4 research outputs found
Mark E A Novel Device to Apply Controlled Flexion and Extension to the Rat Knee Following Anterior Cruciate Ligament Reconstruction
- Author
- Publication venue
- Publication date
- 03/04/2020
- Field of study
We designed and validated a novel device for applying flexion-extension cycles to a rat knee in an in vivo model of anterior cruciate ligament reconstruction (ACL-R). Our device is intended to simulate rehabilitation motion and exercise post ACL-R to optimize physical rehabilitation treatments for the improved healing of tendon graft ligament reconstructions. The device was validated for repeatability of the knee kinematic motion by measuring the force versus angular rotation response from repeated trials using cadaver rats. The average maximum force required for rotating an ACL reconstructed rat knee through 100 degrees of flexion-extension was 0.4 N with 95% variability for all trials within 60.1 N
A Novel Device to Apply Controlled Flexion and Extension to the Rat Knee Following Anterior Cruciate Ligament Reconstruction
- Author
- Publication venue
- 'ASME International'
- Publication date
- Field of study
Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial
- Author
- Aditya Guar
- Allison Agwu
- Allison Bearden
- Alyne Baker
- Ana Puga
- Andrea Kovacs
- Andrew Wiznia
- Angulique Outlaw
- Bill G Kapogiannis
- Brandy Rutledge
- Carrie Chambers
- Catherine M Gordon
- Charles B Stephensen
- Charnell Cromer
- Connie Trexler
- Craig M Wilson
- Cynthia G Pan
- D Robert Harris
- Dan Reirden
- Diane Straub
- Diane Tucker
- Donna Futterman
- Donna Maturo
- Elizabeth Enriquez-Bruce
- Erik Gertz
- Eva Operskalski
- Georgine Price
- Gertrud U Schuster
- Jacobo Abadi
- James Homans
- Jane Head
- Joanna Dobroszycki
- John H Stroger
- Joseph Domek
- Julian Dormitzer
- Justin Wheeler
- Kathleen Mulligan
- Kavya Vellala
- Kelly Bojan
- Ken Mayer
- Larry D’Angelo
- Larry Friedman
- Leslie Kozina
- Leslie R Woodhouse
- Lisa Henry-Reid
- Liz Secord
- Lourdes Angeli Nieves
- Maria Campos
- Marlene Burey
- Marta D Van Loan
- Marvin Belzer
- Mary Dillard
- Mary Paul
- Mary Tanney
- Michael Rosenberg
- Midnela Acevedo
- Miguel Martinez
- Nicolas Rosario
- null null
- Pat Flynn
- Patricia Emmanuel
- Patricia M Flynn
- Peter L Havens
- Renata Sanders
- Roger Fielding
- Rohan Hazra
- Steve Douglas
- Sue Ellen Abdalian
- Susie Sanchez
- Tammy Freytag
- Thuy Anderson
- William A Meyer
- Zulma Eysallenne
- Publication venue
- eScholarship, University of California
- Publication date
- 21/08/2017
- Field of study
BackgroundTenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized that vitamin D3 (VITD3) would increase BMD in youth receiving TDF.MethodsThis was a randomized, double-blind, placebo-controlled trial of directly observed VITD3 vs placebo every 4 weeks for 48 weeks in youth aged 16-24 years with HIV, RNA load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N = 214) received a daily multivitamin containing VITD3 400 IU and calcium 162 mg, plus monthly randomized VITD3 50000 IU (n = 109) or placebo (n = 105). Outcome was change from baseline to week 48 in lumbar spine BMD (LSBMD). Data presented are median (Q1, Q3).ResultsParticipants were aged 22.0 (21.0, 