15 research outputs found
Validation of Observed Bedload Transport Pathways Using Morphodynamic Modeling
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Phenomena related to braiding, including local scour and fill, channel bar development, migration
and avulsion, make numerical morphodynamic modeling of braided rivers challenging. This paper investigates
the performance of a Delft3D model, in a 2D depth-averaged formulation, to simulate the
morphodynamics of an anabranch of the Rees River (New Zealand). Model performance is evaluated using
data from field surveys collected on the falling limb of a major high flow, and using several sediment
transport formulas. Initial model results suggest that there is generally good agreement between observed and
modeled bed levels. However, some discrepancies in the bed level estimations were noticed, leading to bed
level, water depth and water velocity estimation errors
Hydrothermal alteration and microbial sulfate reduction in peridotite and gabbro exposed by detachment faulting at the Mid‐Atlantic Ridge, 15°20′N (ODP Leg 209): A sulfur and oxygen isotope study
- Author
- Agrinier
- Agrinier
- Allen
- Allen
- Alt
- Alt
- Alt
- Alt
- Bach
- Bach
- Bach
- Barnes
- Bottinga
- Bougault
- Canfield
- Canfield
- Carbotte
- Carlos J. Garrido
- Charlou
- Chiba
- Clayton
- Coplen
- Davis
- Ding
- Douville
- Escartín
- Frost
- Fruh-Green
- Fujiwara
- Furnes
- Georges Beaudoin
- Harmon
- Hartmann
- Holger Paulick
- Jannasch
- Jeffrey C. Alt
- Kelley
- Kelley
- Lagabrielle
- Lorand
- Malinin
- Mattey
- Mattey
- Mevel
- Moody
- Muehlenbachs
- Ohmoto
- Ohmoto
- Palandri
- Paulick
- Proskurowski
- Rees
- Rice
- Saccocia
- Seyfried
- Seyler
- Sharp
- Taylor
- Toran
- Valley
- Wayne C. Shanks
- Wenner
- Wolfgang Bach
- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- 01/08/2007
- Field of study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95304/1/ggge1087.pd
Mallet Madness - 1990
- Author
- Publication venue
- EWU Digital Commons
- Publication date
- 06/05/1990
- Field of study
Physiology of One-Lung Ventilation
- Author
- Bardsley PA
- Benumof J
- Berend N.
- Bishop M.
- Cohen E.
- Cohen E.
- Cohen E.
- Cornfield D.
- Cremona G.
- Dechman GS
- Domino KB
- Frostell C.
- Gibbs JM
- Hales CA
- Hampl V.
- Hampl V.
- Hampl V.
- Hartigan P.
- Hasunuma K.
- Hogue CWJr
- Kochukoshy K.
- MacNee W.
- Madden J.
- Maroof M.
- Meredith L. Fisher
- Neely CF
- Nunn J
- O'Shea PJ
- Oka M.
- Omar H.
- Pepe P.
- Rees DI
- Rees DI
- Reyes A.
- Rinaldo J.
- Rodman D.
- Romaldini H.
- Saari AF
- Simon C. Body
- Sykes MK
- Toledo C.
- Tryka A.
- Tryka A.
- Valley R.
- Voelkel N.
- Voisin C.
- Weir EK
- Wilson W.
- Yamada M.
- Yuan X-J.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
A critical evaluation of safety (uncertainty) factors for ecological risk assessment
- Author
- Aldenberg
- Aquatic Life Advisory Committee of the Ohio River Valley Water Sanitation Commission.
- Bennett
- Beyer
- Brewers
- Brown
- Cairns
- Cairns
- Cairns
- Chapman
- Chapman
- Chapman
- Chapman
- Chapman
- Chapman
- Chen
- Dhaliwal
- Dourson
- Earll
- Edge
- El-Shaarawi
- Ellis
- Emans
- Fletcher
- Forbes
- Forbes
- Fuerst
- Garcia
- Giesy
- Gilbertson
- Gilbertson
- Gray
- Gray
- Gray
- Henderson
- Henderson
- Jak
- Kenaga
- Kooijman SALM.
- Lehman
- MacGarvin
- MacGarvin
- Maguire
- Martinez-Jeronimo
- McCullagh
- Menzie
- Moore
- Mount
- National Technical Advisory Committee.
- O'Brien
- Organization for Economic Cooperation and Development.
- Pederson
- Persoone
- Persoone
- Peterman
- Porter
- Rand
- Rattner
- Rees
- Rice
- Schudoma
- Shirazi
- Sloof
- Sprague
- Stebbing
- Suter
- Truhaut
- U.S. National Research Council.
