9 research outputs found
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
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- Abramowski A
- Abreu P
- Acernese F
- Acero F
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- Areeda JS
- Aresu G
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- Asakura Y
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- Peiffer P
- Peixoto CJ Todero
- Pekeur NW
- Pekowsky L
- Pelayo R
- Pele A
- Pellegrino C
- Pelletier G
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- Penacchioni AV
- Penn S
- Penuela T
- Pepper JA
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- Perennes C
- Perez CJ
- Perez-Perez EG
- Perley DA
- Perlin M
- Perreca A
- Perri LM
- Perri M
- Perrina C
- Perrodin D
- Perrone L
- Pescalli A
- Pesce-Rollins M
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- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
- Phlhofer G
- Phuntsok J
- Pian E
- Piano G
- Piattelli P
- Piccinni OJ
- Pichot M
- Picozza P
- Piel Q
- Pieloth D
- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
- Plazas AA
- Plum M
- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
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- Pollmann A Obertacke
- Poolakkil S
- Poon H
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- Popolizio P
- Poppi S
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- Porter EK
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- Possenti A
- Post A
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- Powell J
- Pozanenko AS
- Poznanski D
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- Prado RR
- Prasad J
- Pratt JWW
- Pratten G
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- Prestegard T
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- Price PB
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- Principe G
- Principe M
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- Privitera P
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- Prochaska JX
- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
- Pumo ML
- Punch M
- Puncken O
- Punturo M
- Puppo P
- Qi H
- Qi H
- Qu JL
- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
- Quinn L
- Quinn S
- Quinones C
- Quintero EA
- Quirrenbach A
- Quispe ID Vergara
- Quitzow-James R
- Raab C
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- Rabeling DS
- Rabus M
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- Raffai P
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- Raja S
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- Rameez M
- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
- Rana J
- Rando R
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- Rappoldi A
- RATIR RIMAS
- Rau A
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- Rauth R
- Ravignani D
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- Raymond V
- Razza A
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- Razzaque S
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- Rdiger A
- Rea IC
- Read J
- Rebolo R
- Regimbau T
- Rei L
- Reichart DE
- Reid S
- Reimann R
- Reimer A
- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
- Reynolds T
- Rho CD
- Rhode W
- Ribeiro T
- Ricci F
- Ricci R
- Ricciarini S
- Riccobene G
- Richman M
- Ricker PM
- Ridden-Harper R
- Ridky J
- Rieger F
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- Riehn F
- Righini S
- Riguccini L
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- Rinchiuso L
- Rios-Lopez E
- Risse M
- Ristori P
- Rivera A Ramirez
- Riviere C
- Rizi V
- Rizzo M
- Roberts OJ
- Robertson NA
- Robertson S
- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
- Rol E
- Rolland L
- Rollins JG
- Roma VJ
- Romano R
- Romel CL
- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
- Rongen M
- Roodman A
- Roques J-P
- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
- Rosswog S
- Roth M
- Rott C
- Roulet E
- Rovero AC
- Rowan S
- Rowell G
- Rowlinson A
- Rowlinson A
- Roy R
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- Rudak B
- Ruehl P
- Ruggi P
- Ruhe T
- Ruiter AJ
- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
- Ryan K
- Rybicki KA
- Ryckbosch D
- Rykoff ES
- Rysewyk D
- Saba A
- Sachdev S
- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
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- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
- Sandroos J
- Sanguineti M
- Sansom EK
- Santander M
- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
- Sarkar S
- Sarkar S
- Sarmento R
- Sarmiento-Cano C
- Sasaki M
- Sasaki R
- Sassolas B
- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
- Sauseda M
- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
- Sbarufatti B
- Scalzo RA
- Scarpine V
- Schady P
- Schale P
- Schauer M
- Scheel M
- Scherini V
- Scheuer J
- Schieler H
- Schimp M
- Schindler R
- Schipani P
- Schlegel DJ
- Schlickeiser R
- Schlunder P
- Schmalz SE
- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
- Scott SM
- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
- Sergienko Yu P
- Serino M
- Serra G
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- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
- Shaddock DA
- Shadkam A
- Shaffer TJ
- Shafi N
- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
- Shao L
- Shapiro B
- Shappee BJ
- Shara MM
- Sharma I
- Sharp RG
