86 research outputs found
SHIRAZ: an automated histology image annotation system for zebrafish phenomics
- Author
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
Histological characterization is used in clinical and research contexts as a highly sensitive method for detecting the morphological features of disease and abnormal gene function. Histology has recently been accepted as a phenotyping method for the forthcoming Zebrafish Phenome Project, a large-scale community effort to characterize the morphological, physiological, and behavioral phenotypes resulting from the mutations in all known genes in the zebrafish genome. In support of this project, we present a novel content-based image retrieval system for the automated annotation of images containing histological abnormalities in the developing eye of the larval zebrafish
Nutrition and cancer: A review of the evidence for an anti-cancer diet
- Author
- A Sakalova
- A Seow
- AE Fletcher
- AG Schuurman
- AH Mokdad
- AJ Duffield-Lillico
- AL Frazier
- AM Barreto
- AP Femia
- AR Folsom
- AT Fleischauer
- AT Fleischauer
- AW Hsing
- AW Hsing
- AW Hsing
- B Vastag
- BA Lashner
- BC Blount
- BR Goldin
- C Garland
- C La Vecchia
- C La Vecchia
- C La Vecchia
- CF Garland
- CH Hennekens
- CL Hanchette
- CL Rock
- CR Jonas
- CS Fuchs
- CS Tsao
- CS Tsao
- D Bagga
- D Lauer
- D Li
- D Sarkar
- DJ Bernard-Gallon
- DJ Hunter
- DM Harvell
- DS Michaud
- DS Michaud
- DS Michaud
- E Benito
- E Cho
- E Cho
- E De Stefani
- E Fernandez
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Giovannucci
- E Kampman
- E Kampman
- E Riboli
- EA Platz
- EA Platz
- EB Mawer
- ED Gorham
- ED Stefani
- EE Calle
- EE Calle
- EJ Konings
- EM John
- ES Lefkowitz
- EW Tiemersma
- F Levi
- F Marotta
- F Meyer
- FB Hu
- G Block
- GG Schwartz
- GG Schwartz
- GL Hildenbrand
- GS Omenn
- GW Comstock
- H Li
- H Mukhtar
- HD Riordan
- I Kato
- I Kato
- IA Brouwer
- IR Rowland
- J Beuth
- J Chen
- J Chen
- J Chen
- J Ma
- J Ma
- J Matsuzaki
- J Satia-Abouta
- J Tangrea
- JD Brooks
- JD Brooks
- JH Cohen
- JH Fowke
- JL Freudenheim
- JM Yuan
- JM Yuan
- JP Pierce
- JW Fahey
- K Foster-Powell
- K Oh
- K Wu
- K Wu
- K Yoshizawa
- KA Steinmetz
- KB Michels
- KE Anderson
- KJ Helzlsouer
- KJ Joshipura
- KP Tan
- KR Silvester
- KT Khaw
- KW Lee
- L Desser
- L Harnack
- L Le Marchand
- L Le Marchand
- L Le Marchand
- L O'Mahony
- L Yan
- LA Colangelo
- LC Clark
- LJ Su
- LN Kolonel
- LS Augustin
- LS Augustin
- LS Augustin
- LS Augustin
- LU Thompson
- LU Thompson
- M Ferraroni
- M Friedrich
- M Gago-Dominguez
- M Wald
- M Wald
- MD Holmes
- ME Martinez
- ME Martinez
- ME Reid
- MF Holick
- MH Ahonen
- MH Criqui
- Michael S Donaldson
- MJ Dirx
- MJ Shrubsole
- MJ Thun
- ML Cravo
- ML Slattery
- ML Slattery
- ML Slattery
- ML Slattery
- MS Donaldson
- MS Gujral
- MS Sandhu
- MV Grau
- N Shimizu
- N Simonsen
- NH Riordan
- O Kucuk
- P Bowen
- P Cos
- P Ghadirian
- P Knekt
- P Terry
- P Tuohimaa
- P van 't Veer
- PA Egner
- PA Egner
- PA van den Brandt
- PA van den Brandt
- PA van den Brandt
- PA van Noord
- PD Terry
- PH Gann
- PH Gann
- PN Singh
- PR Holt
- PS Dale
- R Garcia-Closas
- R Hughes
- R Medhekar
- R Sinha
- R Sturm
- R Vieth
- RE Schoen
- RM Bostick
- S Chernomorsky
- S Franceschi
- S Franceschi
- S Higginbotham
- S Higginbotham
- S Mannisto
- S Rothman
- S Sieri
- S Zhang
