952 research outputs found
T-wave Right Slope Provides a New Angle in the Prediction of Drug-Induced Ventricular Arrhythmias
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism
- Author
- A Matavel
- A Varro
- C Gang
- C Moreno
- C Ukomadu
- C Zobel
- D Thuringer
- DC Bartos
- DH Overstreet
- DS Grosso
- F Ai
- G Sivagangabalan
- GQ Zhang
- H Zhang
- HC Lee
- J Hayakawa
- K Takaishi
- LL Fan
- M Delmar
- M Dvir
- M Hassinen
- M Kaibara
- N Jost
- Q Gao
- RJ Howard
- RW Jiang
- S Liang
- S Wang
- SF Qureshi
- SM Bryant
- W Cheng
- XG Guo
- XS Chai
- Y Hu
- Y Huang
- Y Qian
- Y Xie
- Y Yuan
- YF Melman
- YL Lin
- YP Zhou
- Z Gao
- ZK Luo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Puerarin, a known isoflavone, is commonly found as a Chinese herb medicine. It is widely used in China to treat cardiac diseases such as angina, cardiac infarction and arrhythmia. However, its cardioprotective mechanism remains unclear. In this study, puerarin significantly prolonged ventricular action potential duration (APD) with a dosage dependent manner in the micromolar range on isolated rat ventricular myocytes. However, submicromolar puerarin had no effect on resting membrane potential (RMP), action potential amplitude (APA) and maximal velocity of depolarization (Vmax) of action potential. Only above the concentration of 10 mM, puerarin exhibited more aggressive effect on action potential, and shifted RMP to the positive direction. Millimolar concentrations of puerarin significantly inhibited inward rectified K+ channels in a dosage dependent manner, and exhibited bigger effects upon Kir2.1 vs Kir2.3 in transfected HEK293 cells. As low as micromolar range concentrations of puerarin significantly inhibited Kv7.1 and IKs. These inhibitory effects may due to the direct inhibition of puerarin upon channels not via the PKA-dependent pathway. These results provided direct preclinical evidence that puerarin prolonged APD via its inhibitory effect upon Kv7.1 and IKs, contributing to a better understanding the mechanism of puerarin cardioprotection in the treatment of cardiovascular diseases
Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism
- Author
- A Bailey
- AC Evans
- AR Gupta
- B Rockstroh
- B Ross
- B Salmon
- C Brown
- C Lord
- C Lord
- C Pantev
- C Pantev
- C Tallon-Baudry
- C Torrence
- CD Tesche
- D Wechsler
- DC Glahn
- DC Rojas
- Donald C Rojas
- DQ Ma
- E Maestrini
- E Peterson
- EH Cook Jr
- EL Nurmi
- ER Ritvo
- EV Orekhova
- G Rippon
- GJ Blatt
- II Gottesman
- J Brock
- J Mast
- JC Boudreau
- JC Edgar
- JD Buxbaum
- JP Hussman
- Keeran Maharajh
- LE Hong
- M Bartos
- M Reite
- M Reite
- M Reite
- MA Whittington
- MK Belmonte
- N Brunel
- N Fisher
- N Hajos
- N Tzourio-Mazoyer
- O David
- P Teale
- P Teale
- P Teale
- Peter Teale
- PJ Uhlhaas
- S Folstein
- S Grice
- S Heim
- S Makeig
- Sally J Rogers
- T Gloveli
- TW Wilson
- TW Wilson
- WJ Freeman
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Gamma-band oscillations recorded from human electrophysiological recordings, which may be associated with perceptual binding and neuronal connectivity, have been shown to be altered in people with autism. Transient auditory gamma-band responses, however, have not yet been investigated in autism or in the first-degree relatives of persons with the autism.</p> <p>Methods</p> <p>We measured transient evoked and induced magnetic gamma-band power and inter-trial phase-locking consistency in the magnetoencephalographic recordings of 16 parents of children with autism, 11 adults with autism and 16 control participants. Source space projection was used to separate left and right hemisphere transient gamma-band measures of power and phase-locking.