The Ursinus Weekly, October 24, 1974

Profs to lecture on Pa. Dutch arts • Dr. Lodge joins U.C. Psych Dept. • Campus Chest plans for funds and fun • Forum features flute and guitar • Is there a ghost in U.C.\u27s haunted hall? • Letters to the editor: Students demand a good education • The origin of The Lantern • Alumni corner • An autumn walk • Mr. Richter goes to school • What\u27s playing at the movies? • Spectrum blues: Joe Cocker • Spanish Club plans outing • Campus Gold activities • Introducing campus leaders • Money given away • Ursinus Homecoming 1974: Fraternity candidates to wear the queen\u27s crown • Homecoming from Ursinus past • Union ripped-off • A football commentary • X-country: three in a rowhttps://digitalcommons.ursinus.edu/weekly/1023/thumbnail.jp

The Ursinus Weekly, November 7, 1974

The Great Pumpkin comes to U.C. • Course Directory Catalogue Committee formed by U.S.G.A. • Antigone is ProTheatre\u27s production • Union does it again • Criminal law featured as Forum topic • Letters to the editor: Epitaph on an Ursinus transfer • Pages from Ursinus past: A legend • Perusing Pfahler\u27s pigeons • New Economics head • Equus reviewed • Concerts: Bizarre and sublime • Record review • Nate DuPree: Can a black man find happiness at Ursinus? • Martha Franklin: A half century of service to our students and campus • Readin\u27, ritin\u27 and new math • Introducing campus leaders • Football wrapup: Swarthmore; Widener • Hockey teams win the big games! • Harriers 6-4 on seasonhttps://digitalcommons.ursinus.edu/weekly/1024/thumbnail.jp

The Lantern Vol. 42, No. 1, Fall 1975

• The House • The Empty Man • Time • Corporea • Take Me • Elements of Nature • Hope • Acclimation • Road to Elat • Sinai • Jerusalem • Fatman • Ode to Grand Rapids • Ode to Cora • The Apple Cart • Next Time You\u27re Down South • Star Wreck • Eulogy to John Doe • A Postal Preoccupation • The Interview May Be Real (But Don\u27t Bet On It) • Winter Eve • My Love • God\u27s Children • A View From a Hill • Freedom For Us • Sleep Demonhttps://digitalcommons.ursinus.edu/lantern/1107/thumbnail.jp

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism.

International audienceAlthough multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

Writing in Britain and Ireland, c. 400 to c. 800

No abstract available

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.Peer reviewe