14 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani O.
- Abbas A.
- Abbas F.
- Abbas M.
- Abbasi S.
- Abbass H.
- Abbott A.
- Abdallah N.
- Abdelaziz A.
- Abdelfattah M.
- Abdelqader B.
- Abdo D.
- Abdul Rasheed A.
- Abdul B.
- Abdul-Kadir R.
- Abdul-Raheem R.
- Abdulakeem A.
- Abdulle A.
- Abdulmumeen A.
- Abdulshukkoor N.
- Abdusamad K.
- Abed El Khaleq Y.
- Abedalla M.
- Abeer Ul Amna A.U.A.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 29/05/2021
- Field of study
Background:
Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
Findings:
Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79).
Interpretation:
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
El problema regulatorio en la distribuciin gassfera colombiana (The Regulatory Problem in the Colombian's Gas Distribution)
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Thigh-length compression stockings and DVT after stroke
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- Waller R
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- Wang N
- Wang R
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- Ward E
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- Warden S Andrew
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- Warmington J
- Warner B
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- Watchorn HJ
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- Watkins L
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- Watson E
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- Weatherly N
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- Weerasinghe T
- Weeratunga J
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- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Schools can improve motivational quality: Profile transitions across early foreign language learning experiences
- Author
- A Bandura
- A Zusho
- AO Hayenga
- B Soenens
- Bureau of Labor Statistics
- C Senécal
- CC Lewis
- CF Ratelle
- CKJ Wang
- E Lehtinen
- E Skinner
- EL Deci
- EM Furtak
- G Schwartz
- H Akaike
- H Jang
- H Jang
- H Jang
- H Jang
- H Sakai
- H Yamauchi
- J Chanal
- J Ciarrochi
- J Howard
- J Magidson
- J Meece
- J Reeve
- JCK Wang
- JH Corpus
- JL Schafer
- JM Carreira
- JS Eccles
- K Nylund-Gibson
- KA Moore
- KL Nylund
- LK Fryer
- LK Fryer
- LM Graves
- Luke K. Fryer
- M Covington
- M Toyama
- M Vansteenkiste
- M Vansteenkiste
- M Vansteenkiste
- MS McEown
- N Gillet
- Organisation for Economic Co-operation and Development (OECD)
- P Cave
- PA Alexander
- PL Hardré
- Q Vuong
- R Berwick
- R Koizumi
- R Langeheine
- RB Kline
- RF Devellis
- RM Ryan
- RM Ryan
- RM Ryan
- RM Ryan
- S Iyengar
- SV Wormington
- T Hiromori
- W. L. Quint Oga-Baldwin
- WLQ Oga-Baldwin
- WLQ Oga-Baldwin
- WLQ Oga-Baldwin
- WLQ Oga-Baldwin
- WS Grolnick
- Y Lo
- YG Butler
- Z Dörnyei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Trade, FDI and Migration
- Author
- A Dixit
- A J Venables
- A K Dixit
- A Saiz
- B Ohlin
- D D Purvis
- D Puga
- E Heckscher
- F Candau
- F Candau
- F Candau
- F Candau
- Fabien Candau
- G Ottaviano
- H Flam
- H Helpman
- J D Reitzes
- J R Markusen
- K Behrens
- K Degen
- L Gonzalez
- M C Kemp
- M Fujita
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- M P ?�ger
- M P ?�ger
- P Krugman
- P Krugman
- P Krugman
- P Martin
- P Neary
- R A Mundell
- R Baldwin
- R Borck
- R E Baldwin
- R E Cave
- R Feenstra
- R Forslid
- R W Jones
- R W Jones
- S Redding
- S Russek
- Simon J Evenett
- T J Hatton
- T Tabuchi
- T Tabuchi
- Tabuchi
- W Alonso
- Y Murata
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Optimal Pandemic Control: Limited Resource and Human Mobility
- Author
- A Atkeson
- A Charpentier
- B Tang
- B Xu
- C Hou
- C J Jones
- C Lef�vre
- D L Martinez
- D O&apos
- D W Berger
- E Hansen
- E Tognotti
- F Brauer
- F E Alvarez
- F Piguillem
- F Zhou
- G Fabbri
- H Fang
- H Seno
- H Tian
- H W Hethcote
- H W Hethcote