- Shawhan P
- Sheldon E
- Shellard RC
- Sheperd A
- Shidatsu M
- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
- Shulevski A
- Siebert MR
- Siegel MH
- Sieger C
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- Siemens X
- Sieniawska M
- Sigg D
- Sigl G
- Silli G
- Silva AD
- Sim SA
- Simon JD
- Simonetti JH
- Simoni R
- Singer LP
- Singh A
- Singhal A
- Sinnis G
- Sintes AM
- Siskind EJ
- Slagmolen BJJ
- Slzer T
- Smartt SJ
- Smida R
- Smirnov OM
- Smith AJ
- Smith B
- Smith JR
- Smith KW
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- Smith M
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- Snow GR
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- Sobreira F
- Sodre L
- Soedingrekso J
- Soffitta P
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- Sollerman J
- Sollerman J
- Somala S
- Sommers P
- Son EJ
- Song LM
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- Sonnenberg JA
- Sonntag S
- Sorazu B
- Soriano JF
- Sorrentino F
- Souradeep T
- Spada F
- Spandre G
- Spanier F
- Spencer AP
- Spera M
- Spiczak GM
- Spiering C
- Spir-Jacob M
- Springer RW
- Spurio M
- Squartini R
- Srivastava AK
- Staats K
- Stachurska J
- Staff J
- Stagni M
- Stalder B
- Staley A
- Stamatikos M
- Stamerra A
- Stanbro M
- Stanca D
- Stanev T
- Stanic S
- Stanway ER
- Starck M
- Starling RLC
- Stasielak J
- Stasik A
- Stassi P
- Stawarz L
- Stebbins A
- Steeghs DTH
- Steele I
- Steele K
- Steenkamp R
- Stegmann C
- Steinke M
- Steinlechner J
- Steinlechner S
- Steinmeyer D
- Stella L
- Steppa C
- Stettner J
- Steuer A
- Stevenson SP
- Stewart AJ
- Stezelberger T
- Stokstad RG
- Stolarczyk Th
- Stolpovskiy M
- Stone R
- Stops DJ
- Stosl A
- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
- Suarez F
- Suarez-Duran M
- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
- Sugizaki M
- Sullivan GW
- Sullivan M
- Sumi T
- Summerscales TZ
- Sun L
- Sun L
- Sun T
- Sunil S
- Suntzeff NB
- Sunyaev R
- Suomijarvi T
- Supanitsky AD
- Supik J
- Surajbali P
- Surcis G
- Suresh J
- Sushch I
- Suson DJ
- Sutherland M
- Sutton PJ
- Svinkin DS
- Swain J
- Swanson MEC
- Swinkels BL
- Szadkowski Z
- Szczepanczyk MJ
- Szegedi H
- Szomoru A
- Taboada A
- Taboada I
- Taborda OA
- Tacca M
- Tachibana Y
- Taddia F
- Tagliaferri G
- Tait SC
- Taiuti M
- Tajitsu A
- Takahashi I
- Takahashi J
- Takahashi M
- Takahashi T
- Takao Y
- Takayama M
- Talbot C
- Talukder D
- Tamura T
- Tamura Y
- Tan Y
- Tanaka I
- Tanaka M
- Tanaka Y
- Tanimoto A
- Tanner DB
- Tanvir NR
- Tao C
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- Tao WH
- Taracchini A
- Tarle G
- Tartaglia L
- Tasson JD
- Tatar J
- Taubenberger S
- Tavani M
- Tavernet J-P
- Tavernier T
- Tayalati Y
- Taylor AM
- Taylor GB
- Taylor JA
- Taylor R
- Team AGILE
- Team Euro VLBI
- Team MAXI
- Team The 1M2H
- Telescope ATCA Australia
- Telescope Fermi Large Area
- Telescope Nordic Optical
- Tello JC
- Telluride AstroSat Cadmium Zinc
- Tenholt F
- Ter Veen S
- Ter-Antonyan S
- Terai T
- Terliuk A
- Terreran G
- Terrier R
- Tesic G
- Testa V
- Tewari SV
- Thayer JB
- Thayer JG
- Theeg T
- Thene CC
- Thierry P
- Thierry P
- Thies F
- Thomas EG
- Thomas M
- Thomas P
- Thomas RC
- Thompson DJ
- Thorne KA
- Thorne KS
- Thrane E
- Tibaldo L
- Tibaldo L
- Tibolla O
- Tilav S
- Timmermans C
- Tingay SJ
- Tiwari S
- Tiwari V
- Tiziani D
- Tjus J Becker
- Tjus J Becker
- Tlatov AG
- Tluczykont M
- Toale PA
- Tobin MN
- Tohuvavohu A
- Tokmakov KV
- Toland K
- Tollefson K
- Toma K
- Tomankova L
- Tomasella L
- Tome B
- Tomida H
- Tominaga N
- Tonelli M
- Tonnis C
- Tonry J
- Torii S
- Tornasi Z
- Tornatore M
- Torres DF
- Torres I
- Torres-Flores S
- Torres-Forn A
- Torresi E
- Torrie CI
- Toscano S
- Tosi D
- Towner MC
- Toyr D
- Tpai M
- Travasso F
- Travnicek P
- Traylor G
- Trichard C
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- Trinastic J
- Tringali MC
- Trini M
- Tristram PJ
- Trois A
- Troja E
- Troja E
- Trott CM
- Trovato A
- Troxel MA
- Trozzo L
- Tsai J
- Tsang KW
- Tse M
- Tselengidou M
- Tsirou M
- Tso R
- Tsuboi Y
- Tsuji N
- Tsukada L
- Tsuna D
- Tsunemi H
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- Tungalag N
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- Turpin D
- Turpin D
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- Ty B
- Tyurina NV
- Ubertini P
- Uchiyama Y
- Ueda Y
- Uemura M
- Ueno K
- Ueno S
- Ugolini D
- Ukwatta TN
- Ulaczyk K
- Ulanov MV
- Ulloa N
- Ulrich R
- Unger E
- Unger M
- Univ Chandra Team McGill
- Univ Texas Tech
- Universe High Time Resolution
- Unnikrishnan CS
- Urban AL
- Urban M
- Ursi A
- Usman SA
- Usner M
- Utsumi Y
- Vacca V
- Vadawale SV
- Vahlbruch H
- Vaisanen P
- Vajente G
- Valdes G
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- Valio I
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- Van der Walt DJ
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- Vander-Hyde DC
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- Vergani D
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- Verkindt D
- Verrecchia F
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- Vibhute A
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- Viets AD
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- Vink J
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- Vitale PF Gomez
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- Vivolo D
