5 research outputs found
Decision analysis in anaesthesia: a tool for developing and analysing clinical management plans
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
What do women with diabetes know about pregnancy and contraception?
- Author
- Abramsky
- Casson
- Clinical Resource Efficiency Support Team
- Confidential Enquiry into Maternal and Child Health
- Confidential Enquiry into Maternal and Child Health
- Dicker
- Dunne
- Fuhrmann
- Goldman
- Gregory
- Hawthorne
- Holing
- Jenson
- Kernaghan
- Miller
- Newnham
- Platt
- Saunders
- The Diabetes Control and Complications Trial Research Group
- Williams
- World Health Organisation (Europe) and International Diabetes Federation (Europe)
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis
- Author
- A. Blauw
- A. Rijnierse
- Aline B. Sprikkelman
- Aline B. Sprikkelman
- Anne L. Wyllie
- B. Dontje
- B. J. Prakken
- B. Papi
- Belinda van’t Land
- Belinda van’t Land
- Clinical Trial Support
- D. H. H. Fandri
- D. Hijnen
- D. Veening
- Debby Bogaert
- Elisabeth A. M. Sanders
- G. W. Ten Tusscher
- I. Groot
- Johan Garssen
- Johan Garssen
- L. E. M. Willemsen
- Leon M. J. Knippels
- Leon M. J. Knippels
- Lies Hulshof
- M. A. Middelkamp-Hup
- M. Boks
- M. Roelofs
- Mei Ling J. N. Chu
- R. A. Tupker
- Saskia A. Overbeek
- Saskia A. Overbeek
- The Clinical Study Group
- W. H. C. de Boom
- Wilco de Jager
- Wim M. C. van Aalderen
- Y. C. M. Duijvestein
- Y. van Kooyk
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/03/2018
- Field of study
BackgroundAtopic dermatitis (AD) is the most common chronic inflammatory skin disease in infancy with a complex pathology. In adults, the clinical severity of AD has been associated with increases in T helper cell type (Th) 2, Th22, and Th17 serum markers, including high levels of CC chemokine ligand (CCL) 17 and CCL22 chemokines.ObjectiveTo explore the possible association between serum chemokine levels and AD severity in infants with moderate-to-severe AD and elevated immunoglobulin E (IgE).Subjects and methodsSerum samples (n = 41) obtained from a randomized, double-blind, and clinical dietary intervention study were used to study biomarkers in infants with AD. Baseline- and post-intervention samples (4 months) were used, six chemokines and nine ratios thereof were analyzed using Luminex and correlated to AD severity. In the initial study, the infants were randomized to receive extensively hydrolyzed whey-based formula without (control) or with short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides (9:1) and Bifidobacterium breve M-16V (active).Results31 Infants up to 11 months of age, with an objective-SCORAD score (oSCORAD) ≥ 20 and elevated total-IgE and/or specific-IgE levels were included. In time, the median oSCORAD decreased in both groups by −8 (control, p < 0.05; active, p < 0.01). Irrespective of dietary intervention, several changes in Th2 chemokines (CCL17 and CCL22), inflammatory chemokine (CCL20), and the Th1 chemokine, CXC chemokine ligand (CXCL) 9, were detected over time. Overall CCL17 correlated to oSCORAD (r = 0.446, p < 0.01). After 4 months of dietary intervention, CXCL9 was higher (p < 0.01) in the active group compared with control [active, 2.33 (1.99–2.89); controls, 1.95 (1.77–2.43) log 10 median (range)]. In addition, a reduction in Th2/Th1 chemokine ratios for CCL17/CXCL9, CCL22/CXCL9, CCL20/CXCL10, and CCL20/CXCL11 was detected associated with the active intervention.ConclusionWhile this study is small and exploratory in nature, these data contribute to immune biomarker profiling and understanding of AD in infants
The impact of the National Institute for Health Research Health Technology Assessment programme, 2003–13: a multimethod evaluation
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- Aamir
- Abu-Harb
- Abu-Harb
- Abu-Harb
- Adams
- Aeron-Thomas
- Ainsworth
- Albers
- Altman
- Alvarado
- Anderson
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- Andrew
- Arnedo-Pena
- Arnold
- Arsiwala
- Ashcroft
- Asseburg
- Audit & Research Committee of the Vascular Society of Great Britain & Ireland
- Audit Commission
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- Azariades
- Bagnall
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- British Broadcasting Corporation
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- Vargas-Origel
- Varner
- Vauzelle-Kervroëdan
- Veldman
- Veldman
- Vellodi
- Venkatesh
- Venkatesh
- Venkatesh
- Venkatesh
- Venter
- Vermes
- Vesikari
- Vestergaard
- Veuvonen
- Victorin
- Villain
- Villanueva-García
- Vincent
- Viscardi
- Viscardi
- Vitali
- von Kries
- von Lindern
- von Rosensteil
- Vásquez-Mendoza
- Wade
- Wadsworth
- Wagner
- Wainer
- Waites
- Walker
- Wallon
- Wan
- Wang
- Wang
- Wapner
- Ward
- Ward
- Wardle
- Wardle
- Wardle
- Wastell
- Watanabe
- Wathen
- Watkins
- Watkins
- Watkins
- Watt
- Weale
- Weber
- Weber
- Webster
- Weitkamp
- Wells
- Welzing
- Welzing
- Welzing
- Wenzl
- Werlin
- Werner
- West
- Westergren
- Wheless
- White
- White
- Whitelaw
- Whitelaw
- Whitelaw
- Whitfield
- Whitington
- Whitney
- Wiedmeier
- Wiholm
- Wijburg
- Wijburg
- Wijburg
- Wilby
- Wilcken
- Wilken
- Wilkes
- Wilkins
- Williams
- Williams
- Williams
- Williams
- Williams
- Willmore
- Willot
- Wills
- Wilmer
- Wilson
- Wilson
- Wirth
- Withington
- Wolf
- Wolf
- Wolf
- Wolfe
- Wong
- Woo
- Woodrow
- Worldwide Atosiban versus Beta-agonists Study Group
- Wraith
- Wraith
- Wren
- Wright
- Wright
- Wu
- Wurthwein
- Wyckoff
- Wyckoff
- Wyllie
- Wyllie
- Wynn
- Xie
- Xinias
- Yalaz
- Yanni
- Yaseen
- Yates
- Yeh
- Yeh
- Yeung
- Yoshida
- Young
- Young
- Young
- Young
- Yukawa
- Yüksel
- Zakrzewska-Bode
- Zaman
- Zanetti
- Zar
- Zeidan
- Zelicof-Paul
- Zelnik
- Zempleni
- Zeng
- Zhanel
- Zhang
- Zhao
- Ziaei
- Zuppa
- Publication venue
- 'Wiley'
- Publication date
- Field of study