10 research outputs found
New approaches in the diagnosis and treatment of latent tuberculosis infection
- Author
- A Baena
- A Dorhoi
- A Fraser
- A Kumar
- A Lalvani
- A Lalvani
- A Lalvani
- A Lardizabal
- A Polesky
- A Strassburg
- AA Chackerian
- AAR Tobian
- AC Crampin
- AD Harries
- AG Kinhikar
- AJ Gehring
- AJ Wolf
- AM Cooper
- American Thoracic Society Centers for Disease Control and Prevention
- AT Abal
- B Mathema
- BD Kana
- BV Nikonenko
- C Dye
- C Dye
- C Jafari
- C Kan-Sutton
- C Tortajada
- CA Scanga
- CA Scanga
- CC Whalen
- CD Wells
- CE Barry
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- CM Nolan
- CM Nolan
- CR Horsburg Jr
- CR Sander
- CS Yang
- CV Harding
- CV Rothlin
- D Menzies
- D Menzies
- D Menzies
- DB Young
- DC Barral
- DC Perlman
- DE Snider Jr
- DG Russell
- DJ Kusner
- DM Bowdish
- DS Dickinson
- E Ishikawa
- E Mokaddas
- E Mokaddas
- E Mokaddas
- E Nuermberger
- E Nuermberger
- E Russell-Goldman
- E-K Jo
- EC Hett
- EH Noss
- EK Jo
- EL Nuermberger
- F Gordin
- F Winau
- FM Gordin
- FX Berthet
- FY Liew
- GE Purdy
- GH Mazurek
- GH Mazurek
- GW Comstock
- GW Comstock
- H Ohno
- HE Volkman
- HG Wiker
- HM Blumberg
- I Brock
- I Sutherland
- International Union Against Tuberculosis
- J Chan
- J Chan
- J Ena
- J Ghosh
- J Nigou
- J Pieters
- JC Betts
- JM Davis
- JM Tufariello
- JP Tulsky
- JT van Dissel
- K Andries
- K Dooley
- K Hoebe
- K Rhode
- K Weldingh
- KA Bodnar
- KK Singh
- KM Dennehy
- KM Guinn
- KR Page
- L Grode
- L Sandman
- L Wang
- LA van Pinxteren
- LB Reichman
- LE Bermudez
- LE Bermudez
- LE Bermudez
- LE Via
- LY Gao
- M Al-Zarouni
- M Farhat
- M Gonzalez-Juarrero
- M Harboe
- M Houde
- M Matsumoto
- M Pai
- M Pai
- M Pai
- M Pai
- M Protopopova
- M Sani
- M Schechter
- M Weiner
- M Yadav
- M Yamamoto
- MA Behr
- ME Kimerling
- ME Villarino
- MG Gutierrez
- MI de jonge
- MI Voskuil
- MJ Fenton
- MP Golden
- MU Shiloh
- MU Shiloh
- MV Tullius
- MY Lin
- N Caceres
- N Lounis
- N van der Wel
- NA Halsey
- National Collaborating Centre for Chronic Conditions
- ND Pecora
- NJ Garton
- NP Spyridis
- P Andersen
- P Brodin
- P Guermonprez
- P Peyron
- PA LoBue
- PB Kang
- PC Hill
- PJ Cardona
- PJ Cardona
- PJ Cardona
- PL Lin
- R Bellamy
- R Ridzon
- R Rustomjee
- R Teitelbaum
- RB Byrd
- RE Huebner
- RK Pai
- RM Jasmer
- RM Yates
- RN van Zyl-Smit
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Ahmad
- S Akira
- S Alonso
- S Axelrod
- S Beetz
- S Chitale
- S El-Shazly
- S El-Shazly
- S Fuhrmann
- S Sturgill-Koszycki
- SB Jung
- SC Derrick
- SG Reed
- SH Kaufmann
- SH Kim
- SHE Kaufmann
- SJ Kang
- SK Parida
- SM Arend
- SM Arend
- ST Chang
- ST Cole
- SV Gordon
- T Garnier
- T Lillebaek
- T Ulrichs
- TR Frieden
- TR Rustad
- TW Rennie
- U Mack
- UE Schaible
- V Briken
- World Health Organization
- World Health Organization
- World Health Organization
- X Wu
- X-F Gao
- Y Xu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
With nearly 9 million new active disease cases and 2 million deaths occurring worldwide every year, tuberculosis continues to remain a major public health problem. Exposure to Mycobacterium tuberculosis leads to active disease in only ~10% people. An effective immune response in remaining individuals stops M. tuberculosis multiplication. However, the pathogen is completely eradicated in ~10% people while others only succeed in containment of infection as some bacilli escape killing and remain in non-replicating (dormant) state (latent tuberculosis infection) in old lesions. The dormant bacilli can resuscitate and cause active disease if a disruption of immune response occurs. Nearly one-third of world population is latently infected with M. tuberculosis and 5%-10% of infected individuals will develop active disease during their life time. However, the risk of developing active disease is greatly increased (5%-15% every year and ~50% over lifetime) by human immunodeficiency virus-coinfection. While active transmission is a significant contributor of active disease cases in high tuberculosis burden countries, most active disease cases in low tuberculosis incidence countries arise from this pool of latently infected individuals. A positive tuberculin skin test or a more recent and specific interferon-gamma release assay in a person without overt signs of active disease indicates latent tuberculosis infection. Two commercial interferon-gamma release assays, QFT-G-IT and T-SPOT.TB have been developed. The standard treatment for latent tuberculosis infection is daily therapy with isoniazid for nine months. Other options include therapy with rifampicin for 4 months or isoniazid + rifampicin for 3 months or rifampicin + pyrazinamide for 2 months or isoniazid + rifapentine for 3 months. Identification of latently infected individuals and their treatment has lowered tuberculosis incidence in rich, advanced countries. Similar approaches also hold great promise for other countries with low-intermediate rates of tuberculosis incidence
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
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- Bachetti M
- Backes M
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- Bagherpour H
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- Baker PT
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- Baldaccini F
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- Barber AS
- Barbiellini G
- Barbiellini G
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- Barish BC
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- Barkett K
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- Barnes J