- Vizzoca A
- Vladimirov VV
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- Vo T
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- Vogel E
- Voisin F
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- Vorobiov S
- Vorvick C
- Vos J
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- Wainscoat RJ
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- Walz D
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- Wave GRAWITA GRAvitational
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- Weiland H
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- Wessel EK
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- Wiebusch CH
- Wiedenski M
- Wiencke L
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- Wiersema K
- Wierzcholska A
- Wijers RAMJ
- Wijers RAMJ
- Wilczynski H
- Wilken D
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- Williams PKG
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- Wilms J
- Wilson-Hodge CA
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- Worden J
- Woschnagg K
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- Wrochna G
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- Wundheiler B
- Wyrzykowski L
- Wysocki DM
- Xiao GC
- Xiao S
- Xiong SL
- Xu D
- Xu DL
- Xu H
- Xu XW
- Xu Y
- Xu Y
- Xu YP
- Yamada S
- Yamaguchi MS
- Yamamoto H
- Yamaoka K
- Yamaoka K
- Yamauchi M
- Yan L
- Yan LL
- Yancey CC
- Yanez JP
- Yang J
- Yang J
- Yang JW
- Yang L
- Yang L
- Yang R
- Yang S
- Yang S
- Yang YJ
- Yanny B
- Yap MJ
- Yapici T
- Yaron O
- Yasuda N
- Yatabe F
- Yatsu Y
- Yazback M
- Yock PC
- Yodh G
- Yodh GB
- Yoneyama T
- Yoon Y
- Yoshida A
- Yoshida M
- Yoshida S
- Yoshii T
- Young DR
- Younk PW
- Yu Hang
- Yu Haocun
- Yu P-C
- Yuan T
- Yuan X
- Yurkov VV
- Yushkov A
- Yvert M
- Zaborov D
- Zacharias M
- Zadrozny A
- Zadrozny A
- Zaharijas G
- Zaltzman M
- Zanin R
- Zanolin M
- Zaremba M
- Zarnecki AF
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zdziarski AA
- Zech A
- Zefi F
- Zelenova T
- Zendri J-P
- Zenko T
- Zenteno A
- Zepeda A
- Zertuche L Magaa
- Zevin M
- Zhang AM
- Zhang B-B
- Zhang C
- Zhang CL
- Zhang CM
- Zhang F
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- Zhang HM
- Zhang J
- Zhang L
- Zhang M
- Zhang Q
- Zhang S
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- Zhang T
- Zhang W
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- Zhang Y
- Zhang Y
- Zhang Y
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- Zhang YF
- Zhang YJ
- Zhang Z
- Zhang ZL
- Zhao C
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- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
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- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Pan-cancer analysis of whole genomes
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- V. pr
- V. S. yt
- V. sm
- V. xo
- van As
- van de Vijver
- Van Den Berg
- Van den Eynden
- Van der Kwast
- van Deurzen
- Van Laere
- Van Loo
- Van Meir
- van’t Veer
- Vasudev
- Vazquez
- vb Simon
- vd Biswas
- Vedururu
- Veluvolu U. v
- Vembu
- Vermeulen
- Verrill
- Viari
- Vicente
- Vicentini
- Vilain
- Villasante
- Vincent-Salomon
- vo Taniguchi
- Voet D. b
- von Kalle
- von Mering
- vq Yamamoto
- vx Ong
- Vyas
- Vázquez-García
- W. abo
- W. ae
- W. B. xu
- W. bk
- W. g Valencia
- W. ia
- W. K. aav
- W. lf
- W. M. zy
- W. mn
- W. nn
- W. tw
- W. zc
- Waddell
- Waddell
- Wadi L. k
- Wagener
- Wang
- Wang
- Wang
- Wang
- Wang
- Waring
- Warnatz
- Warrell
- Warren
- Weichenhan
- Weinberger
- Weinstein
- Weischenfeldt J. g
- Weisenberger
- Welch
- Wendl M. C. z
- wf Amary
- Whalley
- Wheeler
- wi Futreal
- Wigle
- Wilkerson M. D. v
- Williams
- Wilmott
- Wilson G. W. k
- Wilson R. K. z
- Wintersinger
- Wiznerowicz
- Wolf
- Wong
- Wong
- Woo
- Wood
- Wouters
- Wright
- Wright
- Wright A. J. k
- ws Ang
- Wu
- Wu
- Wu
- wv abg
- wz Hupp
- x Eils
- x Yung
- X. abp
- X. at
- X. bk
- X. cq
- X. ez
- X. ez
- X. fh
- X. fv
- X. fv
- X. fv
- X. fv
- X. k Mbabaali
- X. oi
- X. S. wd
- X. tc
- X. zv
- xb Danilova
- xb Felau
- xc Lovat
- xh Curley
- xh Fulton
- Xi
- Xia
- Xiang
- Xiong
- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
- Y. ae
- Y. ae
- Y. ae
- Y. ai
- Y. aj
- Y. al
- Y. bk
- Y. dg
- Y. dy
- Y. ef
- Y. ep
- Y. ez
- Y. ff
- Y. fr
- Y. fv
- Y. fv
- Y. gl
- Y. hl
- Y. hq
- Y. hq
- Y. ia
- Y. kq
- Y. lw
- Y. nh
- Y. nk
- Y. nz
- Y. rg
- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
- Yau
- yb Ally
- yd Cherniack
- yd Lai
- yd Schadendorf
- ye Auman
- ye Umbricht
- Yellapantula
- Yellapantula
- yh Bathe
- yj Baylin
- Yoon
- Yu
- Yu
- Yu
- Yuan
- Yugawa
- z ah
- Z. ej
- Z. ep
- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Anthropometric, cardiovascular and functional variables as indicators of health related physical fitness in university professors
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Other parents as a source of support
- Author
- A Bryman
- AR Hochschild
- B Barnet
- B Schreuders
- BC Feeney
- CBS
- CBS
- E Cohen
- E Lam
- F Bredewold
- J Belsky
- J Corcoran
- JA Smith
- JJ Asscher
- JJ Asscher
- JL Fales
- JV van Aar
- K Crnic
- KS Rook
- L Davidson
- L Linders
- Lex Veldboer
- Linde E. Remmelink
- M Schmitz
- M Östberg
- N Bolger
- N Geens
- N Krause
- PA Thoits
- Patty Leijten
- R Engbersen
- RL Simons
- RM Ryan
- S Budde
- S Cohen
- S Cohen