23.0) years, 84% were male, and 74% were black/African American. At baseline, 62% had 25-hydroxy vitamin D (25-OHD) <20 ng/mL. Multivitamin adherence was 49% (29%, 69%), and VITD3/placebo adherence 100% (100%, 100%). Vitamin D intake was 2020 (1914, 2168) and 284 (179, 394) IU/day, and serum 25-OHD concentration was 36.9 (30.5, 42.4) and 20.6 (14.4, 25.8) ng/mL at 48 weeks in VITD3 and placebo groups, respectively (P < .001). From baseline to week 48, LSBMD increased by 1.15% (-0.75% to 2.74%) in the VITD3 group (n = 99; P < .001) and 0.09% (-1.49% to 2.61%) in the placebo group (n = 89; P = .25), without between-group difference (P = .12). VITD3 group changes occurred with baseline 25-OHD <20 ng/mL (1.17% [-.82% to 2.90%]; P = .004) and ≥20 ng/mL (0.93% [-.26% to 2.15%]; P = .033).ConclusionsFor youth taking TDF-cART, LSBMD increased through 48 weeks with VITD3 plus multivitamin, but not with placebo plus multivitamin, independent of baseline vitamin D status.Clinical trials registrationNCT01751646
Drug-induced ocular side effects
- Author
- Aalto-Korte
- Abbey
- Abel
- Abelson
- Abelson
- Abelson
- Abelson
- Abraham
- Abraham
- Abraham
- Abraham
- Abrams
- Abramson
- Abramson
- Abreu
- Abu el-Asrar
- Aceto
- Acheson
- Adams
- Adams
- Adams
- Adkins
- Adler
- Afridi
- Agarwal
- Agarwal
- Agrawal
- Agrawal
- Ah-Song
- Ahern
- Ahluwalia
- Ahmad
- Ahmad
- Ahmad
- Ahmad
- Ahmad
- Akingbehin
- Akingbehin
- Akler
- Akman
- Al-Hazmi
- Al-Jazzaf
- Al-Tweigeri
- Alarcon-Segovia
- AlarcĂłn-Segovia
- AlarcĂłn-Segovia
- AlarcĂłn-Segovia
- AlarcĂłn-Segovia
- AlarcĂłn-Segovia
- Albala
- Albalate
- Albert
- Albert
- Albert
- Albini
- Alder
- Alexander
- Alinlari
- Alkawi
- Allibhai
- Almog
- Almog
- Almog
- Almony
- Alomar
- Alpar
- Alpert
- Alster
- Altan-Yaycioglu
- Alward
- Alwitry
- Amarenco
- Ameen
- Amemiya
- Aminlari
- Aminlari
- Ananthanarayan
- Anastassiades
- Ancelin
- Andersen
- Anderson
- Anderson
- Ando
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- Ang
- Anonymous
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- Ansdell
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- Stafford
- Staffurth
- Stamer
- Stamper
- Stank
- Stapczynski
- Starkey
- Stead
- Steele
- Steg
- Steinberg
- Steinberg
- Steinemann
- Steinemann
- Steinemann
- Steinfeld
- Steinkamp
- Steinmann
- Stempel
- Stern
- Stern
- Stern
- Stern
- Stern
- Stevens
- Stevens
- Stevens
- Stevenson
- Stevenson
- Stewart
- Stewart
- Stewart
- Stewart
- Stoddart
- Stominger
- Stonecipher
- Storr-Paulsen
- Storr-Paulsen
- Stowe
- Stratton
- Stratton
- Strelow
- Strickland
- Strominger
- Strong
- Stucrenschneider
- Sturtevant
- Suarez
- Subramanian
- Sudhir
- Sullivan
- Sullivan
- Sundaram
- Sunderraj
- Suner
- Sunness
- Superstein
- Supino-Viterbo
- Suriyamongkol
- Sutcliffe
- Sutter
- Sutton
- Sveska
- Svihovec
- Swale
- Swan
- Swash
- Sweetman
- Syversen
- Szerenyi
- Szmyd
- Szmyd
- Söylev
- Taaffe
- Taban
- Tabbara
- Tabbara
- Tabor
- Taddio
- Tagawa
- Takahashi
- Tames
- Tammisto
- Tanaka
- Tang
- Tang
- Tang-Liu
- Tangelder
- Tanimura
- TAP and VIP Study Groups
- Taravella
- Tarr
- Taskintuna
- Tate
- Taub
- Tauber
- Taylor
- Taylor
- Taylor
- Taylor
- Taylor
- Tedeschi
- Tedeschi
- Teich
- Teicher
- Teichmann
