175 research outputs found
The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbA1c levels: an observational cross-sectional study
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Functional Remineralization of Dentin Lesions Using Polymer-Induced Liquid-Precursor Process
- Author
- A Dominicus
- AJ van Strijp
- Anora K. Burwell
- F Nudelman
- FD Nascimento
- FR Tay
- Grayson W. Marshall
- GW Marshall
- GW Marshall
- J Kim
- JH Kinney
- Jing Cheng
- JM McIntyre
- JM ten Cate
- JM ten Cate
- JM White
- L Dai
- L Zheng
- Laurie B. Gower
- LB Gower
- LB Gower
- LE Bertassoni
- LE Bertassoni
- LE Bertassoni
- M Balooch
- M Balooch
- M Sulkala
- Michael Glogauer
- Michael Kurylo
- MJ Olszta
- MJ Olszta
- MJ Olszta
- MK Pugach
- Nancy F. Cheng
- S Mai
- S Martin-De Las Heras
- Sally J. Marshall
- SP Ho
- SS Jee
- Stefan Habeliz
- Stuart A. Gansky
- Sunita P. Ho
- T Thula-Mata
- Taili Thula-Mata
- TT Thula
- W Guo
- Y Nishitani
- YK Kim
- Yung-Ching Chien
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
It was hypothesized that applying the polymer-induced liquid-precursor (PILP) system to artificial lesions would result in time-dependent functional remineralization of carious dentin lesions that restores the mechanical properties of demineralized dentin matrix. 140 Âľm deep artificial caries lesions were remineralized via the PILP process for 7â28 days at 37°C to determine temporal remineralization characteristics. Poly-L-aspartic acid (27 KDa) was used as the polymeric process-directing agent and was added to the remineralization solution at a calcium-to-phosphate ratio of 2.14 (mol/mol). Nanomechanical properties of hydrated artificial lesions had a low reduced elastic modulus (ERâ=â0.2 GPa) region extending about 70 Îźm into the lesion, with a sloped region to about 140 Îźm where values reached normal dentin (18â20 GPa). After 7 days specimens recovered mechanical properties in the sloped region by 51% compared to the artificial lesion. Between 7â14 days, recovery of the outer portion of the lesion continued to a level of about 10 GPa with 74% improvement. 28 days of PILP mineralization resulted in 91% improvement of ER compared to the artificial lesion. These differences were statistically significant as determined from change-point diagrams. Mineral profiles determined by micro x-ray computed tomography were shallower than those determined by nanoindentation, and showed similar changes over time, but full mineral recovery occurred after 14 days in both the outer and sloped portions of the lesion. Scanning electron microscopy and energy dispersive x-ray analysis showed similar morphologies that were distinct from normal dentin with a clear line of demarcation between the outer and sloped portions of the lesion. Transmission electron microscopy and selected area electron diffraction showed that the starting lesions contained some residual mineral in the outer portions, which exhibited poor crystallinity. During remineralization, intrafibrillar mineral increased and crystallinity improved with intrafibrillar mineral exhibiting the orientation found in normal dentin or bone
Efficient QR-Based Multi-Mode Precoding for Limited Feedback Multi-User MIMO Systems
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
TD-60 links RalA GTPase function to the CPC in mitosis
- Author
- A Ehrhardt
- A Gerondopoulos
- A Linford
- AE Kelly
- B Xu
- C Mollinari
- CA Cooke
- DF Kashatus
- DF Kashatus
- DF Kashatus
- EM van Dam
- F Wang
- F Yang
- FR Bischoff
- FR Bischoff
- G Dobrynin
- G Vader
- H Horiuchi
- H Saitoh
- I Cascone
- I Sumara
- IM Cheeseman
- IM Cheeseman
- J Dai
- J Rendleman
- JC Wu
- JD Humphries
- JG Deluca
- JP Welburn
- KF DeLuca
- KH Lim
- L Kabeche
- LA Kelley
- LR Gentry
- M Carmena
- M Li
- M Yenjerla
- MA Lampson
- P Chardin
- P Kalab
- P Kalab
- PR Andreassen
- PR Grigera
- R Gassmann
- R Honda
- RE Carazo-Salas
- RK Tyler
- RM Ewing
- RN Bastos
- RR Adams
- RR Adams
- S Hashimoto
- S Moskalenko
- S Ohta
- S Yoshimura
- SA Forbes
- SC Sampath
- SE Rosasco-Nitcher
- T Seki
- TU Mayer
- TU Tanaka
- W Moore
- W Wallace
- WC Earnshaw
- XW Chen
- Y Chien
- Y Yamagishi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/07/2015
- Field of study
TD-60 (also known as RCC2) is a highly conserved protein that structurally resembles the Ran guanine exchange factor (GEF) RCC1, but has not previously been shown to have GEF activity. TD-60 has a typical chromosomal passenger complex (CPC) distribution in mitotic cells, but associates with integrin complexes and is involved in cell motility during interphase. Here we show that TD-60 exhibits GEF activity, in vitro and in cells, for the small GTPase RalA. TD-60 or RalA depletion causes spindle abnormalities in prometaphase associated with abnormal centromeric accumulation of CPC components. TD-60 and RalA apparently work together to contribute to the regulation of kinetochoreâmicrotubule interactions in early mitosis. Importantly, several mitotic phenotypes caused by TD-60 depletion are reverted by the expression of a GTP-locked mutant, RalA (Q72L). The demonstration that a small GTPase participates in the regulation of the CPC reveals a level of mitotic regulation not suspected in previous studies
CMS Data Processing Workflows during an Extended Cosmic Ray Run
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- Afaq MA
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- Aguilar-Benitez M
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- Akgun B
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- Akin IV
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- Antunes JR
- Antunovic Z
- Apanasevich L
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- Apresyan A
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- Arcidiacono R
- Arenton MW
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- Argiro S
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- Ashby S
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- Autermann C
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- Avetisyan A
- Avila C
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- Clemente A
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- Clerbaux B
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- Cockerill DJA
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
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- Alberdi J
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- Alidra M
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- Altenhofer G
- Altsybeev I
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- Alves GA
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- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
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- Andreev V
- Andreev Y
- Anghel IM
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Pan-cancer analysis of whole genomes
- Author
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Wright A. J. k
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- xv Luxton
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- xy Visakorpi
- xz Whitaker
- Y. -E. ot
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- Y. S. jf
- Y. uz
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- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
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- z ah
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- zd Gershenwald
- Zenklusen
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- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
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- Zou
- Zou
- zt Kim
- zw Lewis
- Ă. A. th
- Ă. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the KrĂźppel-associated box zinc finger protein family
- Author
- A Allouch
- A Corsinotti
- A Gupta
- A Hata
- A Hoffmann
- A Lupo
- A Paiva
- A Pelisson
- A Weng
- AA Aravin
- AB Conley
- AC Groner
- AF Smit
- AT Conroy
- AT Hamilton
- AV Persikov
- B Bodega
- B Lamprecht
- C Feschotte
- C Jolly
- C Lavialle
- C Mouse Genome Sequencing
- CB Lowe
- CE Gilling
- CE Grant
- CJ Cohen
- CJ Krebs
- CJ Krebs
- CJ Krebs
- CL Baker
- CP Walsh
- D Brinzevich
- D Ivanov
- D Schmidt
- D Wolf
- D Wolf
- D Wolf
- DC Hancks
- DC Leung
- DC Schultz
- DC Schultz
- DJ Mackay
- DJ Segal
- DR Nelson
- DS Johnson
- E Barklis
- EB Chuong
- ED Parvanov
- EJ Bellefroid
- EJ Grow
- EJ Yu
- ES Lander
- F Baudat
- F Fuks
- F Loreni
- FH Gage
- FM Jacobs
- FR Santoni de Sio
- G Coop
- G Guffanti
- G Kassiotis
- G Meroni
- G St Laurent 3rd
- G Wolf
- G Wolf
- H Kono
- H Liu
- H Nakahashi
- H Nishitsuji
- H Nishitsuji
- H OâGeen
- H Peng
- HA Michaud
- HC Chien
- HE Volkman
- HM Rowe
- HM Rowe
- HM Rowe
- HM Rowe
- HR Chung
- HS Najafabadi
- HS Rhee
- I Barde
- I Barde
- I Katoh
- I Lupan
- IA Maksakova
- IA Tchasovnikarova
- IL Berg
- J Hauschild-Quintern
- J Wang
- J Yun
- JA Law
- JA Plamondon
- JA Yoder
- JB Stavenhagen
- JF Margolin
- JG Mandell
- JH Thomas
- JH Thomas
- JH Thomas
- JJ Schwartz
- JL Buescher
- JR Friedman
- K Bojkowska
- K Nowick
- K Nowick
- K Okumura
- K Padjen
- K Saito
- K Tamura
- KA Carlson
- KA Carlson
- KJ Brayer
- KJ Brayer
- L Carbone
- L Carbone
- L Fasching
- L Reynolds
- L Robbez-Masson
- L Segurel
- L Shen
- LF Lin
- M Cowley
- M Horiba
- M Manghera
- M Ohnuki
- M Wiznerowicz
- M Worobey
- MA Carmell
- MA Hahn
- MC Marchetto
- MF Flajnik
- MJ Gonzalez-Hernandez
- MJ Vogel
- MM Karimi
- MS Lechner
- MT Reilly
- N Castro-Diaz
- NP Pavletich
- NP Pavletich
- O Mihola
- P Aiewsakun
- P Engler
- P Turelli
- PA Dumesic
- PJ Thompson
- PL Collins
- PL Oliver
- Q He
- R Cordaux
- R Jaenisch
- R Mahieux
- R Rizkallah
- R Strogantsev
- R Urrutia
- RC Edgar
- RJ Gifford
- RL Kingston
- RO Emerson
- RO Emerson
- S De Fazio
- S Frietze
- S Frietze
- S Furuta
- S Huntley
- S Iuchi
- S Lukic
- S Myers
- S Myers
- S Quenneville
- S Ratnam
- S Wissing
- S Yamanaka
- SE Ptak
- SH Lockwood
- SR Eberhardy
- SS Rao
- SY Yeo
- T Billings
- T Collins
- T Ishiuchi
- T Kleefstra
- T Matsui
- TP Loh
- TS Macfarlan
- TS Mikkelsen
- U Beyer
- UE Kalsoom
- V Sundaram
- VJ Lynch
- W Nietfeld
- W Winckler
- WD Gifford
- X Li
- X Tan
- Y Liu
- YK Lee
- Z Birtle
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Commissioning of the CMS high-level trigger with cosmic rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
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- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
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- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
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- Amaglobeli N
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- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
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- Andreev V
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- Anghel IM
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- Auffray E
- Aurisano A
- Autermann C
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- Avetisyan A
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- Cline D
- CMS Collaboration
- Cockerill DJA
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- Crotty I
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- Vitulo P
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- Vlasov E
- Vlimant JR
- Vodopiyanov I
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- Volkov A
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- Volyanskyy D
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- Yi K
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- Yoon AS
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- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
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- Zeidler C
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- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
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- Zheng Y
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
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