The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration.

The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species regenerative capacity. To directly test that premise, we humanized the zebrafish p53 pathway by introducing regulatory and coding sequences of the human tumor suppressor ARF into the zebrafish genome. ARF was dormant during development, in uninjured adult fins, and during wound healing, but was highly expressed in the blastema during epimorphic fin regeneration after amputation. Regenerative, but not developmental signals resulted in binding of zebrafish E2f to the human ARF promoter and activated conserved ARF-dependent Tp53 functions. The context-dependent activation of ARF did not affect growth and development but inhibited regeneration, an unexpected distinct tumor suppressor response to regenerative versus developmental environments. The antagonistic pleiotropic characteristics of ARF as both tumor and regeneration suppressor imply that inducing epimorphic regeneration clinically would require modulation of ARF -p53 axis activation

Magnetic fluctuation and cosmic ray diurnal variations

A unified theory of cosmic ray diurnal variations has been proposed in which the first 3 harmonics of the cosmic ray daily variation all results from a single anisotropy produced by the combined effects of adiabatic focusing and anisotropic pitch angle scattering. The theoretical description of steady state cosmic ray anisotropies are simplified and improved. Preliminary results of a study of correlations between cosmic ray diurnal variations and the fluctuation characteristics of the interplanetary magnetic field are presented and discussed in light of the theory

Dave Kindred

Interview of Dave Kindred, National Hall of Fame sportswriter and IWU Class of 1963, by journalist, New York Times best-selling author and Stanford lecturer Gary Pomerantz. Filmed by Beyond Pix Studios with sound by Outpost Studios on June 19, 2019. The Kindred Collection mentioned in this interview is housed in Tate Archives & Special Collections, The Ames Library, Illinois Wesleyan University. Its description is available at iwu.libraryhost.com/repositories/3/resources/1

SULFUR POISONING AND TOLERANCE OF HIGH PERMEANCE Pd/Cu ALLOY MEMBRANES FOR HYDROGEN SEPARATION

This work investigated the long-term stability of sulfur tolerant Pd/Cu alloy membranes for hydrogen separation by performing characterizations lasting several thousand hours in H2, He and H2S/H2 atmospheres ranging in concentration from 0.2 – 50 ppm and temperatures ranging from 250 - 500ºC. Two methods were used for fabricating the Pd/Cu membranes so that the sulfur tolerant fcc alloy would remain on the surface and minimize the decrease in hydrogen permeance inherent with fcc Pd/Cu alloys. The first method consisted of annealing a Pd/Cu bi-layer at high-temperatures and the second consisted of depositing a Pd/Cu/Pd tri-layer with an ultra-thin surface alloy. High temperature X-ray diffraction (HT-XRD) was employed to study the kinetics of the annealing process and atomic adsorption spectroscopy (AAS) was used to investigate the kinetics of the Cu deposition and Pd displacement of Cu. Upon the introduction of H2S, the permeance decrease observed was dependent upon the H2S feed concentration, and not the time of poisoning. However, after the recovery in pure H2 there was a portion of the permeance which could not be recovered due to adsorbed sulfur blocking H2 adsorption sites. The amount of recoverable permeance was dependent on the time of exposure to H2S and reached a limiting value which decreased with temperature. X-ray photoemission spectroscopy (XPS) was used to investigate poisoned samples and it was observed that the permeance not recovered at a given temperature in H2 was caused mostly by Cu sulfides. Both bi-layer and tri-layer membranes had hydrogen permeances which were higher than homogeneous Pd/Cu membranes of the same surface concentration. However, the tri-layer membranes performed as well as Pd membranes thus eliminating the disadvantage of alloying Pd with Cu without sacrificing sulfur tolerance