15 research outputs found
Heatwave planning: the role of the community in co-producing resilience
- Author
- Ben Fagan-Watson
- Boyatzis R. E.
- Boyle D.
- Burchell K.
- CARRI
- Connolly J.
- Cooke B.
- Department of Communities and Local Government (DCLG)
- Department of Energy and Climate Change (DECC)
- HM Government
- Kevin Burchell
- Kovats R.
- Lewis J.
- Mguni N.
- NCVO
- Newman P.
- Office for National Statistics (ONS)
- Office for National Statistics (ONS)
- Petcou C.
- Realpe A.
- Rezaei M.
- Scottish Government
- Twigger-Ross C.
- Watson B.
- Watson B.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2016
- Field of study
Drawing on a thematic analysis of relevant policy documents, the aim of this paper is to comment on an apparent disconnect between two associated contemporary UK policy areas: planning for heatwaves and community resilience. Regional and national policy documents that plan for heatwaves in the UK tend to focus on institutional emergency responses and infrastructure development. In these documents, although communities are mentioned, they are understood as passive recipients of resilience that is provided by active institutions. Meanwhile, contemporary discussion about community resilience highlights the potential for involving communities in planning for and responding to emergencies (although the concept is also the subject of critique). Within this context, the paper proposes that – through engagement with the ‘community resilience’ policy agenda and its critique – effort should be made to articulate and realise greater participation by individuals, and voluntary and community sector groups in heatwave preparation, planning and response
What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems?
- Author
- Publication venue
- A report to the Department for Environment, Food and Rural Affairs. Policy Studies Institute. Defra, London
- Publication date
- 01/01/2014
- Field of study
Pioneering British exploration and scriptural geography: The Syrian Society/The Palestine Association
- Author
- Anderson
- Anderson
- Anville
- Ariel
- Atkin
- Barker
- Ben-Arieh
- Bliss
- Cameron
- Chakrabarty
- Chamberlain
- Courtney
- Dawson
- della Dora
- Driver
- Dunbar
- Edney
- Elgohary
- Evans
- Fagan
- Fahmy
- Freeman
- Frendo
- Gascoigne
- Gascoigne
- Godlewska
- Godlewska
- Goren
- Goren
- Grant
- Hallett
- Hamilton
- Henry
- Home
- Jackson
- Jacotin
- Jacotin
- Kark
- Kark
- Kelly
- Kruse
- Kutluoğlu
- Laughton
- Laurens
- Lester
- Lipman
- Livingstone
- Livingstone
- Mackay
- Markham
- Marlowe
- Mill
- Miller
- Miller
- Moscrop
- No Author
- Rogerson
- Rogerson
- Schienerl
- Seetzen
- Seetzen
- Silberman
- Stafford
- Stoneman
- Tuchman
- von Zach
- Watson
- Webster
- Whithers
- Wood
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Irregular Work Scheduling and Its Consequences
- Author
- . N Jobs With Justice San Francisco
- A L Kalleberg
- Aarons-Mele
- Andrew Heisz
- Andrew Sum
- Anna Beninger
- Anna Haley-Lock
- Ariane Hegewisch
- Ariane Hegewisch
- Arthur Delaney
- Ballotpedia
- Ben Peck
- Boushey Heather
- Bryce Covert
- Charlotte Alexander
- Charlotte Alexander
- Colette Fagan
- D Shin
- Dave Jamieson
- Dilek Yildirim
- Dina Bakst
- Donatella Camerino
- Donggyun Shin
- E Mccrate
- Eileen Appelbaum
- Elaine Mccrate
- Elise Gould
- Ellen K Scott
- Erin L Kelly
- Erin L Kelly
- Filip Jolevski
- Fran�oise Carr�
- G I Kassinis
