9 research outputs found
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Cerebral lateralization and its relation to academic variables in a community college population.
- Author
- Publication venue
- ScholarWorks@UMass Amherst
- Publication date
- 01/01/1981
- Field of study
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
- Author
- A. Abeshouse
- A. Ally
- A. Antenucci
- A. Arnaout
- A. Berchuck
- A. Bergeron
- A. Bossler
- A. Boussioutas
- A. Breggia
- A. Burnette
- A. Chen
- A. Clipca
- A. Davis
- A. De Rienzo
- A. De Rose
- A. Fehrenbach
- A. Gillis
- A. Gimenez-Roqueplo
- A. Gopalan
- A. Haddad
- A. Hartmann
- A. Jimeno
- A. Kastl
- A. Kendler
- A. Kibel
- A. Korkut
- A. Longatto-Filho
- A. Luna
- A. Luna
- A. Malykh
- A. Mariamidze
- A. Mes-Masson
- A. Noss
- A. Ochoa
- A. Perin
- A. Piché
- A. Pickens
- A. Rao
- A. Sankarankuty
- A. Secord
- A. Sepulveda
- A. Shabunin
- A. Sharp
- A. Sood
- A. Spillane
- A. Tam
- A. Tischler
- A. Tsao
- A. Unterberg
- A. Vicha
- A. von Deimling
- A.C. Berger
- A.C. de Carvalho
- A.D. Cherniack
- A.D. Cherniack
- A.E. Sloan
- A.G. Robertson
- A.H. Bryce
- A.H. Perou
- A.J. Kovatich
- A.J. Lazar
- A.J. Mungall
- A.K. Godwin
- A.L. Carvalho
- A.L. Guillermo
- A.M. Hegde
- A.M.A. Gonzalez
- A.P. Hoyle
- A.R. Metwalli
- B. Bernard
- B. Campos
- B. Czerniak
- B. Deyarmin
- B. Drake
- B. Esmaeli
- B. Hermes
- B. Hernandez
- B. Kohl
- B. Kumar
- B. Pollo
- B. Rabeno
- B. Robinson
- B. Singh
- B. Tê
- B. Van Tine
- B. Wullich
- B.D. Phu
- B.E. Gross
- B.M. Broom
- B.P. O&apos
- B.S. Taylor
- B.Y. Karlan
- C. Adebamowo
- C. Andry
- C. Behrens
- C. Benz
- C. Bifulco
- C. Bradford
- C. Brewer
- C. Calatozzolo
- C. Carter
- C. Chen
- C. Cibulskis
- C. Fan
- C. Farver
- C. Feltmate
- C. Goparaju
- C. Guo
- C. Herold-Mende
- C. Hovens
- C. Jungk
- C. Kandoth
- C. Larson
- C. Logothetis
- C. Mcpherson
- C. Mirsaidi
- C. Moran
- C. Morrison
- C. Moser
- C. Sander
- C. Sander
- C. Scapulatempo-Neto
- C. Schilero
- C. Shelton
- C. Shipman
- C. Stoehr
- C. Yau
- C.A. Miller
- C.C. Fronick
- C.D. Jones
- C.D. Shriver
- C.D. Vocke
- C.G. Carlotti
- C.H. Hagedorn
- C.J. Creighton
- C.K. Wong
- C.M. Cebulla
- C.M. Hutter
- C.M. Perou
- C.N. Landen
- C.P. Raut
- C.S. Greene
- C.S. Shelley
- C.W. Seder
- D. Alvaro
- D. Aziz
- D. Beer
- D. Bell
- D. Bigner
- D. Brooks
- D. Chakravarty
- D. Chesla
- D. Crain
- D. Cramer
- D. Hoon
- D. Huntsman
- D. Lee
- D. Mallery
- D. Morton
- D. Murawa
- D. Muzny
- D. Nagorney
- D. O&apos
- D. Raymond
- D. Rice
- D. Schadendorf
- D. Tan
- D. Tcaciuc
- D. Tirapelli
- D. Voet
- D.A. Levine
- D.A. Wheeler
- D.I. Heiman
- D.J. Brat
- D.J. Van Den Berg
- D.J. Weisenberger
- D.M. Rassl
- D.M. Shin
- D.N. Hayes
- D.O. Vidal
- D.T. Maglinte
- E. Baudin
- E. Campo
- E. Castle
- E. Chuah
- E. Curley
- E. Gaudio
- E. Giné
- E. Kebebew
- E. Korpershoek
- E. Lipp
- E. Reznik
- E. Shinbrot
- E. Swisher
- E. Thompson
- E. Zmuda
- E.C. Zwarthoff
- E.G. Van Meir
- E.L. Appelbaum
- E.M. Godwin
- E.M.M. Pinero
- E.R. Duffy
- E.R. Mardis
- F. Beuschlein
- F. Brimo
- F. Carey
- F. Cheng
- F. Dimeco
- F. Facciolo
- F. Giuliante
- F. Khuri
- F. Meric-Bernstam
- F. Moiseenko
- F. Que
- F. Saad
- F. Sanchez-Vega
- F. Sanchez-Vega
- F. Valdivieso
- F. Williams
- F. Zhao
- G. Barnett
- G. Bubley
- G. Carpino
- G. Ciriello
- G. Finocchiaro
- G. Getz
- G. Gorincioi
- G. Grazi
- G. Long
- G. Manikhas
- G. Mann
- G. Mckercher
- G. Petersen
- G. Saksena
- G. Sauter
- G. Setdikova
- G. Sica
- G. Thomas
- G. Wolf
- G.B. Mills
- G.F. Gao
- G.P. Way
- H. Al-Ahmadie
- H. Colman
- H. Dinh
- H. Doddapaneni
- H. Fan
- H. Gabra
- H. Gavin
- H. Hai
- H. Hibshoosh
- H. Huland
- H. Jianhong
- H. Juhl
- H. Kakavand
- H. Liang
- H. Noushmehr
- H. Pass
- H. Sekhon
- H. Shen
- H. Stoop
- H. Taubert
- H. Thai
- H. Timmers
- H. Yang
- H. Zaren
- H. Zhang
- H. Zhang
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- H.C.S. Silveira
- H.G. Rosenthal
- H.J. Sofia
- H.K. Schmidt
- I. Alexopoulou
- I. Caraman
- I. Chemencedji
- I. de Bruijn
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- I. Forgie
- I. Shmulevich
- I. Stancul
- I. Wistuba
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- J. Armenia
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- J.C. Zenklusen
- J.D. Yang
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- J.H. Fregnani
- J.I. Lee
- J.J. Olson
- J.L. Fantacone-Campbell
- J.M. Chan
- J.M. Gastier-Foster
- J.M. Stuart
- J.N. Weinstein
- J.S. Barnholtz-Sloan
- J.S. Dos Santos
- J.S. Parker
- J.T. Auman
- J.V. Simons
- K. Agnew
- K. Ahn
- K. Becker
- K. Birsoy
- K. Chang
- K. Chung
- K. Covington
- K. Delman
- K. Devine
- K. Evason
- K. Janssen
- K. Junker
- K. Kasaian
- K. Kopp
- K. Lau
- K. Lee
- K. Leinonen
- K. Magliocca
- K. Moore
- K. Moxley
- K. Mungall
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- K. Roggin
- K. Senecal
- K. Shannon
- K. Shimmel
- K. Smith-McCune
- K. Smolenski
- K. Tse
- K. Tucker
- K.A. Hoadley
- K.C. Sexton
- K.E. van Kessel
- K.J. Kang
- K.M. Fong
- K.M. Leraas
- L. Cope
- L. Cuppini
- L. Danilova
- L. Desjardins
- L. Ding
- L. Haydu
- L. Jacobus
- L. Jun
- L. Konnor
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- L. Kvecher
- L. Lacombe
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- L. Lewis
- L. Lolla
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- L. Peterson
- L. Ramondetta
- L. Roberts
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- L. Scarpace
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- L. Wang
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- L. Xuan
- L. Yang
- L. Yiling
- L. Zhang
- L.A. Donehower
- L.A. Fulton
- L.A. Zach
- L.E. Mose
- L.S. Schmidt
- M. Albert
- M. Aymerich
- M. Bailey
- M. Balasundaram
- M. Behera
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- M. Birrer
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- M. Carney
- M. Cernat
- M. Couce
- M. Deqin
- M. Dinkin
- M. Dubina
- M. Farnell
- M. Fassnacht
- M. Feldman
- M. Gerken
- M. Goodman
- M. Graefen
- M. Iacocca
- M. Ittmann
- M. Kasapi
- M. Kendrick
- M. Knudson
- M. Ladanyi
- M. Latour
- M. Mannelli
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- M. Mayo
- M. Mcgraw
- M. Meyerson
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- M. Miller
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- M. Sheth
- M. Stanton
- M. Stern
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- M. Tavobilov
- M. Torbenson
- M. Wang
- M. Wiznerowicz
- M. Yussanne
- M.A. Marra
- M.A. Rubin
- M.C. Bragazzi
- M.D. Mclellan
- M.D. Wilkerson
- M.G. Cordes
- M.G. Nissan
- M.G. Soloway
- M.H. Abdel-Rahman
- M.H. Kucherlapati
- M.J. Liptay
- M.L. Anderson
- M.L. Ferguson
- M.S. Bootwalla
- M.S. Lawrence
- M.S. Noble
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- N. Wentzensen
- N.A. Pennell
- N.C. Ramirez
- N.D. Aredes
- N.L. Lehman
- N.P. Hung
- N.V. Tien
- O. Bathe
- O. Mariani
- O. Olabode
- O. Paklina
- O. Potapova
- O. Voronina
- P. Anur
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- S.B. Gabriel
- S.E. Schumacher
- S.J. Caesar-Johnson
- S.J.M. Jones
- S.L. Asa
- S.M. Phillips
- S.M. Staugaitis
- S.N. Adebamowo
- S.O. Sumer
- S.R. Jefferys
- T. Akeredolu
- T. Bocklage
- T. Bodenheimer
- T. Broudy
- T. Carey
- T. Costello
- T. Defreitas
- T. Flotte
- T. Giordano
- T. Hinoue
- T. Knijnenburg
- T. Knutson
- T. Ley
- T. Mikkelsen
- T. Naska
- T. Owonikoko
- T. Patel
- T. Pihl
- T. Schlomm
- T. Shelton
- T. Skelly
- T. Smyrk
- T. Thompson
- T. Wang
- T. Wong
- T. Zelinka
- T.A. Chan
- T.M. Lichtenberg
- U. Veluvolu
- V. Cardinale
- V. Chandan
- V. Dhankani
- V. Jakrot
- V. Korchina
- V. Lyadov
- V. Reuter
- V. Thorsson
- W. Barrett
- W. Eijckenboom
- W. Hale
- W. Kycler
- W. Liu
- W. Oosterhuis
- W. Urba
- W. Ye
- W. Zhang
- W. Zhou
- W.E. Grizzle
- W.G. Richards
- W.J. Edenfield
- W.K. Chatila
- W.K. Chatila
- W.K. Rathmell
- W.M. Linehan
- X. Liu
- X. Liu
- X. Sastre
- Y. Han
- Y. Liu
- Y. Sanchez
- Y. Shi
- Y. Sun
- Y. Tang
- Y. Wan
- Y. Wolinsky
