198 research outputs found
Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study
- Author
- A White
- AC Shen
- CJ Herman
- CJ Hogeboom
- CM Witt
- D Bhatt-Sanders
- E Tukmachi
- Edmund K Li
- ET Koh
- EV Benenson
- FC Arnett
- FJ Zijlstra
- G Stux
- H Tsukayama
- HP Scharf
- J David
- J Ezzo
- J Park
- J Ross
- K Stritberger
- K Trinh
- L Casimiro
- L Lao
- Lai-Shan Tam
- Lang Zhang
- M Angelini
- M Camerlain
- M Karst
- PC Leung
- Ping-Chung Leung
- PK Lee
- PL Man
- QF Huang
- SC Man
- Tena K Li
- YD Kwon
- Publication venue
- BioMed Central
- Publication date
- 01/11/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>In planning a randomized controlled trial of acupuncture, we conducted a pilot study using validated outcome measures to assess the feasibility of the protocol, and to obtain preliminary data on efficacy and tolerability of 3 different forms of acupuncture treatment as an adjunct for the treatment of chronic pain in patients with Rheumatoid arthritis (RA).</p> <p>Methods</p> <p>The study employs a randomized, prospective, double-blind, placebo-controlled trial to evaluate the effect of electroacupuncture (EA), traditional Chinese acupuncture (TCA) and sham acupuncture (Sham) in patients with RA. All patients received 20 sessions over a period of 10 weeks. Six acupuncture points were chosen. Primary outcome is the changes in the pain score. Secondary outcomes included the changes in the ACR core disease measures, DAS 28 score and the number of patients who achieved ACR 20 at week 10.</p> <p>Results</p> <p>From 80 eligible patients, 36 patients with mean age of 58 ± 10 years and disease duration of 9.3 ± 6.4 years were recruited. Twelve patients were randomized to each group. Twelve, 10 and 7 patients from the EA, TCA and Sham group respectively completed the study at 20 weeks (p < 0.03); all except one of the premature dropouts were due to lack of efficacy. At week 10, the pain score remained unchanged in all 3 groups. The number of tender joints was significantly reduced for the EA and TCA groups. Physician's global score was significantly reduced for the EA group and patient's global score was significantly reduced for the TCA group. All the outcomes except patient's global score remained unchanged in the Sham group.</p> <p>Conclusion</p> <p>This pilot study has allowed a number of recommendations to be made to facilitate the design of a large-scale trial, which in turn will help to clarify the existing evidence base on acupuncture for RA.</p> <p>Trial registration</p> <p>ClinicalTrials.gov NCT00404443</p
The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells
- Author
- A Cano
- AB Neil
- AM Bode
- C César
- C Pena
- CC Alves
- Christos Chatziantoniou
- DR Tomlinson
- E Batlle
- E Cano
- E Shaulian
- F Hisayo
- F Strutz
- G Gruden
- G Zheng
- H Tokuda
- H Tokuda
- HG Palmer
- I Masayuki
- J Hess
- J Jung-Hee
- J Massagúe
- J Wolfram
- J Yang
- JI Morgan
- Jian-Gong Lin
- JM Paivi
- M Barría
- M Fatima
- M Zeisberg
- M Zeisberg
- MA Nieto
- MA Nieto
- MA Reddy
- MC Duyndam
- Meng-Si Hu
- MK John
- MM Kathleen
- O Koh
- P Ester
- P Hughes
- P Héctor
- P Shiby
- PB Erwin
- PR Maria
- PW Tsai
- PW Tsai
- Qiang Wan
- Qun Wang
- R Kalluri
- RM Touyz
- Rong Wang
- SW Kang
- T Tanaka
- T Tanaka
- WA Wilmer
- YD Jung
- YD Jung
- You-Xia Liu
- YS Guo
- Z Jiri
- Zhi-Mei Lv
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Epithelial-mesenchymal transition of tubular epithelial cells, which is characterized by a loss of epithelial cell characteristics and a gain of ECM-producing myofibroblast characteristics, is an essential mechanism that is involved in tubulointerstitial fibrosis, an important component of the renal injury that is associated with diabetic nephropathy. Under diabetic conditions, p38 MAPK activation has been reported in glomeruli and mesangial cells; however, studies on p38 MAPK in TECs are lacking. In this study, the role of p38 MAPK in AP-1 activation and in the EMT in the human proximal tubular epithelial cell line (HK-2) under high glucose concentration conditions is investigated.A vector for small interfering RNA that targets p38 MAPK was constructed; the cells were then either transfected with p38 siRNA or pretreated with a chemical inhibitor of AP-1 and incubated with low glucose plus TGF-β1 or high glucose for 48 h. Cells that were not transfected or pretreated and were exposed to low glucose with or without TGF-β1 or high glucose for 48 h were considered to be the controls. We found that high glucose induced an increase in TGF-β1. And high glucose-induced p38 MAPK activation was inhibited by p38 siRNA (P<0.05). A significant decline in E-cadherin and CK expression and a notable increase in vimentin and α-SMA were detected when exposed to low glucose with TGF-β1 or high glucose, and a significant raise of secreted fibronectin were detected when exposed to high glucose; whereas these changes were reversed when the cells were treated with p38 siRNA or AP-1 inhibitor (P<0.05). AP-1 activity levels and Snail expression were up-regulated under high glucose conditions but were markedly down-regulated through knockdown of p38 MAPK with p38 siRNA or pretreatment with AP-1 inhibitor (P<0.05).This study suggests that p38 MAPK may play an important role in the high glucose-induced EMT by activating AP-1 in tubular epithelial cells