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Aamer A
- Aaniana K
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- Abantanga F
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- Abbasy J
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- Abbouch M
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- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
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- Abdelazeam AR
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- Abdelaziz MA
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- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhady S
- Abdelhamed R
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- Mohamed M
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
- Cheong Yj
- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin Px
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- Chiu S
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- Choi J
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- Chong Bfhk
- Chong Cl
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- Chow Cyn
- Chowdhury A
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- Chu K
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- Cirocchi R
- Ciubotaru C
- Claire R
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- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
- Clements Jm
- Clerico G
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- Colombani Jf
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- Da Silva LA
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- Dabessa D
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- Dainius E
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- Dan I
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- Danys D
- Dao W
- Daqeeq A
- Dar M
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- Darweesh M
- Darwish Ak
- Das A
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- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
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- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
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- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
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- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
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- Dissanayake T
- Djivoh F
- Domini E
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- Donoghue D
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- Dragatas D
- Drake Tm
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- Driscoll A
- Drungilas M
- Du Plessis D
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- Du Toit F
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- Dubois A
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- Duhoranenayo D
- Duinhouwer L
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- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
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- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
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- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
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- El-Shahat Ns
- El-Sheemy H
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- Elashmawy M
- Elashry R
- Elazab A
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- Elbatahgy A
- Elbe P
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- Eldafrawy M
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- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
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- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
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- Elfouly N
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- Elgendy Fi
- Elgheriany M
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- Elhendawy Aoa
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- Elkelany A
- Elkelany A
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- Elkholy A
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- Elkolaly Ss
- Elkorashy Am
- Ellison Q
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- Elmasry M
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- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
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- Elsabbagh N
- Elsameea Aa
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- Elsayed M
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- Elsemelawy R
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- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
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- Elwan A
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- Elzahed N
- Elzayat I
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- Elzayyat I
- Elzowawi F
- Emadeldin D
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- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
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- Essam A
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- Estee Mm
- Estupinian S
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- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
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- Ezzat E
- Ezzat T
- Faboya O
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- Fahiem A
- Fahim M
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- Fairfield C
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- Falco N
