114 research outputs found
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
- Author
- ?lvarez I.
- ?lvarez V.
- ?vila J.
- Abdelnour C.
- Abdelnour C.
- Adarmes-G?mez A. D.
- Aguilera N.
- Alarc?n-Mart?n E.
- Alarcon E.
- Alegret M.
- Amer-Ferrer G.
- Ant?nez C.
- Antequera M.
- Baquero M.
- Benaque A.
- Bernal M.
- Blesa R.
- Boada M.
- Buendia M.
- Buiza-Rueda D.
- Bullido M. J.
- Burguera J. A.
- Ca?abate P.
- Calero M.
- Carracedo ?lvarez ?ngel
- Carri?n-Claro M.
- Carrillo F.
- Casajeros M. J.
- Clarim?n J.
- Corbat?n A.
- Cruz-Gamero J. M.
- de Pancorbo M. M.
- de Rojas I.
- del Ser T.
- Diego S.
- Diez-Fairen M.
- Espinosa A.
- Espinosa L.
- Fortea J.
- Franco E.
- Frank-Garc?a A.
- G?mez-Garre P.
- Gailhajenet A.
- Garc?a Gonz?lez P.
- Garc?a-Alberca J. M.
- Garc?a-Ribas G.
- Garcia Madrona S.
- Garcia-Ribas G.
- Gil S.
- Gonz?lez-Perez A.
- Guitart M.
- Hern?ndez I.
- Hern?ndez-Olasagarre B.
- Hevilla S.
- Ibarria M.
- Jes?s S.
- L?pez de Mun?in A.
- L?pez-Garc?a S.
- Lafuente A.
- Lage C.
- Legaz A.
- Lle? A.
- Mac?as J.
- Macias D.
- Macias J.
- Madrid L.
- Manzanares S.
- Mar?n M.
- Mar?n T.
- Mar?n-Mu?oz J.
- Maro?as O.
- Marqui? M.
- Mart?n Montes A.
- Mart?n E.
- Mart?nez B.
- Mart?nez C.
- Mart?nez M. T.
- Mart?nez V.
- Mart?nez-Lage ?lvarez P.
- Maule?n A.
- Medina M.
- Medina M.
- Men?ndez-Gonz?lez M.
- Mendioroz Iriarte M.
- Mir P.
- Molinuevo J. L.
- Mont?-Rubio G.
- Montrreal L.
- Moreno M.
- Moreno-Grau S.
- Orellana A.
- Ortega G.
- P?rez Tur J.
- P?rez-Cord?n A.
- P?stor P.
- Pancho A.
- Pastor A. B.
- Pelej? E.
- Peri??n-Tocino T.
- Pi?ol Ripoll G.
- Pi?ol-Ripoll G.
- Pineda J. A.
- Preckler S.
- Quintela I.
- R?bano A.
- Real de As?a D.
- Real L. M.
- Rodr?guez-G?mez O.
- Rodr?guez-Rodr?guez E.
- Rodrigo S.
- Rosende-Roca M.
- Royo J. L.
- Ruiz A.
- Ruiz A.
- Ruiz S.
- Ruiz S.
- S?ez M. E.
- S?nchez-Juan P.
- Sanabria ?
- Sanabria A.
- Sanchez del Valle D?az R.
- Santos-Santos M. ?
- Sastre I.
- Serrano-Rios M.
- Sotolongo-Grau O.
- T?rraga L.
- Valero S.
- Vargas L.
- Vicente M. P.
- Vivancos L.