- Van Leeuwen
- Van Straalen
- Von Moltke
- Wagner
- Walden
- Warner
- Warren
- Zeeman
- Zeeman
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Implications of aromatic-aromatic interactions: From protein structures to peptide models
- Author
- Andersen
- Anderson
- Andrew
- Aravinda
- Aravinda
- Asensio
- Baker
- Baldwin
- Bhattacharyya
- Bram
- Braun
- Budyak
- Burley
- Butterfield
- Chang
- Chaturvedi
- Chiti
- Cipolla
- Cochran
- Cymer
- Davail
- del Carmen Fernandez-Alonso
- Dill
- Dougherty
- Dougherty
- Eidenschink
- Feller
- Feller
- Fiedler
- Fleming
- Fleming
- Frank
- Frederix
- Ganguly
- Goldstein
- Gray
- Gregersen
- Gupta
- Hill
- Hong
- Hong
- Hunter
- Hunter
- Jager
- Kannan
- Kiehna
- Killian
- Kleinschmidt
- Kleinschmidt
- Kleinschmidt
- Koradi
- Lanzarotti
- Ma
- Mahajan
- Mahajan
- Mahalakshmi
- Mahalakshmi
- Mahalakshmi
- Makwana
- Makwana
- Makwana
- Makwana
- Makwana
- Marek
- Matsumoto
- Meruelo
- Mirassou
- Mooers
- Nesloney
- Otzen
- Pace
- Pace
- Palermo
- Pellach
- Plevin
- Popp
- Reches
- Rees
- Reid
- Riley
- Samanta
- Santiveri
- Santiveri
- Schlebach
- Schottel
- Sengupta
- Setnicka
- Siddiqui
- Sievers
- Singh
- Sonti
- Stevens
- Sun
- Szilagyi
- Takekiyo
- Tatko
- Tatko
- Tatko
- Taylor
- Thomas
- Tu
- Tu
- Valley
- Viguera
- Waters
- Waters
- White
- Wimley
- Woll
- Wu
- Wu
- Zauhar
- Zhao
- Zondlo
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load
- Author
- Perucca P.
- Anderson A.
- Jazayeri D.
- Hitchcock A.
- Graham J.
- Todaro M.
- Tomson T.
- Battino D.
- Perucca E.
- Ferri M. M.
- Rochtus A.
- Lagae L.
- Canevini M. P.
- Zambrelli E.
- Campbell E.
- Koeleman B. P. C.
- Scheffer I. E.
- Berkovic S. F.
- Kwan P.
- Sisodiya S. M.
- Goldstein D. B.
- Petrovski S.
- Craig J.
- Vajda F. J. E.
- O'Brien T. J.
- Leu C.
- Wolking S.
- Peter S.
- Weber Y. G.
- Weckhuysen S.
- Moller R. S.
- Nikanorova M.
- Muhle H.
- Avbersek A.
- Heggeli K.
- Striano P.
- Gambardella A.
- Langley S. R.
- Krenn M.
- Klein K. M.
- McCormack M.
- Borghei M.
- Willis J.
- Berghuis B.
- Jorgensen A.
- Auce P.
- Francis B.
- Srivastava P.
- Sonsma A. C. M.
- Sander Jw.
- Zimprich F.
- Depondt C.
- Johnson M. M.
- Marson A. G.
- Sills G. J.
- Kunz W. S.
- Cavalleri G. L.
- Delanty N.
- Zara F.
- Krause R.
- Lerche H.
- Andrade D.
- Sen A.
- Bazil C. W.
- Boland M.
- Cavalleri G.
- Choi H.
- Colombo S.
- Costello D.
- Delanty N.
- Depondt C.
- Devinsky O.
- Doherty C. P.
- Dugan P.
- Frankel W.
- Heinzen E.
- Johnson M.
- Marson T.
- McCormack M.
- Mikati M.
- Ottman R.
- Pandolfo M.
- Radtke R.
- Rees M.
- Sadoway T.
- Valley N.
- Walley N.
- Wood N.
- Zuberi S.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Objective: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced BDs may result from a genome-wide increase of de novo variants in the embryo, a mechanism that we investigated. Methods: Whole exome sequencing data from child\u2013parent trios were interrogated for de novo single-nucleotide variants/indels (dnSNVs/indels) and de novo copy number variants (dnCNVs). Generalized linear models were applied to assess de novo variant burdens in children exposed prenatally to AEDs (AED-exposed children) versus children without BDs not exposed prenatally to AEDs (AED-unexposed unaffected children), and AED-exposed children with BDs versus those without BDs, adjusting for confounders. Fisher exact test was used to compare categorical data. Results: Sixty-seven child\u2013parent trios were included: 10 with AED-exposed children with BDs, 46 with AED-exposed unaffected children, and 11 with AED-unexposed unaffected children. The dnSNV/indel burden did not differ between AED-exposed children and AED-unexposed unaffected children (median dnSNV/indel number/child [range] = 3 [0\u20137] vs 3 [1\u20135], p = 0.50). Among AED-exposed children, there were no significant differences between those with BDs and those unaffected. Likely deleterious dnSNVs/indels were detected in 9 of 67 (13%) children, none of whom had BDs. The proportion of cases harboring likely deleterious dnSNVs/indels did not differ significantly between AED-unexposed and AED-exposed children. The dnCNV burden was not associated with AED exposure or birth outcome. Interpretation: Our study indicates that prenatal AED exposure does not increase the burden of de novo variants, and that this mechanism is not a major contributor to AED-induced BDs. These results can be incorporated in routine patient counseling. ANN NEUROL 2020;87:897\u2013906
Institutional Investment in Rental Housing in Australia: A Policy Framework and Two Models
- Author
- Abs
- Abs (Australian Bureau Of Statistics)
- Affordable Housing National Research Consortium
- Allen Consulting Group
- Allen Consulting Group
- Argy F.
