135 research outputs found
Tippoo Sultan - The Man and the Beast
- Author
- Publication venue
- DigitalCommons@WayneState
- Publication date
- 06/09/1986
- Field of study
The ship Bengal landed in Philadelphia in June 1821 from Calcutta. Included in its cargo was a male elephant described by a newspaper as being of uncommon size, color and beauty. (Anonymous, 1821a). It was the third male elephant to reach America and is known to us today as Tippoo Sultan. Columbus was the first male to reach these shores, and he did so in 1817. In November 1819, Horatio was unloaded from the ship of the same name. Horatio fell through a bridge in September 1820, thus when Tippoo Sultan landed he was one of two males in the country. The males had been preceded by three females: the Crowninshield import of 1795; Old Bet, imported by Edward Savage in 1804; and Little Bet, imported by Hachaliah Bailey and his partners in 1817. None of these females was very large. (See also Elephant, 2(1):235—237 about first elephants). Columbus and Tippoo Sultan were both over eight feet in height and in advertisements their size was always featured
Passive immunization using purified IgYs against infectious bursal disease of chickens in Pakistan
- Author
- Publication venue
- The Korean Society of Veterinary Science
- Publication date
- 01/01/2006
- Field of study
Infectious bursal disease (IBD) is an acute and highly contagious disease of young chickens caused by Birnavirus. Mortality of infected birds can be best prevented if injected with antibodies. The present study was an attempt to raise specific hyper-immune polyclonal antibodies against IBD virus in Pakistan. Commercial layers divided into four groups were injected with IBD vaccine subcutaneously according to four different treatment regimens. Eggs were collected daily and antibodies were purified from yolk with dextran sulphate. Titers of antibodies in serum and yolk were evaluated with enzyme linked immunosorbant assay and agar gel precipitation test. Antibody titers were significantly higher in yolk than serum. Eggs collected at 28 days post-vaccination had maximum antibody titers. Of treatment regimens, T3 was found to be most effective for hyperimmunization. Lyophilized antibodies stored at 4℃ did not lose their activity till the end of experiment. IBD virus infected birds were injected with purified antibodies which induced 92% recovery as compared to control birds. The study implicates that the purified antibodies may be useful as a therapeutic agent to cure IBD infected birds
The Health Care Costs of Financial Exploitation in Maine
- Author
- Publication venue
- USM Digital Commons
- Publication date
- 01/05/2019
- Field of study
This study sought to determine the Medicare and Medicaid costs experienced by dual eligible older adults in Maine for whom Maine Adult Protective Services (APS) substantiated allegations of elder financial exploitation and to compare them to those of Maine’s general older population. The analysis is an important step forward in estimating the medical costs associated with elder abuse.
Elder financial exploitation may result in significant public burden on Medicare and Medicaid, shouldered by taxpayers. Efforts to detect, investigate, prosecute, and mitigate this abuse will benefit not only the victims, but also the financial stewardship of these public programs
China's crisis: the international implications
- Author
- Publication venue
- Canberra : Strategic and Defence Studies Centre, Research School of Pacific Studies, Australian National University, 1989.
- Publication date
- 01/01/1989
- Field of study
China has always been important to countries in the Asia/Pacific region, whether as a vortex of disarray and discontent or - as it has appeared to be, particularly over the last decade - as a modernising great Asian power. In this latter context, China was increasingly accepted as a responsible participant in regional and global affairs. Although China's military capabilities and its political ambitions were regarded with residual distrust by some neighbouring countries, such misgivings were increasingly overshadowed by expectations of a new China possessing the largest potential market remaining in the world today. The Tiananmen affair, as it is now known, seemed to shatter any assumptions about China's stability, its economic potential and certainly some of the illusions about China's political system. This unique collection of papers begins with an analysis of the political situation in China, as seen from Beijing and Canberra. It provides detailed assessments of the way in which countries throughout the Asia/Pacific region, including Australia, responded or did not respond. There is an overview on Hong Kong and its governability and extensive discussion on the strategic and economic implications, if any, for China and for neighbouring and regional states, of events in Beijing in June 1989
LSST: from Science Drivers to Reference Design and Anticipated Data Products
- Author
- Abel Bob
- Acosta Emily
- Allsman Robyn
- Alonso David
- AlSayyad Yusra
- Anderson Scott F.
- Andrew John
- Angel James Roger P.
- Angeli George Z.
- Ansari Reza
- Antilogus Pierre
- Arancibia Freddy Muñoz
- Araujo Constanza
- Armstrong Robert
- Arndt Kirk T.