- Garth Andrews
- Gerald Mayer
- Giovanni Costa
- Gordon Lafer
- Guy Standing
- H Chung
- H Shaefer
- Heather Boushey
- Heather Boushey
- Heidi Shierholz
- I Zeytinoglu
- J E Swanberg
- J R Henly
- J Williams
- Jacob S Hacker
- Jacquelyn B Ojha
- James E Martin
- James Ziliak
- Jared Bernstein
- Jean Mcguire
- Jennifer E Swanberg
- Jianghong Li
- Joan C Williams
- Joan Williams
- Joann Prause
- Jodi Kantor
- Jody Heymann
- Jonathan Murdoch
- Jonathan Williams
- Julia R Henly
- K S Lyness
- Karen Dynan
- Karen M Olsen
- Katherine Lewis
- Kenneth Matos
- Kenneth Matos
- L Golden
- L Golden
- Lane C Powell
- Liz Ben-Ishai
- Liz Ben-Ishai
- Liz Ben-Ishai
- Liz Watson
- Lonnie Golden
- Lonnie Golden
- Lonnie Golden
- Lonnie Golden
- Lonnie Golden
- Lonnie Golden
- M Basner
- M Wooden
- Maike Andresen
- Maria E Canon
- Maria Mcnamara
- Marianne Kulow
- Mar�a E Enchautegui
- Mcnamara
- Messenger
- Mich :W E Kalamazoo
- Molly Dahl
- N Bloom
- N Skinner
- Nancy K Cauthen
- Nantiya Ruan
- Paul Ziobro
- Peter Berg
- Peter Gottschalk
- Peter Gottschalk
- Philip Bohle
- Philip Tucker
- Philippe Askenazy
- Pilon Annie
- R Julia
- Rebecca Glauber
- Rebecca Joyce Kissane
- Roger Wilkins
- Rothstein
- S J Correll
- S Sweet
- Sara Charlesworth
- Scott M Stringer
- Seth D Harris
- Shane T Jensen
- Shelley Boots
- Short-Shifted
- Starosciak
- Stephanie Luce
- Stephen Sweet
- Stephen Wood
- Steven Kroll
- Susan J Lambert
- Susan J Lambert
- Susan J Lambert
- Susan J Lambert
- Susan Lambert
- Susan Lambert
- Susannah Locke
- The White House
- Wendy Wang
- �ngel Gonz�lez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Acceleration of Coronal Mass Ejection Plasma in the Low Corona as Measured by the Citizen CATE Experiment
- Author
- Adrianna Mitchell
- Alex Falatoun
- Alexander Beltzer-Sweeney
- Alexandria Temple
- Alexus Cochran
- Allyn Smith
- Alyssa Levsky
- Amy Riddle
- Amy Winebarger
- Andi York
- Andreea Boeck
- Andrei Ursache
- Angela Speck
- Anne L. Simacek
- Anthony Allen
- Arianna M. Roberts
- Arnie Cerny
- Ashley Staab
- Austen Kenney
- Austin Ryan
- Bart Tolbert
- Ben Fagan
- Ben Nielsen
- Ben Trumpenski
- Bentley Bee
- Beth Short
- BillyJoe Menard
- Bob Anderson
- Bob Blair
- Brain Baker
- Brian Jackson
- Bruce Alder
- Bruce Callen
- Bruno Acevedo
- Bryan Costanza
- Bryan Scherrer
- Brynn Brettell
- Burton Briggs
- C. Alexandra Hart
- Caitlin Lynch
- Caleb Russell
- Capp Yess
- CDAW Data Center
- Charles Cynamon
- Charles Kennedy
- Charlie Wessinger
- Chris Bremer
- Chris Mandrell
- Chris Midden
- Christian Nations
- Chuck F. Claver
- Cole Bramhall
- Connor Worthen
- Corey Pantuso
- Corina Ursache
- Damani Proctor
- Daniel Smith
- Daniel Stelly
- Daniel Zavala
- Danielle Hoops
- David Anderson
- David Dembinski
- David Elmore
- David Garrison
- David Gerdes
- David Higgins
- David Matthews
- David Slimmer
- David Young
- Dawn Cynamon
- Dawson Poste
- Debbie Penn
- Declan Jensen
- Denese Lighthill
- Dimitri Klebe
- Dinuka Gallaba
- Donald Walter
- Donavan Smith
- Doug Justice
- Doug Scribner
- Drew Hathaway
- Duane Gregg
- Dylan Boggs
- Dylan Garrison
- Dylan Sandbak
- Eleanor Doucette
- Elena Ursache
- Elijah Pelofske
- Ella Erickson
- Elliott Iwen
- Emilie McClellan
- Eric Weitzel & Team
- Erin Thompson
- Esteban Rivera
- Ethan Caudill
- Ethan Orr
- Fred Isberner
- Gabriel Wierzorec
- Gabrielle W. Roberts
- Gage Brandon
- Galen Gisler
- Gallagher P. T.