- Z. Wang
- Z.J. Heins
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these \u201chidden responders\u201d may reveal responsive molecular states. We describe and evaluate a machine-learning approach to classify aberrant pathway activity in tumors, which may aid in hidden responder identification. The algorithm integrates RNA-seq, copy number, and mutations from 33 different cancer types across The Cancer Genome Atlas (TCGA) PanCanAtlas project to predict aberrant molecular states in tumors. Applied to the Ras pathway, the method detects Ras activation across cancer types and identifies phenocopying variants. The model, trained on human tumors, can predict response to MEK inhibitors in wild-type Ras cell lines. We also present data that suggest that multiple hits in the Ras pathway confer increased Ras activity. The transcriptome is underused in precision oncology and, combined with machine learning, can aid in the identification of hidden responders. Way et al. develop a machine-learning approach using PanCanAtlas data to detect Ras activation in cancer. Integrating mutation, copy number, and expression data, the authors show that their method detects Ras-activating variants in tumors and sensitivity to MEK inhibitors in cell lines
Oncogenic Signaling Pathways in The Cancer Genome Atlas
- Author
- A. Abeshouse
- A. Ally
- A. Antenucci
- A. Arnaout
- A. Berchuck
- A. Bergeron
- A. Bossler
- A. Boussioutas
- A. Breggia
- A. Burnette
- A. Chen
- A. Clipca
- A. Davis
- A. De Rienzo
- A. De Rose
- A. Fehrenbach
- A. Gillis
- A. Gimenez-Roqueplo
- A. Gopalan
- A. Haddad
- A. Hartmann
- A. Iavarone
- A. Jimeno
- A. Kastl
- A. Kendler
- A. Kibel
- A. Korkut
- A. Longatto-Filho
- A. Luna
- A. Luna
- A. Malykh
- A. Mariamidze
- A. Mes-Masson
- A. Noss
- A. Ochoa
- A. Ochoa
- A. Perin
- A. Piché
- A. Pickens
- A. Rao
- A. Sankarankuty
- A. Secord
- A. Sepulveda
- A. Shabunin
- A. Sharp
- A. Sood
- A. Spillane
- A. Tam
- A. Tischler
- A. Tsao
- A. Unterberg
- A. Vicha
- A. von Deimling
- A.C. Berger
- A.C. de Carvalho
- A.D. Cherniack
- A.D. Cherniack
- A.D. Tward
- A.E. Sloan
- A.G. Robertson
- A.H. Berger
- A.H. Bryce
- A.H. Perou
- A.J. Kovatich
- A.J. Lazar
- A.J. Lazar
- A.J. Mungall
- A.K. Godwin
- A.L. Carvalho
- A.L. Guillermo
- A.M. Hegde
- A.M.A. Gonzalez
- A.P. Hoyle
- A.R. Metwalli
- B. Bernard
- B. Campos
- B. Czerniak
- B. Deyarmin
- B. Drake
- B. Esmaeli
- B. Gross
- B. Hermes
- B. Hernandez
- B. Kohl
- B. Kumar
- B. Pollo
- B. Rabeno
- B. Robinson
- B. Singh
- B. Tê
- B. Van Tine
- B. Wullich
- B.D. Phu
- B.E. Gross
- B.M. Broom
- B.P. O’
- B.S. Taylor
- B.Y. Karlan
- C. Adebamowo
- C. Andry
- C. Behrens
- C. Benz
- C. Bifulco
- C. Bradford
- C. Brewer
- C. Calatozzolo
- C. Carter
- C. Chen
- C. Cibulskis
- C. Fan
- C. Farver
- C. Feltmate
- C. Goparaju
- C. Guo
- C. Herold-Mende
- C. Hovens
- C. Huang
- C. Jungk
- C. Kandoth
- C. Kandoth
- C. Larson
- C. Logothetis
- C. Mcpherson
- C. Mirsaidi
- C. Moran
- C. Morrison
- C. Moser
- C. Sander
- C. Sander
- C. Scapulatempo-Neto
- C. Schilero
- C. Shelton
- C. Shipman
- C. Stoehr
- C. Wang
- C. Yau
- C.A. Miller
- C.C. Fronick
- C.D. Jones
- C.D. Shriver
- C.D. Vocke
- C.G. Carlotti
- C.H. Hagedorn
- C.J. Creighton
- C.K. Wong
- C.M. Cebulla
- C.M. Hutter
- C.M. Perou
- C.N. Landen
- C.P. Raut
- C.S. Greene
- C.S. Shelley
- C.W. Seder
- D. Alvaro
- D. Aziz
- D. Beer
- D. Bell
- D. Bigner
- D. Brooks
- D. Chakravarty
- D. Chakravarty
- D. Chesla
- D. Crain
- D. Cramer
- D. Hoon
- D. Huntsman
- D. Lee
- D. Mallery
- D. Morton
- D. Murawa
- D. Muzny
- D. Nagorney
- D. O’
- D. Raymond
- D. Rice
- D. Schadendorf
- D. Tan
- D. Tcaciuc
- D. Tirapelli
- D. Voet
- D.A. Levine
- D.A. Wheeler
- D.I. Heiman
- D.J. Brat
- D.J. Van Den Berg
- D.J. Weisenberger
- D.L. Liu
- D.M. Rassl
- D.M. Shin
- D.N. Hayes
- D.O. Vidal
- D.T. Maglinte
- E. Baudin
- E. Campo
- E. Castle
- E. Chuah
- E. Curley
- E. Gaudio
- E. Giné
- E. Kebebew
- E. Korpershoek
- E. Lipp
- E. Reznik
- E. Shinbrot
- E. Swisher
- E. Thompson
- E. Zmuda
- E.C. Zwarthoff
- E.G. Van Meir
- E.L. Appelbaum
- E.M. Godwin
- E.M. Van Allen
- E.M.M. Pinero
- E.R. Duffy
- E.R. Mardis
- F. Beuschlein
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- F. Carey
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- F. Daian
- F. Dimeco
- F. Facciolo
- F. Giuliante
- F. Khuri
- F. Mccormick
- F. Meric-Bernstam
- F. Moiseenko
- F. Que
- F. Saad
- F. Sanchez-Vega
- F. Sanchez-Vega
- F. Valdivieso
- F. Williams
- F. Zhao
- G. Barnett
- G. Bubley
- G. Carpino
- G. Ciriello
- G. Finocchiaro
- G. Getz
- G. Gorincioi
- G. Grazi
- G. Long
- G. Manikhas
- G. Mann
- G. Mcarthur
- G. Mckercher
- G. Petersen
- G. Saksena
- G. Sauter
- G. Setdikova
- G. Sica
- G. Thomas
- G. Wolf
- G.B. Mills
- G.D. Hammer
- G.F. Gao
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- W. Kycler
- W. Liang
- W. Liu
- W. Oosterhuis
- W. Urba
- W. Ye
- W. Zhang
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- X. Liu
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- X. Sastre
- Y. Han
- Y. Liu
- Y. Shi
- Y. Sun
- Y. Tang
- Y. Wan
- Y. Wolinsky
- Y. Xiao
- Z. Heins
- Z. Wang
- Z.J. Heins
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/04/2018
- Field of study
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFb signaling, p53 and beta-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
- Author
- A. Abeshouse
- A. Ally
- A. Antenucci
- A. Arnaout
- A. Berchuck
- A. Bergeron
- A. Bossler
- A. Boussioutas
- A. Breggia
- A. Burnette
- A. Chen
- A. Clipca
- A. Davis
- A. De Rienzo
- A. De Rose
- A. Fehrenbach
- A. Gillis
- A. Gimenez-Roqueplo
- A. Gopalan
- A. Haddad
- A. Hartmann
- A. Jimeno
- A. Kastl
- A. Kendler
- A. Kibel
- A. Korkut
- A. Longatto-Filho
- A. Luna
- A. Malykh
- A. Mariamidze
- A. Mes-Masson
- A. Noss
- A. Ochoa
- A. Perin
- A. Piché
- A. Pickens
- A. Rao
- A. Sankarankuty
- A. Secord
- A. Sepulveda
- A. Shabunin
- A. Sharp
- A. Sood
- A. Spillane
- A. Tam
- A. Tischler
- A. Tsao
- A. Unterberg
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- A. von Deimling
- A.C. Berger
- A.C. de Carvalho
- A.D. Cherniack
- A.D. Cherniack
- A.E. Sloan
- A.G. Robertson
- A.H. Bryce
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- A.J. Lazar
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- J.V. Simons
- K. Agnew
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- M. Quintero-Aguilo
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- T.A. Knijnenburg
- T.M. Lichtenberg
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- W. Barrett
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- W. Hale
- W. Kycler
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- W. Oosterhuis
- W. Urba
- W. Ye
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- X. Liu
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- Y. Han
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- Y. Shi
- Y. Sun
- Y. Tang
- Y. Wan
- Y. Wolinsky
- Y. Xiao
- Z. Wang
- Z. Zhao
- Z.J. Heins
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/04/2018
- Field of study
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in 3c20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein structure-based analyses allowed us to predict functional consequences of rare, recurrent DDR mutations. A new machine-learning-based classifier developed from gene expression data allowed us to identify alterations that phenocopy deleterious TP53 mutations. These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy. Knijnenburg et al. present The Cancer Genome Atlas (TCGA) Pan-Cancer analysis of DNA damage repair (DDR) deficiency in cancer. They use integrative genomic and molecular analyses to identify frequent DDR alterations across 33 cancer types, correlate gene- and pathway-level alterations with genome-wide measures of genome instability and impaired function, and demonstrate the prognostic utility of DDR deficiency scores
Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis
- Author
- Anzai H.