- Publication venue
- Publication date
- 01/01/2019
- Field of study
INTRODUCTION: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. RESULTS: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. DISCUSSION: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series
Nitric Oxide Antagonizes the Acid Tolerance Response that Protects Salmonella against Innate Gastric Defenses
- Author
- A Fite
- A Llama-Palacios
- AJ Baumler
- Alejandro Aballay
- Andrés Vázquez-Torres
- AW van der Velden
- B D'Autreaux
- B Spiegelhalder
- BD McCollister
- BD McCollister
- BL Bearson
- C Duncan
- CD Ellermeier
- CJ Dorman
- CR Hung
- CS Butler
- D Zhou
- D Zhou
- EA Groisman
- FC Soncini
- FC Soncini
- GC Cook
- GJ Leyer
- H Bjorne
- H Hori
- H Reynaert
- Harry Ischiropoulos
- HJ Vogel
- HK Hall
- I Stojiljkovic
- I Zwir
- IS Bang
- IS Lee
- J Deiwick
- J Xu
- JB Dressman
- JH Miller
- JJ Bijlsma
- JW Foster
- JW Foster
- JW Foster
- JW Foster
- K Eichelberg
- KA Datsenko
- KE Klose
- L Puzniak
- LR Prost
- M Husain
- Michael McClelland
- MJ Worley
- N Benjamin
- OL Wijburg
- P Adams
- P Holt
- P Monsieurs
- P Small
- PC Oyston
- PI Fields
- PJ Buchin
- PP Cherepanov
- R Cunningham
- RA Giannella
- RB Canani
- RF Wang
- RS Dykhuizen
- RT Bacon
- Rui Zhao
- RW Stockbruegger
- S Porwollik
- S Uzzau
- SI Miller
- SR Tannenbaum
- Steffen Porwollik
- T Aiso
- Todd Greco
- Travis J. Bourret
- VG Tusher
- YA Golubeva
- YH Lee
- Publication venue
- Public Library of Science
- Publication date
- 01/03/2008
- Field of study
Reactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrogen oxides foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antimicrobial activity in the gastric lumen are, however, poorly understood.The genetically tractable acid tolerance response (ATR) that enables enteropathogens to survive harsh acidity was screened for signaling pathways responsive to RNS. The nitric oxide (NO) donor spermine NONOate derepressed the Fur regulon that controls secondary lines of resistance against organic acids. Despite inducing a Fur-mediated adaptive response, acidified RNS largely repressed oral virulence as demonstrated by the fact that Salmonella bacteria exposed to NO donors during mildly acidic conditions were shed in low amounts in feces and exhibited ameliorated oral virulence. NO prevented Salmonella from mounting a de novo ATR, but was unable to suppress an already functional protective response, suggesting that RNS target regulatory cascades but not their effectors. Transcriptional and translational analyses revealed that the PhoPQ signaling cascade is a critical ATR target of NO in rapidly growing Salmonella. Inhibition of PhoPQ signaling appears to contribute to most of the NO-mediated abrogation of the ATR in log phase bacteria, because the augmented acid sensitivity of phoQ-deficient Salmonella was not further enhanced after RNS treatment.Since PhoPQ-regulated acid resistance is widespread in enteric pathogens, the RNS-mediated inhibition of the Salmonella ATR described herein may represent a common component of innate host defenses
A reference panel of 64,976 haplotypes for genotype imputation.
- Author
- Abecasis G
- Altshuler D
- Anderson CA
- Angius A
- Barrett JC
- Boehnke M
- Boomsma D
- Branham K
- Breen G
- Brummett CM
- Busonero F
- Campbell H
- Chan A
- Chen S
- Chew E
- Cocca M
- Collins FS
- Corbin LJ
- Cucca F
- Danecek P
- Das S
- de Bakker PI
- Dedoussis G
- Dekker A
- Delaneau O
- Dorr M
- Durbin R
- Farmaki AE
- Ferrucci L
- Forer L
- Fraser RM
- Frayling T
- Fuchsberger C
- Gabriel S
- Gandin I
- Gasparini P
- Gillies CE
- Gilly A
- Groop L
- Haplotype Reference Consortium
- Harrison T
- Hattersley A
- Holmen OL
- Hveem K
- Iacono W
- Kang HM
- Kooperberg C
- Koskinen S
- Kretzler M
- Kretzschmar W
- Kwong A
- Lee JC
- Levy S
- Luo Y
- Mahajan A
- Marchini J
- McCarroll S
- McCarthy MI
- McCarthy S
- McGue M
- McInnis M
- Meitinger T
- Melzer D
- Mezzavilla M
- Min JL
- Mohlke KL
- Myers RM
- Nauck M
- Nickerson D
- Palotie A
- Pato C
- Pato M
- Peters U
- Pirastu N
- Richards JB
- Ripatti S
- Sala C
- Salomaa V
- Sampson MG
- Schlessinger D
- Schoenherr S
- Scott LJ
- Sharp K
- Sidore C
- Slagboom PE
- Small K
- Smith GD
- Soranzo N
- Spector T
- Stambolian D
- Swaroop A
- Swertz MA
- Teumer A
- Timpson N
- Toniolo D
- Traglia M
- Tuke M
- Tuomilehto J
- Van den Berg LH
- van Duijn CM
- Van Rheenen W
- Veldink J
- Vincent JB
- Volker U
- Vrieze S
- Walter K
- Wijmenga C
- Willer C
- Wilson JF
- Wood AR
- Zeggini E
- Zhang H
- Publication venue
- Nat Genet
- Publication date
- 01/01/2016
- Field of study
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently
Biased-corrected richness estimates for the Amazonian tree flora
- Author
- Ahuite Reategui MA
- Albuquerque BW
- Alexiades MN
- Alonso A
- Amaral IL
- Andrade A
- Araujo-Murakami A
- Arroyo L
- Assis RL
- Aymard C. GA
- Baider C
- Baker TR
- Balslev H
- Baraloto C
- Barbosa EM
- Barbosa FR
- Barlow J
- Berenguer E
- Brienen R
- Bánki OS
- Camargo JL
- Cano A
- Carrero Márquez YA
- Carvalho FA
- Casas LF
- Castaño Arboleda N
- Castellanos H
- Castilho CV
- Casula KR
- Cerón C
- Chave J
- Cintra BBL
- Comiskey JA
- Cornejo Valverde F
- Correa DF
- Costa FRC
- Costa JBP
- Cárdenas López D
- Cárdenas S
- da Silva Guimarães JR
- Dallmeier F
- Daly D
- Damasco G
- de Aguiar DPP
- de Andrade Lima Filho D
- de Andrade Miranda IP
- de Jesus Rodrigues D
- de Jesus Veiga Carim M
