TT2013 meeting report: the transgenic technology meeting visits Asia for the first time

The 11th Transgenic Technology meeting was held in Guangzhou, China on 25th–27th February 2013. Over 300 scientists and students from round the world gathered to hear the latest developments in the technologies underpinning the creation of transgenic and knockout animals and their application to biological sciences in areas such as the modeling human diseases and biotechnology. As well as informative presentations from leading researchers in the field, an excellent selection of short talks selected from abstracts and posters, attendees were also treated to an inspiring talk from Allan Bradley who was awarded the 9th International Society of Transgenic Technologies Prize for outstanding contributions to the field of transgenic technologies

Living well, dying well - the importance of housing

David Clark and Sandy Whitelaw outline their vision for a new type of ‘care campus’ that would provide an environment in which older people, ranging from those able to live with complete independence to those with palliative care needs, would become part of the community of the Crichton Campus in dumfries

Uncovering the risk-return relation in the stock market

There is an ongoing debate about the apparent weak or negative relation between risk (conditional variance) and expected returns in the aggregate stock market. We develop and estimate an empirical model based on the ICAPM that separately identifies the two components of expected returns–the risk component and the component due to the desire to hedge changes in investment opportunities. The estimated coefficient of relative risk aversion is positive, statistically significant, and reasonable in magnitude. However, expected returns are driven primarily by the hedge component. The omission of this component is partly responsible for the existing contradictory results.Stock market ; Econometric models ; Asset pricing

Physical activity promotion in care homes

Purpose: The purpose of this paper is to report on the implementation of a physical activity (PA) scheme – Let’s Motivate (LM) – within private care homes (CHs) in Dumfries and Galloway (D&G), Scotland; aiming to provide an insight into the different factors which might contribute to its success and further sustainability. Design/methodology/approach: A qualitative study is described in which one-to-one semi-structured interviews were carried out with eight key staff involved in implementing the project within two purposively sampled CHs; in order to explore their views and experiences of implementation. Findings: The paper provides an insight into the different factors which stand to both promote and impede the successful implementation of LM, within the two CHs involved. Originality/value: This paper explores a new and innovative PA initiative in CHs in D&G, Scotland. Studies exploring the factors which can both promote and impede implementation are important as they can help to usefully inform the implementation and sustainability of initiatives

Simulation of preburner sprays, volumes 1 and 2

The present study considered characteristics of sprays under a variety of conditions. Control of these sprays is important as the spray details can control both rocket combustion stability and efficiency. Under the present study Imperial College considered the following: (1) Measurement of the size and rate of spread of the sprays produced by single coaxial airblast nozzles with axial gaseous stream. The local size, velocity, and flux characteristics for a wide range of gas and liquid flowrates were measured, and the results were correlated with the conditions of the spray at the nozzle exit. (2) Examination of the effect of the geometry of single coaxial airblast atomizers on spray characteristics. The gas and liquid tube diameters were varied over a range of values, the liquid tube recess was varied, and the shape of the exit of the gaseous jet was varied from straight to converging. (3) Quantification of the effect of swirl in the gaseous stream on the spray characteristics produced by single coaxial airblast nozzles. (4) Quantification of the effect of reatomization by impingement of the spray on a flat disc positioned around 200 mm from the nozzle exit. This models spray impingement on the turbopump dome during the startup process of the preburner of the SSME. (5) Study of the interaction between multiple sprays without and with swirl in their gaseous stream. The spray characteristics of single nozzles were compared with that of three identical nozzles with their axis at a small distance from each other. This study simulates the sprays in the preburner of the SSME, where there are around 260 elements on the faceplate of the combustion chamber. (6) Design an experimental facility to study the characteristics of sprays at high pressure conditions and at supercritical pressure and temperature for the gas but supercritical pressure and subcritical temperature for the liquid

The changing role of cell culture in the generation of transgenic livestock

Transgenesis may allow the generation of farm animals with altered phenotype, animal models for research and animal bioreactors. Although such animals have been produced, the time and expense involved in generating transgenic livestock and then evaluating the transgene expression pattern is very restrictive. If questions about the ability and efficiency of expression could be asked solely in vitro rapid progress could be achieved. Unfortunately, experiments addressing transcriptional control in vitro have proved unreliable in their ability to indicate whether a transgene will be transcribed or not. However, initial studies suggest that cell culture may be able to predict in vivo post-transcriptional events. We review these issues and propose that strategies which engineer the transgene integration site could enhance the probability for efficient expression. This approach has now become feasible with the development of techniques allowing animals to be generated from somatic cells by nuclear transfer. The important step in this procedure is the use of cells grown in culture as the source of genetic information, allowing the selection of specific transgene integration events. This technology which has dramatically increased the potential use of transgenic livestock for both agricultural and biotechnological applications, is based on standard cell culture methodology. We are now at the start of a new era in large animal transgenics

Uncovering the Risk-Return Relation in the Stock Market

There is an ongoing debate in the literature about the apparent weak or negative relation between risk (conditional variance) and return (expected returns) in the aggregate stock market. We develop and estimate an empirical model based on the ICAPM to investigate this relation. Our primary innovation is to model and identify empirically the two components of expected returns--the risk component and the component due to the desire to hedge changes in investment opportunities. We also explicitly model the effect of shocks to expected returns on ex post returns and use implied volatility from traded options to increase estimation efficiency. As a result, the coefficient of relative risk aversion is estimated more precisely, and we find it to be positive and reasonable in magnitude. Although volatility risk is priced, as theory dictates, it contributes only a small amount to the time-variation in expected returns. Expected returns are driven primarily by the desire to hedge changes in investment opportunities. It is the omission of this hedge component that is responsible for the contradictory and counter-intuitive results in the existing literature.

Palliative care declarations: mapping a new form of intervention

No abstract available

Internet information on birth options after caesarean compared to the RCOG patient information leaflet : a web survey

Peer reviewedPublisher PD