerability can be exploited by an eavesdropper to perform a faked-state attack giving her full knowledge of the key without being noticed. We consider the attack on standard BB84 protocol and a subcarrier-wave scheme, and outline a possible countermeasure.Comment: 6 pages, 5 figure

Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation

Rapid repair of the denuded alveolar surface after injury is a key to survival. The respiratory tract contains several sources of endogenous adult stem cells residing within the basal layer of the upper airways, within or near pulmonary neuroendocrine cell rests, at the bronchoalveolar junction, and within the alveolar epithelial surface, which contribute to the repair of the airway wall. Bone marrow-derived adult mesenchymal stem cells circulating in blood are also involved in tracheal regeneration. However, an organism is frequently incapable of repairing serious damage and defects of the respiratory tract resulting from acute trauma, lung cancers, and chronic pulmonary and airway diseases. Therefore, replacement of the tracheal tissue should be urgently considered. The shortage of donor trachea remains a major obstacle in tracheal transplantation. However, implementation of tissue engineering and stem cell therapy-based approaches helps to successfully solve this problem. To date, huge progress has been achieved in tracheal bioengineering. Several sources of stem cells have been used for transplantation and airway reconstitution in animal models with experimentally induced tracheal defects. Most tracheal tissue engineering approaches use biodegradable three-dimensional scaffolds, which are important for neotracheal formation by promoting cell attachment, cell redifferentiation, and production of the extracellular matrix. The advances in tracheal bioengineering recently resulted in successful transplantation of the world's first bioengineered trachea. Current trends in tracheal transplantation include the use of autologous cells, development of bioactive cell-free scaffolds capable of supporting activation and differentiation of host stem cells on the site of injury, with a future perspective of using human native sites as micro-niche for potentiation of the human body's site-specific response by sequential adding, boosting, permissive, and recruitment impulses

Immunogenetics of Hashimoto's thyroiditis

Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease. It is a complex disease, with a strong genetic component. To date, significant progress has been made towards the identification and functional characterization of HT susceptibility genes. In this review, we will summarize the recent advances in our understanding of the genetic input to the pathogenesis of HT

Secure storage and transfer of data in a smart lock system

The Internet of Things plays a bigger and bigger role in our everyday life. One example of IoT devices are smart locks. Lukoton Experience Oy is a Finnish company working on smart lock systems for businesses. The aims of this work were to analyse their existing smart lock system from the security perspective and to design a new system using the opportunities of an Atmel Corporation EEPROM chip with embedded cryptographic functions. Subsequent to this, the new design was compared to the existing system as well as to similar products on the market. The new system uses AES encryption in CCM mode, stores the keys only in a protected EEPROM chip and the cloud server, and uses Bluetooth Low Energy and HTTPS channels for sending data. The paper presents the new system in detail and shows that it is more secure than the existing one by providing authentication and message integrity as well as better protection of the chip at hardware and software level. It rejects all common attacks and stops Replay attacks at an earlier stage. The new system also resists attacks that many analogues on the market are susceptible to

Pedestrian Dead-Reckoning Algorithms For Dual Foot-Mounted Inertial Sensors

This work proposes algorithms for reconstruction of closed-loop pedestrian trajectories based on two foot-mounted inertial measurement units (IMU). The first proposed algorithm allows calculation of a trajectory using measurements from only one IMU. The second algorithm uses data from both foot-mounted IMUs simultaneously. Both algorithms are based on the Kalman filter and the assumption that while a foot is on the ground its velocity is supposed to be zero. Two methods for comparing the obtained trajectories are proposed, advantages and disadvantages of each method are indicated and a way to optimize the computation time is presented. In addition, a method is proposed for constructing one generalized trajectory of human motion based on the trajectories of each leg.Comment: The data used in the article are available for downloading at http://gartseev.ru/projects/mkins201

Lack of association between genetic markers on chromosome 16q22-Q24 and type 1 diabetes in Russian affected families

Aim To evaluate whether the T1D susceptibility locus on chromosome 16q contributes to the genetic susceptibility to T1D in Russian patients. Method Thirteen microsatellite markers, spanning a 47-centimorgan genomic region on 16q22-q24 were evaluated for linkage to T1D in 98 Russian multiplex families. Multipoint logarithm of odds (LOD) ratio (MLS) and nonparametric LOD (NPL) values were computed for each marker, using GENEHUNTER 2.1 software. Four microsatellites (D16S422, D16S504, D16S3037, and D16S3098) and 6 biallelic markers in 2 positional candidate genes, ICSBP1 and NQO1, were additionally tested for association with T1D in 114 simplex families, using transmission disequilibrium test (TDT). Results A peak of linkage (MLS = 1.35, NPL = 0.91) was shown for marker D16S750, but this was not significant (P = 0.18). The subsequent linkage analysis in the subset of 46 multiplex families carrying a common risk HLA-DR4 haplotype increased peak MLS and NPL values to 1.77 and 1.22, respectively, but showed no significant linkage (P = 0.11) to T1D in the 16q22-q24 genomic region. TDT analysis failed to find significant association between these markers and disease, even after the conditioning for the predisposing HLA-DR4 haplotype. Conclusion Our results did not support the evidence for the susceptibility locus to T1D on chromosome 16q22-24 in the Russian family data set. The lack of association could reflect genetic heterogeneity of type 1 diabetes in diverse ethnic groups