- TG van Tilburg
- VK Bohns
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Family Club Denmark #strongertogether - a volunteer intervention for disadvantaged families: study protocol for a quasi-experimental trial
- Author
- A Chacko
- A MacLeod
- AC Mui
- B Enjolras
- C McAuley
- C Villiger
- C Zhao
- D Kamerāde
- E Wittenberg-Lyles
- F Gardner
- F Wijkström
- H Dickinson
- I Hatzipapas
- J Barnes
- JH Filene
- JJ Asscher
- JMA Hermanns
- JO Berry
- JV van Aar
- K Alam
- L Hustinx
- L Kelleher
- L McWilliams
- L Skov Henriksen
- L Vijayakumar
- LJ Edgar
- LL Mccreary
- M Deković
- M Kamali
- MA Nievar
- MA Sweet
- MC Lovejoy
- N Atif
- O Bilukha
- R Kidman
- R Paris
- RS Allen
- S Dodd
- S Stewart-Brown
- S Stewart-Brown
- Socialstyrelsen
- Socialstyrelsen
- SU Hamdani
- Sundhedsstyrelsen
- Sundhedsstyrelsen
- SV Gentry
- SW Hiatt
- T Brijoux
- T Mooren
- TP Boje
- U Ravens-Sieberer
- V Koushede
- WD Tynan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Swedish coffee (Astragalus boeticus L.), a neglected coffee substitute with a past and a potential future
- Author
- A Badr
- A Badr
- A Fergusson
- A Heistinger
- A Huxley
- A Pretel
- A Tanji
- A Tanji
- A Trichopolou
- A Vogel
- AAR Maassoumi
- Anonymous
- Antonio M. De Ron
- CE Townsend
- CE Townsend
- D Peñas
- D Podlech
- D Podlech
- DJ Mabberley
- DS Sartorelli
- E Burke
- F Campos-Vidal
- F Taeb
- F Taeb
- F Vascellari
- Francisco J. Herraiz
- G Kunkel
- G Sonnante
- GH Wei
- H Lecomte
- H Niles
- HA Mossallam
- HA Weinberg
- HH Zahran
- Isabel Andújar
- J Grisard
- J Prohens
- Jaime Prohens
- JC Bayrhammer
- JC Loudon
- JD Karron
- JL Ríos
- JV Higdon
- K Hammer
- K Hammer
- KW Richards
- LH Bailey
- M Boekel Van
- M El-Bana
- Mariola Plazas
- MJ Vicente
- P Hanelt
- Pietro Gramazio
- Porcher
- Rafael Prohens
- RG Palmer
- RJ Clarke
- S Balaghi
- Santiago Vilanova
- TL King
- UP Hedrick
- W Shurtleff
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Family Helicobacteraceae
- Author
- A Ahmad
- A Alfreider
- A Charlett
- A Covacci
- A Dubois
- A Dubois
- A Garcia
- A Garcia
- A Garcia
- A Garcia
- A Gasbarrini
- A Gonzalez
- A Gustafsson
- A Karnholz
- A Lanzen
- A Lanzoni
- A Lee
- A Lee
- A Lee
- A Meining
- A Morgner
- A Moyaert
- A Nomura
- A Smet
- A Smet
- AAR Ashour
- AB Rogers
- AB Rogers
- AC Wotherspoon
- ACR Tanner
- AE Jergens
- AF Freeman
- AG Oliveira
- AG Oliveira
- AJ Jervis
- AJ Lastovica
- AK Sahu
- AP Burnens
- APA Oxley
- AR Euler
- AT Franco
- ATT Hoor
- B Cuccherini
- B Gebert
- B Hoy
- B Iwanczak
- B Kather
- B Longo-Mbenza
- B Ozpolat
- BA Diwan
- BB Jorgensen
- BB Jorgensen
- BJ Marshall
- BJ Marshall
- BJ Marshall
- BJ Marshall
- BJ Paster
- BM Flores
- BR Robertson
- C Baar
- C Chen
- C Cooksley
- C Geyer
- C Han
- C Jiang
- C Leemann
- C Neubauer
- C Recordati
- C Scully
- CA Fuchsman
- CA Kirkbride
- CA Kirkbride
- CAM McNulty
- CC Chien
- CG Goldman
- CG Goldman
- CG Harper
- CG Harper
- CH Huang
- CJ Gebhart
- CL Franklin
- CL Franklin
- CL Franklin
- CL Moyer
- CL Williams
- CM Sharma
- CMG Harper
- CMG Harper
- CO Wirsen
- CRJ Hubert
- CS Chang
- CS Goodwin
- CS Goodwin
- CW Moss
- CW Radcliffe
- D Alon
- D Basso
- D Dailidiene
- D Gillen
- D Groote De
- D Groote De
- D Groote De
- D Groote De
- D Hofreuter
- D Hofreuter
- D Hofreuter
- D Hofreuter
- D Ilver
- D Kafkewitz
- D Kuck
- D Laharie
- D Rothenbacher
- DE Taylor
- DG Evans
- DG Silva
- DJ Hussey
- DJ Kelly
- DJ Lane
- DJ Reynolds
- DL Weeks
- DM Nelson
- DM Queiroz
- DM Queiroz
- DM Queiroz
- DMD Queiroz
- DMD Queiroz
- DMM Queiroz
- DMM Queiroz
- DR Scott
- DY Graham
- E Bruyne De
- E Rimbara
- EC Bridgeford
- EJ Theve
- EL Carter
- EM El-Omar
- EM El-Omar
- EN Mendes
- EN Mendes
- F Garcia Pichel
- F Haesebrouck
- F Haesebrouck
- F Inagaki
- F Inagaki
- F Megraud
- F Scavizzi
- FE Dewhirst
- FE Dewhirst
- FE Dewhirst
- FE Dewhirst
- FR Traverso
- G Bizzozero
- G Bode
- G Bodtker
- G Cattoli
- G Hinze
- G Makris
- G Muyzer
- GA Rocha
- GD Inglis
- GL Mendz
- GL Mendz
- GL Mendz
- GM Garrity
- H Gressmann
- H Higashi
- H Higashi
- H Higashi
- H Kavermann
- H Kikuchi
- H Lu
- H Moyaert
- H Moyaert
- H Ogiwara
- H Reuse de
- H Reuse De
- H Salomon
- HB Yang
- HC Baggett
- HD Schroder
- HG Truper
- HM Malaty
- HM Malaty
- HM Mitchell
- HM Mitchell
- HM Mitchell
- HMA Schmidt
- HO Nilsson
- HO Nilsson
- HP Zhao
- HQ Jiang
- I Brettar
- I Happonen
- I Mukhopadhya
- I Roalkvam
- I Tammer
- I Vitoriano
- IARC
- IC Arnold
- IL Holster
- J Chow
- J Gerrard
- J Grote
- J Grote
- J Grote
- J Kountouras
- J Kuever
- J Lorenzen
- J Parkhill
- J Parsonnet
- J Prag
- J Reibman
- J Sikorski
- J Simon
- J Simon
- J Stanley
- J Stanley
- J Stoof
- J Stoof
- J Tankovic
- J Waldenstrom
- J Waldenstrom
- J Yakoob
- JA Kiehlbauch
- JC Atherton
- JC Atherton
- JC Machado
- JD Mitchell
- JE Foley
- JE Foley
- JF Tomb
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Fox
- JG Kusters
- JH Bryner
- JH Simmons
- JI Dasti
- JK Battles
- JL Doenges
- JL O’Rourke
- JL O’Rourke
- JL O’Rourke
- JL O’Rourke
- JL Rhead
- JL Telford
- JM Macy
- JM Thomson
- JM Ward
- JM Whitmire
- JP Lorenzen
- JP Maestre
- JP Maestre
- JP Rappin
- JV Solnick
- JV Solnick
- JV Solnick
- JV Solnick
- JV Solnick
- K Bulck Van den
- K Bulck Van den
- K Bulck Van den
- K Bulck Van den
- K Goto
- K Goto
- K Goto
- K Jalava
- K Jalava
- K Jalava
- K Minauchi