- J Cave
- J Cui
- J G Aunins
- J Lee
- J S Jia
- J T Wu
- L A Rvachev
- L Roques
- L Sattenspiel
- L Sattenspiel
- L Sattenspiel
- M C Read
- M Chinazzi
- M Dewatripont
- M Gatto
- M J Keeling
- M J Osborne
- M S Eichenbaum
- M U Kraemer
- N Ferguson
- N Halder
- N M Ferguson
- O Diekmann
- P Bajardi
- P Morris
- P Van Den Driessche
- P Van Den Driessche
- Q Wang
- R Baldwin
- R Boucekkine
- R Boucekkine
- R Boucekkine
- R Djidjou-Demasse
- R E Hall
- R Feng
- R J Barro
- R M Anderson
- S Ai
- S Devi
- S Lai
- S P Adhikari
- T D Hollingsworth
- T Duke
- V Charu
- W T Siow
- W Wang
- W Wang
- Wentao Hu
- X Sun
- Y Nakata
- Y Shi
- Y Takeuchi
- Yufeng Shi
- Ze Chen
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Natural philosophy and the ‘new science’
- Author
- Abbé
- Adolph
- Aguzzi Barbagli
- Aguzzi-Barbagli
- Alberti
- Alberti
- Alberti
- Alberti
- Alciato
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- Alighieri
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- Allen
- Allen
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- Aristotle
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- Arnauld
- Asch
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- Aubigné
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- Baldwin
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- Bentley
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- Borinski
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- Bovelles
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- Turolla
- Tyard
- Ulivi
- Vadianus
- Vaganay
- Valincour
- Valincour
- Valla
- Valla
- Valla
- Valla
- Valla
- Valla
- Varchi
- Vasoli
- Vasoli
- Vasoli
- Vasoli
- Vasoli
- Vaugelas
- Vauquelin de la Fresnaye
- Vellutello
- Verepaeus
- Vesalius
- Viala
- Vickers
- Vida
- Vida
- Vigneulles
- Villey
- Villey
- Villiers
- Viperano
- Vives
- Vives
- Vives
- Vives
- Vives
- Voltz
- Vondel
- Vossius
- Wadsworth
- Walker
- Walker
- Waller
- Warden
- Webbe
- Webbe
- Webbe
- Weddige
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Wencelius
- Wencelius
- Wheeler
- Whigham
- White
- Wilkins
- Wilkins
- Williamson
- Willichius
- Wilson
- Wilson
- Wilson
- Wilson
- Wind
- Wither
- Witherspoon
- Witt
- Wittgenstein
- Wooton
- Workman
- Wutenow
- Yates
- Zappala
- Zarlino
- Zeeberg
- Zesen
- Zobermann
- Zuber
- Zumthor
- Zumthor
- Zumthor
- Zwicker
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/1999
- Field of study
Analysis of the Legal Basis for Establishing the Property Tax in the International Context
- Author
- A A Alchian
- A A Skaar
- A Ashta
- A Berliri
- A Estella De Noriega
- A Fedele
- A Fedele
- A Frye
- A Gorret
- A Hudson
- A L Bovenberg
- A Lymer
- A Miller
- Ali �oban
- B J M Terra
- C Belluzzi
- C Belluzzi
- C M Radaelli
- C M Tiebout
- C U G L Schmitt
- D Campbell
- D Harris
- D M Weber
- D Netzer
- Di Pietro
- E Abery
- E De Mita
- E Graziani
- E Nier
- E Reimer
- E Robert
- F Arcieri
- F Boschini
- F H M Grapperhaus
- F Hammer
- G &
- G Falsitta
- G Falsitta
- G Fuhrich
- G J Vossestein
- H C Yourow
- H Schulze
- J C Bonbright
- J Donnelly
- J Donnelly
- J Fox
- J H Malme
- J J Cordes
- J M Youngman
- J Mertens
- J R Piza
- J Sasseville
- J Youngman
- K Tipke
- L G�rard
- L Kov�cs
- L Sermet
- Le Gall
- M A Desai
- M Badr
- M Daradkeh
- M E Scoppio
- M Greggi
- M Greggi
- M Greggi
- M Ishay
- M Lang
- M Miccinesi
- M Taccolini
- Marco Greggi
- Md: The Frederick
- N Fiorita
- P Alston
- P Baker
- P Baker
- P E Soos
- P Halsall
- P Marchessou
- P Pistone
- P Pistone
- R Almy
- R Altshler
- R Altshuler
- R Borck
- R C Cave
- R E Baldwin
- R Ergec
- R M Bird
- R M Bird
- R M Dworkin
- R S Avi-Yonah
- S Besson
- S Claessens
- S Cnossen
- S Cnossen
- S Eden
- S Evenett
- S H Banzhaf
- S Legg
- S Schulmeister
- T R G V Banning
- W A Fischel
- W E Oates
- W Mccluskey
- Y Brauner
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study