</p> <p>Results</p> <p>Induced gamma-power at 40 Hz was significantly higher in the parent and autism groups than in controls, while evoked gamma-band power was reduced compared to controls. The phase-locking factor, a measure of phase consistency of neuronal responses with external stimuli, was significantly lower in the subjects with autism and the autism parent group, potentially explaining the difference between the evoked and induced power results.</p> <p>Conclusion</p> <p>These findings, especially in first degree relatives, suggest that gamma-band phase consistency and changes in induced versus induced power may be potentially useful endophenotypes for autism, particularly given emerging molecular mechanisms concerning the generation of gamma-band signals.</p
Measurement of the Forward-Backward Asymmetry in the B -> K(*) mu+ mu- Decay and First Observation of the Bs -> phi mu+ mu- Decay
- Author
- Aaltonen T
- Abdullin S
- Acosta D
- Acosta JG
- Adam N
- Adams MR
- Adams T
- Agostino L
- Akgun B
- Akgun U
- Alagoz E
- Albayrak EA
- Albrow M
- Alexander J
- Almenar CC
- Alver B
- Alverson G
- Amerio S
- Amidei D
- Anastassov A
- Anastassov A
- Anderson J
- Anghel IM
- Annovi A
- Antonelli L
- Antos J
- Apanasevich L
- Apollinari G
- Apollinari G
- Appel JA
- Apresyan A
- Arisawa T
- Artikov A
- Asaadi J
- Ashmanskas W
- Askew A
- Atac M
- Auerbach B
- Aurisano A
- Avery P
- Azfar F
- Baarmand MM
- Baden A
- Badgett W
- Bai Y
- Bakken JA
- Bandurin D
- Banerjee S
- Barbaro-Galtieri A
- Barberis E
- Baringer P
- Barnes VE
- Barnes VE
- Barnett BA
- Barnett BA
- Barria P
- Bartos P
- Bauce M
- Bauer G
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bazterra VE
- Bean A
- Bedeschi F
- Beecher D
- Behari S
- Bellettini G
- Bellinger J
- Bendavid J
- Benelli G
- Benjamin D
- Beretvas A
- Beretvas A
- Berry D
- Berry E
- Berryhill J
- Betchart B
- Betts RR
- Bhat PC
- Bhatti A
- Bhatti A
- Bilki B
- Binkley M
- Biselli A
- Bisello D
- Bizjak I
- Bland KR
- Blekman F
- Bloch I
- Blocker C
- Bloom K
- Blumenfeld B
- Blumenfeld B
- Bocci A
- Bochenek J
- Bodek A
- Bodek A
- Boeriu O
- Bolla G
- Bolton T
- Bonato A
- Borcherding F
- Borrello L
- Bortoletto D
- Bortoletto D
- Bose S
- Boudreau J
- Boulahouache C
- Bourilkov D
- Boutemeur M
- Boveia A
- Brau B
- Brigliadori L
- Brisuda A
- Bromberg C
- Brucken E
- Bucciantonio M
- Budagov J
- Budd HS
- Budd S
- Burkett K
- Burkett K
- Busetto G
- Bussey P
- Busza W
- Butler JN
- Butt J
- Butz E
- Buzatu A
- Bylsma B
- Cabrera S
- Calamba A
- Calancha C
- Cali IA
- Callner J
- Camarda S
- Campanelli M
- Campbell M
- Canelli F
- Canepa A
- Cankocak K
- Carls B
- Carlsmith D
- Carosi R
- Carrillo S
- Carroll R
- Carron S
- Casal B
- Casarsa M
- Castro A
- Catastini P
- Cauz D
- Cavaliere V
- Cavalli-Sforza M
- Cavanaugh R
- Ceballos GG
- Ceron C
- Cerri A
- Cerrito L
- Chakaberia I
- Chan M
- Chasco M
- Chatterjee A
- Chen J
- Chen M
- Chen YC
- Chertok M
- Chetluru V
- Cheung HWK
- Chiarelli G
- Chlachidze G
- Chlebana F
- Chlebana F
- Cho K
- Chokheli D
- Chou JP
- Chung WH
- Chung YS
- Chung YS
- Cihangir S
- Ciobanu CI
- Ciocci MA
- Cirino G
- Claes DR
- Clarida W
- Clark A
- Clark D
- Cole P
- Compostella G
- Convery ME
- Conway J
- Cooper SI
- Corbo M
- Cordelli M
- Cox CA
- Cox DJ
- Cremaldi LM
- Crescioli F
- Cuevas J
- Culbertson R
- Cumalat JP
- Cuplov V
- Cushman P
- d'Ascenzo N
- d'Errico M
- D'Onofrio M
- da Costa JG
- Dagenhart D
- Dahmes B
- Das S
- Datta M
- de Barbaro P
- de Barbaro P
- De Benedetti A
- De Cecco S
- De Lorenzo G
- Dell'Orso M
- Deluca C
- Demarteau M
- Demina R
- Demortier L
- Deng J
- Deninno M
- Denis RS
- Devoto F
- Di Canto A
- Di Giovanni GP
- Di Ruzza B
- Diamond B
- Dinardo ME
- Dittmann JR
- Dobur D
- Dominguez A
- Donati S
- Dong P
- Dorigo T