- Australian Housing And Urban Research Institute
- Barker K.
- Barrow M.
- Beer A.
- Berry M.
- Berry M.
- Berry M.
- Berry M.
- Berry M.
- Boreham P.
- Buchanan J.
- Campbell I.
- Carew E.
- Cass B.
- Clough H.
- Commission Of Inquiry Into Poverty
- Commonwealth Advisory Committee On Homelessness
- Crook A.
- Dalton T.
- Department Of Human Services
- Department Of Human Services
- Dullard J.
- Emfa (European Mortgage Finance Agency)
- Feigenbaum H.
- Greater London Council
- Griffin G.
- Hall J.
- Hall J.
- Hall J.
- Harding A.
- Jon Hall
- Jones R.
- Kelly S.
- King S.
- Lee M.
- Lindbeck A.
- Mackenzie D.
- Maher C.
- McCaughey J.
- Mean G.
- Mike Berry
- Miles D.
- National Health Strategy
- National Housing Strategy
- Natsem (National Centre For Social And Economic Modelling)
- Odpm
- Odpm (Office Of The Deputy Prime Minister)
- Oecd (Organisation For EcOnomic Cooperation And Development)
- Oxley M.
- Peacock A.
- Perkins J.
- Pholeros P.
- Productivity Commission
- Pusey M.
- Putnam R.
- Rees S.
- Silicon Valley Manufacturers' Group
- Stilwell F.
- Stretton H.
- Stubbs J.
- Waters A.
- Yates J.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Hegel and Hegelianism
- Author
- Aaron
- Abizadeh
- Abrams
- Abrams
- Acomb
- Acton
- Acton
- Acton
- Acton
- Adams
- Adams
- Adams
- Adams
- Adams
- Adams
- Adas
- Adelman
- Adorno
- Agulhon
- Al-Rashid
- Alcock
- Aldenhoff
- Allen
- Allen
- Amos
- Andelson
- Anderson
- Anderson
- Andrews
- Andrews
- Angell
- Angermann
- Angermann
- Annan
- Annan
- Ansart
- Anthony
- Antoine
- Appleby
- Appleby
- Arendt
- Arendt
- Argov
- Argyll
- Aris
- Armitage
- Armitage
- Arnaud
- Arnaud
- Arnaud
- Arnold
- Arnold
- Arnold
- Arnold
- Ashley
- Ashrama
- Ashton
- Ashton
- August
- Aureau
- Aurobindo
- Austen
- Austen
- Austin
- Austin
- Austin
- Avineri
- Avrich
- Avrich
- Avrich
- Badawi
- Badrawi
- Bagchi
- Bagehot
- Bagehot
- Bagehot
- Bagehot
- Bagehot
- Bagge
- Bailie
- Bailyn
- Bailyn
- Baker
- Baker
- Bakshi
- Bakunin
- Bakunin
- Bakunin
- Bakunin
- Bakunin
- Bakunin
- Bakunin
- Bakunin
- Balfour
- Ball
- Ballanche
- Balzac
- Bancroft
- Bann
- Banning
- Bannister
- Barante
- Barany
- Barclay
- Barker
- Barker
- Barker
- Barker
- Barnard
- Barnard
- Barnett
- Baron
- Barrell
- Barrows
- Bartlett
- Barwis
- Bary
- Bate
- Bate
- Baudelaire
- Bauer
- Bauer
- Bauer
- Bauer
- Baum
- Baumgardt
- Bax
- Bax
- Bax
- Baxter
- Baycroft
- Bayly
- Bayly
- Beasley
- Bebel
- Bebel
- Bebel
- Bebel
- Bebel
- Bebel
- Bebel
- Bebel
- Becker
- Becq
- Beecher
- Beer
- Beer
- Beer
- Beer
- Beer
- Behler
- Beiser
- Beiser
- Beiser
- Belaúnde
- Belchem
- Belich
- Bell
- Bell
- Bellamy
- Bello
- Belloc
- Benjamin
- Bennett
- Benoît
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Bentham
- Benton
- Beramendi
- Berdiaev
- Berend
- Berenson
- Berger
- Bergman
- Berkman
- Berkowitz
- Berlin
- Berlin
- Berlin
- Berlin
- Berlin
- Berlin
- Berlin
- Berlin
- Berlin
- Bernal
- Bernardi
- Bernstein
- Bernstein
- Bernstein
- Bernstein
- Bernstein
- Bernstein
- Bernstein
- Bernstein
- Bertoldi
- Besant
- Beseler
- Best
- Bestor
- Bevir
- Bevir
- Bexon
- Biagini
- Bichat
- Biddiss
- Biddiss
- Biefang
- Billig
- Billington
- Binyon
- Birker
- Birtsch
- Bishop
- Bishop
- Blackbourn
- Blackbourn
- Blacker
- Blackstone
- Blake
- Blake
- Blakemore
- Blanc
- Blanc
- Blanke
- Blanning
- Blatchford
- Blatchford
- Blatchford
- Blau
- Blaug
- Blight
- Blight
- Blit
- Block
- Bluntschli
- Blyden
- Bodei
- Boesche
- Boffa
- Bohrer
- Bolt
- Bolt
- Bonald
- Bonald
- Bonald
- Bonald
- Bonald
- Bongie
- Bonham
- Bonnecase
- Bonner
- Bonnot de Mably
- Booth
- Booth
- Booth
- Borritt
- Borsche
- Bosanquet
- Bosanquet
- Bosanquet
- Bosanquet
- Bosanquet
- Bosanquet
- Bosanquet
- Bose
- Boucher
