Factors That Contribute to Persistence and Retention of Underrepresented Minority Undergraduate Students in Science, Technology, Engineering, and Mathematics (STEM)

The objective of this research was to identify specific factors that contribute to underrepresented minority (African American, Hispanic, Native American) undergraduate students‟ success in STEM disciplines at a regional university during the 2007-2010 timeframe. As more underrepresented minority (URM) students complete STEM degrees, many will possess the skills to become part of the domestic human capital needed to meet U. S. workforce demands and enhance the nation‟s STEM innovation. According to Burke and Mattis (2007), the lack of URM students in STEM education and in the workforce is one of the major contributors to STEM shortages in the United States. In this study, the investigator employed a sequential mixed method design to comprehensively examine which specific factors contributed to URM student success in STEM. Mixed methods design was necessary in order to capture the complexities of factors contributing to URM persistence and retention in STEM disciplines. Data collection and analysis was conducted to address four research objectives in two distinct sequential phases. In Phase I, quantitative analysis of archival data (taken from the regional university‟s ISIS and SAM databases) was used to explore the impact of specific factors on URM student persistence and retention. Logistic regression was used as the statistical procedure to examine objectives one and two. In Phase II, qualitative data were collected and analyzed using a nominal group technique. The researcher met with eighteen URM students (11 African American, four Hispanics, and three Native American) and posed two questions based on the quantitative findings as to why they persisted and were retained in STEM disciplines. This study was designed to help students and this institution better understand how URM students can navigate and overcome barriers to obtaining STEM degrees. According to George, Neale, Van Horne, and Malcolm (2001), tapping the reservoir of URM could help in meeting the STEM workforce demand as these minorities continue to show great increases in college enrollment. The findings for objectives one and two revealed four factors that were statistically significant contributors of URM student success in STEM disciplines. They included college GPA, academically rigorous curriculum, percent of hours completed, and percent of hours passed. The findings of objectives three and four revealed the top five rankings of URM persistence and retention factors in STEM success. The researcher employed a nominal group technique to collect and analyze this qualitative data

Mucedorus: the last ludic playbook, the first stage Arcadia

This article argues that two seemingly contradictory factors contributed to and sustained the success of the anonymous Elizabethan play Mucedorus (c. 1590; pub. 1598). First, that both the initial composition of Mucedorus and its Jacobean revival were driven in part by the popularity of its source, Philip Sidney's Arcadia. Second, the playbook's invitation to amateur playing allowed its romance narrative to be adopted and repurposed by diverse social groups. These two factors combined to create something of a paradox, suggesting that Mucedorus was both open to all yet iconographically connected to an elite author's popular text. This study will argue that Mucedorus pioneered the fashion for “continuations” or adaptations of the famously unfinished Arcadia, and one element of its success in print was its presentation as an affordable and performable version of Sidney's elite work. The Jacobean revival of Mucedorus by the King's Men is thus evidence of a strategy of engagement with the Arcadia designed to please the new Stuart monarchs. This association with the monarchy in part determined the cultural functions of the Arcadia and Mucedorus through the Interregnum to the close of the seventeenth century

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

German natural law

No abstract available