- SA Bingham
- SA Bingham
- SA Glynn
- SD Hursting
- SH Saydah
- SJ London
- SJ London
- SJ Padayatty
- SL Goodstine
- SM Finegold
- SM Zhang
- SM Zhang
- SS Coughlin
- SW Choi
- T Fung
- T Norat
- T Popiela
- TA Sellers
- TA Sellers
- TA Shapiro
- TE Rohan
- TE Rohan
- V Maillard
- V Pala
- V Tangpricha
- W Demark-Wahnefried
- WB Grant
- WB Grant
- WC Willett
- WCRF/AICR
- WE Moore
- X Lin
- Y Aso
- Y Aso
- Y Ito
- Y Nishizawa
- Y Nishizawa
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
It has been estimated that 30–40 percent of all cancers can be prevented by lifestyle and dietary measures alone. Obesity, nutrient sparse foods such as concentrated sugars and refined flour products that contribute to impaired glucose metabolism (which leads to diabetes), low fiber intake, consumption of red meat, and imbalance of omega 3 and omega 6 fats all contribute to excess cancer risk. Intake of flax seed, especially its lignan fraction, and abundant portions of fruits and vegetables will lower cancer risk. Allium and cruciferous vegetables are especially beneficial, with broccoli sprouts being the densest source of sulforophane. Protective elements in a cancer prevention diet include selenium, folic acid, vitamin B-12, vitamin D, chlorophyll, and antioxidants such as the carotenoids (α-carotene, β-carotene, lycopene, lutein, cryptoxanthin). Ascorbic acid has limited benefits orally, but could be very beneficial intravenously. Supplementary use of oral digestive enzymes and probiotics also has merit as anticancer dietary measures. When a diet is compiled according to the guidelines here it is likely that there would be at least a 60–70 percent decrease in breast, colorectal, and prostate cancers, and even a 40–50 percent decrease in lung cancer, along with similar reductions in cancers at other sites. Such a diet would be conducive to preventing cancer and would favor recovery from cancer as well
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.
- Author
- Hugh Calkins
- Gerhard Hindricks
- Riccardo Cappato
- Young-Hoon Kim
- Eduardo B. Saad
- Luis Aguinaga
- Joseph G. Akar
- Vinay Badhwar
- Josep Brugada
- John Camm
- Peng-Sheng Chen
- Shih-Ann Chen
- Mina K. Chung
- Jens Cosedis Nielsen
- Anne B. Curtis
- D. Wyn Davies
- John D. Day
- André d’Avila
- N.M.S. de Groot
- Luigi Di Biase
- Mattias Duytschaever
- James R. Edgerton
- Kenneth A. Ellenbogen
- Patrick T. Ellinor
- Sabine Ernst
- Guilherme Fenelon
- Edward P. Gerstenfeld
- David E. Haines
- Michel Haissaguerre
- Robert H. Helm
- Elaine Hylek
- Warren M. Jackman
- Jose Jalife
- Jonathan M. Kalman
- Josef Kautzner
- Hans Kottkamp
- Karl Heinz Kuck
- Koichiro Kumagai
- Richard Lee
- Thorsten Lewalter
- Bruce D. Lindsay
- Laurent Macle
- Moussa Mansour
- Francis E. Marchlinski
- Gregory F. Michaud
- Hiroshi Nakagawa
- Andrea Natale
- Stanley Nattel
- Ken Okumura
- Douglas Packer
- Evgeny Pokushalov
- Matthew R. Reynolds
- Prashanthan Sanders
- Mauricio Scanavacca
- Richard Schilling
- Claudio Tondo
- Hsuan-Ming Tsao
- Atul Verma
- David J. Wilber
- Teiichi Yamane
- H Calkins
- H Calkins
- AK Jacobs
- JL Anderson
- CT January
- P Kirchhof
- P Jais
- H Calkins
- DL Packer
- KH Kuck
- SR Dukkipati
- VY Reddy
- A Natale
- DJ Wilber
- H Sohara
- C Pappone
- G Stabile
- GB Forleo
- A Verma
- D Scherr
- D Tamborero
- J Hummel
- M Bassiouny
- R Krittayaphong
