216 research outputs found
Delayed diagnosis of intermittent mesenteroaxial volvulus of the stomach by computed tomography: a case report
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
10.1186/1752-1947-2-343Journal of Medical Case Reports234
The novel chicken interleukin 26 protein is overexpressed in T cells and induces proinflammatory cytokines
- Author
- A Dige
- A Knappe
- A Ribas
- Anh Duc Truong
- Boyeong Park
- C Sedwick
- C Watts
- D Igawa
- F Sheikh
- G Bouma
- G Gallagher
- HQ Yang
- J Dambacher
- Jihye Ban
- KA Schat
- KJ Livak
- M Corvaisier
- M Iqbal
- MF Neurath
- ML Nagalakshmi
- NJ Wilson
- NP Weng
- O Braum
- P Conti
- P Kaiser
- P Kaiser
- P Reichelt
- Q Yao
- RP Donnelly
- S Commins
- S Hor
- SV Kotenko
- T Alanara
- T Annamalai
- T Chtanova
- TK Teague
- Y Qi
- YC Lu
- Yeong Ho Hong
- YH Hong
- YH Hong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A real-life observational study of the effectiveness of FACT in a Dutch mental health region
- Author
- A Jones
- A Thorup
- American Psychiatric Association
- Arthur de Bie
- C Bonsack
- D Salkever
- G Driessen
- GB Teague
- Ger Driessen
- Giovanni Poddighe
- GJ McHugo
- GR Bond
- H Killaspy
- HL Graham
- J Aagaard
- J Catty
- J Dekker
- J van Os
- J Ventura
- J Yang
- JA Joannette
- Jim van Os
- Joost à Campo
- JR van Veldhuizen
- K Horiuchi
- L Petersen
- Landelijke stuurgroep richtlijnen ontwikkeling in de GGZ
- LI Stein
- M Bak
- M Bak
- M Drukker
- M Phelan
- Maarten Bak
- Marjan Drukker
- MP Salyers
- Myrte Maarschalkerweerd
- NC Andreasen
- P Jorgensen
- P Soderberg
- PAEG Delespaul
- PAEG Delespaul
- PC Austin
- Philippe Delespaul
- RH Dehejia
- S Sytema
- S Sytema
- SD Phillips
- StataCorp
- T Burns
- T Snijders
- The Lewin group
- TK Craig
- WK Fakhoury
- Publication venue
- BioMed Central
- Publication date
- 01/12/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>ACT is an effective community treatment but causes discontinuity of care between acutely ill and currently stable patient groups. The Dutch variant of ACT, FACT, combines both intensive ACT treatment and care for patients requiring less intensive care at one time point yet likely to need ACT in the future. It may be hypothesised that this case mix is not beneficial for patients requiring intensive care, as other patient groups may "dilute" care provision. The effectiveness of FACT was compared with standard care, with a particular focus on possible moderating effects of patient characteristics within the case mix in FACT.</p> <p>Methods</p> <p>In 2002, three FACT teams were implemented in a Dutch region in which a cumulative routine outcome measurement system was in place. Patients receiving FACT were compared with patients receiving standard treatment, matched on "baseline" symptom severity and age, using propensity score matching. Outcome was the probability of being in symptomatic remission of psychotic symptoms.</p> <p>Results</p> <p>The probability of symptomatic remission was higher for SMI patients receiving FACT than for controls receiving standard treatment, but only when there was an unmet need for care with respect to psychotic symptoms (OR = 6.70, p = 0.002; 95% CI = 1.97 – 22.7).</p> <p>Conclusion</p> <p>Compared to standard care, FACT was more rather than less effective, but only when a need for care with respect to psychotic symptoms is present. This suggests that there is no adverse effect of using broader patient mixes in providing continuity of care for all patients with severe mental illness in a defined geographical area.</p
The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes
- Author
- A Chen
- A Ivetic
- A Schambach
- AL Marzo
- C Berger
- CA Klebanoff
- CC Chao
- D Hamann
- D Masopust
- DJ Killock
- E Aktas
- E Diaz-Rodriguez
- E Galkina
- EJ Blott
- EJ Wherry
- F Sallusto
- F Sallusto
- Fang Liu
- FM Pavalko
- G Alter
- G de Saint Basile
- GJ de Bree
- H Richards
- H Tomiyama
- H Unsoeld
- J Kahn
- JJ Campbell