- K Schauer
- K Simpson
- K Takai
- K Trebesius
- K Watanabe
- K Watanabe
- KA Eaton
- KA Eaton
- KA Eaton
- KA Eaton
- KA Eaton
- KA Eaton
- KA Miller
- KEL McColl
- KL Heilmann
- KM Handley
- KR Fernandez
- L Cellini
- L Dhaenens
- L Munson
- L Munson
- L Zenner
- L Zhang
- LAS Snyder
- LB Comunian
- LJ Doorn van
- LJ Reigstad
- LK Handt
- LM Ceelen
- LP Andersen
- LP Hale
- M Ashorn
- M Aspholm
- M Baele
- M Baele
- M Baele
- M Beisele
- M Bock De
- M Bokranz
- M Bronder
- M Chichlowski
- M Craven
- M Eppinger
- M Fabisiak
- M Funato
- M Gerhard
- M Gong
- M Grehan
- M Haque
- M Hatakeyama
- M Hatakeyama
- M Ihrig
- M Izadi
- M Kern
- M Kern
- M Kern
- M Kern
- M Kodama
- M Naito
- M Nakayama
- M Oleastro
- M Oleastro
- M Oleastro
- M Pflock
- M Poppe
- M Rossi
- M Rossi
- M Selbach
- M Stein
- M Stolte
- M Suzuki
- M Vermoote
- M Yamamoto
- M Zhang
- MA Bronsdon
- MA García-Amado
- MB Piazuelo
- MB Skirrow
- MC Justino
- MC Marino
- MCA Ungria De
- MD Schrenzel
- MF Shao
- MJ Blaser
- MJ Blaser
- MJ Blaser
- MJ Blaser
- MJ Blaser
- MJ Blaser
- MJ Wolin
- ML Hanninen
- ML Hanninen
- ML Hanninen
- ML Porter
- ML Schubert
- MM Estabrook
- MM Oliva
- MM Patterson
- MM Patterson
- MM Patterson
- MM Patterson
- MP Dore
- MP Mammen
- MR Wessels
- MT Whary
- MT Whary
- MY Tsao
- MZ Abidi
- N Charoenlap
- N Guimaraes
- N Matsukura
- N Salama
- N Yoshida
- ND Yeomans
- NE Wittekindt
- NJ Loman
- NL Trivett Moore
- NO Kaakoush
- NPM Liyanage
- NR Hussein
- NS Taylor
- NS Taylor
- P Bauerfeind
- P Boquet
- P Correa
- P Farinha
- P Gill
- P Gueneau
- P Nebbia
- P Nedenskov
- P Robino
- P Sipponen
- P Suarez
- P Vandamme
- P Vandamme
- P Voland
- P Yarza
- PA Chalk
- PA Totten
- PG Medihala
- PG Medihala
- PJ Romaniuk
- PL Melito
- PR Harris
- PR Hsueh
- PR Jungblut
- PR Jungblut
- PR Nambiar
- PW O’Toole
- PW O’Toole
- PW O’Toole
- QV Tu
- R Hansen
- R Kivisto
- R Neiger
- R Pellicano
- R Roosendaal
- R Stasi
- R Thar
- R Thar
- R Thar
- R Tsutsumi
- RA Alm
- RD Leunk
- RF Petersen
- RF Wack
- RG Ge
- RH Argent
- RM Ferreira
- RM Peek
- S Backert
- S Backert
- S Buczolits
- S Bury-Mone
- S Bury-Mone
- S Bury-Mone
- S Censini
- S Glaubitz
- S Glaubitz
- S Kato
- S Khan
- S Kleinsteuber
- S Kostia
- S Krueger
- S Nakagawa
- S Nakagawa
- S Nell
- S Odenbreit
- S Romero
- S Suerbaum
- S Suerbaum
- SA Batista
- SB Citino
- SB Moura
- SC Weir
- SC Wen
- SCM Haaijer
- SE Erdman
- SE Turvey
- SH Zhang
- SJ Bell
- SJ Park
- SK Johansson
- SL Hazell
- SL Hazell
- SL On
- SL Orlicek
- SLC Shartau
- SLW On
- SLW On
- SM Man
- SM Sievert
- SR Boutin
- SR Pernitzch
- SW Han
- SY Xuan
- T Azuma
- T Boren
- T Borén
- T Coldham
- T Fenchel
- T Goto
- T Hamada
- T Krafft
- T Kwok
- T Miyoshi-Akiyama
- T Morner
- T Schott
- T Schott
- T Takahashi
- T Yoshinari
- TC Quinn
- TC Quinn
- TD Haggerty
- TG Blanchard
- TP Mikkonen
- TW Steele
- U Braun
- URM Bohr
- URM Bohr
- URM Bohr
- V Castiglioni
- V Tolia
- Validation List
- Validation List
- Validation List
- Validation List
- Validation List
- Validation List
- Validation List
- Validation List
- Validation List
- VB Young
- VB Young
- VJ Torres
- VQ Nguyen
- VR Gusmao De
- W Hermanns
- W Jakob
- W Krienitz
- W Qu
- W Tee
- Wasimuddin
- XH Qu
- XW Huijsdens
- Y Chen
- Y Germani
- Y Hirai
- Y Kodama
- Y Okiyama
- Y Wen
- Y Yamaoka
- Y Yamaoka
- YH Han
- YK Choi
- YS Won
- YS Won
- Z Ge
- Z Shen
- Z Shen
- Z Shen
- ZL Shen
- ZM Ge
- ZM Ge
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
First flavor-tagged determination of bounds on mixing-induced CP violation in B-s(0)-> J/psi phi decays
- Author
- Aaltonen Tw
- Adelman Jm
- Akimoto Tbb
- Albrow Mgq
- Amerio Sap
- Amidei Dah
- Anastassov Aay
- Annovi As
- Antos Jn
- Aoki Mx
- Apollinari Gq
- Apresyan Aau
- Arisawa Tbd
- Artikov Ao
- Ashmanskas Wq
- Attal Ac
- Aurisano Aaz
- Azfar Fao
- Azzi-Bacchetta Pap
- Azzurri Pas
- Bacchetta Nap
- Badgett Wq
- Barbaro-Galtieri Aab
- Barnes Veau
- Barnett Bay
- Baroiant Sg
- Bartsch Vad
- Bauer Gaf
- Beauchemin P-Hag
- Bedeschi Fas
- Bednar Pn
- Behari Sy
- Bellettini Gas
- Bellinger Jbf
- Belloni Av
- Benjamin Dp
- Beretvas Aq
- Beringer Jab
- Berry Tac
- Bhatti Aaw
- Binkley Mq
- Bisello Dap
- Bizjak Iad
- Blair Reb
- Blocker Cf
- Blumenfeld By
- Bocci Ap
- Bodek Aav
- Boisvert Vav
- Bolla Gau
- Bolshov Aaf
- Bortoletto Dau
- Boudreau Jat
- Boveia Aj
- Brau Bj
- Bridgeman Ax
- Brigliadori Le
- Bromberg Cai
- Brp Ko
- Brubaker Em
- Budagov Jo
- Budd Hsav
- Budd Sx
- Burkett Kq
- Busetto Gap
- Bussey Pu
- Buzatu Aag
- Byrum Klb
- Cabrera Sp
- Campanelli Mai
- Campbell Mah
- Canelli Fq
- Canepa Aar
- Carlsmith Dbf
- Carosi Ras
- Carrillo Sr
- Carron Sag
- Casal Bk
- Casarsa Mq
- Castro Ae
- Catastini Pas
- Cauz Dba
- Cavalli-Sforza Mc
- Cerri Aab
- Cerrito Lad
- Chang Shaa
- Chen Yca
- Chertok Mg
- Chiarelli Gas
- Chlachidze Gq
- Chlebana Fq
- Cho Kaa
- Chokheli Do
- Chou Jpv
- Choudalakis Gaf
- Chuang Shay
- Chung Kl
- Chung Whbf
- Chung Ysav
- Ciobanu Cix
- Ciocci Maas
- Clark At
- Clark Df
- Compostella Gap
- Convery Meq
- Conway Jg
- Cooper Bad
- Copic Kah
- Cordelli Ms
- Cortiana Gap
- Crescioli Fas
- Cuenca Almenar Cg
- Cuevas Jk
- Culbertson Rq
- Cully Jcah
- D'Onofrio Mc
- Dagenhart Dq
- Datta Mq
- Davies Tu
- De Barbaro Pav
- De Cecco Sax
- De Lentdecker Gav
- De Lorenzo Gc
- De Pedis Dax
- Deisher Aab
- Dell'Orso Mas
- Demortier Law
- Deng Jp
- Deninno Me
- Derwent Pfq
- Di Giovanni GPaq
- Di Ruzza Bba
- Dionisi Cax
- Dittmann Jrd
- Donati Sas
- Dong Ph
- Donini Jap
- Dorigo Tap
- Dube Say
- Efron Jal
- Erbacher Rg
- Errede Dx
- Errede Sx
- Eusebi Rq
- Fang Hcab
- Farrington Sac
- Fedorko Wtm
- Feild Rgbg
- Feindt Mz
- Fernandez Jpae
- Ferrazza Cas
- Field Rr
- Flanagan Gau
- Forrest Rg
- Forrester Sg
- Franklin Mv
- Freeman Jcab
- Furic Ir
- Gallinaro Maw
- Galyardt Jl
- Garberson Fj
- Garcia Jeas
- Garfinkel Afau
- Gbav Yu
- Genser Kq
- Gerberich Hx
- Gerdes Dah
- Giagu Sax
- Giakoumopolou Vas
- Giannetti Pas
- Gibson Kat
- Gimmell Jlav
- Ginsburg Cmq
- Giokaris No
- Giordani Mba
- Giromini Ps
- Giunta Mas
- Giurgiu Gy
- Glagolev Vo
- Glenzinski Dq
- Gold Maj
- Goldschmidt Nr
- Golossanov Aq
- Gomez Gk
- Gomez-Ceballos Gaf
- Goncharov Maz
- González Oae
- Gorelov Iaj
- Goshaw Atp
- Goulianos Kaw
- Gresele Aap
- Grinstein Sv
- Grosso-Pilcher Cm
- Group Rcq
- Grundler Ux
- Guimaraes Da Costa Jv
- Gunay-Unalan Zai
- Haber Cab
- Hahn Kaf
- Hahn Srq
- Halkiadakis Eay
- Hamilton At
- Han B-Yav
- Han Jyav
- Handler Rbf
- Happacher Fs
- Hara Kbb
- Hare Day
- Hare Mbc
- Harper Sao
- Harr Rfbe
- Harris Rmq
- Hartz Mat
- Hatakeyama Kaw
- Hauser Jh
- Hays Cao
- Heck Mz
- Heijboer Aar
- Heinemann Bab
- Heinrich Jar
- Henderson Caf
- Herndon Mbf
- Heuser Jz
- Hewamanage Sd
- Hidas Dp
- Hill Csj
- Hirschbuehl Dz
- Hocker Aq
- Hou Sa
- Houlden Mac
- Hsu S-Ci
- Huffman Btao
- Hughes Real
- Husemann Ubg
- Huston Jai
- Iaa Yu
- Incandela Jj
- Introzzi Gas
- Iori Max
- Ivanov Ag
- Iyutin Baf
- James Eq
- Jayatilaka Bp
- Jeans Dax
- Jeon Ejaa
- Jindariani Sr
- Johnson Wg
- Jones Mau
- Joo Kkaa
- Jun Syl
- Jung Jeaa
- Junk Trx
- Kamon Taz
- Kar Dr
- Karchin Pebe
- Kato Yan
- Kephart Rq
- Kerzel Uz
- Khotilovich Vaz
- Kilminster Bal
- Kim Dhaa
- Kim Hsaa
- Kim Jeaa
- Kim Mjq
- Kim Sbaa
- Kim Shbb
- Kim Ykm
- Kimura Nbb
- Kirsch Lf
- Klimenko Sr
- Klute Maf
- Knuteson Baf
- Koay Saj
- Kondo Kbd
- Kong Djaa
- Konigsberg Jr
- Korytov Ar
- Kotwal Avp
- Kraus Jx
- Kreps Mz
- Kroll Jar
- Krumnack Nd
- Kruse Mp
- Krutelyov Vj
- Kubo Tbb
- Kuhlmann Seb
- Kuhr Tz
- Kulkarni Npbe
- Kusakabe Ybd
- Kwang Sm
- Laasanen Atau
- Labarga Lae
- Lai Sag
- Lami Sas
- Lammel Sq
- Lancaster Mad
- Lander Rlg
- Lannon Kal
- Lath Aay
- Latino Gas
- Lazzizzera Iap
- Lecompte Tb
- Lee Jaa
- Lee Jav
- Lee Swaz
- Lee Yjaa
- Lefèvre Rt
- Leonardo Naf
- Leone Sas
- Levy Sm
- Lewis Jdq
- Lin Cbg
- Lin Csab
- Linacre Jao
- Lindgren Mq
- Lipeles Ei
- Lister Ag
- Litvintsev Doq
- Liu Cat
- Liu Tq
- Lockyer Nsar
- Loginov Abg
- Loreti Map
- Lovas Ln
- Lucchesi Dap
- Luci Cax
- Lueck Jz
- Lujan Pab
- Lukens Pq
- Lungu Gr
- Lyons Lao
- Lys Jab
- Lysak Rn
- Lytken Eau
- Mack Pz
- Macqueen Dag
- Madrak Rq
- Maeshima Kq
- Makhoul Kaf
- Maki Tw
- Maksimovic Py
- Malde Sao
- Malik Sad
- Manca Gac
- Manousakis Ao
- Margaroli Fau
- Marino Cpx
- Marino Cz
- Martin Abg
- Martin My
- Martin Vu
- Martínez Mc
- Martínez-Ballarín Rae
- Maruyama Tbb
- Mastrandrea Pax
- Masubuchi Tbb
- Mattson Mebe
- Mazzanti Pe
- Mcfarland Ksav
- Mcintyre Paz
- Mcnulty Rac
- Mehta Aac
- Mehtala Pw
- Menzemer Sk
- Menzione Aas
- Merkel Pau
- Mesropian Caw
- Messina Aai
- Miao Tq
- Miladinovic Nf
- Miles Jaf
- Miller Rai
- Mills Cv
- Milnik Mz
- Mitra Aa
- Mitselmakher Gr
- Miyake Hbb
- Moed Sv
- Moggi Ne
- Moon Csaa
- Moore Rq
- Morello Mas
- Movilla Fernandez Pab
- Mukherjee Aq
- Muller Tz
- Mumford Ry
- Murat Pq
- Mussini Me
- Mülmenstädt Jab
- Nachtman Jq
- Nagai Ybb
- Nagano Abb
- Naganoma Jbd
- Nakamura Kbb
- Nakano Iam
- Napier Abc
- Necula Vp
- Neu Car
- Neubauer Msx
- Nielsen Jab
- Nodulman Lb
- Norman Mi
- Norniella Ox
- Nurse Ead
- Oksuzian Ir
- Okusawa Tan
- Oldeman Rac
- Orava Rw
- Osterberg Kw
- Pagan Griso Sap
- Pagliarone Cas
- Palencia Eq
- Papadimitriou Vq
- Papaikonomou Az
- Paramonov Aam
- Parks Bal
- Pashapour Sag
- Patrick Jq
- Pauletta Gba
- Paulini Ml
- Paus Caf
- Pellett Deg
- Penzo Aba
- Phillips Tjp
- Piacentino G
- Piedra Jaq
- Pinera Lr
- Pitts Kx
- Plager Ch
- Pondrom Lbf
- Portell Xc
- Poukhov Oo
- Pounder Nao
- Prakoshyn Fo
- Pronko Aq
- Proudfoot Jb
- Ptohos Fq
- Punzi Gas
- Pursley Jbf
- R-Sa Lu
- Rademacker Jao
- Rahaman Aat
- Ramakrishnan Vbf
- Ranjan Nau
- Redondo Iae
- Reisert Bq
- Rekovic Vaj
- Renton Pao
- Rescigno Max
- Richter Sz
- Rimondi Fe
- Ristori Las
- Robson Au
- Rodrigo Tk
- Rogers Ex
- Rolli Sbc
- Roser Rq
- Rossi Mba
- Rossin Rj
- Roy Pag
- Ruiz Ak
- Russ Jl
- Rusu Vq
- Saarikko Hw
- Safonov Aaz
- Sakumoto Wkav
- Salamanna Gax
- Saltó Oc
- Santi Lba
- Sarkar Sax
- Sartori Las
- Sato Kq
- Savoy-Navarro Aaq
- Scheidle Tz
- Schlabach Pq
- Schmidt Eeq
- Schmidt Mam
- Schmidt Mpbg
- Schmitt Mak
- Schwarz Tg
- Scodellaro Lk
- Scott Alj
- Scribano Aas
- Scuri Fas
- Sedov Aau
- Seidel Saj
- Seiya Yan
- Semenov Ao
- Sexton-Kennedy Lq
- Sfyrla At
- Shalhout Szbe
- Shapiro Mdab
- Shears Tac
- Shepard Pfat
- Sherman Dv
- Shimojima Mbb
- Shochet Mm
- Shon Ybf
- Shp Oh
- Shreyber It
- Sidoti Aas
- Sinervo Pag
- Sisakyan Ao
- Slaughter Ajq
- Slaunwhite Jal
- Sliwa Kbc
- Smith Jrg
- Snider Fdq
- Snihur Rag
- Soderberg Mah
- Soha Ag
- Somalwar Say
- Sorin Vai
- Spalding Jq
- Spinella Fas
- Spreitzer Tag
- Squillacioti Pas
- Ssq Yu
- St Denis Ru
- Stanitzki Mbg
- Stelzer Bh
- Stelzer-Chilton Oao
- Stentz Dak
- Strologas Jaj
- Stuart Dj
- Suh Jsaa
- Sukhanov Ar