- H Oral
- L Mont
- N Calvo
- F Furlanello
- OM Wazni
- J Cosedis Nielsen
- CA Morillo
- A Hakalahti
- M Hocini
- YW Chen
- K Inada
- MS Chen
- PJ Gentlesk
- MN Khan
- MR MacDonald
- RJ Hunter
- C Tondo
- BA Lutomsky
- AD Choi
- T Potter De
- YM Cha
- DG Jones
- T Machino-Ohtsuka
- S Halabi Al
- TJ Bunch
- TJ Lobo
- LH Ling
- LF Hsu
- DD Spragg
- F Kusumoto
- TJ Bunch
- P Santangeli
- K Nademanee
- TJ Bunch
- I Metzner
- TJ Bunch
- I Olivotto
- R Providencia
- P Leong-Sit
- KR Chun
- P Koopman
- GB Forleo
- L Wu
- S Mohanty
- V Badhwar
- CA Abreu Filho
- G Doukas
- C Blomstrom-Lundqvist
- P Chevalier
- DC Cheng
- P Budera
- K Phan
- AM Gillinov
- JS Rankin
- Y Louagie
- B Chiappini
- SD Barnett
- JR Edgerton
- JR Edgerton
- D Lockwood
- SC Malaisrie
- A Cherniavsky
- JS Yoo
- AH Driessen
- LV Boersma
- MC Henn
- SP Krul
- JL Cox
- E Rodriguez
- RK Wolf
- JR Edgerton
- JR Edgerton
- E Beyer
- K Kearney
- N Ad
- AH Driessen
- K Khargi
- OM Wazni
- AR Magnano
- HT McElderry
- PM McCarthy
- Y Zeng
- R Lee
- KH Kuck
- A Verma
- L Macle
- A Cheema
- K Rajappan
- D Bansch
- K Nakamura
- XH Wang
- WH Sauer
- Y Ninomiya
- T Yamane
- A Kobori
- C Pratola
- RH Jiang
- T Arentz
- M Tritto
- T Datino
- PD Dallaglio
- S Kapa
- JG Andrade
- C Eitel
- D Steven
- JG Andrade
- D Steven
- B Schaeffer
- EP Gerstenfeld
- P Vijayaraman
- JE Ip
- P Spector
- S Chen
- JY Kim
- FJ Perez
- NJ Patel
- O Wazni
- A Natale
- C Pappone
- N Sawhney
- S Chae
- F Ouyang
- S Matsuo
- S Tzeis
- SA Chen
- M Haissaguerre
- SH Lee
- MH Hsieh
- D Shah
- D Lin
- L Biase Di
- P Santangeli
- WS Lin
- RJ Lee
- Y Zhao
- S Dixit
- P Neuzil
- K Yokoyama
- A Ikeda
- H Nakagawa
- H Nakagawa
- S Kumar
- S Kumar
- VY Reddy
- S Haldar
- F Perna
- M Kimura
- C Sohns
- M Martinek
- E Marijon
- E Sigmund
- W Ullah
- R Wakili
- K Kumagai
- Y Yamaguchi
- K Kumagai
- JS Kim
- X He
- L Biase Di
- L Biase Di
- CA Morillo
- A Harada
- RA Gray
- O Berenfeld
- M Mansour
- S Lazar
- F Atienza
- F Atienza
- J Vogler
- M Haissaguerre
- K Nademanee
- MD O'Neill
- LW Lo
- Z Zhang
- TH Kim
- GJ Wynn
- H Kottkamp
- H Kottkamp
- S Rolf
- R Bai
- MJ Cutler
- G Yang
- A Verma
- S Kapa
- RS Oakes
- C McGann
- N Dagres
- K Nademanee
- M Haissaguerre
- M Haissaguerre
- Y Takahashi
- SM Singh
- SM Narayan
- A Verma
- JG Quintanilla
- BJ Hansen
- PS Cuculich
- M Haissaguerre
- SM Narayan
- YJ Lin
- Y-J Lin
- JM Miller
- YJ Lin
- SM Narayan
- WJ Rappel
- C Gianni
- SM Narayan
- P Sommer
- E Buch
- P Benharash
- C Ramanathan
- HS Lim
- S Yamashita
- MS Guillem
- MS Guillem
- M Rodrigo
- JA Armour
- SS Po
- E Patterson
- EK Choi
- DG Katritsis
- H Nakagawa
- M Bettoni
- DH Pauza
- BJ Scherlag
- E Patterson
- K Lemola
- K Nishida
- K Nishida
- S Stavrakis
- E Pokushalov
- E Pokushalov
- E Pokushalov
- E Pokushalov
- DM Lloyd-Jones
- R Mahajan
- A Wokhlu
- S Dublin
- AS Gami
- UB Tedrow
- RR Huxley
- TM Munger
- HS Abed
- B Richter
- K Jongnarangsin
- AN Shah
- SL Chang
- KP Letsas
- RB Tang
- H Jin Hwang
- D Patel
- D Patel
- D Patel
- TF Chao
- RA Winkle
- CX Wong
- JH Kang
- S Mohanty
- K Ejima
- KP Letsas
- CX Wong
- A Alonso
- RK Pathak
- T Bitter
- EC Fletcher
- H Kraiczi
- M Ghias
- D Linz
- D Linz
- D Linz
- YK Iwasaki
- YK Iwasaki
- H Dimitri
- IH Stevenson
- F Holmqvist
- Y Kwon
- R Kanagala
- AS Fein
- M Matiello
- Y Naruse
- TG Neilan
- L Li
- MH Raitt
- N Chalfoun
