70 research outputs found
The role of trauma team activation by emergency physicians on outcomes in severe trauma patients
- Publication venue
- Published by Elsevier B.V.
- Publication date
- 31/03/2014
- Field of study
AbstractBackgroundIn our region, trauma team activation (TTA) is initiated by emergency physicians once an injured patient meets any of the criteria of TTA after the injured patient arrives at the emergency department (ED).PurposeTo evaluate the role of TTA on outcomes in patients with severe trauma.MethodsAll trauma patients who had injury severity score (ISS) >15 and were admitted from ED between January 2010 to December 2010 were included in the study. MannâWhitney U test (non-normal distribution) or Student's t test (normal distribution) for continuous variables and Fisher exact test or Chi-square test for categorical variables were used to compare the statistically significant differences between TTA and non-TTA groups. Logistic regression was applied to determine any significant differences found in the statistical analysis for 30-day mortality.ResultsA total of 231 patients were signed up in the study. The TTA group had shorter time from ED to operation room (170 minutes vs. 534 minutes, p = 0.02) and tended to have more emergent operations (42.7% vs. 23.2%, p = 0.002). Emergent operation [odds ratio (OR), 0.34; 95% confidence interval (CI), 0.12â0.92, p = 0.035) was associated with lower mortality while ISS > 25 (OR, 7.48; 95% CI, 2.48â22.57, p < 0.0001), Glasgow coma scale score <13 (OR, 32.1; 95% CI, 4.30â94.6, p < 0.0001), hypotension (OR, 3.0; 95% CI, 1.1â7.9, p = 0.03), and coagulopathy (OR, 9.3; 95% CI, 1.2â71.4, p = 0.033) were associated with higher mortality.ConclusionThis study shows that TTA may shorten the time from ED to operation room in trauma patients with an ISS > 15
The Infection of Chicken Tracheal Epithelial Cells with a H6N1 Avian Influenza Virus
- Author
- A Buschiazzo
- A Gambaryan
- A Vines
- AS Gambaryan
- AS Gambaryan
- Ching-Ho Wang
- Ching-I Shen
- CI Shen
- CI Thompson
- CN Hsu
- CW Naeve
- CW Wang
- D Cavanagh
- E Nobusawa
- EC Brinkman-Van der Linden
- EC Claas
- G Lamblin
- GN Rogers
- H Wan
- Hong-Lin Su
- Hsiu-Chin Lee
- IP Mo
- Jiunn-Wang Liao
- JM Nicholls
- JM Nicholls
- JN Couceiro
- K Viswanathan
- KU Hong
- KU Hong
- L Glaser
- M Kesimer
- M Matrosovich
- MN Matrosovich
- R Schauer
- RJ Connor
- RK Rowe
- RN Knibbs
- Robert J. Geraghty
- Shih-Cheng Shen
- SP Pillai
- Y Konami
- Y Suzuki
- YT Chen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Sialic acids (SAs) linked to galactose (Gal) in α2,3- and α2,6-configurations are the receptors for avian and human influenza viruses, respectively. We demonstrate that chicken tracheal ciliated cells express α2,3-linked SA, while goblet cells mainly express α2,6-linked SA. In addition, the plant lectin MAL-II, but not MAA/MAL-I, is bound to the surface of goblet cells, suggesting that SA2,3-linked oligosaccharides with GalÎČ1â3GalNAc subterminal residues are specifically present on the goblet cells. Moreover, both α2,3- and α2,6-linked SAs are detected on single tracheal basal cells. At a low multiplicity of infection (MOI) avian influenza virus H6N1 is exclusively detected in the ciliated cells, suggesting that the ciliated cell is the major target cell of the H6N1 virus. At a MOI of 1, ciliated, goblet and basal cells are all permissive to the AIV infection. This result clearly elucidates the receptor distribution for the avian influenza virus among chicken tracheal epithelial cells and illustrates a primary cell model for evaluating the cell tropisms of respiratory viruses in poultry
Raman spectroscopy: techniques and applications in the life sciences
- Author
- Agarwal
- Agenant
- Alfonso-GarcĂa
- Andreana
- Anshup
- Ashikawa
- Ashok
- Auchinvole
- Austin
- Azrad
- Babar
- Bai
- Bailo
- Baker
- Balu
- Bando
- Barkur
- Barman
- Baumgartl
- Bechtel
- Beier
- Beier
- Beier
- Benevides
- Bergeson
- Bergholt
- Bergholt
- Bergholt
- Bhattacharjee
- Bielecki
- Bitar
- Bloembergen
- Blum
- BodelĂłn
- Bohndiek
- Boitor
- Borchman
- Bowden
- Brunetti
- Buchwald
- Buckley
- Buckley
- Burke
- Calmettes
- Camp
- Camp
- Canetta
- Carden
- Caspers
- Cepeda-PĂ©rez
- Chan
- Chan
- Chan
- Chen
- Chen
- Chen
- Cheng
- Cheng
- Cheng
- Cheng
- Chiu
- Chu
- Cialla
- Conti
- Conti
- Conti
- Craig
- Cross
- Cui
- Cui
- Das
- Day
- De Gelder
- De Luca
- De Luca
- Deckert-Gaudig
- Deckert-Gaudig
- Delhaye
- Demers