- JJ Peschon
- JR Mora
- K Kannan
- K Ley
- K Ley
- KJ Garton
- L Gattinoni
- L Lefrancois
- LA Johnson
- M Lettau
- ML Arbones
- MR Betts
- O Dwir
- PA Baars
- Qiong J. Wang
- R Forster
- Richard A. Morgan
- Ryan M. Teague
- S Jones
- S Jones
- S Yang
- S Yang
- S Yang
- S Yang
- Shicheng Yang
- SL Topalian
- Steven A. Rosenberg
- TK Kishimoto
- Y Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
CD62L/L-selectin is a marker found on naïve T cells and further distinguishes central memory (Tcm, CD62L+) from effector memory (Tem, CD62L−) T cells. The regulation of CD62L plays a pivotal role in controlling the traffic of T lymphocytes to and from peripheral lymph nodes. CD62L is shed from the cell membrane following T cell activation, however, the physiological significance of this event remains to be elucidated. In this study, we utilized in vitro generated anti-tumor antigen T cells and melanoma lines as a model to evaluate the dynamics of CD62L shedding and expression of CD107a as a marker of lytic activity. Upon encounter, with matched tumor lines, antigen reactive T cells rapidly lose CD62L expression and this was associated with the acquisition of CD107a. By CD62L ELISA, we confirmed that this transition was mediated by the shedding of CD62L when T cells encountered specific tumor antigen. The introduction of a shedding resistant mutant of CD62L into the tumor antigen-reactive T cell line JKF6 impaired CD107a acquisition following antigen recognition and this was correlated with decreased lytic activity as measured by 51Cr release assays. The linkage of the shedding of CD62L from the surface of anti-tumor T cells and acquisition of lytic activity, suggests a new function for CD62L in T cell effector functions and anti-tumor activity
Applications of microarray technology in breast cancer research
- Author
- A Milosavljevic
- AA Alizadeh
- AC Pease
- AC Syvanen
- AJ Carlisle
- AJ Maniotis
- AR Karpf
- B Lin
- BA Gusterson
- CA Afshari
- CM Perou
- CM Perou
- Colin S Cooper
- D Pinkel
- DB Villaret
- DC Sgroi
- DE Bassett
- DJ Lockhart
- DJ Slamon
- DP Harkin
- DT Ross
- DW Voehringer
- E Southern
- E Wang
- EF Nuwaysir
- F Forozan
- FA Scholl
- G Johannes
- G McGall
- G Ramsay
- G Yershov
- GP Yang
- H Li
- H Moch
- HA Coller
- J DeRisi
- J Elek
- J Khan
- J Khan
- J Kononen
- J Ollila
- J Phillips
- J Xu
- JG Hacia
- JG Hacia
- JG Hacia
- JR Pollack
- JW Wilson
- K Wang
- L Bubendorf
- L Rogge
- M Chee
- M Schena
- MA Heiskanen
- ME Rusiniak
- MJ Marton
- MM Tanner
- NP Gerry
- NP Gerry
- NS Gray
- O Jbilo
- PA Clarke
- R Favis
- R Favis
- R Radtkey
- R Zhao
- RJ Lipshutz
- RL Phillips
- S Drmanac
- S Drmanac
- S Sen
- SA Ahrendt
- SA Amundson
- SB Lee
- SD Der
- SG Hilsenbeck
- SL Anzick
- SM Welford
- SP Fodor
- T Okamoto
- T Trenkle
- T Wang
- TA Lehman
- TJ Aitman
- TK Teague
- TR Golub
- TR Hughes
- U Alon
- U Brinkmann
- U Scherf
- UR Pendurthi
- VG Cheung
- VR Iyer
- W-H Wen
- YE Chang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2001
- Field of study
Microarrays provide a versatile platform for utilizing information from the Human Genome Project to benefit human health. This article reviews the ways in which microarray technology may be used in breast cancer research. Its diverse applications include monitoring chromosome gains and losses, tumour classification, drug discovery and development, DNA resequencing, mutation detection and investigating the mechanism of tumour development
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Aspell P
- Atakisi IO
- Atanassov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Baginyan A
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakirci MN
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bechtel J
- Bedoya CF
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belchior Batista Das Chagas E
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Beni N
- Benitez JF
- Benussi L
- Berardi V
- Berenguer Antequera J