- Gerald Matzek
- Geri Hall-Conley
- Grady Boyce
- Gregory Ojakangas
- Harrison Leiendecker
- Harrison Roberts
- Honor Hare
- Howard Harper
- Hudson H. S.
- Ignacio Birriel
- Ione Chandler
- Irene Pease
- Isaac Mangin
- Isabel Crooker
- Jack Benner
- Jack Erickson
- Jack Jensen
- Jacob Watson
- Jagert Ernzen
- Jalynne Brough
- James Foster
- James Stith
- Jane Earp
- Janet Jorgensen
- Jared Hettick
- Jasmyn Taylor
- Jay Kerr
- Jean A. Dupree
- Jeannine Schilling
- Jeffrey DiMatties
- Jeffrey Johnson
- Jennifer A. Claver
- Jennifer Birriel
- Jennifer Hammock
- Jennifer Wellman
- Jeremy Weremeichik
- Jerry Zissett
- Jesse Anderson
- Jessica Lewis
- Jim Dickens
- Jim Payne
- Joe Earp
- Joe Meyer
- Joe Shaw
- Jonathan Mangin
- Jordan Bavlnka
- Jordan Duncan
- Joseph Wright
- Josh Byrnes
- Jubier X.
- Julia Kamenetzky
- Julian Web
- Julie VanVoorhis
- Kaleb Kautzsch
- Kallen Smith
- Kameron Brough
- Karan Davis
- Kate Allen-Penn
- Kateri Cardenas
- Katherine Weber
- Katie Barngrover
- Katsina Cardenas
- Kelly Quinn-Hughes
- Kellyn Chandler
- Kerry Glenn
- Kiley Brown
- Kolby Pisciotti
- Kristen Stives
- Kyle Dawson
- Kyle Scholtens
- LaVor R Jenkins
- Liam Brook
- Lindsay Adams
- Llanee Gibson
- Logan Jensen
- Logan Neuroth
- Lucy Kegley
- Lydia Hinkle
- Lynn Powers
- Lynne Dorsey
- Madison Kroeger
- Madison Mas
- Makai Jensen
- Margaret Cortez
- Maria Baker
- Marianna Lazarova
- Mark Bremer
- Mark Redecker
- Mark Roy
- Mark Steward
- Marley Carey
- Martin Hiner
- Mary Kidd
- Mary-Beth Ledford
- Maryanne Angliongto
- Mason Moore
- Mason Perrone
- Matthew J Penn
- Maya Rogers
- Michael Foster
- Michael Freed
- Michael LaRoche
- Michael Meo
- Michael Pierce
- Michael Rodgers
- Michaela Springer
- Michele McClellan
- Michele Wistisen
- Michelle Deady
- Mike Conley
- Mine Anderson
- Mohammad Ahmadbasir
- Monty Laycox
- Morgyn Church
- Myles McKay
- N. R. Sheeley
- Nathan Pindell
- Ned Smith
- Nolan Sump
- Orion Bellorado
- Padma A. Yanamandra-Fisher
- Pasachoff J. M.
- Pasachoff J. M.
- Pat Boyce
- Patricia Thompson
- Peggy Hill
- Penn M. J.
- Peter Nguyen
- Philip Blanco
- Prescott Moore
- Rachel Manspeaker
- Rackley S. R.
- Reba Doucette
- Rein Lann
- Reva A. A.
- Richard Gelderman
- Richard Kautz
- Richard Lighthill
- Richard McFate
- Rita Wright
- Rob Sobnosky
- Robert Baer
- Robert McGowen
- Ruchi Gosain
- Russ Longhurst
- Russell Lucas
- Ryan Alder
- Ryan H. Claver
- Ryan Maderak
- Sam Fincher
- Sam Streeter
- Samantha Hasler
- Samuel Cynamon
- Sanjay Gosain
- Sarah Kovac
- Savannah Shoffner
- Scott Dixon
- Sean Baldridge
- Sean Brittain
- Sean Patrick
- Seaton D. B.