- Demers
- Deng
- Desroches
- Di Napoli
- Diem
- Dingari
- Dochow
- Dochow
- Domke
- Downes
- Draga
- Draux
- Drescher
- Drescher
- Duncan
- Duraipandian
- Duraipandian
- Duraipandian
- Dustin W. Shipp
- Eckhardt
- Edwards
- Eikje
- Ekgasit
- El-Mashtoly
- Eliasson
- Eliasson
- Eliasson
- Erfurth
- Espina Palanco
- Evans
- Evans
- Evans
- Falagan-Lotsch
- Faraday
- Faris Sinjab
- Farquharson
- Fast
- Faubel
- Feng
- Fischer
- Fleischmann
- Frank
- Freudiger
- Freudiger
- Freudiger
- Freudiger
- Friedmann
- Frushour
- Fu
- Fu
- Fu
- Fu
- Ganikhanov
- GarcĂa-Flores
- Gardner
- Gardner
- Garrett
- Ghita
- Ghita
- Gniadecka
- Goeller
- Gregas
- Gregas
- Haaland
- Haka
- Haka
- Hanlon
- Harper
- Hart
- Harz
- Hayazawa
- Hellerer
- Hellwarth
- Hirschfeld
- Hodges
- Hong
- Horsnell
- Hu
- Huang
- Huang
- Huang
- Huang
- Huang
- Huang
- Huang
- Huang
- Huefner
- Huefner
- Ideguchi
- Indrasekara
- Ioan Notingher
- Ivleva
- Ivleva
- Ivleva
- Jarvis
- Jaworska
- Jeanmaire
- Ji
- Jiang
- Johnson
- Jones
- Jung
- Jung
- Jung
- Kang
- Kang
- Kang
- Kann
- Karata
- Katainen
- Kazemi-Zanjani
- Keller
- Kelly
- Kim
- Kneipp
- Kneipp
- Kneipp
- Kneipp
- Kneipp
- Kneipp
- Ko
- Kogelnik
- Koljenovic
- Koljenovic
- Koljenovic
- Kong
- Kong
- Kong
- Kong
- Kong
- Kong
- Kong
- Kostamovaara
- Krafft
- Krafft
- Krafft
- Krimm
- Kumar
- Kurihara
- Kurouski
- Kurouski
- Kurouski
- König
- König
- Lakshmi
- Larraona-Puy
- Latorre
- Lau
- Lau
- Le
- Le
- Lee
- Lee
- Lee
- Lee
- Lee
- Leiterer
- Leitz
- Lekprasert
- Lekprasert
- Li
- Li
- Liang
- Liao
- Liao
- Liao
- Lieber
- Lin
- Lin
- Link
- Liu
- Lu
- Lu
- Lucht
- Ly
- Ma
- Magee
- Mahadevan-Jansen
- Maher
- Maher
- Maher
- Maiti
- Maiti
- Maker
- Malini
- Mansfield
- Manson
- Matousek
- Matousek
- Matousek
- Matousek
- Matousek
- Matousek
- Matousek
- Matschulat
- Matthews
- MatthÀus
- MatthÀus
- Mazilu
- McAughtrie
- McAughtrie
- McNay
- McPeak
- Meksiarun
- Mert
- Meyer
- Min
- Mitchell
- Mo
- Mo
- Moger
- Morris
- Moskovits
- Mourant
- Mulliken
- MĂŒller
- Naemat
- Nan
- Nan
- Naumann
- Nelson
- Neufeld
- Neugebauer
- Neugebauer
- Neugebauer
- Neuman
- Nie
- Nijssen
- Nijssen
- Notingher
- Notingher
- Notingher
- Notingher
- Notingher
- Notingher
- Notingher
- Notingher
- Okada
- Okagbare
- Okuno
- Ong
- Opilik
- Oshima
- Overman
- Owyoung
- Ozeki
- Paret
- Pascut
- Pascut
- Patel
- Patil
- Patil
- Patil
- Patil
- Pavillon
- Pegoraro
- Pegoraro
- Pelaz
- Perna
- Pezacki
- Ploetz
- Porto
- Potma
- Potma
- Premasiri
- Prince
- Pudney
- Puppels
- Puppels
- Puppels
- Puppels
- Puppels
- Puppels
- PĂźnzaru
- Qian
- Qian
- Qin
- Radziuk
- Raman
- Ramser
- Robichaux Viehoever
- Rodriguez
- Ropers
- Rossi
- Rousseau
- Rousseau
- Rowlands
- Ruiz-Chica
- Rycenga
- Ryu
- Rösch
- Saar
- Saar
- Saatkamp
- Saha
- Salmaso
- Samanta
- Samek
- Samuel
- Santos
- Sathuluri
- Saxena
- Schleusener
- SchlĂŒcker
- SchlĂŒcker
- SchlĂŒcker
- Schmid
- Schmid
- Schulz
- Schulze
- Schumacher
- SchĂŒtz
- Shamsaie
- Sharma
- Shaw
- Shetty
- Shih
- Short
- Sijtsema
- Sil
- Silveira
- Sinjab
- Sinjab
- Sinjab
- Slipchenko
- Slipchenko
- Smith
- Smith
- Smith
- Sperling
- Steinle
- Steuwe
- Steuwe
- Stewart
- Stone
- Stone
- Stone
- Stone
- Stone
- Stöckel
- Sujith
- Susi
- Swain
- Sweetenham
- Takamori
- Talley
- Tang
- Teh
- Teh
- Thurn
- Treffer
- Tu
- Turkevich
- Urban
- Utzinger
- Uzunbajakava
- van Manen
- van Manen
- Vasconcelos
- Venkata
- Vitol
- Vitol
- Wabuyele
- Walter
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Watanabe
- Wei
- Wei
- Welz
- Wiens
- Williams
- Wood
- Wood
- Wood
- Wood
- Wood
- Wood
- Woodbury
- Wurpel
- Xia
- Xie
- Xie
- Xu
- Yakovlev
- Yamakoshi
- Yamakoshi
- Yamakoshi
- Yang
- Yang
- Yeo
- You
- Yuen
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhu
- Zhu
- Zoladek
- Zoladek
- Zumbusch
- Publication venue
- 'The Optical Society'
- Publication date
- 09/06/2017
- Field of study
Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine. It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration
Shorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells
- Author
- C Li
- CC Fang
- CC Huang
- F Schaefer
- G Del Peso
- H Ha
- H Nakamoto
- Hao-Kuang Wang
- Hong-Arh Fan
- Hsi-Hao Wang
- Hsiang-Chun Liu
- Hsin-Pao Chen
- Hung-Hsiang Liou
- JH Cho
- JY Do
- JY Do
- K Araki-Sasaki
- KN Lai
- Kuang-Wen Liu
- Li-Chun Ho
- LS Aroeira
- LS Aroeira
- LS Aroeira
- M Erixon
- M Lopez-Cabrera
- M Yanez-Mo
- M Yanez-Mo
- MA Bajo
- MA Yu
- Min-Yu Chang
- R Mehrotra