- de Leão Novo EMM
- de Lima RAF
- de Matos Bonates LC
- de Medeiros MB
- de Oliveira EA
- de Queiroz HL
- de Sousa Farias E
- de Souza Coelho L
- de Souza FC
- de Sá Carpanedo R
- de Toledo JJ
- Demarchi LO
- Dexter KG
- Di Fiore A
- Dionízia de Almeida Matos F
- do Amaral DD
- Doza HPD
- Draper F
- Duivenvoorden JF
- Duque A
- Dávila N
- Engel J
- Farfan-Rios W
- Farfan-Rios W
- Feeley KJ
- Feitosa YO
- Feldpausch TR
- Ferreira C
- Ferreira J
- Ferreira LV
- Fine PVA
- Flores BM
- Fonty É
- Fuentes A
- Galbraith D
- Gamarra LV
- Garcia-Cabrera K
- García-Villacorta R
- Gomes VHF
- Gonzales GPG
- Gonzales T
- Gribel R
- Guedes MC
- Guevara JE
- Gómez RZ
- Henkel TW
- Hernandez L
- Hilário RR
- Hoffman B
- Holmgren M
- Honorio Coronado EN
- Huamantupa-Chuquimaco I
- Irume MV
- Jimenez EM
- Junqueira AB
- Kalamandeen M
- Killeen TJ
- Klitgaard B
- Laurance SGW
- Laurance WF
- Levesley A
- Licona JC
- Linares-Palomino R
- Lloyd J
- Lopes A
- Lopes MA
- Lozada JR
- Luize BG
- Maas P
- Magalhães JLL
- Magnusson WE
- Malhi Y
- Manzatto AG
- Marimon BS
- Marimon-Junior BH
- Melgaço K
- Mendoza C
- Mesones I
- Milliken W
- Mogollón HF
- Molino J-F
- Monteagudo Mendoza A
- Montero JC
- Mostacedo B
- Nascimento HEM
- Nascimento MT
- Neill D
- Noronha JC
- Núñez Vargas P
- Oliveira AA
- Palacios Cuenca W
- Pansini S
- Pansonato MP
- Paredes MR
- Pauletto D
- Pena JLM
- Pennington T
- Peres CA
- Petronelli P
- Peñuela Mora MC
- Phillips JF
- Phillips OL
- Pickavance G
- Piedade MTF
- Pinto LFM
- Pires Martins M
- Pitman NCA
- Pos E
- Prado PI
- Prieto A
- Quaresma A
- Ramirez Arevalo F
- Ramirez-Angulo H
- Ramos JF
- Reis NFC
- Revilla JDC
- Rincón LM
- Rivas-Torres G
- Rocha M
- Rudas A
- Ruschel AR
- Sabatier D
- Salomão RP
- Sampaio AF
- Schietti J
- Schöngart J
- Scudeller VV
- Sierra R
- Silman MR
- Silva N
- Silva TSF
- Silveira M
- Simon MF
- Sousa TR
- Stevenson PR
- Stropp J
- Tello JS
- ter Steege H
- Terborgh J
- Thomas R
- Tirado M
- Torres-Lezama A
- Umaña MN
- Urrego Giraldo LE
- Valderrama Sandoval EH
- van Andel TR
- van der Heijden G
- Vasquez R
- Vela CIA
- Venticinque EM
- Vicentini A
- Vieira ICG
- Vilanova Torre E
- Villa B
- Villarroel D
- von Hildebrand P
- Vos VA
- Vriesendorp C
- Wang O
- Wittmann F
- Young KR
- Zagt R
- Zartman CE
- Zent EL
- Zent S
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
Amazonian forests are extraordinarily diverse, but the estimated species richness is very much debated. Here, we apply an ensemble of parametric estimators and a novel technique that includes conspecific spatial aggregation to an extended database of forest plots with up-to-date taxonomy. We show that the species abundance distribution of Amazonia is best approximated by a logseries with aggregated individuals, where aggregation increases with rarity. By averaging several methods to estimate total richness, we confirm that over 15,000 tree species are expected to occur in Amazonia. We also show that using ten times the number of plots would result in an increase to just ~50% of those 15,000 estimated species. To get a more complete sample of all tree species, rigorous field campaigns may be needed but the number of trees in Amazonia will remain an estimate for years to come
Pan-cancer analysis of whole genomes
- Author
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- aaa Mardis
- aab Marks
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- aag Mose
- aaz Schein
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- abd Sipahimalani
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- abpEmail Author
- Aburatani
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- Bullman S. b
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- Cafferkey A. f
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- Caldas
- Calvo
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- Campbell P. J. a
- Campo
- Cantù
- Cao
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- Cazzola
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- cg Sabarinathan
- Chadwick
- Chakravarty
- Chalmers
- Chan
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- Chandan
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Yachida
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- zd Gershenwald
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- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
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- Zhu
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- zi zj
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- Zou
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- Ó. A. th
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
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- Aad G
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- Abhayasinghe DK
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- Zhemchugov A
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
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- Hanekom S
- Haniffa R
- Hanna AA
- Haritydi T
- Harm S
- Harridge SD
- Harrison D
- Harrison M
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- Hassanin H
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- Hawkins K
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayashi K
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- Hebert P
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- Helmy TA
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- Helyar S