- Sepehr Ardebilianfard
- Serena Hill LaRoche
- Shae Aagard
- Shaedyn Miller
- Sonna Smith
- Spencer Buckner
- Stanley Jensen
- Stephen Gulley
- Stephen McNeil
- Steven Somes
- Taylor Shivelbine
- Tessa Hoffman
- Theresa Bautz
- Thomas Ballew
- Thomas Garrison
- Thomas K Simacek
- Thomas Schad
- Thomas Vanderhorst
- Tiffany Rivera
- Tim Nelson
- Trevor Schmale
- Tyler Howard
- Valerie Granger
- Vanshita Gosain
- Wayne Boeck
- Wesley Sandidge
- William Garrison
- Wilson Harris
- Yolanta G Simacek
- Zach Stockbridge
- Zachary Watson
- Zachary Whipps
- Zachery Brasier
- Zack Nelson
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
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- Katsuki
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- Mongin
- Mongin
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- Monti
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- Moody
- Mooradian
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- Morales-Rios
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- Morel
- Morel
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- Morgan
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- Müller
- Müller
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- Nair
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- Ruano
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- Ruoff
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- Russell
- Ruščić
- Rybakov
- Rybakova
- Ryu
- Ràmila
- Sabitha
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- Sahli
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- Sainte
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- Saito
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- Sakamoto
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- Sakya
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- Salcedo
- Salcedo
- Saldabol
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- Salomon
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- Sammes
- Sammes
- Sammes
- Sammes
- Sammes
- Sammes
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- Sanchez
- Sanchez-Garcia
- Sanda
- Sander
- Sanders
- Sanemitsu
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- Sano
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- Schroth
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- Schroth
- Schrott
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- Schuda
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- Seio
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- Seitz
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- Seko
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- Seller
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- Sengül
- Sepulcri
- Settambolo
- Seybold
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- Sezen
- Sha
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- Shaban
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- Shafiee
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- Shao
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- Sharghi
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- Shefali
- Sheinker
- Sheinker
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- Sheradsky
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- Sheremetev
- Sheremetev
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- Shevchuk
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- Sorbye
- Sordo
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- Stangeland
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- Stanovnik
- Stanton
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- Steel
- Stefani
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- Sterk
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- Stewart
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- Stiefvater
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- Sundberg
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- Taber
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- Trofimov
- Trofimov
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- Trofimov
- Trofimov
- Tron
- Trost
- Trudell
- Trujillo
- Trécourt
- Tse
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- Tsuchiya
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- Tsunoda
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- von Rague Schleyer
- Vondrak
- Voronina
- Vorreither
- Vovk
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- Vuilhorgne
- Vvedensky
- Vázquez
- Vögeli
- Wacker
- Wafford
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- Wahhab
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- Walden
- Waldo
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- Walker
- Walsh
- Wamhoff
- Wan
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- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Ward
- Ward
- Wassmundt
- Wasylishen
- Watanabe