- Teller
- ten Tusscher
- Terao
- Teravainen
- Terrin
- Teus
- Textorius
- Thaler
- Thaler
- Thambi
- Theil
- Theodossiadis
- Theodossiadis
- Thomann
- Thomas
- Thomas
- Thomasen
- Thompson
- Thompson
- Thompson
- Thurairajan
- Thylefors
- Tiamkao
- Ticho
- Tilanus
- Tilanus
- Tilden
- Tiliakos
- Tjalve
- Tobin
- Tognetto
- Tokai
- Toker
- Toler
- Tomida
- Tomlinson
- Tomsak
- Tomsak
- Tonini
- Toole
- Topaloglu
- Tordjman
- Torres Estrada
- Tran
- Trattner
- Trau
- Traub
- Treffert
- Treister
- Treusch
- Tripathi
- Tripathi
- Tripathi
- Trope
- Trousdale
- Tsai
- Tsai
- Tsao
- Tse
- Tseng
- Tseng
- Tseng
- Tseng
- Tsuchiya
- Tuchmann-Duplessis
- Tullio
- Turacli
- Turgeon
- Tyagi
- Tyrer
- Tzekov
- Uchida
- Uddin
- Udell
- Uemoto
- Uemura
- Ueno
- Ueyama
- Ullrich
- Umez-Eronini
- Ung
- Uno
- Uoshima
- Ursell
- Vachon
- Valentic
- Valeyrie
- Valibhai
- Valvano
- Van de Geijn
- Van Deenen
- Van den Berg
- van den Berg
- Van den Enden
- Van Der Merwe
- Van der Meyden
- Van Der Torren
- van Dooren
- Van Dop
- Van Dyk
- Van Dyk
- Van Joost
- van Leeuwen
- van Rens
- Vandenbroucke
- Vanheule
- Vanier
- Vankatesh
- Vaphiades
- Vardizer
- Varela
- Varssano
- Vasconcelos
- Vastine
- Vaudaux
- Vaughn
- Vela
- Velasque
- Verkijk
- Verma
- Verma
- Vermeer
- Vermeeren
- Vessey
- Vesterhauge
- Vidal
- Viestenz
- Vignes
- Villada
- Villarreal
- Vinas
- Vincent
- Vinding
- Vital-Herne
- Vizel
- Vogel
- Vogel
- Vogel
- Vogt
- Von Knorring
- von Noorden
- Vonvoigtlander
- Vote
- Vrabec
- Waddell
- Waheep
- Waikhom
- Waisbren
- Wakeno
- Waldock
- Walinder
- Walker
- Walker
- Wall
- Wall
- Wallace
- Wallar
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walsh
- Walter
- Walter
- Walter-Ryan
- Walters
- Waltz
- Wand
- Wand
- Wand
- Wand
- Wandel
- Wang
- Wang
- Wark
- Warwar
- Wasserman
- Watanabe
- Watanabe
- Watanabe
- Wayne
- Weaver
- Weaver
- Weaver
- Webber
- Weber
- Weber
- Weber
- Weese-mayer
- Wei
- Weidle
- Weinberg
- Weinberg
- Weiner
- Weiner
- Weinke
- Weir
- Weir
- Weiss
- Weiss
- Weleber
- Wellington
- Werner
- Wertheim
- Wesley
- West
- West
- West
- Wetheim
- Wheller
- Whitcup
- Whitcup
- White
- Whitson
- Whittington
- Whitwam
- Wictorin
- Wiholm
- Wijaya
- Wilcox
- Wild
- Wilde
- Wilding
- Wilhelm
- Wilhelmus
- Wilhelmus
- Wilhelmus
- Wilhelmus
- Wilhelmus
- Williams
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilsonholt
- Wilton
- Winrow
- Winther-Nielson
- Wirtitsch
- Wittbrodt
- Wittbrodt
- Wittbrodt
- Wittbrodt
- Wittbrodt
- Wittpenn
- Wittpenn
- Wizemann
- Wizemann
- Wiznia
- Woelfle
- Wolbarsht
- Wolf
- Wolf
- Wollensak
- Wolter
- Woo
- Wood
- Wood
- Worden
- Wright
- Wright
- Wright
- Wright
- Wu
- Wu
- Wu
- Wutthiphan
- Wymore
- Ya mur
- Yalvac
- Yang
- Yang
- Yannuzzi
- Yannuzzi
- Yannuzzi
- Yaqoob
- Yeatts
- Yee
- Yee
- Yeh
- Yellowless
- Yen
- Yeomans
- Yiannikas
- Yoshizumi
- You
- Young
- Young
- Young
- Younger
- Yuen
- Yung
- Yung
- Zagelbaum
- Zahn
- Zaidman
- Zaidman
- Zambarakji
- Zamir
- Zamir
- Zanini
- Zaratzian
- Zarnowski
- Zeiter
- Zeiter
- Zenzen
- Zhan
- Zhao
- Zimran
- Zinchuk
- Zitelli
- Zrenner
- Zuckerman
- Zugerman
- Zurcher
- Zurcher
- Zurcher
- Zurcher
- Çekiç
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2008
- Field of study