- Hempel D
- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
- Hernández-Tejedor A
- Herpain A
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
- Hillier SD
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- Himpe D
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- Hirata A
- Hirayama T
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- Hodgson LE
- Hodgson LE
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- Hollands S
- Hom H
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- Hopkins PA
- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
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- Houzé S
- Houzé S
- Howes D
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- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Ishimatsu S
- Itenov TS
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- Jaber S
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- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
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- Jian Z
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- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Keep J
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- Kellner F
- Kelly JM
- Kenardy J
- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
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- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latini R
- Latorre J
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- Lavrentieva A
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- Lee S
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
- Leone M
- Lerma FA
- Lesmes SP
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- Lheureux O
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- Li SH
- Liao X
- Lichtenstein D
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- Limuti R
- Lin KC
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- Lin WC
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- Lischinsky A
- Lissonde F
- Lissonde F
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- Liu CP
- Liu CP
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- Liu D
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- Llorente B
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- Lobato MS
- Lobo-Civico A
- Loizou C
- Lombardo MD
- Londoño JG
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- Lopez R
- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
- Lortat-Jacob B
- Lotay R
- Loudet CI
- Louf-Durier A
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- Louis B
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- Lukaszewicz AC
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- MacKay A
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- MacPhee I
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- Maekawa K
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- Merino-Vega D
- Messenger D
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- Mihara Y
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- Okamoto H
- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Romero I
- Romero JC
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- Romeu JD
- Rood PJ
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- Rossini P
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- Rota L
- Roth GA
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- Ruiz A
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- Santiago AI
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- Scales DC
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- St George’s University of London
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- Álvarez JT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
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- Alessandri C
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- Alizadeh J
- Almacellas E
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- Atanasov AG
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- Cheetham ME
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- Chen X
- Chen X-M
- Chen X-W
- Chen Y
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- Chen Y-G
- Chen Y-J
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- Chen Z
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- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
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- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
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- Chiaradonna F
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- Chiurchiù V
- Cho D-H
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- Choudhury KR
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- Chua JP
- Chung H
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- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
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- Clementi E
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- Colasuonno F
- Colbert RA
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- Colombo MI
- Colón-Ramos DA
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- Cominetti MR
- Consiglio A
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- Corasaniti MT
- Cordes N
- Corkery DP
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- Crack PJ
- Crespo JL
- Criollo A
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- Csizmadia T