- Watanabe
- Watanabe
- Watanabe
- Watson
- Watson
- Watson
- Watson
- Watt
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- Weber
- Weber
- Wege
- Wehn
- Wei
- Weigert
- Weinstock
- Weintraub
- Weis
- Weissman
- Wells
- Wender
- Wensbo
- Wentrup
- Westermaier
- Westermann
- Wheatley
- Wheatley
- White
- White
- White
- Wiemer
- Wiese
- Wieser
- Wieser
- Wild
- Wiley
- Wilkie
- Wilkinson
- Wille
- Wille
- Williams
- Williams
- Willis
- Willis
- Wilson
- Winkler
- Wipf
- Wipf
- Wipf
- Witanowski
- Witanowski
- Witanowski
- Witanowski
- Witanowski
- Witker
- Witty
- Wladkowski
- Wohl
- Wolfe
- Wolfe
- Wolfgang
- Wolkenberg
- Wolter
- Wong
- Wong
- Woniak
- Wood
- Wood
- Wrackmeyer
- Wright
- Wright
- Wrobel
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wu
- Wudl
- Wynberg
- Wysoeka
- Wünsch
- Xia
- Xiong
- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Yadav
- Yadav
- Yadav
- Yadav
- Yadav
- Yadav
- Yadav
- Yagi
- Yagupolskii
- Yamaguchi
- Yamaguchi
- Yamaguchi
- Yamamoto
- Yamamoto
- Yamamoto
- Yamamoto
- Yamana
- Yamanaka
- Yamashita
- Yamashita
- Yamashita
- Yamashkin
- Yamazaki
- Yamazaki
- Yan
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yao
- Yap
- Yarovenko
- Yashunskii
- Yasuike
- Yato
- Yavari
- Yavari
- Yavari
- Yavari
- Yavolovskii
- Yavolovskii
- Ye
- Ye
- Ye
- Yeung
- Yeung
- Yin
- Ykman
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- Yogi
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- Yoon
- Yoshida
- You
- You
- You
- You
- Youn
- Young
- Young
- Youssef
- Youssif
- Yu
- Yu
- Yue
- Yue
- Yue
- Yus
- Yus
- Yus
- Yuzuri
- Zacharie
- Zagorski
- Zaitseva
- Zaleska
- Zaleska
- Zaleska
- Zamora
- Zappal
- Zarranz
- Zarudnitskii
- Zelenin
- Zeller
- Zeller
- Zey
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zhilin
- Zhou
- Zhou
- Zhou
- Zhu
- Zhumabaeva
- Zienkiewicz
- Zificsak
- Zilverschoon
- Zimmerman
- Zimmermann
- Zimmermann
- Ziyaev
- Zlotin
- Zolfigol
- Zoltewicz
- Zoltewicz
- Zoltewicz
- Zoltewicz
- Zong
- Zonta
- Zotti
- Zouhiri
- Zubarev
- Zubarev
- Zubarev
- Zubarev
- Zugrvescu
- Zumbrunn
- Çavdar
- Özdemir
- Ünaleroglu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz María Jesús
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Safety of hospital discharge before return of bowel function after elective colorectal surgery
- Author
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- Abdelgalil R
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- Hansmann M
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- Haran C
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- Hernández L C García
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- Hosfield T
- Hoskyns L
- Hossaini S
- Hotchkies A
- Houdek O
- Howard E O
- Howarth N
- Howlader M
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- Humayun S
- Hunt G
- Huot A
- Huq T
- Hurný M Hanušová M
- Husain S
- Hussain M
- Hübner M
- Hylands A
- Ibrahim B
- Ibrahim I
- Idoate C Pastor
- Ike S I
- Iliev S
- Ilieva I
- Illahi M
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- Imadalou L
- Imam L
- Impellizzeri H
- Impellizzeri H
- Imperatore M
- Imtiaz M
- Inama M
- Incollingo P
- Ioannidis A
- Ioannidis A
- Ipor A
- Iqbal R
- Iqbal Z
- Irwin E
- Isabello A
- Isik A
- Isik A E
- Isik K
- Iskan N G
- Isler V C
- Isse M
- ItSURG null
- Ivanov T
- Ivanov V
- Ivanov V
- Izzarina A
- İşlek E C
- Jackson A
- Jackson L
- Jacobson A
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- Jaich R
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- Jegathees T
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- Jepsen B N
- Jerí-McFarlane S
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- Jiménez F A Ramos
- Jiménez S Figueroa
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- Jiménez-Gómez L M
- Jimulia D
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- Jobson J
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- Kamarajah S
- Kamath P J
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- Karagöz E
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- Karampinis I
- Karanikas I
- Karapinar Y E
- Karelia S
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- Kavaliauskas P
- Kavar R C
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- Kaya Y
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- Kearney J
- Keating R
- Kechagias A
- Kechagias A
- Kechagias A
- Kefleyesus A
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- Khadka P
- Khaled N Ben
- Khalid N
- Khalil M
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- Klail M Farkašová T
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- Komolafe O
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- Kontovounisios C
- Kopac O
- Kopp A
- Korkolis D
- Koutserimpas C
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- Kowal M
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- Köseoglu E