- Baltz R. H.
- Baltz R. H.
- Baltz R. H.
- Baltz R. H.
- Barany F.
- Bibb M. J.
- Binnie C.
- Birch A. W.
- Cundliffe E.
- Feinberg A. P.
- Feinberg A. P.
- Fishman S. E.
- Hanahan D.
- Hara O.
- Hopwood D. A.
- Hopwood D. A.
- Hutchinson C. R.
- Ikeda H.
- Ingram C.
- Kendall K.
- Kieser T.
- Kuhstoss S.
- Larson J. L.
- Malpartida F.
- Malpartida F.
- Martin J. F.
- Matsushima P.
- Motamedi H.
- Muth G.
- Omura S.
- Omura S.
- Pinnert-Sindico M. S.
- Rao R. N.
- Reed K. C.
- Richardson M. A.
- Richardson M. A.
- Rigby P. W.
- Rosenberg S. M.
- Sherman D. H.
- Stanzak R.
- Stutzman-Engwall K. J.
- Way J. C.
- Wold M. S.
- Yanisch-Perron C.
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
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- Forschler
- Forschler
- Foster
- Foster
- Foster
- Foster
- Foster
- Fournier
- Fournier
- Fox
- Fox
- Franclemont
- Frank
- Frank
- Frank
- Frank
- Fransen
- Frantz
- Frazer
- Frazer
- Free
- Frick
- Friend
- Friend
- Friend
- Friend
- Fritz
- Froeschner
- Fronk
- Frost
- Frost
- Fuchs
- Fuglie
- Fullaway
- Fuller
- Fulton
- Fulton
- Fulton
- Funderburk
- Funderburk
- Funderburk
- Funderburk
- Funderburk
- Funderburk
- Furutani
- Furutani
- Fye
- Gammon
- Gardner
- Gardner
- Garman
- Garman
- Gaum
- Gauthier
- Gauthier
- Gelernter
- Gentile
- Gentile
- Gentile
- Gentile
- Gentner
- Gentry
- Gentry
- Genung
- Genung
- Genung
- Genung
- George
- George
- George
- George
- Gerber
- Gerber
- Gerber
- Gerber
- Gerber
- Gerber
- Gerber
- Gerber
- Gerber
- Gergerich
- Gerling
- Gerson
- Gerson
- Gerson
- Gerson
- Gerson
- Gesell
- Getz
- Getzin
- Getzin
- Getzin
- Getzin
- Getzin
- Gharib
- Ghidiu
- Gholson
- Gibson
- Giebink
- Giebink
- Giebink
- Gilbertson
- Gilbertson
- Gilbertson
- Gilboa
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- Gillespie
- Gillespie
- Gillette
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- Gilstrap
- Girault
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- Gladstone
- Glass
- Glen
- Gliessman
- Goats
- Godan
- Godfrey
- Godfrey
- Godfrey
- Godin
- Godin
- Godin
- Goettel
- Goettel
- Goettel
- Goff
- Goff
- Goh
- Goh
- Gojmerac
- Golden
- Golino
- Golino
- Gonzalez
- Gonzalez
- Goodenough
- Gooding
- Gorder
- Gordon
- Gordon
- Gould
- Gould
- Gould
- Gould
- Graf
- Graf
- Grafius
- Grafius
- Graham
- Graham
- Graham
- Granados
- Gray
- Gray
- Grayson
- Greene
- Greene
- Greene
- Greene
- Greenough
- Greenstone
- Gregory
- Griffith
- Grigarick
- Grissell
- Gross
- Gross
- Gross
- Gross
- Gross
- Gross
- Grundler
- Guppy
- Guppy
- Guppy
- Guppy
- Guppy
- Guppy
- Guss
- Guss
- Guss
- Gustin
- Gwynne
- Gwynne
- Gyrisco
- Habeck
- Habeck
- Habeck
- Habib
- Hackett
- Hagel
- Hagel
- Hagel
- Hagel
- Hagel
- Hagen
- Hagen
- Halfhill
- Halfhill
- Halfhill
- Hall
- Hall
- Hall
- Hall
- Hall
- Hallock
- Hallock
- Hallock
- Hallock
- Hamilton
- Hamilton
- Hamilton
- Hamilton
- Hamm
- Hammond
- Hammond
- Hammond
- Hammond
- Hammond
- Hamon
- Hamon
- Hamon
- Hander
- Hanna
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- Hanson
- Hanson
- Hanula
- Hao
- Hara
- Hara
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harcourt
- Harding
- Harding
- Harding
- Hardman
- Hardman
- Hardwick
- Hardwick
- Hardy
- Hare
- Hare
- Hare
- Hare
- Hargreaves
- Harman
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- Harper
- Harper
- Harper
- Harper
- Harper
- Harper
- Harper
- Harrell
- Harries
- Harrington
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harris
- Harrison
- Harrison
- Harrison
- Harrison
- Harrison
- Harrison
- Hartley
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- Hatch
- Hatch
- Hatch
- Hatchett
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- Havukkala
- Hawkins
- Hawkins
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- Hawley
- Hawley
- Hayakawa
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- Hayes
- Hayes
- Hayes
- Haynes
- Haynes
- Haynes
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- Hazan
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- Heath
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- Heichel
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- Hein
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- Heinz
- Heinz
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- Henderson
- Henderson
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- Henneberry
- Henneberry
- Henry
- Henry
- Henry
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- Heppner
- Herrick
- Herzog
- Herzog
- Herzog
- Hesler
- Hetrick
- Hickman
- High
- Highland
- Highland
- Higley
- Hildebrand
- Hill
- Hill
- Hill
- Hill
- Hill
- Hinds
- Hinks
- Hinsch
- Hirose
- Hirose
- Hobbs
- Hodges
- Hodson
- Hodson
- Hoebeke
- Hoerner
- Hoerner
- Hoerner
- Hoffman
- Hoffmann
- Hoffmann
- Hoffmann
- Hoffmann
- Hoffmann
- Hoffmann
- Hoffmann
- Hofmaster
- Hofmaster
- Hogg
- Hollingsworth
- Hollingsworth
- Holloway
- Holt
- Holtzer
- Hooker
- Hopkin
- Hopkin
- Horn
- Horne
- Horne
- Horowitz
- Horsfall
- Horsfall
- Horsfall
- Horsfall
- Horsfall
- Horton
- Horton
- Horton
- Hostetter
- Hostetter
- Hou
- Hough-Goldstein
- Hough-Goldstein
- Hough-Goldstein
- Hough-Goldstein
- Hough-Goldstein
- Houser
- Houser
- Howard
- Howard
- Howard
- Howe
- Howe
- Howe
- Howell
- Howell
- Howitt
- Howitt
- Howitt
- Howitt
- Howlader
- Hoy
- Hoy
- Hoy
- Hruska
- Hsaio
- Hsiao
- Hsing-Yeh
- Huckett
- Huckett
- Hudon
- Hudon
- Hudon
- Hudon
- Hudson
- Hudson
- Hudson
- Hudson
- Hudson
- Huffaker
- Huffaker
- Huffman
- Hughes
- Hughes
- Hughes
- Hughes
- Hung
- Hunter
- Hunter
- Hunter
- Hutchison
- Hutchison
- Hyslop
- Hyslop
- Hyslop
- Hyslop
- Idris
- Ignoffo
- Ignoffo
- Inglis
- Ingram
- Isely
- Isely
- Isely
- Isely
- Isman
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jackson
- Jacob
- Jacobson
- Jacobson
- Jacobson
- Jacques
- Janes
- Jansen
- Jansen
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jansson
- Jaques
- Jaques
- Jaronski
- Jarvis
- Jarvis
- Javahery
- Jaworska
- Jedlinski
- Jefferson
- Jeffords
- Jemal
- Jensen
- Jensen
- Jeppson
- Jewett
- Jewett
- Johannsen
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Johnston
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jones
- Jouvenaz
- Jouvenaz
- Jubb
- Jubb
- Judd
- Judd
- Judd
- Judd
- Judge
- Jyani
- Kaakeh
- Kabashima
- Kabissa
- Kajita
- Kamau
- Kamm
- Kamm
- Kamm
- Kamm
- Kanga
- Kanga
- Kard
- Kard
- Kareiva
- Kareiva
- Kaster
- Katsoyannos
- Kaufmann
- Kawada
- Kawai
- Kawate
- Kaya
- Kearns
- Keaster
- Keep
- Keever
- Keifer
- Kelleher
- Keller
- Kelly
- Kelly
- Kelsheimer
- Kelsheimer
- Kelton
- Kendall
- Kendall
- Kendall
- Kendall
- Kennedy
- Kennedy
- Kennedy
- Kennedy
- Khaemba
- Khalsa
- Khan
- Khattat
- Khattat
- Khattat
- Khomyakova
- Kieckhefer