Evolution in the profile of thyroid cancer cases treated in an oncology reference service: what changed in the last 20 years
- Author
- Aschebrook-Kilfoy B
- Chen AY
- Coeli CM
- Cooper DS
- Cramer JD
- Davies L
- De Carlucci D Jr
- Enewold L
- Filho JG
- Genival Barbosa de Carvalho
- João Gonçalves Filho
- Kent WD
- Koh YW
- Kowalski LP
- Lang BH
- Lira RB
- Liu S
- Luiz Paulo Kowalski
- Maia AL
- Mazzaferri EL
- McHenry CR
- Miller FR
- Nixon IJ
- Pitoia F
- Podnos YD
- Renan Bezerra Lira
- Simard EP
- Sippel RS
- Tuttle RM
- Vaiman M
- Zhu C
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
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- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barsov S
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becot C
- Beddall A
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- Bednyakov VA
- Bedognetti M
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Bell AS
- Bella G
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- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
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- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
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- Bergsten LJ
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- Berlingen JM
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- Bernlochner FU
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- Billoud TR
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- Bogdanchikov AG
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- Bolz AE
- Bomben M
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- Bonilla JS
- Boonekamp M
- Booth CD
- Borecka-Bielska HM
- Borgna LS
- Borisov A
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- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
- Buescher V
- Bugge MK
- Bulekov O
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund OB
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
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- Calafiura P
- Calandri A
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- Castillo FL
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- Catinaccio A
- Catmore JR
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- Charlton DG
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- Chevalerias TJA
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- de Renstrom PAB
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- Zimmermann S
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- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: A randomized, double-blind, placebo-controlled study
- Author
- AR Harrop
- BM Saunders
- C Hoflich
- C Pilette
- C Yazici
- CA Benson
- Carmen M Valenzuela-Silva
- Carmen Rodríguez-Acosta
- CF Nathan
- DE Griffith
- DE Griffith
- DS Prince
- G Chatte
- G Harth
- G Martinez-Sanchez
- G Ozdermirler
- G Raghu
- Gaspar Jiménez-Madrigal
- Gregorio Martínez-Sánchez
- GS Shukla
- H Esterbauer
- H Hale-Donze
- H Muhl
- I Raad
- Idrian García-García
- Iraldo Bello-Rivero
- J Macdonald
- J Wang
- JR Requena
- KE Squires
- KM Antoniou
- L Ulloa
- Lidia González-Méndez
- M Levin
- M Muszlak
- Magalys Valdés-Quintana
- María T Milanés-Virelles
- MS Gomes
- Norma Fernández-Olivera
- P Remiszewski
- Pedro A López-Saura
- PK Lam
- R Appelberg
- R Condos
- R Pietersen
- R Suarez-Mendez
- Reinaldo B Sánchez-de la Osa
- S Sundar
- SE Dorman
- SK Field
- SM Holland
- SM Holland
- SM Holland
- SV Guide
- SW Chensue
- SY Patel
- T Vial
- Thelvia I Ramos-Gómez
- TS Hallstrand
- V Witko-Sarsat
- WJ Koh
- Yamilet Santos-Herrera
- YD Xu
- YJ Lee
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>High antibiotic resistance is described in atypical Mycobacteriosis, mainly by <it>Mycobacterium avium </it>complex (MAC).</p> <p>Methods</p> <p>A randomized, double-blind, placebo-controlled clinical trial was carried out in two hospitals to evaluate the effect of interferon (IFN) gamma as immunoadjuvant to chemotherapy on patients with atypical mycobacteria lung disease. Patients received placebo or 1 × 10<sup>6 </sup>IU recombinant human IFN gamma intramuscularly, daily for one month and then three times per week up to 6 months as adjuvant to daily oral azithromycin, ciprofloxacin, ethambutol and rifampin. Sputum samples collection for direct smear observation and culture as well as clinical and thorax radiography assessments were done during treatment and one year after. Cytokines and oxidative stress determinations were carried out in peripheral blood before and after treatment.</p> <p>Results</p> <p>Eighteen patients were included in the IFN group and 14 received placebo. Groups were homogeneous at entry; average age was 60 years, 75% men, 84% white; MAC infection prevailed (94%). At the end of treatment, 72% of patients treated with IFN gamma were evaluated as complete responders, but only 36% in the placebo group. The difference was maintained during follow-up. A more rapid complete response was obtained in the IFN group (5 months before), with a significantly earlier improvement in respiratory symptoms and pulmonary lesions reduction. Disease-related deaths were 35.7% of the patients in the placebo group and only 11.1% in the IFN group. Three patients in the IFN group normalized their globular sedimentation rate values. Although differences in bacteriology were not significant during the treatment period, some patients in the placebo group converted again to positive during follow-up. Significant increments in serum TGF-beta and advanced oxidation protein products were observed in the placebo group but not among IFN receiving patients. Treatments were well tolerated. Flu-like symptoms predominated in the IFN gamma group. No severe events were recorded.</p> <p>Conclusion</p> <p>These data suggest that IFN gamma is useful and well tolerated as adjuvant therapy in patients with pulmonary atypical Mycobacteriosis, predominantly MAC. Further wider clinical trials are encouraged.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN70900209.</p
Perfil do cirurgião de coluna brasileiro
- Author
- Aebi M
- Allen BL
- Bazan PL
- Blauth M
- Bono CM
- Buttermann GR
- Chan P
- Crockard A
- Defino HL
- Delitis V
- Delorme S
- Denis F
- Diab M
- Enneking WF
- Fleury S
- Freitas AA
- Garfin SR
- Gibson S
- Glaser JA
- Gumprecht HK
- Hansen MM
- Harms J
- King HA
- Koh YD
- Kothbauer KF
- Lenke LG
- Li J
- Louis R
- Luk KD
- Magerl F
- Mehlman CT
- Mermelstein LE
- Modi HN
- Moe JH
- Puertas EB
- Puertas EB
- Richards BS
- Schellinger PD
- Schoenfeld AJ
- Tomycz ND
- Vaccaro AR
- Vialle EN
- Yasuaki H
- Yousefzadeh CS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2013
- Field of study
Pan-cancer analysis of whole genomes
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- bd Ye
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- Thayer
- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
- Thomas
- Thomas
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- vo Taniguchi
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- vq Yamamoto
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- Waddell
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- Wintersinger
- Wiznerowicz
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- Wright
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- xc Lovat
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- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
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- Y. fr
- Y. fv
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- Y. rg
- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
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- yb Ally
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- Yellapantula
- yh Bathe
- yj Baylin
- Yoon
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- Yu
- Yu
- Yuan
- Yugawa
- z ah
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- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
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- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
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- Zogheib Eh
- Ñamendys-Silva Sa
- Ünal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Search for heavy neutral Higgs bosons produced in association with b-quarks and decaying into b-quarks at root s=13 TeV with the ATLAS detector
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- Alberghi GL
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- Aleksandrov IN
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu CG
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- Zhuang X
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- Zhulanov V
- Zieminska D
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- Zivkovic L
- Zobernig G
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 13/08/2020
- Field of study
A search for heavy neutral Higgs bosons produced in association with one or two
b
-quarks and decaying to
b
-quark pairs is presented using
27.8
fb
−
1
of
√
s
=
13
TeV
proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. No evidence of a signal is found. Upper limits on the heavy neutral Higgs boson production cross section times its branching ratio to
b
¯
b
are set, ranging from 4.0 to 0.6 pb at 95% confidence level over a Higgs boson mass range of 450 to 1400 GeV. Results are interpreted within the two-Higgs-doublet model and the minimal supersymmetric Standard Model
Measurement of single top-quark production in association with a W boson in the single-lepton channel at \sqrt{s} = 8\,\text {TeV} with the ATLAS detector
- Author
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at \sqrt{s} = 8\,\text {TeV}. The dataset corresponds to an integrated luminosity of 20.2\,\text {fb}^{-1}, and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant t{\bar{t}} background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is \sigma _{tW} = 26 \pm 7\,\text {pb}, in good agreement with the Standard Model expectation
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