- Bowie
- Bowie
- Bowlby
- Bowler
- Bowler
- Bowman
- Boxer
- Boyle
- Brading
- Bradley
- Bradley
- Brady
- Brantlinger
- Brazill
- Breckman
- Breckman
- Bredin
- Breuilly
- Breuilly
- Breuilly
- Breuilly
- Bridger
- Brinkmann
- Brinton
- Bronstein
- Brooke
- Brooks
- Brougham
- Brouilhet
- Brown
- Brown
- Brown
- Brown
- Browne
- Browne
- Bruford
- Brunschwig
- Bryan
- Bryce
- Bubner
- Buche
- Buckle
- Buhlbring
- Bulmer
- Bulwer
- Bunsen
- Burbank
- Burckhardt
- Burckhardt
- Buret
- Burke
- Burke
- Burke
- Burke
- Burke
- Burke
- Burnham
- Burns
- Burrow
- Burrow
- Burrow
- Burrow
- Bury
- Bury
- Bussy
- Butler
- Butler
- Butler
- Butler
- Butt
- Butterfield
- Byrne
- Byrnes
- Byron
- Byron
- Bédé
- Bénichou
- Böhm-Bawerk
- Cabanis
- Cain
- Caine
- Caine
- Caine
- Caird
- Caird
- Caird
- Calhoun
- Calkins
- Callot
- Calloway
- Cambacérès
- Campbell
- Campbell
- Cappellini
- Carcassonne
- Carcopino
- Carey
- Carlisle
- Carlisle
- Carlson
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carnall
- Carpenter
- Carpenter
- Carr
- Carruthers
- Carsten
- Carter
- Carver
- Carver
- Cash
- Cassirer
- Cavell
- Cavell
- Cavell
- Cesa
- Chaadaev
- Chace
- Chadwick
- Chadwick
- Chalmers
- Chamberlain
- Chamberlain
- Chamley
- Chandler
- Charcot
- Charlton
- Charlton
- Charlton
- Charlton
- Charlton
- Charléty
- Chase
- Chase
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Chateaubriand
- Cherbuliez
- Chernock
- Chevalier
- Chicherin
- Chikeka
- Chirol
- Chowdhury
- Christie
- Christoff
- Chunder
- Chytry
- Cioran
- Claeys
- Claeys
- Claeys
- Claeys
- Claeys
- Claeys
- Claeys
- Claeys
- Claeys
- Clark
- Clark
- Clark
- Clark
- Clark
- Clarke
- Clarke
- Cliffe Leslie
- Cliffe Leslie
- Clive
- Clément
- Cobban
- Cobbe
- Cobbett
- Cobbett
- Cobbett
- Cobbett
- Cobden
- Cockram
- Coetzee
- Cofer
- Cohen
- Cohen
- Cohen
- Cohen
- Cohen
- Cole
- Cole
- Cole
- Cole
- Cole
- Cole
- Cole
- Coleman
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Collini
- Collini
- Collini
- Collini
- Collins
- Colmer
- Colmer
- Colp
- Comerford
- Comte
- Comte
- Comte
- Comte
- Comte
- Comte
- Comte
- Comte
- Conan-Doyle
- Condorcet
- Condorcet
- Confino
- Conklin
- Connelly
- Conner
- Connolly
- Connolly
- Conry
- Constant
- Constant
- Constant
- Constant
- Constant
- Conway
- Conway
- Cook
- Coole
- Coppa
- Cornewall Lewis
- Cornewall Lewis
- Cornford
- Cornwall
- Corsi
- Corwin
- Cott
- Cottier
- Courtney
- Cox
- Cox
- Craig
- Craig
- Craig
- Crais
- Craiutu
- Craiutu
- Crisp
- Cromwell
- Cromwell
- Crook
- Crook
- Crossick
- Crowder
- Crowder
- Crummell
- Crummell
- Cummins
- Curtin
- Curtis
- D'Arcy
- D'Hondt
- D'Hondt
- Dahl
- Dain
- Dalberg
- Dale
- Daley
- Daly
- Dangerfield
- Dann
- Darcel
- Darcel
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- David
- Davidoff
- Davidoff
- Davidson
- Davidson
- Davies
- Davies
- Davies
- Davis
- Davis
- Davis
- Davis
- Davis
- Davis
- Davis
- Davitt
- Davitt
- Davitt
- Dawley
- Dawley
- Dawson
- Dawson
- Dawson
- Dawson
- Dawson
- Day
- De Man
- De Mattei
- De Potter
- De Sanctis
- De Silva
- Deak
- Deane
- Debout
- Decker
- DeGérando
- Delap
- Delbanco
- Delbanco
- DeLeon
- Deme
- Demetriou
- Denes
- Denieffe
- Dermenghem
- Desai
- Desai
- Desmond
- Desmond
- Destler
- Destutt de Tracy
- Destutt de Tracy
- Destutt de Tracy
- Detwiler
- Deutsch
- Devyr
- Dewey
- Di Gregorio
- Di Scala
- Dicey
- Dicey
- Dicey
- Dicey
- Dicey
- Dicey
- Dicey
- Dickens
- Dickey
- Dickey
- Diggins
- Diggins
- Dijkstra
- Dikötter
- Dilke
- Dillon
- Dinwiddy
- Dinwiddy
- Dippel
- Dobo
- Dohrn
- Dolléans
- Dominick
- Donald
- Donnachie
- Donner
- Dooley
- Dorpalen
- Dostian
- Dostoevsky
- Dostoevsky
- Doty
- Douglass
- Douglass
- Dowe
- Dowe
- Drage
- Draper
- Draper
- Draus
- Drescher