- Beretvas A
- Bergauer T
- Berger P
- Berger T
- Beri SB
- Bermúdez Martínez A
- Bernardes CA
- Bernet C
- Berretti M
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Beschi A
- Bhal E
- Bhardwaj A
- Bharti M
- Bhat MA
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bheesette S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boletti A
- Bologna S
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonham B
- Bonomally S
- Boos E
- Boran F
- Borchsh V
- Borg J
- Borgonovi L
- Bornheim A
- Borras K
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Bottigli U
- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
- Bozzo M
- Bragagnolo A
- Braghieri A
- Braibant-Giacomelli S
- Brainerd C
- Brandao Malbouisson H
- Brandt S
- Branson JG
- Breedon R
- Breeze S
- Brew C
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brondolin E
- Brooke JJ
- Brown RM
- Brunner D
- Bruno G
- Brzhechko D
- Brücken E
- Bucci R
- Buccilli A
- Buchanan J
- Buchmuller O
- Buchot Perraguin A
- Bueghly J
- Bundock A
- Bunkowski K
- Buontempo S
- Burkett K
- Burkhardt H
- Burkle B
- Burt K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bylinkin A
- Bylsma B
- Cabrera A
- Cabrillo IJ
- Cadamuro L
- Cafagna FS
- Caillol C
- Cakir A
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Call K
- Calligaris L
- Calzaferri S
- Camen C
- Caminada L
- Campagnari C
- Campanini R
- Campbell A
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capeans Garrido M
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carle A
- Carlin R
- Carrera Jarrin E
- Carrillo Montoya CA
- Carrillo Moreno S
- Cartiglia N
- Carvalho Antunes De Oliveira A
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castilla-Valdez H
- Castro A
- Catanesi MG
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chahal GS
- Chang P
- Chang P
- Chanon N
- Chao Y
- Chapon E
- Charaf O
- Charlot C
- Chatterjee RM
- Chatterjee S
- Chaudhary G
- Chauhan S
- Chauhan S
- Chawla R
- Chazin Quero B
- Checchia P
- Chekhovsky V
- Chen C
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PH
- Chen X
- Chen Y
- Chen Y
- Chen Z
- Chenarani S
- Cheng T
- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhibra SS
- Chiarito B
- Chinellato J
- Chistov R
- Chlebana F
- Cho S
- Choi J
- Choi S
- Choi Y
- Chou JP
- Choudhary BC
- Choudhury S
- Chu J
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocca C
- Ciocci MA
- Cipriani M
- Ciriolo V
- Cirkovic P
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- CMS Collaboration<sup>†</sup>
- Cockerill DJA
- Coelho E
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Cometti S
- Connor P
- Consuegra Rodríguez S
- Contardo D
- Conway J
- Conway R
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cornelis T
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremonesi M
- Cristella L
- Csanád M
- Csörgő T
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cummings G
- Cussans D
- Cutts D
- Czellar S
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Rold A
- Da Silveira GG
- Dabrowski A
- Daci N
- Dalchenko M
- Dallavalle GM
- Damarseckin S
- Damgov J
- Danilov M
- Danilov V
- Daponte V
- Darwish MR
- Das P
- Das S
- Dasgupta A
- Dash D
- Daskalakis G
- Dasu S
- Datta A
- Dauncey P
- David A
- David P
- Davies G
- Davignon O
- De Barbaro P
- De Boer W
- De Bruyn I
- De Castro Manzano P
- De Clercq J
- De Cosa A
- De Filippis N
- De Guio F
- De Iorio A
- De Jesus Damiao D
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Leo K
- De Leonardis F
- De Palma M
- De Roeck A
- De Trocóniz JF
- De Wit A
- De Wolf EA
- Deelen N
- Defranchis MM
- Deile M
- Dejardin M
- Del Burgo R
- Del Re D
- Delaere C
- Delannoy AG
- Delcourt M
- Delgado Peris A
- Delgado A
- Dell'Orso R
- Della Negra M
- Della Ricca G
- Demaria N
- Demina R
- Demiragli Z
- Demiroglu ZS
- Denegri D
- Depasse P
- Dermenev A
- Dev N
- Dewanjee RK
- Dezoort G
- Dharmaratna WGD
- Dhingra N
- Di Croce D
- Di Domenico MR
- Di Florio A
- Di Marco E