- M Igarashi
- L Rivard
- S Mohanty
- IM Robbins
- S Ernst
- M Mansour
- DR Holmes Jr
- EA Fender
- L Biase Di
- LR Prieto
- DL Packer
- GW Taylor
- T Arentz
- HF Tse
- L Kasper
- J Dong
- RH Hoyt
- EB Saad
- S Hilbert
- S Hilbert
- EA Fender
- TJ Potter De
- KR Kanter
- NS Patel
- A Bharat
- SP Ponamgi
- L Biase Di
- R Cappato
- C Pappone
- M Martinek
- SM Singh
- TJ Bunch
- R Cappato
- C Tan
- S Mohanty
- S Mohanty
- R Cappato
- AM Gillinov
- FW Mohr
- N Doll
- B Sonmez
- MI Scanavacca
- B Borchert
- KK Ghia
- GW Gilcrease
- F Stockigt
- O Yousuf
- PG Jackson
- G Nolker
- JT Medeiros De Vasconcelos
- A Rillig
- P Chavez
- JC Mateos
- HB Shim
- E Black-Maier
- P Santangeli
- L Biase Di
- OM Wazni
- M Schmidt
- A Hakalahti
- L Biase Di
- SH Hohnloser
- H Calkins
- R Cappato
- L Biase Di
- M Bassiouny
- AA Bin Abdulhak
- R Providencia
- RA Winkle
- HL Armbruster
- JF Ren
- S Saksena
- J Baran
- JF Ren
- E Anter
- CS Sriram
- K Maleki
- OM Wazni
- D Shah
- JF Ren
- CJ Bruce
- S Asbach
- DF Briceno
- K Chilukuri
- K Thygesen
- SC Helps
- GS Krivonyak
- B Cauchemez
- T Kuwahara
- OW Franzen
- KH Ryu
- F Gaita
- C Herrera Siklody
- A Verma
- Y Greef De
- T Deneke
- FM Merchant
- L Lickfett
- F Gaita
- JW Schrickel
- T Deneke
- LD Sauren
- M Wieczorek
- M Bendszus
- RW Kruis
- C Medi
- H Ichiki
- E Nagy-Balo
- SE Vermeer
- K Neven
- KL Ripley
- H Ahmed
- R Kawasaki
- HW Lim
- K Yokoyama
- SM Singh
- T Kuwahara
- FM Contreras-Valdes
- LR Leite
- CM Tschabrunn
- T Deneke
- BJ Carroll
- P Muller
- T Tsuchiya
- MS Arruda
- T Kuwahara
- T Kuwahara
- A Chugh
- JS Koruth
- S Zellerhoff
- S Zellerhoff
- M Khan
- PJ Kahrilas
- NJ Shaheen
- U Halm
- H Knopp
- N Dagres
- C Eitel
- W Hazell
- A Cazavet
- E Podgaetz
- L Queneherve
- MF Gunes
- MA Qadeer
- CR Ellis
- SR Markar
- JG Andrade
- A Deshmukh
- R Cappato
- OJ Eick
- JD Fisher
- LF Hsu
- TJ Bunch
- LF Hsu
- Y Michowitz
- TS Tsang
- MD O'Neill
- Y Takahashi
- A Chugh
- H Makimoto
- T Kitamura
- S Ouali
- A Mykytsey
- C Sticherling
- KC Wong
- G Fayad
- JP Piccini
- D Lakkireddy
- JM Dumonceau
- TJ Bunch
- T Kuwahara
- S Miyazaki
- N Chopra
- TW Schwartz
- W Ajaj
- CF Pisani
- T Kanaeda
- LW Lo
- J Janssens
- MP Jones
- R Tavernier
- R Grove
- D Lakkireddy
- HM Zeljko
- CV Desimone
- O Gurbuz
- M Mansour
- RC Wu
- S Deftereos
- S Deftereos
- G Stabile
- M Luckie
- T Lambert
- S Torihashi
- DR Kim
- M Kesek
- KH Kuck
- H Sohara
- RF Evonich
- KR Chun
- H Hoyt
- EN Guhl
- MJ Earley
- AV Sarabanda
- A Guiot
- A Metzner
- Y Okumura
- M Arruda
- S Miyazaki
- E Wissner
- CS Elayi
- H Liu
- S Yong Ji
- F Franceschi
- S Miyazaki
- B Mondesert
- F Sacher
- JG Andrade
- C Pappone
- SR Dukkipati
- ES Katz
- D Caponi
- R Proietti
- JD Ferguson
- H Calkins
- BD Lindsay
- P Kovoor
- L Macle
- L Lickfett
- J Ector
- J Chen
- Y Khaykin
- G Stabile
- R Ponti De
- T Kleemann
- D Steven
- JP Weiss
- O Dragusin
- VY Reddy
- A Bulava
- H Cochet
- DN Gibson
- MB Shoemaker
- TD Welch
- C Witt
- L Pilote
- J Kosiuk
- H Ghanbari
- D Scherr
- Y Liu
- PA Noseworthy
- D Patel
- S Kochhauser
- J Kosiuk
- F Abhishek
- B Aldhoon
- G Mugnai
- Y Murakawa
- C Palaniswamy
- P Peichl
- J Waigand
- D Lakkireddy
- CC Tanaka-Esposito
- A Errahmouni
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
S
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