- Droz
- Droz
- Du Bois
- Du Bois
- Du Bois
- DuBois
- DuBois
- Dufau
- Duffy
- Duffy
- Dugard
- Dumond
- Dumont
- Duncan
- Dupuis
- Durant
- Durbin
- Durkheim
- Durkheim
- Durkheim
- Duverger
- Eagleton
- Eckhardt
- Eckstein
- Eddy
- Edgeworth
- Edie
- Edwards
- Edwards
- Eichner
- Einaudi
- Eisfeld
- Eisner
- Eley
- Elkins
- Elkins
- Ellis
- Ellis
- Ellis
- Elm
- Elm
- Elster
- Eltzbacher
- Ely
- Ely
- Ely
- Ely
- Emerson
- Emerson
- Emerson
- Emerson
- Emminghaus
- Engelhardt
- Engels
- Engels
- Engels
- Engels
- Engels
- Engels
- Engels
- Engelstein
- Engs
- Epstein
- Epstein
- Esenwein
- Etzler
- Evans
- Evans
- Evans
- Evans
- Evans
- Everett
- Everson
- Ewald
- Faber
- Faber
- Fadner
- Faguet
- Fanon
- Farr
- Fassò
- Faure
- Faust
- Feeley
- Fehrenbach
- Feiling
- Fenet
- Fenton
- Fenton
- Ferri
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- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2011
- Field of study
Vorapaxar in the secondary prevention of atherothrombotic events
- Author
- A. Ahsan
- A. Albirini
- A. Altschuller
- A. Antolick
- A. Arthur
- A. Bank
- A. Belemer
- A. Berni
- A. Betriu
- A. Biton
- A. Brady
- A. Brito
- A. Brock
- A. Bura-Riviere
- A. Caceres
- A. Cale
- A. Camp
- A. Campolongo
- A. Carvalho
- A. Centurion
- A. Cerny
- A. Claxton
- A. Cohen
- A. Comerota
- A. Csanyi
- A. Czlonkowska
- A. Da Silva
- A. DaCosta
- A. Dahlmans
- A. Del Rio Ligorit
- A. Desai
- A. Dijkshoorn
- A. Doerr
- A. Domzal-Stryga
- A. Don
- A. Elgasen
- A. Elis
- A. Engstrom
- A. Fallden-Gunnnarsson
- A. Fernandez
- A. Findik
- A. Fiscella
- A. Ford
- A. Frey
- A. Galla
- A. Gallino
- A. Garcia Pastor
- A. Gatkova
- A. Gavazzi
- A. Gil Nunez
- A. Giordano
- A. Glanz
- A. Goldhaber
- A. Gottsater
- A. Gruszka
- A. Guenther
- A. Guimaraes
- A. Gupta
- A. Habermeier
- A. Hakansson
- A. Hallmann
- A. Hamer
- A. Hellberg
- A. Hill
- A. Horak
- A. Howard
- A. Jakal
- A. Jaltier
- A. Joergensen
- A. Kaakkomaki
- A. Katz
- A. Kilian
- A. Kofmel
- A. Koralewska
- A. Korsnack
- A. Kubiak
- A. Kuhn
- A. Kuijper
- A. Labroo
- A. Lamy
- A. Lau-Sieckman
- A. Lazzari
- A. Ledda
- A. Ledger
- A. Lewis
- A. Linhart
- A. Linor
- A. Long
- A. Looney
- A. Loxton
- A. Lozada
- A. Manoj
- A. Martignoni
- A. Matoltsy
- A. McCann
- A. Milnerowicz
- A. Minisi
- A. Moore
- A. Morissette
- A. Mukherjee
- A. Munoz
- A. Murally
- A. Niederman
- A. Norden
- A. Odero
- A. Odhav
- A. Opdal
- A. Orozco
- A. Orpen
- A. Pande
- A. Pawlak
- A. Pedersen
- A. Peeters
- A. Pell
- A. Piti
- A. Podczeck-Schweighofer
- A. Prado
- A. Ramachandran
- A. Rees
- A. Rek
- A. Remes
- A. Renouf
- A. Revilla
- A. Rizzo
- A. Roach
- A. Roodt
- A. Rynkiewicz
- A. Salvador
- A. Sasaki
- A. Schaffranka
- A. Schlesinger
- A. Schmidt
- A. Scholtze
- A. Schut
- A. Shepler
- A. Shirwany
- A. Singhal
- A. Sjol
- A. Skene
- A. Slattery
- A. Souza
- A. Stilman
- A. Stoll
- A. Suzuki
- A. Szczudlik
- A. Tang
- A. Tarulla
- A. Teklinski
- A. Tilkian
- A. Turner
- A. Vadala
- A. Valikovics
- A. van der Spoel
- A. Vlastaris
- A. Walton
- A. Wardeh
- A. Whelan
- A. Wiseman
- A. Wojtarowicz
- A. Yoshioka
- A. Zangerle
- A.A. Chu
- A.B. Brum
- A.B. Chandler
- A.B. Teixeira
- A.H. Morsund
- A.H. Pereira
- A.J. Bradley
- A.J. Dalby
- A.J.O. Ophuis
- A.L. Marques
- A.L. Tetrault
- A.M. Kaalaas
- A.M. Zeiher
- A.O. Ophuis
- A.P. Horokosky
- A.P. Macagnan
- A.P. Vieira
- A.R. Alves
- A.R. Rajakumar
- A.S. Pandey
- A.S. Wong
- B. Abramson
- B. Amann-Vesti
- B. Aral-Becher
- B. Atkinson
- B. Bagnato
- B. Bertolet
- B. Birkeland
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- B. Bozek
- B. Brott
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- B. Cederin
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- B. Conway
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- B. Foeger
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- B. Gross
- B. Hairsine
- B. Hamer
- B. Hunter
- B. Indredavik
- B. Jones
- B. Kandasamy
- B. Kirkhuff
- B. Lamb
- B. Lewis
- B. Lindblad
- B. Mihara
- B. Mortensen
- B. Novakova
- B. O Rourke
- B. Palme
- B. Peart
- B. Pelvet
- B. Persson
- B. Ramotowski
- B. Rif
- B. Ross
- B. Samad
- B. Singh
- B. Stein
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- B. Sutton
- B. Vagner
- B.A. Crippa
- B.B. Kaspersen
- B.B. Olsen
- B.F. Lloyd
- B.J. Iteld
- B.M. Reen
- B.M. Scirica
- B.S. Jensen
- B.T. McLaurin
- C. Anderson
- C. Andersson
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- C. Aroney
- C. Back
- C. Barnes
- C. Beltra
- C. Berger
- C. Bobak
- C. Boudreault
- C. Braun
- C. Brike
- C. Bruney
- C. Burton
- C. Butter
- C. Caussin
- C. Cavallini
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- C. Cereno
- C. Chen
- C. Constance
- C. Corbett
- C. Cuneo
- C. Darveau
- C. Davis
- C. DeMers
- C. Dille-Amo
- C. Downey
- C. Espinola-Klein
- C. Estol
- C. Ferretti
- C. Fortin
- C. Frey
- C. Funosas
- C. Garcia Davila
- C. Garcia Mendez
- C. Gilbert
- C. Green
- C. Gros
- C. Guevara
- C. Gully
- C. Herzau
- C. Hilbe
- C. Ho
- C. Hogan
- C. Ishigaki
- C. Jaramillo
- C. Judd
- C. Juri
- C. Kase
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- C. Kochounian
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- C. Marentette
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- C. Mejia
- C. Monte
- C. Moore
- C. Mueller
- C. Munoz
- C. Myers
- C. Nienaber
- C. Olesen
- C. Paci
- C. Payne
- C. Pedrosa
- C. Perez
- C. Pincetti
- C. Pistarini
- C. Primus
- C. Queirantes
- C. Retief
- C. Sadekoski
- C. Saenz
- C. Savage
- C. Shaw
- C. Sotolongo
- C. Stafford
- C. Stastny
- C. Stollberger
- C. Tamburino
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- C. Tessmar
- C. Trickett
- C. Trussell
- C. Valenzuela
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- C. Vandenhoven
- C. Viau
- C. Vickers
- C. Vilag
- C. Villan
- C. Vissers
- C. Wandaller
- C. Warrener
- C. Werner
- C. Whited
- C. Yu
- C. Zambakides
- C.A. Piedrahita
- C.A. Quintero
- C.B. Tauil
- C.F. Brilman
- C.H. Diehm
- C.H. McCabe
- C.J. Bayron
- C.M. Wahlgren
- C.R. Gomez
- C.R. Zayas Torres
- C.S. Brown
- C.S. Queirantes
- C.S. Staniloae
- C.T. Ormundo
- D. Adler
- D. Alexander
- D. Ardissino
- D. Barreto
- D. Basart
- D. Bettin
- D. Bongiorni
- D. Bridges
- D. Chew
- D. Chiezzo
- D. Cianflone
- D. Cleveland
- D. Cochran
- D. Coisne
- D. Connolly
- D. Crimmins
- D. Das
- D. Dion
- D. Domingo
- D. Drenning
- D. Dureau
- D. Dutka
- D. Elian
- D. Erlinge
- D. Fintel
- D. Fraser
- D. French
- D. Gagne
- D. Galley
- D. Gavish
- D. Genne
- D. Gorog
- D. Gupta
- D. Hainzer
- D. Henderson
- D. Hischier
- D. Holly
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- D. Isaza
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- D. Jacoby
- D. Jefferson
- D. Jenkinson
- D. Jeter
- D. Kissos
- D. Leeman
- D. Lewis
- D. Logwood
- D. Lopez
- D. Manns
- D. McDuffie
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- D. Nilsen
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- D. Overbeck
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- D. Peek
- D. Riou
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- D. Rueda
- D. Schmid
- D. Schneider
- D. Scott
- D. Scrutinio
- D. Seaton
- D. Seraphin
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- D. Southam
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- D. Strootman
- D. Tanne
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- D. Wohns
- D. Wroblewski
- D. Zaniol
- D.A. Hinchman
- D.A. Morrow
- D.C. de Albuquerque
- D.E. Bragin-Sanchez