- Di Maria R
- Di Mattia A
- Di Pilato A
- Diab B
- Diamantopoulou M
- Diaz D
- Didukh L
- Diemoz M
- Dierlamm A
- Dildick S
- Dilsiz K
- Dimitrov A
- Dimova T
- Dinardo ME
- Dini P
- Diotalevi T
- Dissertori G
- Dittmann J
- Dittmar M
- Dittmer S
- Dobson M
- Dobur D
- Dogra S
- Dolek F
- Dolen J
- Dominguez A
- Domínguez Damiani D
- Donato S
- Donegà M
- Donertas IS
- Dordevic M
- Dorfer C
- Dorigo T
- Dorney B
- Doroba K
- Dorsett A
- Doubek M
- Dozen C
- Dragicevic M
- Dremin I
- Dreyer T
- Droll A
- Druzhkin D
- Duarte Campderros J
- Duarte J
- Dube S
- Dubinin M
- Dudko L
- Dugad S
- Duh YT
- Dulemba JL
- Dumanoglu I
- Dupont N
- Durgut S
- Duric S
- Durkin LS
- Dutta D
- Dutta I
- Dutta S
- Dutta V
- Dziwok C
- Dünser M
- Ebrahimi A
- Eckerlin G
- Ecklund KM
- Eckstein D
- Eerola P
- Eggert K
- Ehataht K
- Eich M
- Eichhorn T
- El Mamouni H
- El Morabit K
- Elgammal S
- Eliseev D
- Elkafrawy T
- Elliott-Peisert A
- Ellis KV
- Ellithi Kamel A
- Elmer P
- Elmetenawee W
- Elvira VD
- Eminizer M
- Emriskova N
- Eno SC
- Epshteyn V
- Erbacher R
- Erdmann M
- Erdmann W
- Eremin V
- Erice C
- Erodotou E
- Errico F
- Ershov A
- Erö J
- Escalante Del Valle A
- Eskut E
- Estevez Banos LI
- Etesami SM
- Eusebi R
- Evangelou I
- Evans A
- Evdokimov O
- Everaerts P
- Eysermans J
- Fabbri F
- Fabozzi F
- Faccioli P
- Fackeldey P
- Fallavollita F
- Fallon C
- Falmagne G
- Faltermann N
- Fanfani A
- Fang W
- Fangmeier C
- Fanò L
- Fasanella D
- Faure JL
- Favart L
- Fay J
- Fedi G
- Feindt F
- Felcini M
- Feld L
- Feng Y
- Ferbel T
- Ferencek D
- Ferguson T
- Fernandez Menendez J
- Fernandez M
- Fernández Manteca PJ
- Fernández Ramos JP
- Ferri F
- Ferro F
- Field RD
- Fienga F
- Fiergolski A
- Finco L
- Finger M
- Finger M
- Fiore L
- Fiorendi S
- Fiori F
- Fiorina D
- Fischer B
- Flacher H
- Flix J
- Florent A
- Flores C
- Florez C
- Flöh K
- Flügge G
- Focardi E
- Folgueras S
- Fonseca De Souza S
- Fontaine J-C
- Fontanesi E
- Ford WT
- Forthomme L
- Foudas C
- Fouz MC
- Fraga J
- Francis B
- Francois B
- Frankenthal A
- Franzoni G
- Freed S
- Freeman J
- Freer C
- Frueboes T
- Fröhlich A
- Frühwirth R
- Fulcher J
- Funk G
- Funk W
- Gadallah MMA
- Gadek T
- Galanti M
- Gallinaro M
- Gallo E
- Galloni C
- Gandrajula RP
- Gandrakota A
- Ganjour S
- Gao X
- Garbers C
- Garcia F
- Garcia-Bellido A
- García Alonso A
- Garg RB
- Garutti E
- Gary JW
- Gascon S
- Gasparini F
- Gasparini U
- Gastler D
- Gavrilenko M
- Gavrilov G
- Gavrilov V
- Gecse Z
- Geiser A
- Gelmi A
- Gelé D
- Gennai S
- Georgiev V
- Geralis T
- Gerber CE
- Gerosa R
- Gershtein Y
- Geurts FJM
- Ghezzi A
- Ghosh S
- Ghosh S
- Giacomelli P
- Giammanco A
- Giani S
- Gianneios P
- Giannini L
- Giassi A
- Giffels M
- Gigi D
- Gilbert A
- Gilbert D
- Giljanovic D
- Gill K
- Gilmore J
- Giommi L
- Giraldi A
- Givernaud A
- Glege F
- Gleyzer SV
- Gninenko S
- Go Y
- Godinovic N
- Goerlach U
- Goh J
- Gola M
- Goldouzian R
- Goldstein J
- Golf F
- Golovtcov V
- Golubev N
- Golunov A
- Golutvin I
- Gomber B
- Gomez Ceballos G
- Gomez G
- Goncharov M
- Gonzalez Caballero I
- Gonzalez Lopez O
- González Fernández JR
- Gorbunov I
- Gottmann A
- Gottschalk E
- Gouskos L
- Gouzevitch M
- Govoni P
- Goy Lopez S
- Grab C
- Grandi C
- Granier de Cassagnac R
- Gras P
- Gray L
- Grebenyuk A
- Green D
- Greenberg B
- Greene S
- Gregores EM
- Gribushin A
- Grimault C
- Grippo MT
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- Zarubin A
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- Zeuner WD
- Zghiche A
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- Zhang W
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- Zhokin A
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- Zhu RY
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- Zorbilmez C
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- Álvarez Fernández A
- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
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