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- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Yachida
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- z ah
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- zd Gershenwald
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- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
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- zi zj
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- Zou
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- Ó. A. th
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
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- Abdeen ZA
- Abdrakhmanova S
- Abu-Rmeileh NM
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- Adams RJ
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- Al-Hazzaa HM
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- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 09/05/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories
Search for gravitational waves associated with gamma-ray bursts detected by Fermi and Swift during the LIGO–Virgo run O3b
- Author
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- Vijaykumar A
- Villa-Ortega V
- Vinet J-Y
- Virtuoso A
- Vitale S
- Vivanco FH
- Vo T
- Vocca H
- von Reis ERG
- von Wrangel JSA
- Vorvick C
- Vyatchanin SP
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- Yap MJ
- Yeeles DW
- Yelikar AB
- Ying M
- Yokogawa K
- Yokoyama J
- Yokozawa T
- Yoo J
- Yoshioka T
- Yu H
- Yu H
- Yuzurihara H
- Zadrozny A
- Zanolin M
- Zeidler S
- Zelenova T
- Zendri J-P
- Zevin M
- Zhan M
- Zhang H
- Zhang J
- Zhang L
- Zhang T
- Zhang Y
- Zhao C
- Zhao G
- Zhao Y
- Zhao Y
- Zheng Y
- Zhou R
- Zhou Z
- Zhu XJ
- Zhu Z-H
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC–2020 March 27 17:00 UTC). We conduct two independent searches: a generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
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- Alkerwi A
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- Allin K
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- Amarapurkar DN
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- Araújo J
- Ariansen I
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- Żegleń M
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- 'Springer Science and Business Media LLC'
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AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
Microstructure evolution and tensile creep behavior of Sn–0.7Cu lead-free solder reinforced with ZnO nanoparticles
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genetics and systemic lupus erythematosus
- Author
- A Studnicka-Benke
- AJ Duits
- AN Theofilopoulos
- AN Theofilopoulos
- Betty P. Tsao
- BP Tsao
- BP Tsao
- CC Mok
- DA Horwitz
- EJ Davies
- EJ Davies
- ES Sobel
- FC Arnett
- FK Tan
- G Senaldi
- G Sturfelt
- GS Cooper
- H Sato
- HR Koene
- IO Tassiulas
- J Eskdale
- J Lu
- J Wu
- JB Harley
- JD Reveille
- JE Salmon
- JE Salmon
- Jennifer M. Grossman
- JH Slingsby
- K Manger
- KE Sullivan
- KE Sullivan
- KG Becker
- KL Moser
- L Morel
- M Botto
- M Botto
- M Lazarus
- M Linker-Israeli
- M Oh
- M Super
- MJ Rood
- PH Schur
- PH Schur
- PM Gaffney
- R Mehrian
- RW Hoffman
- S Miyagawa
- SC Bae
- SY Park
- TJ Vyse
- W Jarjour
- WK Ip
- YL Lau
- YW Song
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …