105 research outputs found

    CP-violating top quark couplings at future linear e+e−e^+e^- colliders

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    We study the potential of future lepton colliders to probe violation of the CP symmetry in the top quark sector. In certain extensions of the Standard Model, such as the two-Higgs-doublet model (2HDM), sizeable anomalous top quark dipole moments can arise, that may be revealed by a precise measurement of top quark pair production. We present results from detailed Monte Carlo studies for the ILC at 500~\GeV{} and CLIC at 380~\gev{} and use parton-level simulations to explore the potential of high-energy operation. We find that precise measurements in e+e−→ttˉe^+e^- \rightarrow t\bar{t} production with subsequent decay to lepton plus jets final states can provide sufficient sensitivity to detect Higgs-boson-induced CP violation in a viable two-Higgs-doublet model. The potential of a linear e+e−e^+e^- collider to detect CP-violating electric and weak dipole form factors of the top quark exceeds the prospects of the HL-LHC by over an order of magnitude

    Implementing Sustainability Criteria for Selecting a Roof Assembly Typology in Medium Span Buildings

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    Technological advances have allowed the development of new roof assembly typologies with higher efficiency and less waste. However, in the construction sector the focus is generally on reducing cost and not in sustainable development factors. Short-sighted building planning based only on economic criteria should be avoided improving decision support systems. In addition, the selection of an appropriate roof assembly in a building s design stage is a complex problem due to the existence of different tangible and intangible factors and the multiple alternatives available. The roof typologies under study involve prefabricated concrete, steel and laminated wood structures. This research work applies a multi-criteria hybrid model combining the Analytical Hierarchy Process with the Delphi method and the VIKOR technique for implementing sustainability criteria in the selection of a roof assembly in medium span buildings. The proposed decision support system enables the use of the triple bottom line that considers economic, social and environmental criteria. Under the criteria analyzed, the compromise solution found is the self-supporting curved system.Canto-Perello, J.; Martinez-Garcia, MP.; Curiel Esparza, J.; MartĂ­n Utrillas, MG. (2015). Implementing Sustainability Criteria for Selecting a Roof Assembly Typology in Medium Span Buildings. Sustainability. 7(6):6854-6871. doi:10.3390/su7066854S6854687176United Nations 1998 Kyoto Protocol to the United Nations Framework Convention on Climate Changehttp://unfccc.int/resource/docs/convkp/kpeng.pdfCanto-Perello, J., & Curiel-Esparza, J. (2013). Assessing governance issues of urban utility tunnels. Tunnelling and Underground Space Technology, 33, 82-87. doi:10.1016/j.tust.2012.08.007Aguado, A., Caño, A. del, de la Cruz, M. P., GĂłmez, D., & Josa, A. (2012). Sustainability Assessment of Concrete Structures within the Spanish Structural Concrete Code. Journal of Construction Engineering and Management, 138(2), 268-276. doi:10.1061/(asce)co.1943-7862.0000419Ramesh, T., Prakash, R., & Shukla, K. K. (2010). Life cycle energy analysis of buildings: An overview. Energy and Buildings, 42(10), 1592-1600. doi:10.1016/j.enbuild.2010.05.007Reza, B., Sadiq, R., & Hewage, K. (2011). Sustainability assessment of flooring systems in the city of Tehran: An AHP-based life cycle analysis. Construction and Building Materials, 25(4), 2053-2066. doi:10.1016/j.conbuildmat.2010.11.041Zadeh, S., Hunt, D., Lombardi, D., & Rogers, C. (2013). Shared Urban Greywater Recycling Systems: Water Resource Savings and Economic Investment. Sustainability, 5(7), 2887-2912. doi:10.3390/su5072887Hunt, D., & Rogers, C. (2014). A Benchmarking System for Domestic Water Use. Sustainability, 6(5), 2993-3018. doi:10.3390/su6052993Curiel-Esparza, J., & Canto-Perello, J. (2012). Understanding the major drivers for implementation of municipal sustainable policies in underground space. International Journal of Sustainable Development & World Ecology, 19(6), 506-514. doi:10.1080/13504509.2012.732973Collier, Z. A., Wang, D., Vogel, J. T., Tatham, E. K., & Linkov, I. (2013). Sustainable roofing technology under multiple constraints: a decision-analytical approach. Environment Systems and Decisions, 33(2), 261-271. doi:10.1007/s10669-013-9446-5Ozdemir, M. S., & Saaty, T. L. (2006). The unknown in decision making. European Journal of Operational Research, 174(1), 349-359. doi:10.1016/j.ejor.2004.12.017Lee, G. K. L., & Chan, E. H. W. (2007). The Analytic Hierarchy Process (AHP) Approach for Assessment of Urban Renewal Proposals. Social Indicators Research, 89(1), 155-168. doi:10.1007/s11205-007-9228-xSyamsuddin, I., & Hwang, J. (2010). The Use of AHP in Security Policy Decision Making: An Open Office Calc Application. Journal of Software, 5(10). doi:10.4304/jsw.5.10.1162-1169Thapa, R. B., & Murayama, Y. (2010). Drivers of urban growth in the Kathmandu valley, Nepal: Examining the efficacy of the analytic hierarchy process. Applied Geography, 30(1), 70-83. doi:10.1016/j.apgeog.2009.10.002Canto-Perello, J., Curiel-Esparza, J., & Calvo, V. (2013). Criticality and threat analysis on utility tunnels for planning security policies of utilities in urban underground space. Expert Systems with Applications, 40(11), 4707-4714. doi:10.1016/j.eswa.2013.02.031Marchais-Roubelat, A., & Roubelat, F. (2011). The Delphi method as a ritual: Inquiring the Delphic Oracle. Technological Forecasting and Social Change, 78(9), 1491-1499. doi:10.1016/j.techfore.2011.04.012Von der Gracht, H. A. (2012). Consensus measurement in Delphi studies. Technological Forecasting and Social Change, 79(8), 1525-1536. doi:10.1016/j.techfore.2012.04.013Curiel-Esparza, J., & Canto-Perello, J. (2013). Selecting utilities placement techniques in urban underground engineering. Archives of Civil and Mechanical Engineering, 13(2), 276-285. doi:10.1016/j.acme.2013.02.001Mela, K., Tiainen, T., & Heinisuo, M. (2012). Comparative study of multiple criteria decision making methods for building design. Advanced Engineering Informatics, 26(4), 716-726. doi:10.1016/j.aei.2012.03.001San CristĂłbal, J. R. (2012). Contractor Selection Using Multicriteria Decision-Making Methods. Journal of Construction Engineering and Management, 138(6), 751-758. doi:10.1061/(asce)co.1943-7862.0000488Lee, W.-S. (2013). Merger and acquisition evaluation and decision making model. The Service Industries Journal, 33(15-16), 1473-1494. doi:10.1080/02642069.2011.634905Rostamzadeh, R., Ismail, K., & Zavadskas, E. K. (2014). MULTI CRITERIA DECISION MAKING FOR ASSISTING BUSINESS ANGELS IN INVESTMENTS. Technological and Economic Development of Economy, 20(4), 696-720. doi:10.3846/20294913.2014.984364Tsai, P.-H., & Chang, S.-C. (2014). COMPARING THE APPLE IPAD AND NON-APPLE CAMP TABLET PCS: A MULTICRITERIA DECISION ANALYSIS. Technological and Economic Development of Economy, 19(Supplement_1), S256-S284. doi:10.3846/20294913.2013.881929San-JosĂ©, J. T., Garrucho, I., Losada, R., & Cuadrado, J. (2007). A proposal for environmental indicators towards industrial building sustainable assessment. International Journal of Sustainable Development & World Ecology, 14(2), 160-173. doi:10.1080/13504500709469716Martin-Utrillas, M., Reyes-Medina, M., Curiel-Esparza, J., & Canto-Perello, J. (2014). Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills. Clean Technologies and Environmental Policy, 17(4), 873-885. doi:10.1007/s10098-014-0834-4ƁowiƄska-Kluge, A., & BƂaszczyƄski, T. (2012). The influence of internal corrosion on the durability of concrete. Archives of Civil and Mechanical Engineering, 12(2), 219-227. doi:10.1016/j.acme.2012.03.002Khosrowshahi, F., & Alani, A. (2011). Visualisation of impact of time on the internal lighting of a building. Automation in Construction, 20(2), 145-154. doi:10.1016/j.autcon.2010.09.012Kim, S., Kim, G.-H., & Lee, Y.-D. (2013). Sustainability Life Cycle Cost Analysis of Roof Waterproofing Methods Considering LCCO2. Sustainability, 6(1), 158-174. doi:10.3390/su6010158Lo, S. M., Zhao, C. M., Liu, M., & Coping, A. (2008). A simulation model for studying the implementation of performance-based fire safety design in buildings. Automation in Construction, 17(7), 852-863. doi:10.1016/j.autcon.2008.02.014Markelj, J., Kitek Kuzman, M., GroĆĄelj, P., & ZbaĆĄnik-Senegačnik, M. (2014). A Simplified Method for Evaluating Building Sustainability in the Early Design Phase for Architects. Sustainability, 6(12), 8775-8795. doi:10.3390/su6128775ALwaer, H., & Clements-Croome, D. J. (2010). Key performance indicators (KPIs) and priority setting in using the multi-attribute approach for assessing sustainable intelligent buildings. Building and Environment, 45(4), 799-807. doi:10.1016/j.buildenv.2009.08.019Malmqvist, T., Glaumann, M., Scarpellini, S., Zabalza, I., Aranda, A., Llera, E., & DĂ­az, S. (2011). Life cycle assessment in buildings: The ENSLIC simplified method and guidelines. Energy, 36(4), 1900-1907. doi:10.1016/j.energy.2010.03.026Shao, L., Chen, G. Q., Chen, Z. M., Guo, S., Han, M. Y., Zhang, B., 
 Ahmad, B. (2014). Systems accounting for energy consumption and carbon emission by building. Communications in Nonlinear Science and Numerical Simulation, 19(6), 1859-1873. doi:10.1016/j.cnsns.2013.10.003Zabalza BribiĂĄn, I., Valero Capilla, A., & Aranda UsĂłn, A. (2011). Life cycle assessment of building materials: Comparative analysis of energy and environmental impacts and evaluation of the eco-efficiency improvement potential. Building and Environment, 46(5), 1133-1140. doi:10.1016/j.buildenv.2010.12.002Goggins, J., Keane, T., & Kelly, A. (2010). The assessment of embodied energy in typical reinforced concrete building structures in Ireland. Energy and Buildings, 42(5), 735-744. doi:10.1016/j.enbuild.2009.11.013Broun, R., Babaizadeh, H., Zakersalehi, A., & Menzies, G. (2014). Integrated Life Cycle Energy and Greenhouse Gas Analysis of Exterior Wall Systems for Residential Buildings. Sustainability, 6(12), 8592-8603. doi:10.3390/su6128592Parasonis, J., Keizikas, A., & Kalibatiene, D. (2012). The relationship between the shape of a building and its energy performance. Architectural Engineering and Design Management, 8(4), 246-256. doi:10.1080/17452007.2012.675139Saaty, T. L., & Ozdemir, M. S. (2003). Why the magic number seven plus or minus two. Mathematical and Computer Modelling, 38(3-4), 233-244. doi:10.1016/s0895-7177(03)90083-5Kuo, Y., Yang, T., & Huang, G.-W. (2008). The use of grey relational analysis in solving multiple attribute decision-making problems. Computers & Industrial Engineering, 55(1), 80-93. doi:10.1016/j.cie.2007.12.002Opricovic, S., & Tzeng, G.-H. (2004). Compromise solution by MCDM methods: A comparative analysis of VIKOR and TOPSIS. European Journal of Operational Research, 156(2), 445-455. doi:10.1016/s0377-2217(03)00020-1Curiel-Esparza, J., Cuenca-Ruiz, M., Martin-Utrillas, M., & Canto-Perello, J. (2014). Selecting a Sustainable Disinfection Technique for Wastewater Reuse Projects. Water, 6(9), 2732-2747. doi:10.3390/w6092732Sayadi, M. K., Heydari, M., & Shahanaghi, K. (2009). Extension of VIKOR method for decision making problem with interval numbers. Applied Mathematical Modelling, 33(5), 2257-2262. doi:10.1016/j.apm.2008.06.002Opricovic, S., & Tzeng, G.-H. (2007). Extended VIKOR method in comparison with outranking methods. European Journal of Operational Research, 178(2), 514-529. doi:10.1016/j.ejor.2006.01.02

    Le Mort dans la ville

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    Le dĂ©veloppement de rites mortuaires complexes dans l’histoire de l’Homme a rĂ©sultĂ© dans un rĂŽle croissant jouĂ© par les pratiques funĂ©raires utilisĂ©es comme moyen de resserrer les liens Ă  l’intĂ©rieur d’une mĂȘme communautĂ©. À cet Ă©gard, le singulier usage d'inhumer un individu au cƓur de la communautĂ© rĂ©vĂšle avec acuitĂ© la force de cette relation que pouvaient entretenir les vivants et les morts. Les dĂ©couvertes archĂ©ologiques rĂ©centes ont soulignĂ© l’importance de telles pratiques liĂ©es aux inhumations intra-muros en Anatolie. Bien qu’il semble possible de tisser un lien continu entre ces coutumes, les contextes dans lesquels s’inscrivent la pratique d’inhumer une personne au cƓur mĂȘme de la communautĂ©, depuis l’enfant du NĂ©olithique Ă  ÇatalhöyĂŒk Ă  la libraire de Celsius Ă  EphĂšse, en passant par le MausolĂ©e d'Halicarnasse, ont nĂ©anmoins radicalement changĂ©s en fonction des Ă©poques et des lieux. L’objectif de ce volume, en rassemblant des spĂ©cialistes de pĂ©riodes et d’horizons diffĂ©rents, est d’offrir non seulement un point gĂ©nĂ©ral de nos connaissances sur ces questions, mais aussi un Ă©clairage concernant le mĂ©canisme de ces pratiques, leur contexte et leur impact en Anatolie, du dĂ©but de l’Âge du Bronze Ă  l’époque romaine

    Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills

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    “The final publication is available at Springer via http://dx.doi.org/10.1007/s10098-014-0834-4”Leachate from waste landfill or treatment plants is a very complex and highly contaminated liquid effluent. In its composition, it is found dissolved organic matter, inorganic salts, heavy metals, and other xenobiotic organic compounds, so it can be toxic, carcinogenic, and capable of inducing a potential risk to biota and humans. European law does not allow such leachate to leave the premises without being depolluted. There are many procedures that enable debugging, always combining different techniques. Choosing the best method to use in each case is a complex decision, as it depends on many tangible and intangible factors that must be weighed to achieve a balance between technical, cost, and environmental sustainability. It is presenting a hybrid method for choosing the optimal combination of techniques to apply in each case, by combining a multicriteria hierarchical analysis based on expert data obtained by the Delphi method with an analysis by the method of VIKOR to reach a consensus solution.MartĂ­n Utrillas, MG.; Reyes Medina, M.; Curiel Esparza, J.; CantĂł PerellĂł, J. (2015). Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills. Clean Technologies and Environmental Policy. 17(4):873-885. doi:10.1007/s10098-014-0834-4S873885174Abbas AA, Guo J, Ping LZ, Ya PY, Al-Rekabi WS (2009) Review on landfill leachate treatments. AJAS 6(4):672–684Abood AR, Bao J, Abudi Z, Zheng D, Gao C (2013) Pretreatment of nonbiodegradable landfill leachate by air stripping coupled with agitation as ammonia stripping and coagulation–flocculation processes. Clean Technol Environ Policy 15(6):1069–1076Ahn WY, Kang MS, Yim SK, Choi KH (2002) Advanced landfill leachate treatment using an integrated membrane process. Desalination 149(1–3):109–114Al-Subhi Al-Harbi KM (2001) Application of the AHP in project management. Int J Proj Manag 19:19–27Bernasconi M, Choirat C, Seri R (2014) Empirical properties of group preference aggregation methods employed in AHP: theory and evidence. Eur J Oper Res 232(3):584–592Boopathy R, Karthikeyan S, Mandal AB, Sekaran G (2013) Characterization and recovery of sodium chloride from salt-laden solid waste generated from leather industry. Clean Technol Environ Policy 15(1):117–124Brechet T, Tulkens H (2009) Beyond BAT: selecting optimal combinations of available techniques, with an example from the limestone industry. J Environ Manag 90:1790–1801Canto-Perello J, Curiel-Esparza J, Calvo V (2013) Criticality and threat analysis on utility tunnels for planning security policies of utilities in urban underground space. Expert Syst Appl 40(11):4707–4714Chen Y, Liu C, Nie J, Wu S, Wang D (2014) Removal of COD and decolorizing from landfill leachate by Fenton’s reagent advanced oxidation. Clean Technol Environ Policy 16(1):189–193Chiochetta CG, Goetten LC, Almeida SM, Quaranta G, Cotelle S, Radetski CM (2014) Leachates from solid wastes: chemical and eco(geno)toxicological differences between leachates obtained from fresh and stabilized industrial organic sludge. Environ Sci Pollut R 21:1090–1098Chiumenti A, da Borso F, Chiumenti R, Teri F, Segantin P (2013) Treatment of digestate from a co-digestion biogas plant by means of vacuum evaporation: tests for process optimization and environmental sustainability. Waste Manag 33(6):1339–1344Council Directive 1999/31/EC (1999) April 26th 1999, on the landfill of waste. European Union Council, Official Journal L 182, 16/07/1999 P. 0001–0019Curiel-Esparza J, Canto-Perello J (2012) Understanding the major drivers for implementation of municipal sustainable policies in underground space. Int J Sust Dev World 19(6):506–514Curiel-Esparza J, Canto-Perello J (2013) Selecting utilities placement techniques in urban underground engineering. Arch Civ Mech Eng 13(2):276–285Curiel-Esparza J, Canto-Perello J, Calvo MA (2004) Establishing sustainable strategies in urban underground engineering. Sci Eng Ethics 10(3):523–530Dong Y, Zhang G, Hong WC, Xu Y (2010) Consensus models for AHP group decision making under row geometric mean prioritization method. Decis Support Syst 49:281–289Duckstein L, Opricovic S (1980) Multiobjective Optimization in River Basin Development. Water Resour Res 16(1):14–20Ersahin ME, Ozgun H, van Lier JB (2013) Effect of support material properties on dynamic membrane filtration performance. Separ Sci Technol 48(15):2263–2269Gracht HA (2012) Consensus measurement in Delphi studies, review and implications for future quality assurance. Forecast Soc Chang 79(8):1525–1536Grisey E, Laffray X, Contoz O, Cavalli E, Mudry J, Aleya L (2012) The bioaccumulation performance of reeds and cattails in a constructed treatment wetland for removal of heavy metals in landfill leachate treatment (Etueffont, France). Water Air Soil Pollut 223:1723–1741Guoliang Z, Lei Q, Qin M, Zheng F, Dexin W (2013) Aerobic SMBR/reverse osmosis system enhanced by Fenton oxidation for advanced treatment of old municipal landfill leachate. Bioresour Technol 142:261–268Gupta SK, Singh G (2007) Assessment of the Efficiency and Economic Viability of Various Methods of Treatment of Sanitary Landfill Leachate. Environ Monit Assess 135:107–117Heyer KU, Stegmann R (2005) Landfill systems, sanitary landfilling of solid wastes, and long-term problems with leachate. In: Jördening HJ, Winter J (eds) Environmental Biotechnology. Wiley-VCH, Weinheim, p 375Hsu CC, Sandord BA (2007) The Delphi technique: making sense of consensus. PARE 12(10):1–7Kjeldsen P, Barlaz MA, Rooker AP, Baun A, Ledin A, Christensen TH (2002) Present and long-term composition of MSW landfill leachate: a review. Crit Rev Environ Sci Technol 32(4):297–336Lee WS (2013) Merger and acquisition evaluation and decision making model. Serv Ind J 33(15–16):1473–1494Lee GKL, Chan EHW (2008) The analytic hierarchy process (AHP) approach for assessment of urban renewal proposals. Soc Indic Res 89(1):155–168Li G, Wang W, Du Q (2010) Applicability of nanofiltration for the advanced treatment of landfill leachate. 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Waste Manag 33(2):382–389Yang W, Zhang KN, Chen YG, Zhou XZ, Jin FX (2013) Prediction on contaminant migration in aquifer of fractured granite substrata of landfill. J Cent South Univ 20(11):3193–3201Zavadskas EK, Turskis Z, Tamosaitiene J (2011) Selection of construction enterprises management strategy based on SWOT and multi-criteria analysis. ACME 11(4):1063–108

    Writing in Britain and Ireland, c. 400 to c. 800

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    Wellbeing indicators affecting female entrepreneurship in OECD countries

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    [EN] The objective of this research is to know which wellbeing indicators, such as work-life balance, educational level, income or job security, are related to the rate of female entrepreneurship in 29 OECD countries. In addition, these countries have been classified according to the motivation of the entrepreneur either by necessity or by opportunity. The empiric study is focused on 29 OECD countries covering the different geographic areas (Western Europe, Central and Eastern Europe, Middle East, etc.) Due to the fact that the sample is relatively small, it is essential to use a selective approach when selecting the causal conditions. To this end, fsQCA is the most appropriate methodology for such a small data set. A total of 5 variables have been used: an independent variable (female TEA ratio), and four dependent variables (work life balance, educational level, sustainable household income and job security). Data measuring female TEA ratio have been obtained from Global Entrepreneur Monitor (GEM in Global report, 2015) data base, while data measuring wellbeing dimensions were taken from the Better Life Index (OECD in HowÂżs life? Measuring wellbeing, 2015. http://www.oecdbetterlifeindex.org). The results of this piece of research show that countries with high sustainable household income together with high level of education achieves high female entrepreneurship ratio with both, a good work-life balance (despite of a high unemployment probability), or a high labour-personal imbalance (in this latter, with a low probability of unemployment).This work has been funded by the R + D project for emerging research groups with reference (GVA) GV/2016/078.Ribes-Giner, G.; Moya Clemente, I.; CervellĂł Royo, RE.; PerellĂł MarĂ­n, MR. (2019). Wellbeing indicators affecting female entrepreneurship in OECD countries. Quality & Quantity. 53(2):915-933. https://doi.org/10.1007/s11135-018-0796-4S915933532Ahl, H., Nelson, T.: How policy positions women entrepreneurs: a comparative analysis of state discourse in Sweden and the United States. J. Bus. Ventur. 30(2), 273–291 (2015). https://doi.org/10.1016/j.jbusvent.2014.08.002Andersson, P.: Happiness and health: wellbeing among the self-employed. J. Socio-Econ. 37(1), 213–236 (2008). https://doi.org/10.1016/j.socec.2007.03.003Bardasi, E., Sabarwal, S., Terrell, K.: How do female entrepreneurs perform? Evidence from three developing regions. Small Bus. Econ. 37(4), 417–441 (2011). https://doi.org/10.1007/s11187-011-9374-zBergheim, S., Schneider, S., Giesel, B., Walter, N.: Measures of Wellbeing. There is More to it Than GDP. Deutsche Bank Research, Frankfurt (2006)Berglund, H.: Between cognition and discourse: phenomenology and the study of entrepreneurship. Int. J. Entrep. Behav. 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    Top-quark physics at the CLIC electron-positron linear collider

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    ABSTRACT: The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies √s = 380 GeV, 1.5 TeV, and 3 TeV. Its aim is to explore the energy frontier, providing sensitivity to physics beyond the Standard Model (BSM) and precision measurements of Standard Model processes with an emphasis on Higgs boson and top-quark physics. The opportunities for top-quark physics at CLIC are discussed in this paper. The initial stage of operation focuses on top-quark pair production measurements, as well as the search for rare flavour-changing neutral current (FCNC) top-quark decays. It also includes a top-quark pair production threshold scan around 350 GeV which provides a precise measurement of the top-quark mass in a well-defined theoretical framework. At the higher-energy stages, studies are made of top-quark pairs produced in association with other particles. A study of t̄tH production including the extraction of the top Yukawa coupling is presented as well as a study of vector boson fusion (VBF) production, which gives direct access to high-energy electroweak interactions. Operation above 1 TeV leads to more highly collimated jet environments where dedicated methods are used to analyse the jet constituents. These techniques enable studies of the top-quark pair production, and hence the sensitivity to BSM physics, to be extended to higher energies. This paper also includes phenomenological interpretations that may be performed using the results from the extensive top-quark physics programme at CLIC.the Spanish Ministry of Economy, Industry and Competitiveness under projects MINEICO/FEDER-UE, FPA2015-65652-C4-3-R, FPA2015-71292-C2-1-Pand FPA2015-71956-REDT; and the MECD grant FPA2016-78645-P, Spai

    CNS targets of adipokines

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    This is the author accepted manuscript. The final version is available from American Physiological Society via the DOI in this record.Our understanding of adipose tissue as an endocrine organ has been transformed over the last twenty years. During this time a number of adipocyte-derived factors or adipokines have been identified. This paper will review evidence for how adipokines acting via the central nervous system (CNS) regulate normal physiology and disease pathology. The reported CNS-mediated effects of adipokines are varied and include the regulation of energy homeostasis, autonomic nervous system activity, the reproductive axis, neurodevelopment, cardiovascular function, and cognition. Due to the wealth of information available and the diversity of their known functions, the archetypal adipokines leptin and adiponectin will be the focused on extensively. Other adipokines with established CNS actions will also be discussed. Due to the difficulties associated with studying CNS function on a molecular level in humans, the majority of our knowledge, and as such the studies described in this paper, comes from work in experimental animal models; however, where possible the relevant data from human studies are also highlighted
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