5,485 research outputs found

    No, Ne\u27er Can Thy Home Be Mine

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    First verse solo by 1st voice, 2nd verse solo by 2nd voice. [verse 1]I have told thee how sweet the roses are In my home beyond the sea;Where the dark-eyed maid with her sweet guitar,Sits under the orange tree;Then fly, Oh! fly from this isle of storm,Where all that is fair must pine,To a sky more blue, and a sun more warm,Hence-forth let my home be thine.I will sing to thee, If with me thou\u27lt rove,The song of the olden time;Thou wilt never compare with my ardent love,The love of this colder clime;Thou wilt scorn the fruits of thy mountain home,Be holding the purple vine;Then come to the land of my birth,Oh come, henceforth let my home be thine. [verse 2]I have heard thee tell of a sky more blueAnd a sun more warm than this;And I\u27ve sometimes tho\u27t if thy tale be trueTo dwell in that clime were bliss;But Oh! when I gaze on my tranquil cot Where the clematis boughs entwine,The land of the stranger tempts me not,No ne\u27er can thy home be mine.Alas! \u27tis plain that my mountain home Must ever be scorned by thee;And may I not fear that a time will comeWhen thous will have scorn for me,And oh! there is one who loves me here,Who\u27s voice is less sweet than thine,To my simple taste is far more dear, No ne\u27er can thy home be mine

    Design and Synthesis of New Modulators of Liver Receptor Homologue – 1

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    Nuclear receptor (NR) liver receptor homologue-1 (LRH-1) is a potential target for the treatment of breast cancers as a consequence of its regulation of aromatase and the estrogen receptor (ER). Development of modulators of NRs historically focuses on production of high affinity small molecules that compete for binding with natural ligands at the ligand-binding pocket (LBP) of the NR ligandbinding domain (LBD). Ligand-bound NRs induce transcriptional activity by subsequent recruitment of coactivator proteins. The majority of this thesis describes approaches towards the development of the first antagonists of LRH-1. In the first instance, small molecules that bind at the LBP of the receptor were developed through use of ligand-based virtual screening (VS) programs Cresset and SHop. Secondly, small molecules that directly disrupt the binding of cofactor proteins to the NR activation function-2 (AF-2) were developed through use of rational design and further Cresset VS

    New species of Boeckella (Copepoda: Calanoida)

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    The new species, Boeckella bispinosa, is described and figured from Tasmanian material. The male fifth legs of B. opaqua Fairbridge, a Western Australian species, are figured and the original description supplemented. The female genital segment of B. pseudocheZae Searle is figured. New records of B. symmetrica Sars, B. minuta Sars, and B. major Searle are given

    Fatalism and an absence of public grief: how British society dealt with the 1918 flu

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    Although the ‘Spanish Flu’ killed almost a quarter of million Britons – many young – it went uncommemorated. Martin Bayly explains how British society attempted to deal with the pandemic

    Anyone Can Lead: A Workshop for Individualized Leadership Discovery

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    The traditional leadership paradigm recognizes a narrow group of people as possessing the capability to be leaders. Specifically, educated white heterosexual males are overrepresented in leadership positions, and characteristics traditionally expected of leaders come more naturally to that demographic. This narrow paradigm is problematic, because it creates barriers to leadership for individuals who do not identify as educated, white, heterosexual, or male. Moreover, it does not acknowledge leadership as diverse and malleable. Individuals who do not identify with the characteristics acknowledged as leaderly by the tradition paradigm, but who have potential to be strong leaders tend not to seek leadership roles. Undergraduate college students who seek to create altruistic change, but lack the identities associated with the traditional leadership paradigm have much to gain from a paradigm shift toward a more inclusive idea of leadership. This thesis seeks to address this issue and opportunity through developing a leadership workshop focused on instilling the belief that leadership should be fit to the individual, not the other way around. The Anyone Can Lead workshop, developed through this project, creates a space for diverse undergraduate students to reconceptualize leadership. The workshop is built on the values of servant leadership and guides participants in discovering the unique version of leadership that will allow them to create positive change

    Fatalism and an absence of public grief: the 1918-19 flu pandemic

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    Although the ‘Spanish Flu’ killed almost a quarter of million Britons – many young – it went uncommemorated. Martin Bayly (LSE) explains how British society attempted to deal with the pandemic

    Negotiating Legitimacy: An Evaluation of the Negotiation Class Proposal

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