- Kraria L
- Kristensen E S
- Kristensen F P
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- Kudelkina N
- Kudva V
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- Kulendrarajah B
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- Kus D
- Kushairi A
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- Kürklü Ö
- Kwak S Y
- Kwan K W L
- Kwek I
- Kwek I
- Kwok K
- Kyaw H A
- Kybransiene M
- La Manna V
- La Torre F
- Ladak N
- Lafranceschina S
- Lages R R
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- Lai R Siaw Yen
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- Lérias R
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- Liberatore P
- Libri I
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- Liebenberg P
- Liebenberg P
- Liébana M M Soriano
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- Lim S Wei
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- Limnatitou D
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- Litvin A
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- Liversedge G
- Livie J
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- Llavall A Clavé
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- Logue G
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- Longshaw A
- Looijen R C
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- Martínez A Portugal
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- Miguel I
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- Mijalkov D
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- Montesinos I Ruiz
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- Moosa A
- Mora A
- Mora-Guzmán I
- Morais S
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- Moreno C Olmedo
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- Muddasani T
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- Muriel P
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- Nadama H H
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- Nair A
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- Naja M
- Nakakande D
- Nardi M
- Nascimento C
- Nasimi B
- Nastro P
- Navasquillo M
- Navidad M Serrano
- Navidad M Serrano
- Navío A
- Nawaz E
- Nayak C
- Nayeem A
- Negoi I
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- Neilson A
- Nelli T
- Nelson L
- Nepogodiev D
- Netke T
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- Neugebauer N
- Nevado C
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- Ng B
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- Ng S Y
- Ngai C
- Ngu W S
- Nguen D
- Ngwenya Z
- Nicol P
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- Nielsen C V
- Nieuwenhuizen S
- Nikookam Y
- Niolu P
- Niskakangas M
- Njoku P
- Noriega Z
- Norman J G
- Norwood M
- Nossier R
- Novický R
- Novotny S A
- Ntakomyti E
- null null
- Nuñez S Orozco
- Nutautiene V
- Nyamali I
- O'Brien F
- O'Callaghan H
- O'Connell E
- O'Connell M
- O'Connor D B
- O'Dwyer N
- O'Neill A
- O'Neill D
- Obukofe R
- Obukofe R
- Obukofe R
- Odovic M
- Ogundiya E
- Ogunmwonyi I
- Ojakããr A
- Ojofeitimi O
- Oke O
- Olavarria A Landaluce
- Olawi F
- Oliphant R
- Oliveira J
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- Oliveira N
- Oliveira S
- Olivieri M
- Olivieri M
- Olmo D García
- Omundsen M
- Onafowokan O O
- Ong A
- Ong E H
- Ong H I
- Ong L
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- Orbell J
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- Orozco J J Garcia
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- Ortega C
- Ortega G Sanz
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- Osborn G
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- Osunronbi T
- Otero M López
- Otto A
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- Ottonello R
- Ourô S
- Owen M
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- Oyebola T
- Oyomno M
- Ozbalci G S
- Ozben V
- Ozkan B B
- Ozmen B B
- Ozolins A
- Ölmez M
- Önsal U
- Örhalmi J
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- Özbek M
- Özen D
- Pace C
- Pacheco A
- Paclík A
- Padillo A Díaz
- Pagano G
- Pagano G
- Page O
- Pagnanelli M
- Pagnanelli M
- Pahalawatta U
- Paixão I
- Paixão V
- Pala C
- Palano G
- Palkhi A
- Palmer A
- Palmer C
- Panaccio P
- Panagiotou D
- Pando B
- Pandya A
- Pang Y L
- Panikkar M
- Panizzo V
- Panyko A
- Paolucci A
- Papaconstantinou D
- Papagni V
- Papandrea M
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- Parisi A
- Parker D
- Parmar S
- Parnell J
- Parra D Negre
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- Pascoe R
- Paspala A
- Pasquali S
- Pata F
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- Pata F
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- Pata G
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- Patel M
- Patel N
- Patel P
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- Patel V
- Patil P
- Patrawala S
- Patrício J