- Sun Hbc
- Suslov Io
- Suzuki Tbb
- Taffard Ax
- Takashima Ram
- Takeuchi Ybb
- Tanaka Ram
- Tecchio Mah
- Teng Pka
- Terashi Kaw
- Thom Jq
- Thompson Asu
- Thompson Gax
- Thomson Ear
- Tipton Pbg
- Tiwari Vl
- Tkaczyk Sq
- Toback Daz
- Tokar Sn
- Tollefson Kai
- Tomura Tbb
- Tonelli Dq
- Torre Ss
- Torretta Dq
- Tourneur Saq
- Trischuk Wag
- Turini Nas
- Ukegawa Fbb
- Uozumi Sbb
- Vallecorsa St
- Van Remortel Nw
- Varganov Aah
- Vataga Eaj
- Velev Gq
- Vellidis Cas
- Veszpremi Vau
- Vidal Mae
- Vidal Rq
- Vila Ik
- Vilar Rk
- Vine Tad
- Vogel Maj
- Volobouev Iab
- Volpi Gas
- Vázquez Fr
- Wagner Par
- Wagner Rgb
- Wagner Rlq
- Wagner Wz
- Wagner-Kuhr Jz
- Wakisaka Tan
- Wallny Rh
- Wang Sma
- Warburton Aag
- Waters Dad
- Weinberger Maz
- Wester Wcq
- Whitehouse Bbc
- Whiteson Dar
- Wicklund Abb
- Wicklund Eq
- Williams Gag
- Williams Hhar
- Wilson Pq
- Winer Blal
- Wittich Pq
- Wolbers Sq
- Wolfe Cm
- Wright Tah
- Wu Xt
- Wynne Smac
- Würthwein Fi
- Yagil Ai
- Yamamoto Kan
- Yamaoka Jay
- Yamashita Tam
- Yang Cbg
- Yang Ukm
- Yang Ycaa
- Yao Wmab
- Yar Tu
- Ydaa Oh
- Yeh Gpq
- Yoh Jq
- Yorita Km
- Yoshida Tan
- Yun Jcq
- Zanello Lax
- Zanetti Aba
- Zaw Iv
- Zhang Xx
- Zheng Yh
- Zucchelli Se
- Álvarez González Bk
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2008
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
- Author
- Abdelrazik M
- Abedalthagafi M
- Abel L
- Abel L
- Abellan J
- Abernathy C
- Abraheem A
- Acklery A
- Acosta-Isaac R
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afolabi D
- Agasou A
- Agravante K
- Agravante K
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar PM
- Aguilera-Albesa S
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Moasseb H
- Alasdair F
- Alba J
- Albu S
- Alcalá-Gallardo KAM
- Alcoba-Florez J
- Aldridge J
- Alex B
- Alexander P
- Alfonso J
- Algarin-Lara HR
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allibone S
- Allison KS
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almeida J
- Almoguera B
- Alonso MR
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alves MDM
- Amamio M
- Amamio M
- Amin V
- Anastasescu E
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Andreou P
- Andreu-Bernabeu Á
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrikopoulos P
- Antcliffe D
- Antoine P
- Antonijoan MR
- Antony S
- Anumakonda V
- Anwer M
- Apetri E
- Aquino M
- Arana-Arri E
- Aranda C
- Arango C
- Araque C
- Araujo IMT
- Araujo NK
- Aravindan L
- Arbane G
- Arcanjo AC
- Archer K
- Arden T
- Arias SS
- Arif S
- Armistead J
- Armstrong D
- Armstrong L
- Armstrong R
- Arnaiz A
- Arnott A
- Arora M
- Arranz MJ
- Artiga M-J
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Aslibekyan S
- Astin-Chamberlain R
- Atayeva N
- Attwood B
- Atwal I
- Auld F
- Austin K
- Austin P
- Auton A
- Avello-Malaver Y
- Ayers A
- Ayuso C
- Bach B
- Badal B
- Baddeley A
- Bafitis V
- Baikady RR
- Bailey L
- Baillie JK
- Baillie JK
- Baillie K
- Baines D
- Baines K
- Baird T
- Baird Y
- Baker M
- Bakthavatsalam D
- Baldión-Elorza AM
- Bamford A
- Bamford A
- Bamford P
- Banach D
- Bancroft H
- Bandla N
- Bano S
- Baptista D
- Baptista-Rosas RC
- Barber R
- Barberis L
- Barberis L
- Barclay C
- Barclay L
- Barclay WS
- Barker J
- Barker M
- Barnes N
- Barr J
- Barranco-Díaz A
- Barreda-Sánchez M
- Barrera-Penagos V
- Barrett F
- Barron A
- Barrow E
- Barry P
- Bartley S
- Barton J
- Baruah R
- Bashyal A
- Basikolo C
- Bastion V
- Bates H
- Bates M
- Batres SA
- Battle C
- Bauchmuller K
- Baxter N
- Baxter-Dore S
- Bayo L-A
- Beadle J
- Bean S
- Beasley A
- Beaumont K
- Beavis S
- Beech E
- Beech V
- Beekes M
- Beer S
- Beesley K
- Begg C
- Behan T
- Beith C
- Beith C
- Belagodu Z
- Belfield H
- Belhassen-Garcia M
- Bell D
- Bell G
- Bell J
- Bell M
- Bell S
- Bellamy M
- Bellini A
- Bellwood R
- Bemand T
- Benham L
- Benito HG
- Benkenstein S
- Bennett S
- Bentley M
- Benyon S
- Beranova E
- Bercades G
- Bernal E
- Bernal-Bello D
- Bevan E
- Bewley J
- Bezerra JF
- Bezerra MAC
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bi R
- Bibi F
- Biddle J
- Biggs H
- Birch J
- Birch J
- Birch S
- Birch S
- Birchall K
- Birchall K
- Bircham S
- Bird S
- Birkinshaw I
- Birt M
- Birt M
- Bishop L
- Biss J
- Black C
- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanca-López N
- Blancas R
- Bland Y
- Blow S
- Blowing H
- Blunt M
- Board S
- Bociek A
- Bogaert D
- Boix-Palop L
- Bokhari M
- Bolger A
- Bolger C
- Bolton M
- Bolton R
- Boltwood K
- Bonner S
- Bonnici J
- Booker L
- Borislavova B
- Borja AL
- Borobia A
- Borra C
- Botello A
- Botfield D
- Botfield L
- Bough L
- Bowes A
- Bowey A
- Bowles R
- Bowman F
- Boxall H
- Boyd E
- Boyer N
- Boyle P
- Boyle R
- Boz C
- Bradley C
- Bradley P
- Bradley-Potts J
- Bradley-Potts J
- Bradshaw Z
- Brady A
- Brady L
- Brady M
- Brady R
- Brandwood C
- Brandwood C
- Branney D
- Bravo E
- Brayne A
- Brealey D
- Brealey D
- Brearey S
- Bremmer P
- Bretherick AD
- Brett M
- Brett S
- Brickell K
- Bridgett V
- Brimfield L
- Brinkworth E
- Brion M
- Briton K
- Briton K
- Brochado-Kith Ó
- Bromley M
- Brooke H
- Brooks J
- Brooks J
- Brooks S
- Brown A
- Brown A
- Brown A
- Brown CW
- Brown E
- Brown J
- Bruce M
- Brugada R
- Brunton M
- Bryant J
- Buckley C
- Buckley J
- Buckley S
- Bull R
- Bullock E
- Bullock E
- Bunni L
- Burchett C
- Burda D
- Burgoyne A
- Burn I
