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    Isocitrate Dehydrogenase mutations in diffuse glioma: Unraveling metabolic rewiring in search of novel therapies

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    Contains fulltext : 241554.pdf (Publisher’s version ) (Open Access)Radboud University, 18 januari 2023Promotores : Wesseling, P., Brock, R.E. Co-promotor : Leenders, W.P.J.187 p

    SoK: SCA-secure ECC in software – mission impossible?

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    Contains fulltext : 286011.pdf (Publisher’s version ) (Open Access

    Quantifying quality: Practices of drinking water quality knowledge-making in Kaolack, Senegal

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    Contains fulltext : 283817.pdf (Publisher’s version ) (Open Access)This paper examines the production of drinking water quality knowledge in Kaolack, Senegal, showing that the state apparatus of scientific knowledge production can struggle to incorporate consumer perceptions and preferences. The article builds on contributions from geography and science and technology studies which show that environmental knowledges emerge through heterogeneous social and biophysical interactions, with political consequences. Relying on eight months of ethnographic field work in Kaolack including observation, participation, and interviews, I develop a qualitative case study of four state knowledge production practices. These practices include: quantifying quality, judging sources of water, locating possible sites of knowledge-making, and attributing responsibility. Each of these practices produces boundaries around what kind of knowledge about drinking water quality is allowed to be influential and obscure elements including embodied consumer perceptions, change after delivery, heterogeneity within households and over time, and long-term effects. I argue that these processes have important implications for the inclusion and exclusion of consumers from the Senegalese state's processes of knowledge-making about drinking water quality, with consequences for how people experience access to drinking water and exposure to potentially harmful substances in water in Kaolack.14 p

    The continuation of criminalization by other means: the role of judicial agency in the Italian policing of humanitarian assistance at sea

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    Contains fulltext : 284718.pdf (Publisher’s version ) (Closed access)20 oktober 202

    Behavioral inhibition, negative parenting, and social withdrawal: Longitudinal associations with loneliness during early, middle, and late adolescence

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    Contains fulltext : 285229.pdf (Publisher’s version ) (Open Access)Adolescent loneliness can have detrimental effects on physical and mental health, but there is limited understanding of its antecedents in infancy and childhood. A 20-year longitudinal, multi-informant, and multi-methods study (first data collection in 1998) was conducted to examine mechanisms underlying adolescent loneliness (N = 128, 52% boys, Mage_baseline = 1.23, SD = 0.02, 99% White, recruitment in Dutch urban, healthcare centers). Structural equation modeling showed that high infant behavioral inhibition (BI) was indirectly associated with high loneliness during adolescence via high childhood social withdrawal. This indirect effect was equally strong during early, middle, and late adolescence. Contrary to expectations, infant parenting did not moderate the relation between BI and social withdrawal. The results suggest a developmental cascade with infant BI showing long-lasting indirect effects on adolescent loneliness up to 20 years later via childhood social withdrawal.17 p

    Role of small acute hyperintense lesions in long-term progression of cerebral small vessel disease and clinical outcome: A 14-year follow-up study

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    Contains fulltext : 283553.pdf (Publisher’s version ) (Closed access)Background: Small hyperintense lesions are found on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD). Their exact role in SVD progression remains unclear due to their asymptomatic and transient nature. The main objective is to investigate the role of DWI+lesions in the radiological progression of SVD and their relationship with clinical outcomes. Methods: Participants with SVD were included from the Radboud University Nijmegen Diffusion tensor MRI Cohort. DWI+lesions were assessed on four time points over 14 years. Outcome measures included neuroimaging markers of SVD, cognitive performance and clinical outcomes, including stroke, all-cause dementia and all-cause mortality. Linear mixed-effect models and Cox regression models were used to examine the outcome measures in participants with a DWI+lesion (DWI+) and those without a DWI+lesion (DWI-). Results: DWI+lesions were present in 45 out of 503 (8.9%) participants (mean age: 66.7 years (SD=8.3)). Participants with DWI+lesions and at least one follow-up (n=33) had higher white matter hyperintensity progression rates (β=0.36, 95% CI=0.05 to 0.68, p=0.023), more incident lacunes (incidence rate ratio=2.88, 95% CI=1.80 to 4.67, p<0.001) and greater cognitive decline (ß=-0.03, 95% CI=-0.05 to -0.01, p=0.006) during a median follow-up of 13.2 (IQR: 8.8-13.8) years compared with DWI- participants. No differences were found in risk of all-cause mortality, stroke or dementia. Conclusion: Presence of a DWI+lesion in patients with SVD is associated with greater radiological progression of SVD and cognitive decline compared with patients without DWI+lesions. Data are available upon reasonable request.7 p

    Forensic vigilance in forensic professionals: Development, reliability and factor structure of the forensic vigilance estimate

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    Item does not contain fulltextPurpose: Forensic vigilance is a central competency that forensic professionals need to meet the complex demands of working in forensic settings. Until recently, no instrument for forensic vigilance was available. This study aims to develop a self-assessment tool of forensic vigilance for individuals and teams working in forensic settings, and investigated its psychometric properties. Design/methodology/approach: The Forensic Vigilance Estimate (FVE) was presented to 367 forensic psychiatric professionals and 94 non-forensic psychiatric professionals by means of an online survey. Professionals rated themselves on 15 aspects of forensic vigilance. Findings: The results indicated that the FVE had good psychometric properties, reflected by a good to excellent internal consistency (Cronbach’s α of 0.903), a good split-half reliability (0.884) and good test–retest reliability (0.809). The factor structure of the FVE was captured by a one-factor model (RMSEA 0.09, SRMR 0.05, TLI 0.91 and CFI 0.92). Proportion of explained variance was 52%. Forensic professionals scored significantly higher than non-forensic professionals on the FVE (t(459) = 3.848, p = 0.002). Practical implications: These results suggest that the FVE may reliably be used for research purposes, e.g. to study the effects of targeted training or intervention or increasing work experience on forensic vigilance or to study which factors influence forensic vigilance. Originality/value: This study represents the first attempt to capture forensic vigilance with a measuring instrument.12 p


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