AIR Universita degli studi di Milano

    Pentraxin 3 in cardiovascular disease

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    The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The prototype of the pentraxin family is C reactive protein (CRP), a widely-used biomarker in human pathologies with an inflammatory or infectious origin. Data so far describe PTX3 as a multifunctional protein acting as a functional ancestor of antibodies and playing a regulatory role in inflammation. Cardiovascular disease (CVD) is a leading cause of mortality worldwide, and inflammation is crucial in promoting it. Data from animal models indicate that PTX3 can have cardioprotective and atheroprotective roles regulating inflammation. PTX3 has been investigated in several clinical settings as possible biomarker of CVD. Data collected so far indicate that PTX3 plasma levels rise rapidly in acute myocardial infarction, heart failure and cardiac arrest, reflecting the extent of tissue damage and predicting the risk of mortality

    Georgia towards a parliamentary republic?

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    The ongoing constitutional reform in Georgia is one of the priorities of the ruling party since it aims to reduce the competences of the President, consolidate democratic system and strengthen legislative power. The international community is therefore seriously worried about the risk of concentration of power in the hands of a single party

    Measurement of the charge asymmetry in dileptonic decays of top quark pairs in pp collisions at root s=7 TeV using the ATLAS detector

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    A measurement of the top-antitop (t (t) over bar) charge asymmetry is presented using data corresponding to an integrated luminosity of 4.6 fb(-1) of LHC pp collisions at a centre-of-mass energy of 7 TeV collected by the ATLAS detector. Events with two charged leptons, at least two jets and large missing transverse momentum are selected. Two observables are studied: A(C)(ll) based on the identified charged leptons, and A(C)(t (t) over bar), based on the reconstructed t (t) over bar final state. The asymmetries are measured to be A(C)(ll) =0.024 +/- 0.015 (stat.) +/- 0.009 (syst.), A(C)(t (t) over bar) = 0.021 +/- 0.025 (stat.) +/- 0.017 (syst.). The measured values are in agreement with the Standard Model predictions

    Muscle sparing versus posterolateral thoracotomy for pulmonary lobectomy: Randomised controlled trial

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    Muscle sparing thoracotomy (MST) has been proposed as an alternative to posterolateral thoracotomy (PLT) for pulmonary lobectomy. This issue has been addressed by few clinical reports. To explore that subject, a prospective, controlled randomised, double-blind trial comparing MST through the auscultatory triangle and PLT was planned. The study included patients scheduled for pulmonary lobectomy for stage I or II non-small-cell lung cancer and were followed for three years. The primary endpoints were pain, analgesic consumption and post-thoracotomy pain syndrome. The secondary endpoints included morbidity plus shoulder and pulmonary functions. The trial randomised 100 patients into two groups. Postoperative pain results were similar, although analgesic consumption was higher in the PLT group (Ps0.001). The MST group had a shorter hospital stay (Ps0.003). Three years post-thoracotomy syndrome was unaffected by the type of incision. The women suffered more than men during the early and late postoperative time. An inverse correlation between incision length and pain was found. Immediate shoulder strength was significantly better in the MST group (Ps0.004) but postoperative pulmonary function and complications were comparable. The two incisions results were very similar in the patient outcome, however, few aspects indicated the MST as the more suitable incision for pulmonary lobectomy

    Cultural sociology as a tool for art policies

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    During the last decades, the discipline of cultural sociology has produced a considerable amount of knowledge on cultural production. Institutional approaches, notably inspired by DiMaggio and Powell (1982) classical article, have notably given the production of culture perspective (Peterson and Anand, 2004). Field analysis (Bourdieu, 1979) have inspired many works that have enlighted the link between social boundaries (Lamont and Molnar, 2002) of cultural practices. Symbolic interactionism, best represented by Howard Becker art worlds (1982) explored the different modes of collaboration between actors and have highlighten the collective aspect of artistic production. Finally, study of mediations have highlighten the role of artworks in constructing social life (Hennion, 1993 ; DeNora, 2000). All these theoretical fields of study have produced a considerable empirical knowledge of different artistic fields, in different countries, both at the level of production and consumption. At the same time, cultural policies seems to take a more and more important position in political life. The best exemple of this might be the dynamism around the 2005 UNESCO convention on the promotion and protection of the diversity of cultural expressions. This convention is used, for instance, by State Parties to inspire cultural policies that they want to develop. It is also used as a platform of exchange of good practices, that it tries to define through directives. For instance, the last Conference of Parties has stated that net neutrality was necessary to cultural diversity. However, the knowledge produced by cultural sociology, mainly through qualitative methods, is curiously absent of the debates of the organization, that produces reports mainly based on quantitative approaches, and make little or no reference to the corpus we have enunciated. This absence can also be found in different states. In our presentation, we will explore some of the possible ways in which the theoretical and empirical knowledge produced in cultural sociology can practically inform arts policies and provide useful practical tools for their conception


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