- R Vargha
- RT Krediet
- SH Han
- Sheng-Hsiang Lin
- Shih-Yuan Hung
- SJ Davies
- Tsun-Mei Lin
- Yau-Sheng Tsai
- Yi-Che Lee
- Yi-Ting Chen
- Yuan-Yow Chiou
- Yung-Tang Kung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2
- Author
- A Chao
- A Jemal
- A Kong
- AJ Pawson
- B Bauvois
- B Davidson
- B Davidson
- B Mo
- C Grundker
- C Grundker
- Chyi-Long Lee
- Chyong-Huey Lai
- CK Cheng
- F Amant
- G Emons
- G Emons
- H Sato
- HC Thoeny
- HM Wu
- HM Wu
- Hong-Yuan Huang
- Hsien-Ming Wu
- Hsin-Shih Wang
- J Engel
- J Sanceau
- JL Guinot
- K Morgan
- KY Kim
- KY Kim
- LA Liotta
- LW Cheung
- M Jedryka
- M Monge
- M Nishida
- M Ohmichi
- N Ramakrishnappa
- P Crespo
- PC Leung
- Peter CK Leung
- R Millar
- S Kraus
- S Maudsley
- SC Sealfon
- SK Kang
- SS Stojilkovic
- T Yano
- TL Moser
- Yung-Kuei Soong
- Z Naor
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pan-cancer analysis of whole genomes
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- Assenov
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- Banks
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- Bartolome
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- Bazant W. f
- bd Ye
- Beardsmore
- Beck T. A. n
- Behjati
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- Berchuck
- Bergmann
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- Birney E. f
- Birrer M. r
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- Chadwick
- Chakravarty
- Chalmers
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- Chan-Seng-Yue
- Chandan
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- Chanock
- Chateigner A. n
- Chatterjee
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- Chomienne
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- cj Mularoni
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- cl abp
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- Cleary
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- cm Tarabichi
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- Cordes M. G. z
- Cordner
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- Creighton
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- Czerniak
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Yachida
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- Yamamoto
- Yamaue
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- z ah
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- Z. hv
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- Z. kt
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- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
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- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
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- Zou
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- Ă. A. th
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
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- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
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- Antier Sarah
- Antonio Font Roda Jose
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- Betzwieser Joseph
- Beveridge Damon
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- KARATHANASIS CHRISTOS.
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- LEE SUNGHO.
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- LIETO ALBERTO. DI.
- LIGO Collaboration
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- MASCIOLI ADRIANO. FRATTALE.
- Masserot A.
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- MORALES ESTER. RUIZ.
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- PACE SIBILLA. DI.
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- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Araya Melody
- Areeda Joseph
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- Armato F.
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- Arogeti Megan
- Aronson Scott
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- Zheng Yanyan
- Zhong Haowen
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- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Abadie WM
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- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
Analysis of Patients with Helicobacter pylori Infection and the Subsequent Risk of Developing Osteoporosis after Eradication Therapy: A Nationwide Population-Based Cohort Study.
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