- D.F. Guanaes
- D.G. da Silva
- D.G. Nabavi
- D.H. Banish
- D.J. Kereiakes
- D.J. O&apos
- D.M. Unks
- D.O. Mauro
- D.P. Suresh
- D.S. Scott
- D.W. Dietrich
- E. Araujo
- E. Arbenser
- E. Awtry
- E. Barbieri
- E. Bjurling
- E. Blank
- E. Blessing
- E. Braunwald
- E. Butkus
- E. Cardozo
- E. Carter
- E. Casares
- E. Coetsee
- E. Collings
- E. Corrada
- E. Dagher
- E. de Mingo
- E. deGrande
- E. Dhondt
- E. Diez Tejedor
- E. Du Toit
- E. Duronto
- E. Escobar
- E. Escolar
- E. Flagstad
- E. Fossati
- E. Galve
- E. Gelfand
- E. Genova
- E. Gershman
- E. Graf
- E. Grochenig
- E. Hejna
- E. Hernandez
- E. Hernandez Triana
- E. Hsu
- E. Johnson
- E. Jooste
- E. Kerssen
- E. Kim
- E. Klainman
- E. Korban
- E. Kurosaki
- E. Lasri
- E. Mahmud
- E. Marcelis
- E. Marin Araez
- E. Marshall
- E. Martinez
- E. Mirek-Bryniarska
- E. Molina Aguirre
- E. Mostacero
- E. Mostel
- E. Murena
- E. Muskoczki
- E. Nieto
- E. Nowalany-Kozielska
- E. Paolasso
- E. Parker
- E. Pilger
- E. Probst
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- E. Reich
- E. Rivera
- E. Ronner
- E. Sabbah
- E. Schidemantle
- E. Schmidt
- E. Segal
- E. So
- E. Solano
- E. Soos
- E. Soto
- E. Stensgaard
- E. Suazo
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- E. Swets
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- E. Tsirulnikov
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- E. Verdini
- E. Vergara
- E. Villa
- E. Weber
- E. Yonezawa
- E.C. Barbosa
- E.J. Haskel
- E.K. Moles
- E.L. Gillespie
- E.M. Roth
- E.P. Martins
- E.S. Resende
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- F.J. Pittella
- G. Agnelli
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- G. Bartels
- G. Berman
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- G. Danzi
- G. De Ferrari
- G. Devlin
- G. Donnan
- G. Esposito
- G. Fini
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- G. Gosselin
- G. Guandolini
- G. Hamann
- G. Hankey
- G. Hannah
- G. Herrera
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- G. Houde
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- G. Marenzi
- G. Marinsalta
- G. Martinez
- G. Masszi
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- G. Nelson
- G. Opolski
- G. Ortega
- G. Oszkinis
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- G. Povedano
- G. Silver
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- G. Tadros
- G. Telman
- G. Tietjen
- G. Tincani
- G. Torres
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- G. Youssef
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- H. Havenaar
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- H. Hempel
- H. Hendrix
- H. Heuer
- H. Hosseini
- H. Jeffers
- H. Lau
- H. Linkova
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- S. Hosbond
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- S. Ichikawa
- S. Inkrot
- S. Johnson
- S. Jones
- S. Katayama
- S. Kawano
- S. Kiechl
- S. Koch
- S. Kong
- S. Konstantinides
- S. Kouz
- S. Krishnamoorthy
- S. Kuroda
- S. Kusano
- S. Lee
- S. Lehinant
- S. Lieberman
- S. Lim
- S. Logvinenko
- S. Lord
- S. Madelung
- S. Marcheselli
- S. Marquette
- S. Martinez
- S. Mekaru
- S. Meyuhas
- S. Miedl
- S. Molski
- S. Morin
- S. Moser
- S. Motte
- S. Nakagawa
- S. Nash
- S. Nawaz
- S. Newman
- S. Novo
- S. Oshiba
- S. Parker
- S. Peska
- S. Petrolo
- S. Pollock
- S. Puri
- S. Quinlan
- S. Quinones
- S. Reverte
- S. Rezkalla
- S. Rhoades
- S. Rohrbeck
- S. Roth-Zetzsche
- S. Rousseau
- S. Sakota
- S. Savvidis
- S. Schacherl
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- S. Severi
- S. Shuman
- S. Silliman
- S. Silverman
- S. Sivertsen
- S. Stalpaert
- S. Stoger
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- S. Swafford
- S. Taguchi
- S. Tahon
- S. Takagi