- Kieckhefer
- Kim
- Kim
- Kim
- Kim
- King
- King
- King
- King
- King
- King
- King
- King
- King
- King
- Kinoshita
- Kinoshita
- Kinzer
- Kirby
- Kirfman
- Kirk
- Kirk
- Kirk
- Kirk
- Kirk
- Kitch
- Kjaer-Pedersen
- Klahn
- Klein
- Kloen
- Klostermeyer
- Klostermeyer
- Klun
- Klun
- Klun
- Klun
- Klun
- Klun
- Knight
- Knowles
- Knowlton
- Knowlton
- Knutson
- Knutson
- Knutson
- Knutson
- Knutson
- Knutson
- Knutson
- Kochansky
- Kodet
- Kogan
- Kogan
- Koinzan
- Kok
- Kono
- Kostal
- Koul
- Koyama
- Kozlowski
- Kraemer
- Krasnoff
- Krasnoff
- Kring
- Kring
- Kring
- Kring
- Kring
- Krombein
- Kroschel
- Krueger
- Krysan
- Krysan
- Krysan
- Krysan
- Kuba
- Kuba
- Kuitert
- Kundu
- Ladd
- Ladd
- Ladd
- LaFontaine
- LaFontaine
- Lafrance
- Lafrance
- Laing
- Lamb
- Lamb
- Lamb
- Lamb
- Lamb
- Lamb
- Lamb
- Lambert
- Lamp
- Lamp
- Lampert
- Lampman
- Lamson
- Lance
- Lance
- Lance
- Lanchester
- Landis
- Landis
- Landis
- Landolt
- Landolt
- Landolt
- Landolt
- Lane
- Lange
- Lange
- Lange
- Lange
- Lange
- Langford
- Langford
- Langford
- Langridge
- Langston
- Lanteri
- Larew
- Larsen
- Larson
- Larson
- Lasack
- Lasack
- Lasota
- Latheef
- Latheef
- Latheef
- Latheef
- Latheef
- Latheef
- Latin
- Latta
- Latta
- Laub
- Launchbaugh
- Lavoipierre
- Lawson
- Lawson
- Lawson
- Layland
- Leather
- Leather
- Leather
- Lederhouse
- Lee
- Lee
- Lee
- Legg
- Lei
- Leibee
- Leibee
- Leibee
- Leiby
- Leigh
- Leigh
- Lema
- Lentz
- Lentz
- Leonard
- Leonard
- Leonard
- Leszczynski
- Letourneau
- Letourneau
- Leuck
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levine
- Levins
- Levy
- Lewis
- Lewis
- Lewis
- Lewis
- Lextrait
- Li
- Liburd
- Lilly
- Lilly
- Lim
- Lim
- Lim
- Lim
- Lim
- Lin
- Lin
- Lindegren
- Lindegren
- Lindsay
- Linduska
- Lingren
- Linn
- Linn
- Liquido
- Liquido
- List
- List
- List
- Litsinger
- Liu
- Liu
- Liu
- Liu
- Loan
- Loan
- Loan
- Loan
- Loebenstein
- Loera
- Lofgren
- Lofgren
- Logan
- Long
- Loomans
- Lopez
- Lopez
- Losey
- Losey
- Loughran
- Loughran
- Lovell
- Lovett
- Lower
- Lowery
- Lowery
- Lowry
- Lublinkhof
- Luckmann
- Luckmann
- Ludwig
- Luginbill
- Luginbill
- Luginbill
- Luginbill
- Luginbill
- Luginbill
- Lund
- Lye
- Lye
- Lye
- Lye
- Lynch
- Lynch
- MacFarlane
- MacGillivray
- Mack
- Mack
- Mack
- Mack
- Mackauer
- Mackauer
- Mackenzie
- Mackenzie
- MacLean
- MacVean
- MacVean
- MacVean
- MacVean
- Madden
- Maddock
- Madueke
- Mahr
- Mahrt
- Mahrt
- Maiteki
- Maiteki
- Maiteki
- Majchrowicz
- Mani
- Manson
- Manuwoto
- Maple
- Marco
- Marco
- Maredia
- Marenco
- Margolies
- Markham
- Marrone
- Marrone
- Marrone
- Marrone
- Marsh
- Marsh
- Marsh
- Marsh
- Marsh
- Marsh
- Marsh
- Martel
- Martel
- Martel
- Martel
- Martin
- Martin
- Martin
- Martin
- Martin
- Martin
- Martin
- Martin
- Martinson
- Martinson
- Mason
- Mason
- Mason
- Matheny
- Matheny
- Matheny
- Matteson
- Matthews-Gehringer
- Mattson
- Maxson
- Mayer
- Mayer
- Maynard
- Mays
- McAuslane
- McAvoy
- McAvoy
- McCarthy
- McClanahan
- McClanahan
- McClanahan
- McCloud
- McCoy
- McCreight
- McCutcheon
- McDonald
- McDonald
- McDonald
- McEwen
- McEwen
- McEwen
- McEwen
- McGovern
- McHugh
- McKenzie
- McKinlay
- McKinlay
- McKinlay
- McKinney
- McLain
- McLaughlin
- McLaughlin
- McLaughlin
- McLean
- McLeod
- McLeod
- McLeod
- McLeod
- McLeod
- McLeod
- McLeod
- McMillian
- McMurtry
- McNeil
- McPhail
- McPhail
- McPherson
- McPherson
- McPherson
- McPherson
- McSorley
- McSorley
- Mead
- Mead
- Meade
- Meade
- Meade
- Meats
- Medina-Gaud
- Medler
- Melander
- Mellors
- Mena-Covarrubias
- Mendoza
- Mendoza
- Mertz
- Messina
- Metcalf
- Metcalf
- Metcalf
- Metcalf
- Metcalf
- Meyerdirk
- Meyerdirk
- Michelbacher
- Michelbacher
- Michelbacher
- Michelbacher
- Michelbacher
- Michelbacher
- Michels
- Michels
- Michelsen
- Middlekauff
- Milbrath
- Miles
- Miles
- Miles
- Miles
- Miles
- Miles
- Miles
- Miles
- Miles
- Millar
- Miller
- Miller
- Miller
- Miller
- Miller
- Miller
- Miller
- Milliken
- Milliken
- Milliken
- Mills
- Milner
- Miner
- Minkenberg
- Minkenberg
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Mittler
- Miyatake
- Mohamed
- Monti
- Moon
- Moore
- Moran
- Morgan
- Morgan
- Morrill
- Morris
- Morris
- Morris
- Morris
- Morrison
- Morrison
- Morrow
- Moulton
- Mound
- Muchmore
- Mueller
- Mueller
- Mueller
- Mukerji
- Mukerji
- Mulkern
- Mulkern
- Mullen
- Mullen
- Mullen
- Munkvold
- Munroe
- Munroe
- Munroe
- Munroe
- Munyaneza
- Musick
- Musick
- Mussen
- N'Guessan
- Nair
- Nair
- Namba
- Namba
- Naranjo
- Naranjo
- Naranjo
- Natwick
- Nault
- Nault
- Nault
- Nault
- Nault
- Nechols
- Nechols
- Negron
- Negron
- Negron
- Negron
- Neilson
- Neiswander
- Neuenschwander
- Neunzig
- Neunzig
- Neunzig
- Newman
- Newsom
- Ng
- Ng
- Nguyen
- Ni
- Nickle
- Nickle
- Nielsen
- Nielson
- Niemczyk
- Nihoul
- Nilakhe
- Nilakhe
- Nishida
- Nishida
- Nishida
- Nishida
- Nitao
- Nolting
- North
- North
- Norton
- Novero
- Nuessly
- Nuttycombe
- Nwanze
- O'Hayer
- O'Neal
- O'Neal
- O'Neill
- O'Rourke
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Oatman
- Obrycki
- Oetting
- Ofuya
- Ogenga-Latigo
- Ogunwolu
- Ogunwolu
- Ohinata
- Ohnesorge
- Okabe
- Okumura
- Oliver
- Oliver
- Olmstead
- Olmstead
- Olsen
- Olson
- Onillon
- Onsager
- Onsager
- Onsager
- Opler
- Oramas
- Orozco-Santos
- Orr
- Osborn
- Osborne
- Osborne
- Ota
- Overholt
- Overholt
- Own
- Ozaki
- Paddock
- Paddock
- Paddock
- Paddock
- Paddock
- Pair
- Pair
- Pair
- Palamiswamy
- Palaniswamy
- Palaniswamy
- Palaniswamy
- Palaniswamy
- Palanswamy
- Pallant
- Palmer
- Palmer
- Palumbo
- Palumbo
- Palumbo
- Palumbo
- Paris
- Parish
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parkman
- Parkman
- Parkman
- Parkman
- Parkman
- Parkman
- Parmenter
- Parrella
- Parrella
- Parrella
- Parrella
- Parrella
- Parrella
- Parrella
- Parrella
- Parrella
- Pashley
- Passoa
- Patch
- Patch
- Patch
- Patch
- Patel
- Patel
- Pathak
- Patrock
- Patton
- Pausch
- Pausch
- Pavuk
- Payne
- Payne
- Pearson
- Peay
- Pedigo
- Pedigo
- Pedigo
- Pelletier
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pena
- Pencoe
- Peng
- Peng
- Pepper
- Pepper
- Pepper
- Pepper
- Perfecto
- Perfecto
- Perkins
- Perring
- Perring
- Perring
- Perring
- Perring
- Perron
- Perron
- Perron
- Persoons
- Persoons
- Pesho
- Peters
- Peters
- Peterson
- Peterson
- Peterson
- Peterson
- Peterson
- Peterson
- Peterson
- Petitt
- Petitt
- Petralia
- Pfadt
- Pfadt
- Pfadt
- Pfadt
- Pfadt
- Pfadt
- Pfadt
- Pfaffenberger
- Phelan
- Phelan
- Phillips
- Phillips
- Phillips
- Phillips
- Phillips
- Pickel
- Pickering
- Pickett
- Pickford
- Pierce
- Pierce
- Pierce
- Pike
- Pike
- Pimentel
- Pinto
- Pinto
- Pinto
- Pitre
- Pitre
- Pitre
- Pitre
- Pivnick
- Pivnick
- Platner
- Pletsch
- Poe
- Poinar
- Poinar
- Polaszek
- Polivka
- Pond
- Poos
- Poos
- Poos
- Poos
- Poos
- Poos
- Poos
- Poos
- Poos
- Poprawski
- Poprawski
- Port
- Porter
- Porter
- Portillo
- Portillo
- Portillo
- Poston
- Poston
- Poswal
- Potts
- Powell
- Powell
- Powell
- Power
- Power
- Prabhaker
- Prando
- Prescott
- Prescott
- Price
- Price
- Price
- Prokopy
- Prostak
- Pruess
- Pruess
- Pruess
- Pruess
- Pruess
- Prystupa
- Purcell
- Puttarudriah
- Puttler
- Puttler
- Puttler
- Päts
- Quaintance
- Quaintance
- Quaintance
- Quaintance
- Quate
- Quintela
- Rabasse
- Rabb
- Rabb
- Rabb
- Radcliffe
- Radcliffe
- Radcliffe
- Radke
- Raina
- Raina
- Raman
- Raman
- Ramoska
- Ramoska
- Ramsey
- Rausher
- Rawlins
- Rawlins
- Raworth
- Reagan
- Redak
- Redfern
- Redfern
- Reed
- Reed
- Reed
- Rees
- Rees
- Reese
- Rehn
- Reid
- Reid
- Reid
- Reidell
- Reinert
- Reinhard
- Reinhard
- Reinink
- Rennie
- Rentz
- Rice
- Richards
- Richards
- Richman
- Richman
- Richman
- Ridgway
- Riggin
- Riggin
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Riley
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Rings
- Risch
- Ritcey
- Ritcey
- Ritcher
- Ritcher
- Rivers
- Ro
- Roach
- Robert
- Roberts
- Roberts
- Robinson
- Robinson
- Rock
- Rockburne
- Rockwood
- Rockwood
- Rodriguez-del-Bosque
- Roe
- Roe
- Roelofs
- Roessler
- Rogers
- Rogers
- Rogers
- Rogers
- Rogers
- Rogers
- Roitberg
- Rollo
- Rolston
- Rolston
- Rolston
- Rolston
- Rolston
- Roltsch
- Romanow
- Rose
- Rosenheim
- Rosenstiel
- Rottger
- Rowe
- Rowley
- royalty
- Royalty
- Royer
- Royer
- Ru
- Ruberson
- Ruesink
- Rummel
- Runner
- Rusoke
- Russell
- Russell
- Russell
- Russell
- Russin
- Rust
- Rust
- Saba
- Saba
- Sailer
- Sakimura
- Sakimura
- Salas
- Salas-Aguilar
- Salguero Navas
- Salguero Navas
- Salguero Navas
- Sanborn
- Sanborn
- Sanborn
- Sanchez
- Sanchez
- Sanderson
- Sands
- Sandstrom
- Santiago-Alvarez
- Santigo-Alvarez
- Santos
- Sappington
- Sappington
- Satterthwait
- Satterthwait
- Saunders
- Saxena
- Saynor
- Scales
- Schaaf
- Schaafsma
- Schaber
- Schaefer
- Schalk
- Schalk
- Schalk
- Schalk
- Schalk
- Schalk
- Schalk
- Schalk
- Schalk
- Scharff
- Scheffrahn
- Schlinger
- Schneider
- Schoenbohm
- Schoene
- Schoene
- Schoof
- Schoonhoven
- Schoonhoven
- Schotzko
- Schotzko
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- Tulisalo
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- Tumlinson
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- Tuskes
- Tuthill
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- Umesh
- Underhill
- Underhill
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- Underhill
- Utida
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- Vail
- Vail
- Vail
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- Valles
- Valles
- Valles
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- van Alphen
- van Dam
- van de Vrie
- van den Bosch
- van Emden
- van Emden
- van Houten
- van Keymeulen
- van Lenteren
- Van Name
- Van Name
- Van Name
- van Rijn
- van Roermund
- van Steenwyk
- van Steenwyk
- van Steenwyk
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- VanWoerkom
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- Vea
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- Vernon
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- Weigel
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- Weintraub
- Weintraub
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- Weissling
- Weissling
- Weisz
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- Wiesenborn
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- Willson
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- Wipfli
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- Witkowski
- Wittenborn
- Wojcik
- Wojcik
- Wojcik
- Wolcott
- Wolcott
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- Wolfenbarger
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- Wolfenbarger
- Wolfenbarger
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- Wolfenbarger
- Wolfenbarger
- Wong
- Wong
- Wong
- Wood
- Wood
- Woodruff
- Woodside
- Woodson
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- Woodson
- Woodson
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- Woodson
- Workman
- Workman
- Worsham
- Wozniak
- Wright
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- Wukasch
- Wylie
- Wylie
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- Wylie
- Wylie
- Wyman
- Wyman
- Wyman
- Wyman
- Wyman
- Wymore
- Wynne
- Yamamoto
- Yamamoto
- Yamamoto
- Yang
- Yano
- Yathom
- Yeargan
- Yokomi
- Yosef
- Yoshida
- Yoshiyasu
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Young
- Youssef
- Yudin
- Yudin
- Yudin
- Zacharuk
- Zacharuk
- Zacharuk
- Zalom
- Zalom
- Zalom
- Zalom
- Zalom
- Zalom
- Zalom
- Zalom
- Zangerl
- Zangerl
- Zehnder
- Zehnder
- Zehnder
- Zehnder
- Zehnder
- Zehnder
- Zehnder
- Zehnder
- Zeiss
- Zepp
- Zhang
- Zhao
- Zimmerman
- Zuk
- Zurlini
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2001
- Field of study
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
- Author
- A. Gordon Robertson
- Aaron Bossler
- Ad Gillis
- Adam Abeshouse
- Adam Kibel
- Adam R. Metwalli
- Adhemar Longatto-Filho
- Adrian Ally
- Adrian Clipca
- Ady Kendler
- Agostino De Rose
- Ajith Sankarankuty
- Alain Bergeron
- Alain Piché
- Alan H. Bryce
- Alan P. Hoyle
- Alan Pickens
- Albert J. Kovatich
- Ales Vicha
- Alessandro Perin
- Alex Boussioutas
- Alexander J. Lazar
- Alexey Shabunin
- Alexis Sharp
- Alison Kastl
- Amy Chen
- Amy Davis
- Amy H. Perou
- Ana C. de Carvalho
- Ana Maria Angulo Gonzalez
- Andre L. Carvalho
- Andrea Haddad
- Andreas Unterberg
- Andreas von Deimling
- Andrei Malykh
- Andrew Berchuck
- Andrew Burnette
- Andrew D. Cherniack
- Andrew D. Cherniack
- Andrew E. Sloan
- Andrew J. Mungall
- Andrew K. Godwin
- Andrew Spillane
- Angel Arnaout
- Angela Tam
- Angeles Secord
- Angelica Ochoa
- Anil Korkut
- Anil Sood
- Anna Antenucci
- Anne Breggia
- Anne Tsao
- Anne-Marie Mes-Masson
- Anne-Paule Gimenez-Roqueplo
- Antonia Sepulveda
- Antonio Jimeno
- Anuradha Gopalan
- Apurva M. Hegde
- Ardene Noss
- Armando López Guillermo
- Armaz Mariamidze
- Arndt Hartmann
- Arthur Tischler
- Arvind Rao
- Ashley Fehrenbach
- Ashton C. Berger
- Assunta De Rienzo
- Augustin Luna
- Augustin Luna
- Bahavna Kumar
- Barry S. Taylor
- Benito Campos
- Benjamin E. Gross
- Bernard Kohl
- Bernard Têtu
- Bernd Wullich
- Beth Hermes
- Beth Y. Karlan
- Bettina Drake
- Bhuvanesh Singh
- Bianca Pollo
- Bita Esmaeli
- Bogdan Czerniak
- Bradley M. Broom
- Brady Bernard
- Brenda Deyarmin
- Brenda Hernandez
- Brenda Rabeno
- Brian Patrick O’Neill
- Brian Van Tine
- Bruce Robinson
- Bui Duc Phu
- Candace Carter
- Candace Shelton
- Carl Morrison
- Carl Simon Shelley
- Carlo Bifulco
- Carlos Gilberto Carlotti Jr.
- Carmen Behrens
- Carol Bradford
- Carol Farver
- Caroline Larson
- Carolyn M. Hutter
- Carrie Cibulskis
- Casey S. Greene
- Cassaundra Shipman
- Catherine Moser
- Cathy Brewer
- Cathy D. Vocke
- Cathy Schilero
- Catrina C. Fronick
- Cesar Moran
- Chad J. Creighton
- Chandra Goparaju
- Chandrajit P. Raut
- Charles Guo
- Charles M. Perou
- Charles N. Landen
- Cheng Fan
- Chiara Calatozzolo
- Chris Andry
- Chris Sander
- Chris Sander
- Christel Herold-Mende
- Christin Jungk
- Christina Yau
- Christine Stoehr
- Christopher A. Miller
- Christopher Benz
- Christopher Hovens
- Christopher K. Wong
- Christopher Logothetis
- Christopher McPherson
- Christopher W. Seder
- Chu Chen
- Clement Adebamowo
- Colleen Feltmate
- Colleen M. Cebulla
- Corbin D. Jones
- Craig D. Shriver
- Cristovam Scapulatempo-Neto
- Curt H. Hagedorn
- Cyriac Kandoth
- Cyrus Mirsaidi
- D. Neil Hayes
- Daniel Crain
- Daniel Cramer
- Daniel J. Brat
- Daniel J. Weisenberger
- Daniel O. Vidal
- Daniel O’Brien
- Daniel Raymond
- Daniela Tirapelli
- Darell Bigner
- Darlene Lee
- Dave Hoon
- David A. Wheeler
- David Beer
- David Chesla
- David Huntsman
- David I. Heiman
- David J. Van Den Berg
- David Mallery
- David Nagorney
- David Rice
- Dawid Murawa
- Debra Bell
- Debyani Chakravarty
- Denise Brooks
- Dennis T. Maglinte
- Deqin Ma
- Diana Tcaciuc
- Dina Aziz
- Dirk Schadendorf
- Domenico Alvaro
- Dong M. Shin
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doris M. Rassl
- Doug Voet
- Douglas A. Levine
- Ed Reznik
- Edna M. Mora Pinero
- Elaine R. Mardis
- Electron Kebebew
- Elias Campo
- Elizabeth L. Appelbaum
- Elizabeth R. Duffy
- Elizabeth Swisher
- Ellen C. Zwarthoff
- Eric Baudin
- Eric Chuah
- Eric Lipp
- Eric Thompson
- Erik Castle
- Erik Zmuda
- Erin Curley
- Erwin G. Van Meir
- Eryn M. Godwin
- Esther Korpershoek
- Eugenio Gaudio
- Eva Giné
- Eve Shinbrot
- Fadi Brimo
- Fadlo Khuri
- Federico Valdivieso
- Fedor Moiseenko
- Feixiong Cheng
- Felice Giuliante
- Felicia Williams
- Felix Beuschlein
- Fengmei Zhao
- Florencia Que
- Francesco DiMeco
- Francesco Facciolo
- Francis Carey
- Francisco Sanchez-Vega
- Francisco Sanchez-Vega
- Fred Saad
- Funda Meric-Bernstam
- Gabriel Sica
- Gad Getz
- Gaetano Finocchiaro
- Galen F. Gao
- Galiya Setdikova
- Gavin Ha
- Gene Barnett
- George Manikhas
- George Thomas
- Georgina Long
- Ghenadie Gorincioi
- Gianluca Grazi
- Ginette McKercher
- Giovanni Ciriello
- Glenn Bubley
- Gloria Petersen
- Gordon B. Mills
- Gordon Saksena
- Graham Mann
- Gregory P. Way
- Gregory Wolf
- Guido Carpino
- Guido Sauter
- Hai Hu
- Hailei Zhang
- Han Liang
- Hani Gabra
- Hanina Hibshoosh
- Hannah Yang
- Hans Stoop
- Harman Sekhon
- HarshaVardhan Doddapaneni
- Hartmut Juhl
- Hartwig Huland
- Harvey Pass
- Heather K. Schmidt
- Heidi J. Sofia
- Helge Taubert
- Henri Timmers
- Henrique C.S. Silveira
- Hikmat Al-Ahmadie
- Hojabr Kakavand
- Hongxin Zhang
- Hongzheng Zhang
- Houtan Noushmehr
- Howard Colman
- Howard G. Rosenthal
- Howard Zaren
- Hui Shen
- Huihui Fan
- Huyen Dinh
- Iakovina Alexopoulou
- Ian Forgie
- Ian Yang
- Ignacio Wistuba
- Ilya Shmulevich
- Ina Felau
- Inga Chemencedji
- Ino de Bruijn
- Irina Caraman
- Irina Stancul
- J. Bradley Elder
- J. Leigh Fantacone-Campbell
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Jaffer A. Ajani
- James Catto
- James Lang
- James Luketich
- James Powers
- James Wilmott
- Janae V. Simons
- Jay Bowen
- Jay Engel
- Jean C. Zenklusen
- Jean-Pierre Kocher
- Jeffey Moyer
- Jeffrey A. Borgia
- Jeffrey A. Hooke
- Jeffrey Gershenwald
- Jeffrey J. Olson
- Jeffrey Marks
- Jeffrey Roach
- Jeffry Simko
- Jenette Creaney
- Jennifer Drummond
- Jennifer Eschbacher
- Jennifer Smith
- Jens Waldmann
- Jeremy Parfitt
- Jerome Myers
- Jia Liu
- Jianhong Hu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jiexin Zhang
- Jill S. Barnholtz-Sloan
- Jing Wang
- Jioajiao Wang
- Jireh Santibanez
- Joan Walker
- Joanna Phillips
- Jodi Harr
- Joe Hilty
- Joel Henderson
- Joel S. Parker
- Johanna Gardner
- John A. Copland
- John A. Demchok
- John A. Martignetti
- John Bartlett
- John Chabot
- John Cheville
- John DiPersio
- John Eckman
- John Houck
- John N. Weinstein
- John Thompson
- Jolanta Bondaruk
- Jonathan Melamed
- Jonathan Stretch
- Joong-Won Park
- Jordonna Fulop
- Jose Sebastião Dos Santos
- Joseph Bennett
- Joseph Galbraith
- Joseph Paulauskis
- Joshua Armenia
- Joshua Armenia
- Joshua M. Stuart
- José H. Fregnani
- Ju Dong Yang
- Judy Miller
- Julia Slotta-Huspenina
- Julian Hess
- Juliann Shih
- Julie M. Gastier-Foster
- Julie Martin
- Jun Li
- June M. Chan
- Jung Il Lee
- Junya Fujimoto
- Juok Cho
- Kalle Leinonen
- Kane Tse
- Karan Rai
- Karel Pacak
- Karen Devine
- Karen Mungall
- Karen Smith-McCune
- Karl-Friedrich Becker
- Karla Kopp
- Katayoon Kasaian
- Katherine A. Hoadley
- Katherine C. Sexton
- Katherine Moxley
- Kathleen Moore
- Kathy Agnew
- Kathy Smolenski
- Keith Delman
- Kelinda Tucker
- Kelly Magliocca
- Kelly Senecal
- Kenneth Lee
- Kerstin Junker
- Kerwin Shannon
- Keunsoo Ahn
- Kevin Lau
- Kevin Roggin
- Ki Chung
- Kim E. van Kessel
- Kimberley Evason
- Kivanc Birsoy
- Klaus-Peter Janssen
- Konnor La
- Konnor La
- Koo Jeong Kang
- Kristen M. Leraas
- Kristen Shimmel
- Kwok-Shing Ng
- Kwun M. Fong
- Kyle Chang
- Kyle Covington
- Larsson Omberg
- Laura Jacobus
- Laura Rozek
- Laura S. Schmidt
- Lauren Haydu
- Laurence Desjardins
- Lawrence A. Donehower
- Laxmi Lolla
- Leendert Looijenga
- Leigh Anne Zach
- Leonid Kvecher
- Leslie Cope
- Lewis Roberts
- Li Ding
- Liming Yang
- Linghua Wang
- Lisa Landrum
- Lisa Peterson
- Lisa Scarpace
- Lisa Wise
- Lisle E. Mose
- Liu Xi
- Lizhi Zhang
- Lois Ramondetta
- Lora Lewis
- Louis Lacombe
- Luca Mattei
- Lucia Cuppini
- Lucinda A. Fulton
- Ludmila Danilova
- Lynn Schoenfield
- Maciej Wiznerowicz
- Madhusmita Behera
- Marc Goodman
- Marc Ladanyi
- Marc Moncrieff
- Marc-Henri Stern
- Marco A. Marra
- Marco Mina
- Margaret Morgan
- Margi Sheth
- Maria Consiglia Bragazzi
- Maria Pirtac
- Maria Synott
- Mario Quintero-Aguilo
- Mark A. Rubin
- Mark Gerken
- Mark Nelson
- Mark Pool
- Mark Prince
- Mark Schiffman
- Mark Sherman
- Markus Graefen
- Marta Aymerich
- Marta Couce
- Martin Fassnacht
- Martin L. Ferguson
- Mary Iacocca
- Mary McGraw
- Massimo Mannelli
- Mathieu Latour
- Matthew Bailey
- Matthew D. Wilkerson
- Matthew G. Cordes
- Matthew G. Soloway
- Matthew L. Anderson
- Matthew Meyerson
- Melanie H. Kucherlapati
- Melissa Stanton
- Melpomeni Kasapi
- Michael Birrer
- Michael Carney
- Michael D. McLellan
- Michael Dubina
- Michael Farnell
- Michael Feldman
- Michael Ittmann
- Michael J. Liptay
- Michael Kendrick
- Michael Knudson
- Michael Mayo
- Michael Miller
- Michael Muto
- Michael Prados
- Michael Quinn
- Michael Rivera
- Michael Ryan
- Michael S. Lawrence
- Michael S. Noble
- Michael Torbenson
- Michelle Bellair
- Mikhail Dinkin
- Mikhail Tavobilov
- Min Wang
- Mircea Cernat
- Mirella Marino
- Miruna Balasundaram
- Mitesh Borad
- Mohamed H. Abdel-Rahman
- Mohammed Milhem
- Moiz S. Bootwalla
- Monique Albert
- Moriah G. Nissan
- Myron Peto
- Nasra Giama
- Natalia Botnariuc
- Nathan A. Pennell
- Natália D. Aredes
- Neil Horowitz
- Nguyen Phi Hung
- Nguyen Van Bang
- Nguyen Viet Tien
- Niall Corcoran
- Nicholas Hayward
- Nicolas Girard
- Nicolas Wentzensen
- Nikolaus Schultz
- Nikolaus Schultz
- Nils Gehlenborg
- Nilsa C. Ramirez
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- Vincenzo Cardinale
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- W. Jeffrey Edenfield
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- Walid K. Chatila
- Walid K. Chatila
- Walker Hale
- Walter Urba
- Wanding Zhou
- Wei Li
- Wei Zhang
- Wenbin Liu
- Wendi Barrett
- Wil Eijckenboom
- William E. Grizzle
- William G. Richards
- Witold Kycler
- Wolter Oosterhuis
- Xavier Sastre
- Xiuping Liu
- Xuan Le
- Yan Shi
- Ye Wu
- Yi Han
- Yichao Sun
- Yiling Lu
- Yingli Wolinsky
- Yolanda Sanchez
- Yuexin Liu
- Yufang Tang
- Yunhu Wan
- Yussanne Ma
- Zachary J. Heins
- Zhenlin Ju
- Zhining Wang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2018
- Field of study
Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate a machine-learning approach to classify aberrant pathway activity in tumors, which may aid in hidden responder identification. The algorithm integrates RNA-seq, copy number, and mutations from 33 different cancer types across The Cancer Genome Atlas (TCGA) PanCanAtlas project to predict aberrant molecular states in tumors. Applied to the Ras pathway, the method detects Ras activation across cancer types and identifies phenocopying variants. The model, trained on human tumors, can predict response to MEK inhibitors in wild-type Ras cell lines. We also present data that suggest that multiple hits in the Ras pathway confer increased Ras activity. The transcriptome is underused in precision oncology and, combined with machine learning, can aid in the identification of hidden responders. : Way et al. develop a machine-learning approach using PanCanAtlas data to detect Ras activation in cancer. Integrating mutation, copy number, and expression data, the authors show that their method detects Ras-activating variants in tumors and sensitivity to MEK inhibitors in cell lines. Keywords: Gene expression, machine learning, Ras, NF1, KRAS, NRAS, HRAS, pan-cancer, TCGA, drug sensitivit
Oncogenic Signaling Pathways in The Cancer Genome Atlas
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGF\u3b2 signaling, p53 and \u3b2-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy. An integrated analysis of genetic alterations in 10 signaling pathways in >9,000 tumors profiled by TCGA highlights significant representation of individual and co-occurring actionable alterations in these pathways, suggesting opportunities for targeted and combination therapies
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
- Author
- A. Gordon Robertson
- Aaron Bossler
- Ad Gillis
- Adam Abeshouse
- Adam Kibel
- Adam R. Metwalli
- Adhemar Longatto-Filho
- Adrian Ally
- Adrian Clipca
- Ady Kendler
- Agostino De Rose
- Ajith Sankarankuty
- Alain Bergeron
- Alain Piché
- Alan H. Bryce
- Alan P. Hoyle
- Alan Pickens
- Albert J. Kovatich
- Ales Vicha
- Alessandro Perin
- Alex Boussioutas
- Alexander J. Lazar
- Alexey Shabunin
- Alexis Sharp
- Alison Kastl
- Amy Chen
- Amy Davis
- Amy H. Perou
- Ana C. de Carvalho
- Ana Maria Angulo Gonzalez
- Andre L. Carvalho
- Andrea Haddad
- Andreas Unterberg
- Andreas von Deimling
- Andrei Malykh
- Andrew Berchuck
- Andrew Burnette
- Andrew D. Cherniack
- Andrew D. Cherniack
- Andrew E. Sloan
- Andrew J. Mungall
- Andrew K. Godwin
- Andrew Spillane
- Angel Arnaout
- Angela Tam
- Angeles Secord
- Angelica Ochoa
- Anil Korkut
- Anil Sood
- Anna Antenucci
- Anne Breggia
- Anne Tsao
- Anne-Marie Mes-Masson
- Anne-Paule Gimenez-Roqueplo
- Antonia Sepulveda
- Antonio Jimeno
- Anuradha Gopalan
- Apurva M. Hegde
- Ardene Noss
- Armando López Guillermo
- Armaz Mariamidze
- Arndt Hartmann
- Arthur Tischler
- Arvind Rao
- Ashley Fehrenbach
- Ashton C. Berger
- Assunta De Rienzo
- Augustin Luna
- Bahavna Kumar
- Barry S. Taylor
- Benito Campos
- Benjamin E. Gross
- Bernard Kohl
- Bernard Têtu
- Bernd Wullich
- Beth Hermes
- Beth Y. Karlan
- Bettina Drake
- Bhuvanesh Singh
- Bianca Pollo
- Bin Feng
- Bita Esmaeli
- Bogdan Czerniak
- Bradley M. Broom
- Brady Bernard
- Brenda Deyarmin
- Brenda Hernandez
- Brenda Rabeno
- Brian Patrick O’Neill
- Brian Van Tine
- Bruce Robinson
- Bui Duc Phu
- Candace Carter
- Candace Shelton
- Carl Morrison
- Carl Simon Shelley
- Carlo Bifulco
- Carlos Gilberto Carlotti Jr.
- Carmen Behrens
- Carol Bradford
- Carol Farver
- Caroline Larson
- Carolyn M. Hutter
- Carrie Cibulskis
- Casey S. Greene
- Cassaundra Shipman
- Catherine Moser
- Cathy Brewer
- Cathy D. Vocke
- Cathy Schilero
- Catrina C. Fronick
- Cesar Moran
- Chad J. Creighton
- Chandra Goparaju
- Chandrajit P. Raut
- Charles Guo
- Charles M. Perou
- Charles N. Landen
- Chase Miller
- Chen Wang
- Cheng Fan
- Chiara Calatozzolo
- Chris Andry
- Chris Sander
- Christel Herold-Mende
- Christin Jungk
- Christina Yau
- Christina Yau
- Christine Stoehr
- Christopher A. Miller
- Christopher Benz
- Christopher Hovens
- Christopher K. Wong
- Christopher Logothetis
- Christopher McPherson
- Christopher W. Seder
- Chu Chen
- Clement Adebamowo
- Colleen Feltmate
- Colleen M. Cebulla
- Corbin D. Jones
- Craig D. Shriver
- Cristovam Scapulatempo-Neto
- Curt H. Hagedorn
- Cyriac Kandoth
- Cyrus Mirsaidi
- D. Neil Hayes
- Daniel Crain
- Daniel Cramer
- Daniel J. Brat
- Daniel J. Weisenberger
- Daniel O. Vidal
- Daniel O’Brien
- Daniel Raymond
- Daniela Tirapelli
- Darell Bigner
- Darlene Lee
- Dave Hoon
- David A. Wheeler
- David A. Wheeler
- David Beer
- David Chesla
- David Huntsman
- David I. Heiman
- David J. Van Den Berg
- David Mallery
- David Nagorney
- David Rice
- Dawid Murawa
- Debra Bell
- Debyani Chakravarty
- Denise Brooks
- Denise Wolf
- Dennis T. Maglinte
- Deqin Ma
- Diana Tcaciuc
- Dina Aziz
- Dirk Schadendorf
- Domenico Alvaro
- Dong M. Shin
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doris M. Rassl
- Doug Voet
- Douglas A. Levine
- Ed Reznik
- Edna M. Mora Pinero
- Elaine R. Mardis
- Electron Kebebew
- Elias Campo
- Elizabeth L. Appelbaum
- Elizabeth R. Duffy
- Elizabeth Swisher
- Ellen C. Zwarthoff
- Eric Baudin
- Eric Chuah
- Eric Lipp
- Eric Thompson
- Erik Castle
- Erik Zmuda
- Erin Curley
- Erwin G. Van Meir
- Eryn M. Godwin
- Esther Korpershoek
- Eugenio Gaudio
- Eva Giné
- Eve Shinbrot
- Eve Shinbrot
- Fadi Brimo
- Fadlo Khuri
- Federico Valdivieso
- Fedor Moiseenko
- Feixiong Cheng
- Felice Giuliante
- Felicia Williams
- Felix Beuschlein
- Fengmei Zhao
- Florencia Que
- Francesco DiMeco
- Francesco Facciolo
- Francis Carey
- Francisco Sanchez-Vega
- Fred Saad
- Funda Meric-Bernstam
- Gabriel Sica
- Gad Getz
- Gaetano Finocchiaro
- Galen F. Gao
- Galen F. Gao
- Galiya Setdikova
- Gavin Ha
- Gene Barnett
- George Manikhas
- George Thomas
- Georgina Long
- Ghenadie Gorincioi
- Gianluca Grazi
- Ginette McKercher
- Glenn Bubley
- Gloria Petersen
- Gordon B. Mills
- Gordon B. Mills
- Gordon Saksena
- Graham Mann
- Gregory P. Way
- Gregory Wolf
- Guido Carpino
- Guido Sauter
- Hai Hu
- Hai Hu
- Hailei Zhang
- Han Liang
- Hani Gabra
- Hanina Hibshoosh
- Hannah Yang
- Hans Stoop
- Haoran Chen
- Harman Sekhon
- HarshaVardhan Doddapaneni
- Hartmut Juhl
- Hartwig Huland
- Harvey Pass
- Heather K. Schmidt
- Heidi J. Sofia
- Helge Taubert
- Henri Timmers
- Henrique C.S. Silveira
- Hikmat Al-Ahmadie
- Hojabr Kakavand
- Hongxin Zhang
- Hongzheng Zhang
- Houtan Noushmehr
- Howard Colman
- Howard G. Rosenthal
- Howard Zaren
- Hui Shen
- Hui Shen
- Huihui Fan
- Huihui Fan
- Huyen Dinh
- Iakovina Alexopoulou
- Ian Forgie
- Ian Yang
- Ignacio Wistuba
- Ilya Shmulevich
- Ilya Shmulevich
- Ina Felau
- Inga Chemencedji
- Ino de Bruijn
- Irina Caraman
- Irina Stancul
- J. Bradley Elder
- J. Leigh Fantacone-Campbell
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Jaffer A. Ajani
- James Catto
- James Lang
- James Luketich
- James Powers
- James Wilmott
- Janae V. Simons
- Jay Bowen
- Jay Engel
- Jean C. Zenklusen
- Jean-Pierre Kocher
- Jeffey Moyer
- Jeffrey A. Borgia
- Jeffrey A. Hooke
- Jeffrey Gershenwald
- Jeffrey J. Olson
- Jeffrey Marks
- Jeffrey Roach
- Jeffry Simko
- Jenette Creaney
- Jennifer Drummond
- Jennifer Eschbacher
- Jennifer Smith
- Jens Waldmann
- Jeremy Parfitt
- Jerome Myers
- Jia Liu
- Jianfang Liu
- Jianhong Hu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jiexin Zhang
- Jill S. Barnholtz-Sloan
- Jing Wang
- Jioajiao Wang
- Jireh Santibanez
- Joan Walker
- Joanna Phillips
- Jodi Harr
- Joe Hilty
- Joel Henderson
- Joel S. Parker
- Johanna Gardner
- John A. Copland
- John A. Demchok
- John A. Martignetti
- John Bartlett
- John Chabot
- John Cheville
- John DiPersio
- John Eckman
- John Houck
- John N. Weinstein
- John N. Weinstein
- John Thompson
- Jolanta Bondaruk
- Jonathan Melamed
- Jonathan Stretch
- Joong-Won Park
- Jordonna Fulop
- Jose Sebastião Dos Santos
- Joseph Bennett
- Joseph Galbraith
- Joseph Paulauskis
- Joshua Armenia
- Joshua M. Stuart
- José H. Fregnani
- Ju Dong Yang
- Judy Miller
- Julia Slotta-Huspenina
- Julian Hess
- Juliann Shih
- Julie M. Gastier-Foster
- Julie Martin
- Jun Li
- June M. Chan
- Jung Il Lee
- Junya Fujimoto
- Juok Cho
- Kalle Leinonen
- Kane Tse
- Karan Rai
- Karel Pacak
- Karen Devine
- Karen Mungall
- Karen Smith-McCune
- Karl-Friedrich Becker
- Karla Kopp
- Katayoon Kasaian
- Katherine A. Hoadley
- Katherine C. Sexton
- Katherine Moxley
- Kathleen Moore
- Kathy Agnew
- Kathy Smolenski
- Keith Delman
- Kelinda Tucker
- Kelly Magliocca
- Kelly Senecal
- Kenneth Lee
- Kerstin Junker
- Kerwin Shannon
- Keunsoo Ahn
- Kevin Lau
- Kevin Roggin
- Ki Chung
- Kim E. van Kessel
- Kimberley Evason
- Kivanc Birsoy
- Klaus-Peter Janssen
- Konnor La
- Koo Jeong Kang
- Kristen M. Leraas
- Kristen Shimmel
- Kwok-Shing Ng
- Kwun M. Fong
- Kyle Chang
- Kyle Covington
- Larsson Omberg
- Laura Jacobus
- Laura Rozek
- Laura S. Schmidt
- Lauren Haydu
- Laurence Desjardins
- Lawrence A. Donehower
- Lawrence A. Donehower
- Laxmi Lolla
- Leendert Looijenga
- Lei Li
- Leigh Anne Zach
- Leonid Kvecher
- Leslie Cope
- Lewis Roberts
- Li Ding
- Li Ding
- Liming Yang
- Linghua Wang
- Linghua Wang
- Lisa Landrum
- Lisa Peterson
- Lisa Scarpace
- Lisa Wise
- Lisle E. Mose
- Liu Xi
- Lizhi Zhang
- Lois Ramondetta
- Lora Lewis
- Louis Lacombe
- Luca Mattei
- Lucia Cuppini
- Lucinda A. Fulton
- Ludmila Danilova
- Lynn Schoenfield
- Maciej Wiznerowicz
- Madhusmita Behera
- Marc Goodman
- Marc Ladanyi
- Marc Moncrieff
- Marc-Henri Stern
- Marco A. Marra
- Margaret Morgan
- Margi Sheth
- Maria Consiglia Bragazzi
- Maria Pirtac
- Maria Synott
- Mario Quintero-Aguilo
- Mark A. Rubin
- Mark Gerken
- Mark Nelson
- Mark Pool
- Mark Prince
- Mark Schiffman
- Mark Sherman
- Markus Graefen
- Marta Aymerich
- Marta Couce
- Martin Fassnacht
- Martin L. Ferguson
- Mary Iacocca
- Mary McGraw
- Massimo Mannelli
- Mathieu Latour
- Matthew Bailey
- Matthew D. Wilkerson
- Matthew G. Cordes
- Matthew G. Soloway
- Matthew H. Bailey
- Matthew L. Anderson
- Matthew Meyerson
- Melanie H. Kucherlapati
- Melissa Stanton
- Melpomeni Kasapi
- Michael Birrer
- Michael Carney
- Michael D. McLellan
- Michael Dubina
- Michael Farnell
- Michael Feldman
- Michael Ittmann
- Michael J. Liptay
- Michael Kendrick
- Michael Knudson
- Michael Mayo
- Michael Miller
- Michael Muto
- Michael Prados
- Michael Quinn
- Michael Rivera
- Michael Ryan
- Michael S. Lawrence
- Michael S. Noble
- Michael T. Zimmermann
- Michael Torbenson
- Michelle Bellair
- Mikhail Dinkin
- Mikhail Tavobilov
- Min Wang
- Mircea Cernat
- Mirella Marino
- Miruna Balasundaram
- Mitesh Borad
- Mohamed H. Abdel-Rahman
- Mohammed Milhem
- Moiz S. Bootwalla
- Monique Albert
- Moriah G. Nissan
- Mostafa Karimi
- Myron Peto
- Nasra Giama
- Natalia Botnariuc
- Nathan A. Pennell
- Natália D. Aredes
- Neil Horowitz
- Nguyen Phi Hung
- Nguyen Van Bang
- Nguyen Viet Tien
- Niall Corcoran
- Nicholas Hayward
- Nicolas Girard
- Nicolas Wentzensen
- Nikolaus Schultz
- Nils Gehlenborg
- Nilsa C. Ramirez
- Nina Thiessen
- Noreen Dhalla
- Norman L. Lehman
- Nyasha Chambwe
- Nyasha Chambwe
- Odette Mariani
- Olga Potapova
- Olga Voronina
- Oliver Bathe
- Oluwole Olabode
- Oxana Paklina
- Pat Glenn
- Patricia D. Castro
- Patricia Swanson
- Patricia Troncoso
- Paul Drwiega
- Paul Hansen
- Paul Spellman
- Paul Wakely
- Pavana Anur
- Pawadee Lohavanichbutr
- Payal Sipahimalani
- Peggy Yena
- Pei Lin
- Peilin Jia
- Peter A. Pinto
- Peter Hersey
- Peter R. Carroll
- Peter R. Dottino
- Peter W. Laird
- Peter W. Laird
- Peter Westervelt
- Phan Thi Hanh
- Pheroze Tamboli
- Philip Disaia
- Phillip H. Lai
- Phuong Nguyen
- Pierre Tennstedt
- Piotr A. Mieczkowski
- Pora Kim
- Praveen Nair
- Qiang Sun
- Quinn T. Ostrom
- R. Houston Thompson
- Rafael Kemp
- Raina Tamakawa
- Rajiv Dhir
- Raju S. Kucherlapati
- Ramaswamy Govindan
- Rameen Beroukhim
- Randy Mandt
- Raphael Bueno
- Rashi Naresh
- Rashna Madan
- Rayleen Bowman
- Raymond J. Monnat Jr.
- Reanne Bowlby
- Rebecca Carlsen
- Rebecca Duell
- Rehan Akbani
- Rehan Akbani
- Renumathy Dhanasekaran
- Richard A. Gibbs
- Richard A. Moore
- Richard J. Mural
- Richard K. Wilson
- Richard Kefford
- Richard Scolyer
- Richard Thorp
- Rita Sigmund
- Ritika Kundra
- Robert C. Rintoul
- Robert Glenn
- Robert Holt
- Robert Korst
- Robert Mannel
- Robert Penny
- Robert Pilarski
- Robert S. Fulton
- Robert Sheridan
- Robert Smallridge
- Robert Stoehr
- Robert Worrell
- Roberta Merola
- Robin K. Kelley
- Robyn Saw
- Roger Kramer
- Roger McLendon
- Ronald de Krijger
- Ronald Ghossein
- Ronald Lechan
- Ronald Simon
- Ronald Warnick
- Rosemary Zuna
- Ross Berkowitz
- Rosy Singh
- Roy Tarnuzzer
- Rui M. Reis
- Rupa S. Kanchi
- Russel Postier
- Russell Broaddus
- Ruth Steele
- S. Onur Sumer
- Sabina Signoretti
- Saianand Balu
- Sally N. Adebamowo
- Sam Meier
- Samantha J. Caesar-Johnson
- Samuel Singer
- Sandra Cottingham
- Sandra Lee
- Sara Kendall
- Sara Sadeghi
- Sarah M. Phillips
- Scott Frazer
- Scott Morris
- Scott VandenBerg
- Sebastien Gilbert
- Serghei Doruc
- Serghei Stepa
- Sergio Roman-Roman
- Sergiu Mura
- Seth Force
- Shannon McCall
- Shaojun Zhang
- Shaowu Meng
- Sharon Heath
- Sheila Reynolds
- Shishir Maithel
- Shiyun Ling
- Sima Porten
- Simone Chevalier
- Stacey B. Gabriel
- Stefania Cuzzubbo
- Stella Somiari
- Stephen Baylin
- Steven E. Schumacher
- Steven J.M. Jones
- Steven Kalkanis
- Stuart R. Jefferys
- Sudha Chudamani
- Sue Bell
- Suresh Ramalingam
- Susan M. Staugaitis
- Suzanne Sifri
- Sven Wach
- Sylvia L. Asa
- Tao Su
- Taofeek Owonikoko
- Tara M. Lichtenberg
- Tara Skelly
- Teniola Akeredolu
- Thai Ho
- Theo A. Knijnenburg
- Theo Knijnenburg
- Theresa Naska
- Therese Bocklage
- Thomas Broudy
- Thomas Carey
- Thomas Flotte
- Thomas Giordano
- Thomas Smyrk
- Thorsten Schlomm
- Timothy A. Chan
- Timothy DeFreitas
- Timothy Ley
- Timothy Thompson
- Timothy Wang
- Tina Knutson
- Tina Wong
- Todd Pihl
- Tom Bodenheimer
- Tom Mikkelsen
- Tomas Zelinka
- Tony Costello
- Toshinori Hinoue
- Troy Shelton
- Tushar Patel
- Umadevi Veluvolu
- Valerie Jakrot
- Varsha Dhankani
- Vesteinn Thorsson
- Victor Reuter
- Viktoriya Korchina
- Vincenzo Cardinale
- Vishal Chandan
- Vladimir Lyadov
- W. Jeffrey Edenfield
- W. Kimryn Rathmell
- W. Marston Linehan
- Walid K. Chatila
- Walker Hale
- Walter Urba
- Wanding Zhou
- Wei Li
- Wei Zhang
- Wenbin Liu
- Wendi Barrett
- Wil Eijckenboom
- William E. Grizzle
- William G. Richards
- Witold Kycler
- Wolter Oosterhuis
- Xavier Sastre
- Xiuping Liu
- Xuan Le
- Yan Shi
- Yang Shen
- Ye Wu
- Yi Han
- Yichao Sun
- Yiling Lu
- Yingli Wolinsky
- Yonghong Xiao
- Yuexin Liu
- Yuexin Liu
- Yufang Tang
- Yunhu Wan
- Yussanne Ma
- Zachary J. Heins
- Zhenlin Ju
- Zhining Wang
- Zhongming Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2018
- Field of study
Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein structure-based analyses allowed us to predict functional consequences of rare, recurrent DDR mutations. A new machine-learning-based classifier developed from gene expression data allowed us to identify alterations that phenocopy deleterious TP53 mutations. These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy. : Knijnenburg et al. present The Cancer Genome Atlas (TCGA) Pan-Cancer analysis of DNA damage repair (DDR) deficiency in cancer. They use integrative genomic and molecular analyses to identify frequent DDR alterations across 33 cancer types, correlate gene- and pathway-level alterations with genome-wide measures of genome instability and impaired function, and demonstrate the prognostic utility of DDR deficiency scores. Keywords: The Cancer Genome Atlas PanCanAtlas project, DNA damage repair, somatic mutations, somatic copy-number alterations, epigenetic silencing, DNA damage footprints, mutational signatures, integrative statistical analysis, protein structure analysi