Acupuncture for sleep quality, BDNF levels and immunosenescence: A randomized controlled study

AbstractPoor sleep in elderly populations is associated with detrimental neuropsychological, and physiological changes including premature immunosenescence and reduced brain derived neurotrophic factor (BDNF). Here, we evaluated the effects of acupuncture on sleep quality, psychological distress and immunosenescence in elderly, as well as effects on BDNF levels. Forty-eight community-dwelling elderly were randomized into true or placebo acupuncture, and intervention consisted of ten sessions. Sleep quality, depression and stress scores were evaluated by the Pittsburgh sleep quality index (PSQI), beck depression inventory (BDI II) and perceived stress scale (PSS), respectively, before and after the intervention. Lymphocyte subsets commonly associated with stress, sleep impairment and immunosenescence were phenotyped by flow cytometry. BDNF plasma levels were assessed by ELISAs. Acupuncture was highly effective for improving sleep quality (−53.23%; p<0.01), depression (−48.41%; p<0.01), and stress (−25.46%; p<0.01). However, neither lymphocyte subpopulations nor BDNF levels changed following the intervention

CMS Physics Technical Design Report: Addendum on High Density QCD with Heavy Ions

This report presents the capabilities of the CMS experiment to explore the rich heavy-ion physics programme offered by the CERN Large Hadron Collider (LHC). The collisions of lead nuclei at energies $\sqrt{s_{NN}}= 5.5\,{\rm TeV}$ , will probe quark and gluon matter at unprecedented values of energy density. The prime goal of this research is to study the fundamental theory of the strong interaction \u2014 Quantum Chromodynamics (QCD) \u2014 in extreme conditions of temperature, density and parton momentum fraction (low- x ). This report covers in detail the potential of CMS to carry out a series of representative Pb-Pb measurements. These include "bulk" observables, (charged hadron multiplicity, low p T inclusive hadron identified spectra and elliptic flow) which provide information on the collective properties of the system, as well as perturbative probes such as quarkonia, heavy-quarks, jets and high p T hadrons which yield "tomographic" information of the hottest and densest phases of the reaction