- Astier Pierre
- Aubourg Éric
- Auza Nicole
- Axelrod Tim S.
- Bard Deborah J.
- Barr Jeff D.
- Barrau Aurelien
- Bartlett James G.
- Bauer Amanda E.
- Bauman Brian J.
- Baumont Sylvain
- Bechtol Ellen
- Bechtol Keith
- Becker Andrew C.
- Becla Jacek
- Beldica Cristina
- Bellavia Steve
- Bianco Federica B.
- Biswas Rahul
- Blanc Guillaume
- Blandford Roger D.
- Blazek Jonathan
- Bloom Josh S.
- Bogart Joanne
- Bond Tim W.
- Booth Michael T.
- Borgland Anders W.
- Borne Kirk
- Bosch James F.
- Boutigny Dominique
- Brackett Craig A.
- Bradshaw Andrew
- Brandt William Nielsen
- Brown Michael E.
- Bullock James S.
- Burchat Patricia
- Burke David L.
- Cagnoli Gianpietro
- Calabrese Daniel
- Callahan Shawn
- Callen Alice L.
- Carlin Jeffrey L.
- Carlson Erin L.
- Chandrasekharan Srinivasan
- Charles-Emerson Glenaver
- Chesley Steve
- Cheu Elliott C.
- Chiang Hsin-Fang
- Chiang James
- Chirino Carol
- Chow Derek
- Ciardi David R.
- Claver Charles F.
- Cockrum Joseph J.
- Cohen-Tanugi Johann
- Coles Rebecca
- Connolly Andrew J.
- Cook Kem H.
- Cooray Asantha
- Covey Kevin R.
- Cribbs Chris
- Cui Wei
- Cutri Roc
- Daly Philip N.
- Daniel Scott F.
- Daruich Felipe
- Daubard Guillaume
- Daues Greg
- Dawson William
- De Val-Borro Miguel
- Delgado Francisco
- Dellapenna Alfred
- Digel Seth W.
- Doherty Peter
- Dubois Richard
- Dubois-Felsmann Gregory P.
- Durech Josef
- Economou Frossie
- Eifler Tim
- Emmons Benjamin L.
- Eracleous Michael
- Fausti Neto Angelo
- Ferguson Henry
- Figueroa Enrique
- Fisher-Levine Merlin
- Focke Warren
- Foss Michael D.
- Frank James
- Freemon Michael D.
- Gangler Emmanuel
- Gawiser Eric
- Geary John C.
- Gee Perry
- Geha Marla
- Gessner Charles J.B.
- Gibson Robert R.
- Gilmore D.Kirk
- Glanzman Thomas
- Glick William
- Goldina Tatiana
- Goldstein Daniel A.
- Goodenow Iain
- Graham Melissa L.
- Gressler William J.
- Gris Philippe
- Guy Leanne P.
- Guyonnet Augustin
- Haller Gunther
- Harris Ron
- Hascall Patrick A.
- Haupt Justine
- Hernandez Fabio
- Herrmann Sven
- Hileman Edward
- Hoblitt Joshua
- Hodgson John A.
- Hogan Craig
- Howard James D.
- Huang Dajun
- Huffer Michael E.
- Ingraham Patrick
- Innes Walter R.
- Ivezić Željko
- Jacoby Suzanne H.
- Jain Bhuvnesh
- Jammes Fabrice
- Jee James
- Jenness Tim
- Jernigan Garrett
- Jevremović Darko
- Johns Kenneth
- Johnson Anthony S.
- Johnson Margaret W.G.
- Jones R.Lynne
- Juramy-Gilles Claire
- Jurić Mario
- Kahn Steven M.
- Kalirai Jason S.
- Kallivayalil Nitya J.
- Kalmbach Bryce
- Kantor Jeffrey P.
- Karst Pierre
- Kasliwal Mansi M.
- Kelly Heather
- Kessler Richard
- Kinnison Veronica
- Kirkby David
- Knox Lloyd
- Kotov Ivan V.
- Krabbendam Victor L.
- Krughoff K.Simon
- Ku John
- Kubánek Petr
- Kuczewski John
- Kulkarni Shri
- Kurita Nadine R.
- Lage Craig S.
- Lambert Ron
- Lange Travis
- Langton J.Brian
- Le Guillou Laurent
- Levine Deborah
- Liang Ming
- Lim Kian-Tat
- Lintott Chris J.
- Long Kevin E.
- Lopez Margaux
- Lotz Paul J.
- Lupton Robert H.
- Lust Nate B.
- MacArthur Lauren A.
- Mahabal Ashish
- Mandelbaum Rachel
- Markiewicz Thomas W.
- Marsh Darren S.
- Marshall Philip J.
- Marshall Stuart
- May Morgan
- McKercher Robert
- McQueen Michelle
- Meyers Joshua
- Migliore Myriam
- Miller Michelle
- Mills David J.
- Miraval Connor
- Moeyens Joachim
- Monet David G.
- Moniez Marc
- Monkewitz Serge
- Montgomery Christopher
- Moolekamp Fred E.
- Morrison Christopher B.
- Mueller Fritz
- Muller Gary P.
- Neill Douglas R.
- Newbry Scott P.
- Nief Jean-Yves
- Nomerotski Andrei
- Nordby Martin
- O'Connor Paul
- O'Mullane William
- Oliver John
- Olivier Scot S.
- Olsen Knut
- Ortiz Sandra
- Osier Shawn
- Owen Russell E.
- Pain Reynald
- Palecek Paul E.
- Parejko John K.
- Parsons James B.
- Pease Nathan M.
- Peterson J.Matt
- Peterson John R.
- Petravick Donald L.
- Petrick M.E. Libby
- Petry Cathy E.
- Peyster Robert de
- Pierfederici Francesco
- Pietrowicz Stephen
- Pike Rob
- Pinto Philip A.
- Plante Raymond
- Plate Stephen
- Plutchak Joel P.
- Price Paul A.
- Prouza Michael
- Radeka Veljko
- Rajagopal Jayadev
- Rasmussen Andrew P.
- Regnault Nicolas
- Reil Kevin A.
- Reiss David J.
- Reuter Michael A.
- Ridgway Stephen T.
- Riot Vincent J.
- Ritz Steve
- Robinson Sean
- Roby William
- Roodman Aaron
- Rosing Wayne
- Roucelle Cecille
- Rumore Matthew R.
- Russo Stefano
- Saha Abhijit
- Sassolas Benoit
- Schalk Terry L.
- Schellart Pim
- Schindler Rafe H.
- Schmidt Samuel
- Schneider Donald P.
- Schneider Michael D.
- Schoening William
- Schumacher German
- Schwamb Megan E.
- Sebag Jacques
- Selvy Brian
- Sembroski Glenn H.
- Seppala Lynn G.
- Serio Andrew
- Serrano Eduardo
- Shaw Richard A.
- Shipsey Ian
- Sick Jonathan
- Silvestri Nicole
- Slater Colin T.
- Smith J.Allyn
- Smith R.Chris
- Sobhani Shahram
- Soldahl Christine
- Storrie-Lombardi Lisa
- Stover Edward
- Strauss Michael A.
- Street Rachel A.
- Stubbs Christopher W.
- Sullivan Ian S.
- Sweeney Donald
- Swinbank John D.
- Szalay Alexander
- Takacs Peter
- Tether Stephen A.
- Thaler Jon J.
- Thayer John Gregg
- Thomas Sandrine
- Thornton Adam J.
- Thukral Vaikunth
- Tice Jeffrey
- Trilling David E.
- Turri Max
- Tyson J.Anthony
- Van Berg Richard
- Vanden Berk Daniel
- Vetter Kurt
- Virieux Francoise
- Vucina Tomislav
- Wahl William
- Walkowicz Lucianne
- Walsh Brian
- Walter Christopher W.
- Wang Daniel L.
- Wang Shin-Yawn
- Warner Michael
- Wiecha Oliver
- Willman Beth
- Winters Scott E.
- Wittman David
- Wolff Sidney C.
- Wood-Vasey W.Michael
- Wu Xiuqin
- Xin Bo
- Yoachim Peter
- Zhan Hu
- Publication venue
- 'American Astronomical Society'
- Publication date
- 23/05/2018
- Field of study
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg2 field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5σ
point-source depth in a single visit in r will be ∼24.5 (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg2 with
δ<+34.5∘, and will be imaged multiple times in six bands, ugrizy,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg2 region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to r∼27.5. The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Automatic Emotion Prediction of Song Excerpts: Index Construction, Algorithm Design, and Empirical Comparison
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau Hervé
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
- Du Yutao
- Duarte Suzanne
- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
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- Edwards Jennifer
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- Eichler Evan
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- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
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- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
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- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
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- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
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- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
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- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
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- Flanagan J.
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- Flint Jonathan
- Flint Mark
- Flowers Dave
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- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
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- Fourcade Matthew
- Fowler John
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- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
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- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
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- Gao Anwu
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- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
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- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
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- Gattung Stacie
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- Geng Jianing
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- Ghori Jilur
- Ghose Sayantan
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- Gibbs Richard A.
