The Effect of Biologic Materials and Oral Steroids on Radiographic and Clinical Outcomes of Horizontal Alveolar Ridge Augmentation.

The purpose of this study was to investigate if the addition of biologic materials and/or oral steroids would affect horizontal bone gain, or the bone density of the grafted bone in horizontal alveolar ridge augmentations. A retrospective chart review was completed to assess the clinical and radiographic outcomes of 53 ridge augmentation patients. An average bone gain of 3.6mm of width was found in our study based on radiographic analysis. There were no statistically significant differences found in the linear bone gain with the addition of biologic materials and steroids. A marginally statistically significant difference was found in the bone density when biologics were added (p-value=0.0653). No statistically significant difference found in the bone density with the addition of oral steroids. The use of tenting screws and resorbable occlusive membranes and a combination of allograft and xenograft bone materials provides significant clinical and radiographic dimensional changes in alveolar ridge width

Measurements of mixing and indirect CP violation

LHCb has collected the world's largest sample of charmed hadrons. This sample is used to measure the mixing parameters in the $D^0$-$\bar{D}^0$ system and to search for indirect $CP$ violation. This contribution focuses on measurements of $A_{\Gamma}$ with $D^*$ and semileptonic $B$ decays and on mixing measurements and a search for $CP$ violation in $D\to K\pi$ decays.Comment: To be published in the proceedings of CHARM-2015, Detroit, MI, 18-22 May 2015. arXiv admin note: text overlap with arXiv:1311.244

Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster

Groundbreaking work by Obaid Siddiqi has contributed to the powerful genetic toolkit that is now available for studying the nervous system of Drosophila. Studies carried out in this powerful neurogenetic model system during the last decade now provide insight into the molecular mechanisms that operate in neural stem cells during normal brain development and during abnormal brain tumorigenesis. These studies also provide strong support for the notion that conserved molecular genetic programs act in brain development and disease in insects and mammals including humans

The E-health Strategic Research Orientation at the Centre for Telematics and Information Technology

This report gives an overview of research themes, research groups and research partners of the E-Health Strategic Research Orientation (SRO) at the University of Twente

Exploring the Dynamic Costs of Process-aware Information Systems through Simulation

Introducing process-aware information systems (PAIS) in enterprises (e.g., workflow management systems, case handling systems) is associated with high costs. Though cost evaluation has received considerable attention in software engineering for many years, it is difficult to apply existing evaluation approaches to PAIS. This difficulty particularly stems from the inability of these techniques to deal with the complex interplay of the many technological, organizational and project-driven factors which emerge in the context of PAIS engineering projects. In response to this problem this paper proposes an approach which utilizes simulation models for investigating costs related to PAIS engineering projects. We motivate the need for simulation, discuss the design and execution of simulation models, and give an illustrating example

Keeping the Cost of Process Change Low through Refactoring

With the increasing adoption of process-aware information systems (PAIS) large process model repositories have emerged. Over time respective models have to be re-aligned to the real world business processes through customization or adaptation. This bears the risk that model redundancies are introduced and complexity is increased. If no continuous investment is made in keeping models simple, changes are becoming increasingly costly and error-prone. Although refactoring techniques are widely used in software engineering to address related problems, this does not yet constitute state-of-the art in business process management. Consequently, process designers either have to refactor process models by hand or can not apply respective techniques at all. In this paper we propose a set of techniques for refactoring large process repositories, which are behaviour-preserving. The proposed refactorings enable process designers to effectively deal with model complexity by making process models easier to change, less error-prone and better understandable

Simulation Models for Analyzing the Dynamic Costs of Process-aware Information Systems

Introducing process-aware information systems (PAIS) in enterprises (e.g., workflow management systems, case handling systems) is associated with high costs. Though cost estimation has received considerable attention in software engineering for many years, it is difficult to apply existing approaches to PAIS. This difficulty particularly stems from the inability of existing estimation techniques to deal with the complex interplay of the many technological, organizational and project-driven factors which emerge in the context of PAIS. In response to this problem, this paper proposes an approach which utilizes simulation models for investigating the dynamic costs of PAIS engineering projects. We motivate the need for simulation, discuss the development and execution of simulation models, and give an illustrating example. The present work has been accomplished in the EcoPOST project, which deals with the development of a comprehensive evaluation framework for analyzing PAIS engineering projects from a value-based perspective