- S. Takahashi
- S. Thiessen
- S. Timsit
- S. Uchiyama
- S. Utschig
- S. Valley
- S. Vanhagendoren
- S. Vizel
- S. Vujanic
- S. Webber
- S. Widmer
- S. Worthley
- S. Zuker
- S.A. Murphy
- S.B. Bresee
- S.B. Felix
- S.D. Wiviott
- S.E. Donovan
- S.E. Kasner
- S.F. Ameriso
- S.F. Andrade
- S.J. Gips
- S.K. Varma
- S.L. Sullivan
- S.M. Denning
- S.M. Isserman
- S.P. Guizzardi
- S.R. Broadwater
- S.R. Shaikh
- S.T. Howell
- S.T. Minor
- T. Abell
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- T. Ellis
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- T. Gregory
- T. Hack
- T. Hayek
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- T. Honda
- T. Huynh
- T. Ino
- T. Irei
- T. Itagaki
- T. Ito
- T. Jernberg
- T. Jonasson
- T. Kamitani
- T. Kanbe
- T. Kretschmer
- T. Landi
- T. Larsen
- T. Lee
- T. Levy
- T. Lowenkopf
- T. Mabin
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- T. Mooe
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- T. Zinger
- T.A. Carlson
- T.A. Mayer
- T.J. Chippendale
- T.K. Ong
- T.M. Haddad
- T.O. Ophuis
- U. Baldini
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- U. Hoffmann
- U. Pettersson
- U. Stachnio
- U. Thadani
- V. Amato
- V. Archer
- V. Arrarte Esteban
- V. Bohlscheid
- V. Chilakamarri
- V. Cook
- V. Desai
- V. Diaz
- V. Ercegovac
- V. Fernandez
- V. Freeman
- V. Hagspiel
- V. Herd
- V. Holbrook
- V. Kanashiro
- V. Lopez Garcia
- V. Mansouri
- V. Misra
- V. Mitrovic
- V. Monod
- V. Munevar
- V. Nadar
- V. Noriega
- V. Paddock
- V. Rosal-Greif
- V. Salgado
- V. Sardin
- V. Schaefer
- V. Schotte
- V. Silva
- V. Singh
- V. Stan
- V. Stedham
- V. Thijs
- V. Toyota
- V.H. Hansen
- V.L. Laet
- V.L. Nicely
- V.V. Bonarjee
- V.V. Nilsen
- W. Arnold
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- W. Covell
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- W. Felten
- W. Ferrada
- W. French
- W. Grisold
- W. He
- W. Holt
- W. Horne
- W. Johnson
- W. Leimbach
- W. Palasik
- W. Penny
- W. Pluta
- W. Rogers
- W. Sobiczewski
- W. Staszkiewicz
- W. Stueflotten
- W. Sturm
- W. Szybka
- W. Van Landegem
- W. Zwinnen
- W.B. Campbell
- W.D. Doty
- W.G. Carlini
- W.P. Klinke
- W.P. McGuinn
- W.R. Ardito
- W.R. Cashion
- W.W. Wilson
- X. Garcia-Moll
- X. Liu
- Y. Aladro Benito
- Y. Chandrashekhar
- Y. Cottin
- Y. Feldman
- Y. Hirano
- Y. Hiraoka
- Y. Honda
- Y. Lampl
- Y. Manabe
- Y. Niinuma
- Y. Okada
- Y. Oono
- Y. Pesant
- Y. Rozenman
- Y. Samson
- Y. Shinohara
- Y. Sundqvist
- Y. Swart
- Y. Vandermeeren
- Y.K. Chan
- Z. Ait-m-bark
- Z. Bednarkiewicz
- Z. Chmielak
- Z. Gasior
- Z. Kalita
- Z. Klimsa
- Z. Kornacewicz-Jach
- Z. Lorenc
- Z. Mohamed
- Z. Monhart
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
Item does not contain fulltextBACKGROUND: Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. METHODS: We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage. RESULTS: At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P<0.001). Cardiovascular death, myocardial infarction, stroke, or recurrent ischemia leading to revascularization occurred in 1259 patients (11.2%) in the vorapaxar group and 1417 patients (12.4%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.82 to 0.95; P=0.001). Moderate or severe bleeding occurred in 4.2% of patients who received vorapaxar and 2.5% of those who received placebo (hazard ratio, 1.66; 95% CI, 1.43 to 1.93; P<0.001). There was an increase in the rate of intracranial hemorrhage in the vorapaxar group (1.0%, vs. 0.5% in the placebo group; P<0.001). CONCLUSIONS: Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy. However, it increased the risk of moderate or severe bleeding, including intracranial hemorrhage. (Funded by Merck; TRA 2P-TIMI 50 ClinicalTrials.gov number, NCT00526474.)