- Gibson Diane
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- Golinveaux Kristen
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- Gong Guanghui
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- Gooderham April
- Goodstadt Leo
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- Goodwin Lynne A.
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- Grandbois Edward
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- Grant Michael
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- Gray Bruce
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- Green Lisa
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- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
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- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
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- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
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- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
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- Gustafson Erik
- Guthrie Ian
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- Ha Chi
- Hafez Nabil
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- Hagopian Daniel
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- Hajek Patrick
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- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
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- Han Guiqing
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
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- Hasegawa Tomoko
- Hashimoto Etsuko
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- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
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- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
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- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
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- Hildebrand Carl E.
- Hillier LaDeana
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- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
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- Holden Jane
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- Hooper Alison
- Hopewell Lucy
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- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
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- Howden Philip
- Howe Kevin
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- Howell Latoya Lynette
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- Hsu Fan
- Hu George
- Hu Jie
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- Huang Fang
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- Huang Mei
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- Huang Wei
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- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
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- Hunt Adrienne
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- Huynh Sandy
- Hyde David
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- Ingram Drew
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- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
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- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
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- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
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- Kang Hui
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- Kang Ning
- Kapur Hitesh
- Karolchik Donna
- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
- Kauer Gerhard
- Kaul Rajinder
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- Kay Michael
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- Kearney Lyndal
- Keefe Damian
- Keen Gifford
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- Kegelmeyer Laura
- Kegg Lisa
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- Kershaw Joanna
- Kettleborough Ross
- Keys David
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- Kidd Cathy
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- Kim Jennifer
- Kim Joomyeong
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- Kimura Moe
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- Klingle Gillian
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- Kobayashi Mai
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- Kohlberg Sara
- Kojima Kazuyasu
- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
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- Krawczyk Marie-Claude
- Kremitzki Colin
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- Krogh Anders
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- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
- Kuharic Patrick
- Kuhn Carol
- Kulish Larissa
- Kuroki Yoko
- Kwan Chinnie
- Kyle Amy
- LaButti Kurt
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- Lad Heena
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- Lai Jianghua
- Lai Teresa
- Laidlaw Philip
- Laing Michael
- Laird Gavin
- Lam Edward
- Lam Marissa
- Lama Dawa
- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
- Lansang Christine
- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
- Latreille Phil
- Lau Timun
- Lawlor Stephanie
- Layman Dan
- Leal Belita
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- Lebow Heather
- Lee Byung-in
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- Leger Jean Pierre
- Lehman Karl
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- Lehoczky Jessica
- Lehrach Hans
- Lehvaslaiho Minna
- Lei Meng
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- Leonard Shawn
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- Lesar Kendra
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- Li Lili
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- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
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- Linsdell Sally
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- Liu Boyong
- Liu Boyong
- Liu Cong
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- Luo Chunqing
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- Nguyen Minh
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- Nguyen Ngoc Bich
- Nguyen Thu
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- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
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- Peng Vivian
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- ya Al-Ahmadie
- Yachida
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- Yamaguchi T. N. k
- Yamamoto
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- z ah
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- Zenklusen
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- Zhang
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- Zhang H. b
- Zhao
- Zheng
- Zhou
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- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Good Faith and Fair Dealing as an Underenforced Legal Norm
- Author
- &
- . V Kmart Corp
- Aditi Bagchi
- Alabama V North Carolina
- Alan D Miller &
- Brudney
- Burton &
- Clark V State St
- Cleary V
- D&apos
- Divergence Shiffrin
- Duncan Kennedy
- E
- E G
- E G
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- E G Best V
- E G Hoffman La-Roche V
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- Id
- Id
- Id
- Id
- Inc Tecom
- Indeed
- Info
- James B Thayer
- Kennedy
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- Markovits
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- P Henry
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- Ramos
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- See Berman
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- See Joseph Singer
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- See Robert
- See Robert
- See Seana Valentine Shiffrin
- See Steven Shavell
- See Stuart
- Stephen J See
- Stewart Macaulay
- Summers
- Todd Rakoff
- U S Const
- White
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
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- Brice Aminou
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- Chang Li
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- Chip Stewart
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- Philip Awadalla
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- Ping Shang
- Piotr A Mieczkowski
- Prashant Bavi
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- Priyanka Dhingra
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- Qi Wang
- Qian Xiang
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- Qianyun Guo
- Qinying Xu
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- Vincenzo Corbo
- Vishal S Chandan
- Volker Hovestadt
- W Kimryn Rathmell
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- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
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- Wheeler David A
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- Winghing Wong
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- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
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- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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