6 research outputs found
The benefits and risks of bacille Calmette-Guérin vaccination among infants at high risk for both tuberculosis and severe combined immunodeficiency: assessment by Markov model
- Author
- A Fasth
- A Fischer
- A Frappier
- A Lotte
- A Lotte
- A Rouillon
- A Rouillon
- AL Hersh
- AS Detsky
- AS O'Marcaigh
- BD McNab
- BR Bloom
- C Houde
- Canada Health
- D Scheifele
- D William Cameron
- DE Kopanoff
- DK Miller
- E Vynnycky
- EA Talbot
- FM Muñoz
- GA Colditz
- GC Critchfield
- GJ Wherrett
- GW Comstock
- GW Torrance
- I Dalal
- I Sjögren
- I Sutherland
- Immunization Practices Advisory Committee
- International Union Against Tuberculosis and Lung Disease
- International Union Against Tuberculosis Committee on Prophylaxis
- JA Cunningham
- JF Jones
- JF Schoeman
- JL Casanova
- JL Stephan
- JR Beck
- K Styblo
- K Styblo
- KHK Hsu
- KSL Lam
- LC Rodrigues
- M Clark
- Medical Research Council
- MF Drummond
- Michael Clark
- ML Lindegren
- MN Lobato
- MR Gold
- NE Aronson
- NI Girgis
- O Ryser
- P de March-Ayuela
- P Doubilet
- P Ramachandran
- PEM Fine
- PR Donald
- R Long
- RA Hague
- RG Ferguson
- RH Buckley
- S Berman
- S Houston
- SL Deeks
- TK Young
- TM Doherty
- V Romanus
- VH Springett
- W Vaudry
- W Wobeser
- World Health Organization
- Y Bertrand
- Z Arvanitakis
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
BACKGROUND: Bacille Calmette-GuĂ©rin (BCG) vaccine is given to Canadian Aboriginal neonates in selected communities. Severe reactions and deaths associated with BCG have been reported among infants born with immunodeficiency syndromes. The main objective of this study was to estimate threshold values for severe combined immunodeficiency (SCID) incidence, above which BCG is associated with greater risk than benefit. METHODS: A Markov model was developed to simulate the natural histories of tuberculosis (TB) and SCID in children from birth to 14 years. The annual risk of tuberculous infection (ARI) and SCID incidence were varied in analyses. The model compared a scenario of no vaccination to intervention with BCG. Appropriate variability and uncertainty analyses were conducted. Outcomes included TB incidence and quality-adjusted life years (QALYs). RESULTS: In sensitivity analyses, QALYs were lower among vaccinated infants if the ARI was 0.1% and the rate of SCID was higher than 4.2 per 100,000. Assuming an ARI of 1%, this threshold increased to 41 per 100,000. In uncertainty analyses (Monte Carlo simulations) which assumed an ARI of 0.1%, QALYs were not significantly increased by BCG unless SCID incidence is 0. With this ARI, QALYs were significantly decreased among vaccinated children if SCID incidence exceeds 23 per 100,000. BCG is associated with a significant increase in QALYs if the ARI is 1%, and SCID incidence is below 5 per 100,000. CONCLUSION: The possibility that Canadian Aboriginal children are at increased risk for SCID has serious implications for continued BCG use in this population. In this context, enhanced TB Control â including early detection and treatment of infection â may be a safer, more effective alternative
The Role of the World Health Organization in Epidemiology [ Abridged
- Author
- Edwards L. B.
- Guld J.
- J. D. Cottrell
- Magnus K.
- Medical Research Council Tuberculosis Vaccines Clinical Trials Committee
- Palmer C. E.
- Pollitzer R.
- Pollitzer R.
- WHO
- WHO Advisory Group on Prevention of Accidents in Childhood
- WHO Expert Committee on Cardiovascular Disease and Hypertension
- WHO Expert Committee on Health Statistics
- WHO Expert Committee on Mental Health
- WHO Study Group on the Classification of Atherosclerotic Lesions
- WHO Tuberculosis Research Office
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Factors associated with treatment initiation delay among new adult pulmonary tuberculosis patients in Tigray, Northern Ethiopia
- Author
- A Asefa
- A Asefa
- A Hussen
- A. Hamza
- AA Gele
- Abdurahaman Seid
- Abyot Asres
- Afework Mulugeta
- AS Rabin
- B Xu
- C Temesgen
- D Tsegaye
- DG Storla
- ER Wandwalo
- Frederick Quinn
- Gebretsadik Berhe
- Girmay Medhin
- I Sendagire
- J Ngamvithayapong
- J Virenfeldt
- Kiros Tedla
- KNCV WHO, JATA
- LS Lusignani
- M Belay
- M. N. Mondal
- MM Mesfin
- MM Mesfin
- MM Mesfin
- MR Masjedi
- Nega Berhe
- Netsanet Awoke
- NN Ngangro
- OO Odusanya
- S Yimer
- SA Yimer
- SB Gebreegziabher
- SG MÄŻnÄnĆÄ
- Tuberculosis Research Advisory committee
- V Kumar
- V Mauch
- X Lin
- Z. Z. Zeleke
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Whole-Genome Sequencing in Outbreak Analysis
- Author
- Carol A. Gilchrist
- CDC
- CDC
- CDC
- Centers for Disease Control and Prevention
- Code of Federal Regulations
- Code of Federal Regulations
- Committee on Review of the Scientific Approaches Used During the FBI's Investigation of the 2001 Bacillus Anthracis Mailings National Research Council
- Erik L. Hewlett
- European Commission
- European Parliament Council of the European Union
- Human Microbiome Project Consortium
- Human Microbiome Project Consortium
- Institute of Medicine Forum on Microbial Threat
- Margaret F. Riley
- National Research Council Committee on Metagenomics: Challenges and Functional Applications
- National TB Controllers Association on Genotyping Tuberculosis CDC Advisory Group
- OIE
- Pan American Health Organization
- Public Health Law Program Centers for Disease Control and Prevention
- Stephen D. Turner
- United Nations
- US Congress
- US Congress
- US Congress
- US Department of Health and Human Services
- WHO
- William A. Petri
- Work Group 4
- World Health Organization
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Tuberculosis in Aging Adults
- Author
- Alvarez
- Alvarez
- Alvarez
- Alvarez
- American Thoracic Society
- American Thoracic Society:
- Aziz
- Barry
- Bass
- Battershill
- Bender
- Bobrowitz
- Brashear
- Brisson-Noel
- Byrd
- Case Records of the Massachusetts General Hospital.
- Castle
- Cauthen
- Centers for Disease Control
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Centers for Disease Control.
- Chang
- Chaparas
- Clinical Practice Committee
- Committee on Chemotherapy of Tuberculosis
- Contreras
- Counsell
- Creditor
- Daniel
- Daniel
- Davidson
- Davies
- Donath
- Dorkin
- Dubrow
- Dutt
- Dutt
- Dutt
- Edlin
- Edwards
- Essop
- Evancheck
- Fadda
- Fancourt
- French
- Fulton
- Gardner
- Gelb
- Girling
- Good
- Gordin
- Gorse
- Grossman
- Grzybowski
- Grzybowski
- Haas
- Heinle
- Hsu
- Immunization Practices Advisory Committee
- Johnston
- Katz
- Kelly
- Kennedy
- Klein
- Klofkom
- Kollins
- Kopanoff
- Krambovitis
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- Lichenstein
- Lordi
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- Mason
- Mayock
- Miller
- Molavi
- Montz
- Morgan
- Morris
- Morris
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- Nash
- O'Brien
- O'Brien
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- Orme
- Pan
- Patel
- Paus
- Powell
- Proudfoot
- Puxty
- Quinn
- Radhakrishnan
- Rich
- Rich
- Roberts-Thompson
- Rooney
- Rudd
- Sahn
- Saltzman
- Schulze
- Shankar
- Sherman
- Sim
- Simon
- Singapore Tuberculosis Service British Medical Research Council.
- Slavin
- Snider
- Snider
- Spencer
- Stead
- Stead
- Stead
- Stead
- Stead
- Stead
- Styblo
- Tager
- Thoman
- Thompson
- Toh
- Treip
- Tsukamura
- Tuli
- Tytle
- Umeki
- Van den Brande
- Waldorf
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- Weir
- Weksler
- Welty
- Willcox
- Woodruff
- Yoshikawa
- Yoshikawa
- Yoshikawa
- Yoshikawa
- Yoshikawa
- Yoshikawa
- Young
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Drug monographs
- Author
- Aaby
- AAP
- Abaza
- Abdel-Latif
- Abdulla
- Abdulla
- Abubakar
- Aceng
- Achan
- Achan
- Acocella
- Acosta
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- Adamsons
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- Adefurin
- Adegbola
- Adhikari
- Adler
- Adrianzen Vargas
- Advisory Committee on Immunization Practices
- Aggarwal
- Aggarwal
- Agostoni
- Agostoni
- Agostoni
- Ahmad
- Ahmad
- Ahmadsyah
- Ahola
- Ainsworth
- Aitken
- Akagi
- Akech
- Akech
- Akkawi
- Al-Dahhan
- Al-Sabbagh
- Albersheim
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- Ali-MelkkilÀ
- Allegaert
- Allegaert
- Allegaert
- Allegaert
- Allegaert
- Allegaert
- Allegaert
- Allegaert
- Allen
- Allergaert
- Alshaikh
- Amadi
- Ambalavanan
- Ambrus
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics
- American Academy of Pediatrics Committee on Drugs and Committee on Environmental Health
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- American Academy of Pediatrics Committee on Infectious Diseases
- American Academy of Pediatrics Committee on Infectious Diseases
- American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis
- American Academy of Pediatrics. Committee on Infectious Diseases
- Amin
- Ampofo
- Anand
- Anand
- Anand
- Anand
- Anand KJS and the International Evidence-Based Group for Neonatal Pain
- Anderka
- Anderson
- Anderson
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- Andersson
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- Wyllie
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- Zhanel
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- Publication venue
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