- Burnett C
- Burnish R
- Burns K
- Burrow A
- Burt K
- Burtenshaw A
- Burton M
- Bustos M
- Butcher D
- Butler A
- Butler J
- Butler S
- Butt F
- Butterworth-Cowin N
- Button H
- Buttriss C
- Cabello A
- Cabral-Ortega L
- Cabrelli L
- Caceres-Agra JJ
- Cagova L
- Calbo E
- Calderón EJ
- Cale E
- Callaghan M
- Callam S
- Calvo CM
- Camacho S
- Campbell A
- Campbell B
- Campbell H
- Campbell R
- Campbell S
- Campos MC
- Campos S
- Camsooksai J
- Candalija AC
- Candon AM
- Capitán CF
- Capozzi L
- Capps N
- Carbonell C
- Cardona-Huerta S
- Cardwell A
- Carioca AAF
- Carmody M
- Carmody S
- Carnahan M
- Carpintero MS
- Carracedo A
- Carracedo A
- Carratto TMT
- Carrera LG
- Carrillo-Avila JA
- Carson G
- Cart C
- Carter A
- Carter D
- Carter E
- Carter J
- Carter M
- Carter S
- Cartlidge D
- Carungcong J
- Carvalho MCC
- Casasnovas C
- Casey M
- Castano L
- Castaño CF
- Castaño JAT
- Castelao JE
- Castillo MA
- Caswell M
- Caterson J
- Cathcart S
- Catlow L
- Cavazza A
- Cave A
- Cawley K
- Cawley K
- Cawthron K
- Cañadas Y
- Ceballos FC
- Cha M
- Chablani M
- Chadwick R
- Chan R
- Chand M
- Chandler B
- Chandna H
- Chapman S
- Charles B
- Charlesworth R
- Charnock R
- Charris HM
- Chaux JG
- Chaves-Santiago WG
- Chechi K
- Cheema Y
- Chen J
- Cherian S
- Chesters K
- Chetam L
- Cheyne C
- Chikowore P
- Childs D
- Chiquillo-Gómez S
- Chisholm C
- Choudhr O
- Choudhury Y
- Chukkambotla S
- Chávez MEQ
- Cid-Lopez MA
- Cienfuegos-Jimenez O
- Cinquina Z
- Clamp S
- Clapham M
- Clarey E
- Claridge H
- Clark A
- Clark A
- Clark M
- Clark M
- Clark R
- Clark R
- Clark S
- Clark S
- Clark V
- Clarke N
- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clohisey S
- Coates C
- Cochrane P
- Cockerill H
- Cockrell M
- Coe R
- Coetzee S
- Coghlan P
- Cohrane C
- Coker D
- Cole J
- Cole J
- Cole S
- Coleman C
- Coleman D
- Coles H
- Colley J
- Colley N
- Collier D
- Collier D
- Collier H
- Collins A
- Collins C
- Collins E
- Collins E
- Collins K
- Collins K
- Collins R
- Collins V
- Collis M
- Combes E
- Conde-Vicente R
- Conejo IP
- Connell J
- Connolly K
- Connor M
- Convery K
- Conyngham J-A
- Cooke GS
- Cookson R
- Cooper J
- Cooper L
- Cooper L
- Corcoran E
- Corcoran K
- Cordero-Lorenzana ML
- Corella D
- Corin C
- Cornell S
- Cornell T
- Corner A
- Corral MA
- Corrales A
- Cortes-Sanchez JL
- Corton M
- Cosgrove D
- Cosier T
- Costa TX
- Cother N
- Coton Z
- Cottam L-J
- Cottle J
- Coulding M
- Coutts A
- Coventry T
- Covernton P
- Cowley A
- Cowley N
- Cowton A
- Cox A
- Coyle J
- Craig H
- Craig J
- Crawley R
- Creagh-Brown B
- Crew A
- Crickmore V
- Cristiano D
- Croft M
- Crowe R
- Crowley M
- Cruz C
- Cruz MS
- Cruz R
- Cruz R
- Csabi P
- Cuerda VM
- Cuesta L
- Cullum L
- Cunha GCR
- Cunningham A
- Cunningham M
- Cupitt J
- Curgenven H
- Currie S
- Cusack R
- Cutler S
- Cutting P
- Cutts S
- Da Gloria EF
- Da Rocha J
- da Silva Filipe A
- da Silva GV
- Daglish J
- Dagutao Z
- Dale K
- Dale S
- Dalmau D
- Dalton C
- Dalton J
- Daly Z
- Dalziel J
- DAmato F
- Dance A
- Daniel A
- Daniel E
- Daniel P
- Daniels A
- Dantas-Komatsu RCS
- Dark P
- Darlington K
- Darnaude MT
- Darnell S
- Das M
- Das S
- Dasgin J
- Daubney E
- Davey M
- David B
- Davidson N
- Davies A
- Davies C
- Davies C
- Davies E
- Davies F
- Davies G
- Davies H
- Davies J
- Davies K
- Davies L
- Davies M
- Davies M
- Davies R
- Davies S
- Davis C
- Davis J
- Davison C
- Dawson A
- Dawson D
- Day A
- Day N
- de Andrés R
- de Araújo JNG
- De Beger S
- de Bustamante AD
- de Gordoa LO-R
- de Heredia ML
- de Juan C
- De la Cruz Troca J
- de la Horra C
- de la Hoz AB
- De Martino-Rodríguez A
- de Neef M
- De Queiroz JG
- de Quirós FGB
- de Silva T
- de Sousa Alves Neri JL
- Deacon B
- Deacon B
- Dean C
- Dearden J
- DeAth Y
- Debreceni G
- Deery J
- del Campo-Pérez V
- Dela Rosa A
- Delaney J
- Delgado CC
- Delgado-Cuesta J
- Dell A
- Demetriou C
- Denmade C
- Dennis C
- Dent K
- Dent M
- Depante M
- Dexter C
- Diaba C
- Diaba C
- Diaz-Caneja CM
- Dickson H
- Dietl B
- Digby B
- Digby S
- Ding L
- Diz-de Almeida S
- Djeugam B
- Doble P
- Dobson E
- Docherty AB
- Dodd A
- Dodds S
- Dolan H
- Domingos P
- Domínguez-Garrido E
- Donaldson A
- Donaldson D
- Donegan C
- Donlon S
- Donnachie J
- Donne B
- Donnelly K
- Donnelly L
- Donnison P
- Donohue C
- Dooks E
- Doonan R
- Dore R
- Dormand N
- dos Santos Correia G
- dos Santos KA
- Douglas K
- Doverman K
- Doverman K
- Downes C
- Drake TM
- Drummond A
- Duarte AM
- Dube J
- Duberley S
- Duffield J
- Duffin D
- Duffy K
- Duffy S
- Dumas M-E
- Duncan E
- Duncan T
- Dunhill J
- Dunmore C
- Dunn J
- Dunne K
- Dunning J
- Durga L
- Durie A
- Durrans LJ
- Durrant G
- Duskova M
- Dykes J
- Díaz-Pérez A
- D’Sylva S
- Eapen B
- Earl V
- Eastgate C
- Easthope A
- Easthope A
- Easthope A
- Easton J
- Ebano P
- Echave-Sustaeta J
- Eckbad C
- Edmond I
- Edwards M
- Efford G
- Egan J
- Egginton D
- Eiros R
- Elawamy L
- Elbehery M
- Elcioglu Z
- Elhassan M
- Elliott K
- Ellis H
- Elsaadany M
- Elston K
- Eltayeb A
- Emblem J
- Enciso-Olivera CO
- English K
- Eros A
- Escudero G
- Esparza-Gordillo J
- España PP
- Estévez JV
- Evans G
- Evans J
- Evitts J
- Ezeobu O
- Fagan A
- Fairfax B
- Fairfield CJ
- Fariñas MC
- Farley S
- Farnell-Ward S
- Farquhar F
- Farwell J
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- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)