- Dorney B
- Dragoiu C
- Drell BR
- Drozdetskiy A
- Dudero PR
- Durkin LS
- Duru F
- Dutta V
- Eads M
- Eartly DP
- Ebina K
- Ecklund KM
- Edelmaier CJ
- Eggert N
- Elagin A
- Elmer P
- Elvira VD
- Eno SC
- Eppig A
- Erbacher R
- Errede D
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- Ershaidat N
- Eshaq Y
- Eskew C
- Eusebi R
- Everaerts P
- Everett A
- Fang HC
- Farrington S
- Fehling D
- Feindt M
- Ferencek D
- Ferguson T
- Fernandez JP
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- Ferrazza C
- Field R
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- Fields LJ
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- Flacher H
- Flanagan G
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- Garfinkel AF
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- Joo KK
- Joshi U
- Jun SY
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- Junk TR
- Kaadze K
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- Kamon T
- Karchin PE
- Karmgard DJ
- Kato Y
- Kaufman GN
- Keller J
- Kellogg RG
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- Ketchum W
- Keung J
- Khalatyan S
- Kharchilava A
- Khatiwada R
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- Khukhunaishvili A
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- Klima B
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- Wallny R
- Wan Z
- Wang D
- Wang SM
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- Weinberger M
- Weng Y
- Wenger EA
- Werner JS
- Wester WC
- Wetzel J
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- Wood JS
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- Yamamoto K
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- Yang YC
- Yao WM
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- Yilmaz Y
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- Yoo HD
- Yoon AS
- Yorita K
- Yoshida T
- Yu GB
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- Yun JC
- Zabel J
- Zablocki J
- Zakaria M
- Zanetti A
- Zanetti M
- Zang SL
- Zatserklyaniy A
- Zeng Y
- Zennamo J
- Zhang J
- Zheng Y
- Zhu RY
- Zhukova V
- Ziegler J
- Zielinski M
- Zucchelli SZucchelli Sira D
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
We reconstruct the rare decays B+→K+μ+μ−, B0→K∗(892)0μ+μ−, and Bs0→ϕ(1020)μ+μ− in a data sample
corresponding to 4.4fb−1 collected in ppˉ collisions at
s=1.96TeV by the CDF II detector at the Fermilab Tevatron
Collider. Using 121±16 B+→K+μ+μ− and 101±12 B0→K∗0μ+μ− decays we report the branching ratios. In addition, we report
the measurement of the differential branching ratio and the muon
forward-backward asymmetry in the B+ and B0 decay modes, and the K∗0
longitudinal polarization in the B0 decay mode with respect to the squared
dimuon mass. These are consistent with the theoretical prediction from the
standard model, and most recent determinations from other experiments and of
comparable accuracy. We also report the first observation of the Bs0→ϕμ+μ−decayandmeasureitsbranchingratio{\mathcal{B}}(B^0_s \to
\phi\mu^+\mu^-) = [1.44 \pm 0.33 \pm 0.46] \times 10^{-6}using27 \pm 6signalevents.ThisiscurrentlythemostrareB^0_s$ decay observed.Comment: 7 pages, 2 figures, 3 tables. Submitted to Phys. Rev. Let
Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set
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- Taegtmeyer H
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- U.
- U.K.
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- Umekawa M
- Umemiya-Shira
- Uozumi
- V.
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- V.E.
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- Velev
- Vellidis
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- Vázquez
- W.
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- W.C.
- W.H.
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- Wagner
- Wagner
- Wakisaka
- Wallny
- Wang
- Warburton
- Waters
- Wester
- Whiteson
- Wick
- Wicklund
- Wicklund
- Wilbur
- Williams
- Wilson
- Wilson
- Winer
- Wittich
- Wolbers
- Wolfe
- Wright
- Wu
- Wu
- X.
- Y.
- Y.
- Y.
- Y.
- Y.
- Y.
- Y.
- Y.
- Y.C.
- Y.C.
- Y.D.
- Y.J.
- Y.K.
- Y.S.
- Yamamoto
- Yamato
- Yang
- Yang
- Yang
- Yao
- Yeh
- Yi
- Yoh
- Yorita
- Yoshida
- Yu
- Yu
- Yu
- Yun
- Z.
- Zanetti
- Zeng
- Zhou
- Zucchelli
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We report a measurement of the bottom-strange meson mixing phase \beta_s
using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays
in which the quark-flavor content of the bottom-strange meson is identified at
production. This measurement uses the full data set of proton-antiproton
collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment
at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity.
We report confidence regions in the two-dimensional space of \beta_s and the
B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2,
-1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in
agreement with the standard model expectation. Assuming the standard model
value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +-
0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +-
0.009 (syst) ps, which are consistent and competitive with determinations by
other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012
Measurements of the properties of Lambda_c(2595), Lambda_c(2625), Sigma_c(2455), and Sigma_c(2520) baryons
- Author
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- Abdullin S
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
We report measurements of the resonance properties of Lambda_c(2595)+ and
Lambda_c(2625)+ baryons in their decays to Lambda_c+ pi+ pi- as well as
Sigma_c(2455)++,0 and Sigma_c(2520)++,0 baryons in their decays to Lambda_c+
pi+/- final states. These measurements are performed using data corresponding
to 5.2/fb of integrated luminosity from ppbar collisions at sqrt(s) = 1.96 TeV,
collected with the CDF II detector at the Fermilab Tevatron. Exploiting the
largest available charmed baryon sample, we measure masses and decay widths
with uncertainties comparable to the world averages for Sigma_c states, and
significantly smaller uncertainties than the world averages for excited
Lambda_c+ states.Comment: added one reference and one table, changed order of figures, 17
pages, 15 figure
Search for a New Heavy Gauge Boson Wprime with Electron + missing ET Event Signature in ppbar collisions at sqrt(s)=1.96 TeV
- Author
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- Zanetti M
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- Zatserklyaniy A
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- Zucchelli Slli Sira D
- Zucchelli SYun JC
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/12/2010
- Field of study
We present a search for a new heavy charged vector boson W′ decaying
to an electron-neutrino pair in ppˉ collisions at a center-of-mass
energy of 1.96\unit{TeV}. The data were collected with the CDF II detector
and correspond to an integrated luminosity of 5.3\unit{fb}^{-1}. No
significant excess above the standard model expectation is observed and we set
upper limits on σ⋅B(W′→eν). Assuming standard
model couplings to fermions and the neutrino from the W′ boson decay to
be light, we exclude a W′ boson with mass less than
1.12\unit{TeV/}c^2 at the 95\unit{%} confidence level.Comment: 7 pages, 2 figures Submitted to PR
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
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- Alshehri AA
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- Alviggi MG
- Amaral Coutinho Y
- Ambler A
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- Amelung C
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- An F
- Anastopoulos C
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- Andeen T
- Anders CF
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- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
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- Anthony MT
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- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
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- Armbruster AJ
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- Artz S
- Asai S
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- Asimakopoulou EM
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- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
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- Atlay NB
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- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
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- Bakker PJ
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- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
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- Barisits M-S
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- Barnovska-Blenessy Z
- Baroncelli A
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- Barr AJ
- Barreiro F
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
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- Franklin M
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- Franz S
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- Fraternali M
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- French ST
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- Geich-Gimbel C
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- Genest MH
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- Ghazlane H
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- Giannetti P
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- Giordani MP
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- Giordano R
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
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- Zurzolo G
- Zutshi V
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
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- Abolins M
- AbouZeid OS
- Abramowicz H
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- Acharya BS
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- Agustoni M
- Ahlen SP
- Ahmadov F
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- Akesson TPA
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- Alberghi GL
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
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