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- Dalmasso G
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- de Mattos Barbosa MG
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- Der CJ
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- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
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- Diwan A
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- Dobrowolski R
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- Zorzano A
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Constraints on mediator-based dark matter and scalar dark energy models using root s= 13 TeV pp collision data collected by the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Alberich L Cerda
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexandre D
- Alexopoulos T
- Alfonsi A
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Estevez M
- Alvarez Piqueras D
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Arabidze G
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya S Tapia
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Avramidou R
- Ayoub MK
- Azoulay AM
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
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- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
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- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
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- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Constraints on selected mediator-based dark matter models and a scalar dark energy model using up to 37 fb−1s√ = 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015-2016 are summarised in this paper. The results of experimental searches in a variety of final states are interpreted in terms of a set of spin-1 and spin-0 single-mediator dark matter simplified models and a second set of models involving an extended Higgs sector plus an additional vector or pseudo-scalar mediator. The searches considered in this paper constrain spin-1 leptophobic and leptophilic mediators, spin-0 colour-neutral and colour-charged mediators and vector or pseudo-scalar mediators embedded in extended Higgs sector models. In this case, also s√ = 8 TeV pp collision data are used for the interpretation of the results. The results are also interpreted for the first time in terms of light scalar particles that could contribute to the accelerating expansion of the universe (dark energy).ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW, Austria; FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq, Brazil; FAPESP, Brazil; NSERC, Canada; NRC, Canada; CFI, Canada; CERN; CONICYT, Chile; CAS, China; MOST, China; NSFC, China; COLCIENCIAS, Colombia; MSMT CR, Czech Republic; MPO CR, Czech Republic; VSC CR, Czech Republic; DNRF, Denmark; DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, Germany; HGF, Germany; MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, Israel; Benoziyo Center, Israel; INFN, Italy; MEXT, Japan; JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW, Poland; NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia, Russian Federation; NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS, Slovenia; MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC, Sweden; Wallenberg Foundation, Sweden; SERI, Switzerland; SNSF, Switzerland; Canton of Bern, Switzerland; Canton of Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE, United States of America; NSF, United States of America; BCKDF, Canada; CANARIE, Canada; CRC, Canada; Compute Canada, Canada; COST, European Union; ERC, European Union; ERDF, European Union; Horizon 2020, European Union; Marie Sk lodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG, Germany; AvH Foundation, Germany; Herakleitos programme; Thales programme; Aristeia programme; EU-ESF, Greece; Greek NSRF, Greece; BSF-NSF, Israel; GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; Royal Society, United Kingdom; Leverhulme Trust, United KingdomOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Observation of Electroweak Production of a Same-Sign W Boson Pair in Association with Two Jets in pp Collisions root s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
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- Alimonti G
- Alison J
- Alkire SP
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- Zhemchugov A
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- Zivkovic L
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- Zou R
- Zu Theenhausen HM
- Zur Nedden M
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 18/10/2019
- Field of study
This Letter presents the observation and measurement of electroweak production of a same-sign
W
boson pair in association with two jets using
36.1
fb
−
1
of proton-proton collision data recorded at a center-of-mass energy of
√
s
=
13
TeV
by the ATLAS detector at the Large Hadron Collider. The analysis is performed in the detector fiducial phase-space region, defined by the presence of two same-sign leptons, electron or muon, and at least two jets with a large invariant mass and rapidity difference. A total of 122 candidate events are observed for a background expectation of
69
±
7
events, corresponding to an observed signal significance of 6.5 standard deviations. The measured fiducial signal cross section is
σ
fid
=
2.89
+
0.51
−
0.48
(
stat
)
+
0.29
−
0.28
(
syst
)
fb
- …