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- Faraz A
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- Farhangmehr N
- Farinella E
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- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
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- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
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- Fermani C
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- Ferousis C
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- Fievet L
- Filatau A
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- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald Je
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- Foco M
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- Foo Cc
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- Fouad A
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- Fourcade L
- Fowler Aj
- Fozard T
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- Frade F
- Fraga Gp
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- Francois-Coridon H
- Francone E
- Freitas Av
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- Frisk B
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- Fujii F
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- Gaarder T
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- Gado A
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- Gaignard E
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- Gala T
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- Galiqi G
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- Galvez Cp
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- Gamal S
- Gamaly E
- Gamil D
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- Gan Yy
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- Garaycochea O
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- George R
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- Gerosa A
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- Ghaben A
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- Giuriato Tf
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- Grizhja B
- Grobler Dc
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- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
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- Gui D
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- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gustafsson U
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- Gyedu A
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- Halicioglu I
- Hall E
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- Hamarshi A
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- Ibrahem Aa
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- Ibrahim A
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- Ibrahim I
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- Imoro O
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- Limaye N
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- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
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- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
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- Loizides S
- Lokman Maa
- Longstaff L
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- Lopez M
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- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
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- Luck J
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- Má
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- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
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- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
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- Maison K
- Maistry N
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- Majid Ahha
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- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
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- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
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- Mccarthy M
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- McGarvie S
- Mcguigan A
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- Mclachlan G
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- McMorran D
- Mcnish D
- Mcphee A
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- Mehrez S
- Mejia Agv
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
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- Miguel Gps
- Mihaljevic Al
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- Mikwar Z
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- Minguez G
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- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Moaty M
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- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
- Mohammad A
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- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
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- Morsi A
- Morsi M
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- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
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- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
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- Nassif D
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- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
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- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
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- Nel D
- Nemeth K
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- Neo Yt
- Neophytou C
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- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
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- Ngwa Te
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- Nicholson L
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- Nikoloudis N
- Nikoloudis N
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
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- North As
- Notarnicola M
- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Olugbemi M
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- Ortega-Vazquez I
- Ortiz N
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- Oshati O
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- Owusu F
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- Ozben V
- Ozkan Bb
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- Padmore G
- Pagano G
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- Pagnozzi J
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- Palma Af
- Paludi Ma
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- Papandrea M
- Papaskarlatos Ia
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- Parseliunas A
- Parthiban S
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- Pasquali S
- Pastora J
- Pata D
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- Patoulias I
- Paul M
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- Perino M
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- Perrotta G
- Pesenti G
- Petrikenas S
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- Pezas T
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- Pino W
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- Preckailaite E
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- Puma Cmh
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- Razmdjou S
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- Redota Map
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- Samaniego Cs
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- Senanayake Kj
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- Septiem Jg
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- Shahbaz Ar
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- Sodde P
- Soeselo Da
- Sokratous A
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- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
- Tolotra Tec
- Tori Sa
- Torrance Hd
- Torrance Hd
- Torres Cpg
- Torres Sg
- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
- Tugnoli G
- Tun Ak
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze Rge
- Tze Rge
- Tzikos G
- Uš
- Ubhi Hk
- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
- Velá
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
- Vida Lc
- Vida Lc
- Vilč
- Villa R
- Villalobos S
- Villegas Mi
- Vimalachandran D
- Vincent J
- Violi P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Vth Le
- Wael N
- Wagener M
- Wakefield R
- Walę
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward Ae
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick Am
- Waterman A
- Watson Nf
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein Ms
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini Ta
- Widmer Lw
- Wijayarathna Ls
- Wild Jrl
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson Ms
- Wilson Msj
- Wimalge Pmsn
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold Tb
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong Cs
- Wong Cy
- Wong F
- Wong Hy
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright Nj
- Xerri T
- Xerri T
- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection
- Author
- A Bachem
- A Cambi
- A Granelli-Piperno
- A Mazzoni
- A Moris
- A Moris
- AJ McMichael
- AL Ackerman
- AL Cunningham
- AL Cunningham
- AM Lennon-Dumenil
- AM Mommaas
- AMG Aar van der
- AN Zelensky
- AN Zelensky
- AR Stacey
- B Alberts
- BE Palmer
- C Dong
- C Fortis
- C Riou
- CA Stoddart
- CG Figdor
- CJ Miller
- CS Dong
- DC Douek
- DD Ho
- DF Tough
- DT Fleming
- E Klechevsky
- E Klechevsky
- EC Jong de
- EM Hiltbold
- F Buseyne
- FP Siegal
- G Doitsh
- G Trinchieri
- GD Brown
- GM Barton
- H Feinberg
- H Feinberg
- H Oshiumi
- HB Xu
- J Banchereau
- J Lai
- J Valladeau
- J Valladeau
- JG Donaldson
- JJ Hu
- JM Brenchley
- JWR Hovius
- K Drickamer
- K Eisenacher
- K Lore
- K Palucka
- K Takeda
- L Chatwell
- L Witte de
- L Witte de
- LM Berg van den
- M Carrington
- M Gromme
- M Solis
- M Vlist van der
- M Vlist van der
- M Yamamoto
- M Yamamoto
- M Yoneyama
- M Yoneyama
- MAWP Jong De
- MAWP Jong De
- MAWP Jong De
- ME Taylor
- MLO Brouw den
- MS Cohen
- N Sol-Foulon
- ND Perkins
- NS Stambach
- P Kalinski
- PC Reading
- PR Gorry
- RF Siliciano
- RM Steinman
- S Sato
- S Turville
- SG Turville
- SI Gringhuis
- SI Gringhuis
- SI Gringhuis
- SL Constant
- T Kawai
- T Kawai
- T Kawai
- T Kawamura
- TA Groothuis
- TB Geijtenbeek
- TBH Geijtenbeek
- TBH Geijtenbeek
- TBH Geijtenbeek
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4(+) T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the world-wide pandemic acquired immunodeficiency syndrome (AIDS
Physiological aspects of growth and recombinant DNA stability inSaccharomyces cerevisiae
- Author
- A Hinnen
- A Impoolsup
- A Spalding
- A Toh-e
- AB Futcher
- AB Futcher
- AE Wheals
- AW Murray
- C Gerbaud
- CA Mason
- CA Mason
- CJ Rivin
- CJ Rivin
- CS Newlon
- CV Golpal
- D DiBiasio
- DC Sigurdson
- DJ Mead
- DJ Mead
- DW Zabriskie
- E Erhart
- E Postma
- EL Walls
- F Srienc
- FC Volkert
- GA Bitter
- GC Johnston
- GC Johnston
- HH Topiwala
- J Zhu
- JC Fieschko
- JE Bailey
- JM Ligan
- JP Barford
- JR Broach
- KD Wittrup
- LB Tsai
- LH Hartwell
- M Jayaram
- M Marquet
- MA Hjortsu
- MJ Kleinman
- ML Stephens
- NF Britton
- P Caunt
- P Caunt
- PC Aar van der
- PG Lord
- PG Lord
- PM Doran
- PW Thompson
- R Piñon
- R Piñon
- R Piñon
- RM Walmsley
- SA Parent
- SJ Copella
- SL Sturley
- T Som
- Th Scheper
- TS Lopes
- VA Zakain
- VC Bugeja
- VC Bugeja
- WE Bentley
- Y Kikuchi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Response of aspen genotypes to browsing damage is not influenced by soil community diversity
- Author
- A Kulmatiski
- A Martínez-Medina
- A Pineda
- A-M Manninen
- A-M Manninen
- AAR Kula
- AE Bennett
- AE Bennett
- AE Hagerman
- AN Scioneaux
- B Diner
- BV Barnes
- C Gehring
- C Pizano
- CC Pregitzer
- D Binkley
- E Felker-Quinn
- E Garrido
- EE Batzer
- GM Turchi
- GR Iason
- HL Barker
- J Koricheva
- J Wehner
- JA Bennett
- JB Hughes
- JB Mitton
- JC Sellmer
- JDC Hemming
- JDC Hemming
- JK Bailey
- JR Donaldson
- JR Donaldson
- KF Rubert-Nason
- KF Rubert-Nason
- KL Griffis-Kyle
- KM Vogelsang
- L Edenius
- L Xu
- LJ Porter
- LK Rieske
- LM Holeski
- M Kaling
- M Semchenko
- MT Stevens
- NA Lehr
- NA Lehr
- P Schofield
- P Wang
- PB Reich
- PC Rogers
- RL Lindroth
- RL Lindroth
- S Shinde
- S-Y Hwang
- SA Mangan
- SA Mangan
- SC Wooley
- SM Top
- SS Kanekar
- TJ Kuhn
- TJ Stohlgren
- TP McGonigle
- VA Borowicz
- WC Still
- WH van der Putten
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Glutathione, glutathione S-transferase, and glutathione conjugates, complementary markers of oxidative stress in aquatic biota
- Author
- A Campos
- A Fraternale
- A Roux
- A Ruus
- AA Elskus
- AAR Radi
- AE Mutlib
- AE Salinas
- AJ Ramirez
- AJ Rust
- AM Rocha Da
- AM Sciuto
- B Blanchette
- B Carney Almroth
- B Carney Almroth
- B Ravenzwaay Van
- B Speers-Roesch
- BI Ognjanovic
- BJ Richardson
- BTG Gowland
- C Malbrouck
- C Upshall
- C Wiegand
- C Wiegand
- CA Hinchman
- CAM van Gestel
- CC Franklin
- CCC Cheung
- CJ Gordon
- CM Dieckhaus
- CR Harrington
- D Abele
- D Baganz
- D Schlenk
- D Vuckovick
- D Zhang
- DA Dickinson
- DA Holdway
- DCG Muir
- DR Livingstone
- DR Ownby
- DW Filho
- E Dam
- E Escartin
- E Godat
- E Ito
- E Snowberger Gray
- EP Gallagher
- F Gagné
- F Gagné
- F Gagné
- FC Lu
- G Jonsson
- G Li
- GB Beach
- GB Beach
- GF Jurgella
- GJ Stroomberg
- GLL Pinho
- GM Kirby
- GT Ankley
- GT Ankley
- GW Winston
- HJ Forman
- I Plakunov
- II Rudneva
- J Cazenava
- J Costa
- J Crago
- J Fu
- J Hellou
- J Hellou
- J Hellou
- J Hellou
- J Hellou
- J Limón-Pachecoa
- J Stenersen
- JJ Stegeman
- JM McKim
- Jocelyne Hellou
- K Dettmer
- K Levsen
- K Young-Mog
- KA Beattie
- KL Henson
- KM Kleinow
- L Canesi
- L Guimaraes
- LL Amado
- LL Johnson
- LL Johnson
- M Berg Van den
- M Dai
- M Holcapeck
- M Petala
- M Petrivalsky
- M Sole
- M Sole
- ME Hahn
- MG Barron
- MJ Winters
- MK Eberhardt
- ML Ballesteros
- ML Vidal
- MM Krahn
- MO James
- MR Viant
- Neil W. Ross
- NRC (National Research Council)
- P Monostori
- P Veld Van
- P Yeats
- PA Veld Van
- PC Baumann
- PJ van Bladeren
- R Dringen
- R Kellner
- R Oost Van der
- R Oost Van der
- R Powers
- R Rossi
- RF Staack
- RL Norris
- RST Tjeerdema
- RT DiGuilio
- S Balabaskaran
- S Erskine
- S Pflugmacher
- S Reynaud
- SB Song
- SC Lu
- SC Paetzold
- SC Roberts
- SG George
- SG Ma
- SK Biswas
- SL Armknecht
- SL Pallante
- SP Pflugmacher
- SP Pflugmacher
- SW Ross
- T Fusijawa
- Thomas W. Moon
- TM Scown
- VB Yadwad
- VE Forbes
- VI Lushchak
- VI Lushchak
- WA Korfmacher
- WB Dunn
- WW Hughes
- Y Iwasaki
- YJ Chae
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Scabies
- Author
- A Buczek
- A Dougall
- A Jin-gang
- A Mahe
- A Mika
- A Mika
- A Mika
- A Oleaga
- AC Bowen
- AC Bowen
- AC Steer
- AC Steer
- AC Steer
- AJ McMichael
- AM Aar van der
- AM Vogel
- B Dyring-Andersen
- B Lokuge
- B Wells
- BJ Currie
- BJ Currie
- BJ Currie
- BJ Currie
- BJ Currie
- BJ Currie
- BJ Hales
- C O’Sullivan
- C Pasay
- C Worth
- CA Guzzo
- CM Rapp
- CS Marshall
- D Clucas
- D Landwehr
- D Taplin
- DB Clucas
- DC Holt
- DC Holt
- DR Lines
- E McMeniman
- F Ly
- FC Bergstrom
- FH Jungbauer
- H Feldmeier
- H Feldmeier
- J Craven
- J Heukelbach
- J Thomas
- J Whitehall
- JD Vince
- JO Gyapong
- JR Carapetis
- JR Carapetis
- JR Carapetis
- JRH Andrews
- JS Davis
- K Fischer
- K Fischer
- K Haar
- K Mellanby
- K Mellanby
- K Mounsey
- KA Hewitt
- KE Mounsey
- KE Mounsey
- KE Mounsey
- KE Mounsey
- KE Mounsey
- L Edison
- L Romani
- L Romani
- L Romani
- L Romani
- LC Wong
- LC Wong
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LG Arlian
- LI Rutitzky
- LJ Roberts
- LK Andersen
- LK Andersen
- M Bates
- M del Mar Saez-De-Ocariz
- M Harris
- M Rampton
- M Sfeir
- O Adjei
- O Chosidow
- PC Valery
- PM Swe
- PM Swe
- R Barkwell
- R Boyd
- R Casais
- R Hay
- R Jayaraj
- R Kim
- R Zhang
- RJ Hay
- RJ Hay
- RK Prichard
- RM Andrews
- RM Andrews
- RS Bailie
- RS Sharma
- S Alasaad
- S Alasaad
- S Gray
- S Naz
- S Nishimoto
- S Vincente La
- S Walton
- SA Beckham
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SF Walton
- SL Tonkin
- SS Wong
- SY Tong
- T Kearns
- T Marquardt
- UE Schaible
- UR Hengge
- V Usha
- W Mahmood
- WH Organisation
- WR Thomas
- X Gu
- X Liu
- X Liu
- Y Cai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study