- Patrocinio M Tomé S
- Paul M
- Pavlov V
- Pawa N
- Paycheva T
- Pazzona M
- Peckham H
- Peddis M
- Pedersen A C
- Pedersen J Højgaard
- Pedrazzani C
- Pedro V
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- Peixoto R
- Pellegrino L
- Pellicanò G A
- Pellino G
- Pellino G
- Pellino G
- Peltrini R
- Pendelbury L
- Peng S L
- Peng S L
- Peng S L
- Penningnieuwland G
- Pentony A R
- Pentti E
- Peralta P Uriol
- Peralta P Uriol
- Percassi A
- Perchard W
- Percivale A
- Pereira F
- Pereira J
- Pereira M
- Pereira P Troncoso
- Pereira P Troncoso
- Perez J
- Pergel A
- Perrone G
- Perrone G
- Persiani R
- Pesce A
- Petermann D
- Petrelli F
- Petrelli F
- Petrulionis M
- Peyroteo M
- Peyroteo M
- Pérez-Ajates S
- Pérez-Ajates S
- Pérez-Ajates S
- Pham H D V
- Pherwani S A
- Phillips J
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- Piazza G
- Piazza G
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- Picciariello A
- Picciariello A
- Piccinini A Magri
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- Pietroletti R
- Pike G
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- Pilotta F
- Pimentel A
- Pina S
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- Pinillos A I
- Pinkney T
- Pintabona G
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- Piotet L M
- Piozzi G N
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- Ponomarev N
- Pooley G
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- Popescu S S
- Poponesi V
- Porras V Portugal
- Portelli L
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- Poskus T
- Poškus E
- Poškus T
- Potts O Bauermeister
- Poustie M
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- Powell-Chandler A
- Powell-Chandler A
- Pös M
- Pratas N
- Prats M Alberich
- Praxedes V
- Prem M
- Prieto-Nieto I
- Procacci P
- Prochazka V
- Prodromidou A
- Profita G
- Provenza G
- Pruijssers S R
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- Psaila J
- Puchalski N
- Puglisi S
- Pujana E Romero
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- Queiros T
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- Žebrák M Farkašová R
- Žebrák R
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system. Results A total of 3288 patients were included in the analysis, of whom 301 (9 center dot 2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P < 0 center dot 001). There were no significant differences in rates of readmission between these groups (6 center dot 6 versus 8 center dot 0 per cent; P = 0 center dot 499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0 center dot 90, 95 per cent c.i. 0 center dot 55 to 1 center dot 46; P = 0 center dot 659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34 center dot 7 versus 39 center dot 5 per cent; major 3 center dot 3 versus 3 center dot 4 per cent; P = 0 center dot 110). Conclusion Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57\u201375) years (54\ub79 per cent men). Some 1153 (27\ub77 per cent) received NSAIDs on postoperative days 1\u20133, of whom 1061 (92\ub70 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4\ub76 versus 4\ub78 days; hazard ratio 1\ub704, 95 per cent c.i. 0\ub796 to 1\ub712; P = 0\ub7360). There were no significant differences in anastomotic leak rate (5\ub74 versus 4\ub76 per cent; P = 0\ub7349) or acute kidney injury (14\ub73 versus 13\ub78 per cent; P = 0\ub7666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35\ub73 versus 56\ub77 per cent; P < 0\ub7001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement
Safety of hospital discharge before return of bowel function after elective colorectal surgery
- Author
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- Y K Lim
- Y Karaman
- Y Kaya
- Y Kaya
- Y L Pang
- Y L Wang
- Y Li
- Y M Tissen
- Y Mahmoudi
- Y Majeed
- Y Mitkov
- Y N Goh
- Y Nikookam
- Y Q Yeo
- Y Qamar
- Y Shafiq
- Y Toyi
- Y Vroom
- Y Xiao
- Y Youssef
- Y Z Beh
- Yiz Acherman
- Z Abdulrahman
- Z Akbar
- Z Al-Saraff
- Z Al-Sarraf
- Z Ali
- Z B Koçak
- Z Ballarini
- Z Carrington
- Z Garoufalia
- Z Goolam-Mahomed
- Z H Sam
- Z Habib
- Z Iqbal
- Z Millar
- Z Ngwenya
- Z Noriega
- Z S Demirci
- Z Sheikh
- Z Xuan Tan
- Z Y Boh
- Z Yi Tew
- Z Yi Tew
- Z Yusuf
- Á Navarro Barrios
- Çagri Girit
- É Dockry
- Ö Kürklü
- Ö Uslu
- Ö Uslu
- Ö Yumurtaci
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.Results: A total of 3288 patients were included in the analysis, of whom 301 (9.2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P < 0.001). There were no significant differences in rates of readmission between these groups (6.6 versus 8.0 per cent; P = 0.499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0.90, 95 per cent c.i. 0.55 to 1.46; P = 0.659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34.7 versus 39.5 per cent; major 3.3 versus 3.4 per cent; P = 0.110).Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients