929584 research outputs found

    Circular Statistics

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    Python code for the execution of the Rayleigh Test and Hermans-Rasson Test, along with the code for bootstrapping simulation is included here. These codes can be used for assessing non-random phenologies when marginal totals characterize experimental designs.Citation: Willig M., Rojas-Sandoval J., and Presley S. 2023.</p

    Validation and comprehensive analysis ofStreptococcus pneumoniae IgG WHOenzyme linked immunosorbent assay in anIndian reference laboratory: supplementary data

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    Monitoring serotype-specific IgG levels against pneumococci is crucial for assessing immunity, vaccineefficacy, and evaluating vaccination programs. The WHO ELISA for pneumococci is a standardized assayensuring consistency in testing and comparability of results across laboratories. It involves a rigoroustesting process to confirm accurate, precise, and reliable detection of antibodies. We validated theprotocol for 13 pneumococcal serotypes by assessing its specificity, reproducibility (coefficient of variation≤15%), repeatability (coefficient of variation ≤20%) , accuracy, lower limit of quantification, stability,and robustness. We found these parameters were within acceptable ranges and showed excellentperformance. Our findings imply that the method employed is appropriate for evaluating 13 valentpneumococcal conjugate vaccine which is introduced in the national immunization program by comparingpre-and post-vaccination IgG response.</p


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    Supplementary Material for: Prolonged Button Battery Exposure Leading to Severe Ocular Injury Without Heavy Metal Poisoning

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    Introduction Prolonged exposure to a complete button battery can cause severe tissue necrosis in the eye and permanent impairment of visual function. The main mechanism of injury is the current generated by the hydrolysis of tissue fluid at the negative electrode and the production of hydroxide ions. Case Presentation A 3-year-old girl,went to the local hospital because of swelling and pain in her right eye of 12 hours’ duration. The local doctor performed an orbital CT(Computer Tomography)scan and found a foreign body between the right eyelid and the eyeball. The foreign body was removed immediately under general anesthesia. And it was found that the foreign body was a button battery, but it prolonged 39 hours from the onset of the child’s symptoms. The child underwent a second operation in our hospital and receiving amniotic membrane transplantation combined with conjunctival flap coverage. Topical corticosteroid and antibiotic eye ointment was continue for 3 months after surgery. Local Pigmentation was seen, no symblepharon, but the cornea was still opaque and the visual acuity was only FC(Finger Count). In this particular case, heavy metal testing conducted on the child's blood fortunately revealed that the levels were within the normal range. Conclusion Early detection and urgent removal of button battery is crucial in order to minimise exposure time. We should also be concerned about heavy metals in the blood.Children should be kept away from button batteries as much as possible to avoid such injury

    sj-docx-1-ctj-10.1177_17407745231225618 – Supplemental material for The use of linked administrative data in Australian randomised controlled trials: A scoping review

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    Supplemental material, sj-docx-1-ctj-10.1177_17407745231225618 for The use of linked administrative data in Australian randomised controlled trials: A scoping review by Salma Fahridin, Neeru Agarwal, Karen Bracken, Stephen Law and Rachael L Morton in Clinical Trials</p

    sj-docx-1-pec-10.1177_03010066231224557 - Supplemental material for Crossmodal associations between naturally occurring tactile and sound textures

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    Supplemental material, sj-docx-1-pec-10.1177_03010066231224557 for Crossmodal associations between naturally occurring tactile and sound textures by Vanalata Bulusu and Leslee Lazar in Perception</p

    Hematoxylin and eosin (HE) staining

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    Cross-sections of the gastrocnemius (a-h) and soleus (i-p) muscles were stained with HE. Arrowheads indicate spikes and lakes in cytoplasm (e-h). Scale bar = 50 μm. GAS, gastrocnemius muscle; SOL, soleus muscle; 3M, 3-month-old mice; 24M, 24-month-old mice.</p

    Bathymetry in April 1999.srf

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    Bathymetry in the inner Hangzhou Bay in April 1999.</p

    Extending the Scope of Conceptual Density Functional Theory with Second Order Analytical Methodologies

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    In the context of the growing impact of conceptual density functional theory (DFT) as one of the most successful chemical reactivity theories, response functions up to second order have now been widely applied; in recent years, among others, particular attention has been focused on the linear response function and also extensions to higher order have been put forward. As the larger part of these studies have been carried using a finite difference approach to compute these concepts, we now embarked on (an extension of) an analytical approach to conceptual DFT. With the ultimate aim of providing a complete set of analytically computable second order properties, including the softness and hardness kernels, the hardness as the simplest second order response function is scrutinized again with numerical results highlighting the difference in nature between the analytical hardness (referred to as hardness condition) and the Parr-Pearson absolute chemical hardness. The hardness condition is investigated for its capability to gauge the (de)localization error of density functional approximations (DFAs). The analytical Fukui function, besides overcoming the difficulties in the finite difference approach in treating negatively charged systems, also showcases the errors of deviating from the straight-line behavior using fractional occupation number calculations. Subsequently, the softness kernel and its atom-condensed inverse, the hardness matrix, are accessed through the Berkowitz-Parr relation. Revisiting the softness kernel confirms and extends previous discussions on how Kohn’s Nearsightedness of Electronic Matter principle can be retrieved and identified as the physicist’s version of the chemist’s “transferability of functional groups” concept. The accurate, analytical hardness matrix evaluation on the other hand provides further support for the basics of Nalewajski’s charge sensitivity analysis. Based on Parr and Liu’s functional expansion of the energy functional, a new energy decomposition is introduced with an order of magnitude analysis of the different terms for a series of simple molecules both at their equilibrium geometry and upon variation in bond length and dihedral angle. Finally, for the first time, the perturbation expansion of the energy functional is studied numerically up to second order now that all response functions and integration techniques are at hand. The perturbation expansion energies are in excellent agreement with those obtained directly from DFA calculations giving confidence in the convergence of the perturbation series and its use in judging the importance of the different terms in reactivity investigations


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