26 research outputs found
Morbidity at elementary school entry differs by sex and level of residence urbanization: a comparative cross-sectional study
- Author
- A Bergström
- A Morgan
- AW Wu
- B Varenne
- B Willershausen
- BM Junghans
- C Clemens
- C Maffeis
- C Ní Bhrolchaín
- Centers for Disease Control and Prevention (CDC)
- CS Liu
- D Gustafson
- D Gustafson
- DE Wilcken
- FJ Nieto
- G Gardner
- GR Dagenais
- H Jia
- Hsiu-Li Huang
- Huey-Shys Chen
- IOM
- J Barlow
- J Barlow
- J Schultz
- Jiunn-Jye Sheu
- K Jood
- KC Johnson
- Kuan-Chia Lin
- L Meeks
- LC Goe
- LH St Leger
- LL Lin
- LM Jamieson
- M Elliott
- ME Irigoyen
- MG Fowler
- N Freudenberg
- N Retnakumari
- NASN
- NM Clark
- P Bolton
- P Grandics
- PT Katzmarzyk
- RA Whitmer
- Rea-Jeng Yang
- S Kenchaiah
- S Leff
- S Leff
- SG Wannamethee
- SM Saw
- SM Saw
- T Fry
- T Haven
- T Kurth
- TCG
- TMOE
- TMOI
- USPHS
- W Chen
- Y Wang
- YC Huang
- YT Lin
- Publication venue
- BioMed Central
- Publication date
- Field of study
Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.
- Author
- Chan Yiong Huak
- Chong Yap-Seng
- Chu Collins Wenhan
- De Sessions Paola Florez
- Godfrey Keith M
- Goh Anne
- Goh Daniel YT
- Hibberd Martin Lloyd
- Huang Chiung-Hui
- Kwek Kenneth
- Lay Christophe
- Lee Bee Wah
- Lim Alicia Shi Min
- Ramamurthy Mahesh Babu
- Saw Seang-Mei
- Shek Lynette P
- Soh Jian Yi
- Soh Shu-E
- Ta Le Duc Huy
- Tay Carina Jing Xuan
- Teoh Oon Hoe
- Thomas Biju
- Van Bever Hugo PS
- Yap Gaik Chin
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2018
- Field of study
BACKGROUND: Dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and susceptibility to childhood respiratory disorders. OBJECTIVE: The aim of this case-control study was to monitor, evaluate, and compare development of the nasal microbiota of infants with rhinitis and wheeze in the first 18 months of life with those of healthy control subjects. METHODS: Anterior nasal swabs of 122 subjects belonging to the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort were collected longitudinally over 7 time points in the first 18 months of life. Nasal microbiota signatures were analyzed by using 16S rRNA multiplexed pair-end sequencing from 3 clinical groups: (1) patients with rhinitis alone (n = 28), (2) patients with rhinitis with concomitant wheeze (n = 34), and (3) healthy control subjects (n = 60). RESULTS: Maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared with control subjects. Bacterial diversity increased over the period of 18 months of life in control infants, whereas infants with rhinitis showed a decreasing trend (P < .05). An increase in abundance of the Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adjusted P < .01), whereas the Corynebacteriaceae family (Actinobacteria phylum) and early colonization with the Staphylococcaceae family (Firmicutes phylum; 3 weeks until 9 months) were associated with control subjects (adjusted P < .05). The only difference between the rhinitis and control groups was a reduced abundance of the Corynebacteriaceae family (adjusted P < .05). Determinants of nasal microbiota succession included sex, mode of delivery, presence of siblings, and infant care attendance. CONCLUSION: Our results support the hypothesis that the nasal microbiome is involved in development of early-onset rhinitis and wheeze in infants
MicroMotility: State of the art, recent accomplishments and perspectives on the mathematical modeling of bio-motility at microscopic scales
- Author
- Agostinelli D Alouges F, DeSimone A
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- Bustamante C
- Bustamante C Keller D, Oster G
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- Chauvet H Moulia B, Legué
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- Cicconofri G DeSimone A
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- Doostmohammadi A Ignes-Mullol J, Yeomans JM et al.
- Efrati E Sharon E, Kupferman R
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- Suma A Micheletti C
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2020
- Field of study
Mathematical modeling and quantitative study of biological motility (in particular, of motility at microscopic scales) is producing new biophysical insight and is offering opportunities for new discoveries at the level of both fundamental science and technology. These range from the explanation of how complex behavior at the level of a single organism emerges from body architecture, to the understanding of collective phenomena in groups of organisms and tissues, and of how these forms of swarm intelligence can be controlled and harnessed in engineering applications, to the elucidation of processes of fundamental biological relevance at the cellular and sub-cellular level. In this paper, some of the most exciting new developments in the fields of locomotion of unicellular organisms, of soft adhesive locomotion across scales, of the study of pore translocation properties of knotted DNA, of the development of synthetic active solid sheets, of the mechanics of the unjamming transition in dense cell collectives, of the mechanics of cell sheet folding in volvocalean algae, and of the self-propulsion of topological defects in active matter are discussed. For each of these topics, we provide a brief state of the art, an example of recent achievements, and some directions for future research
Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells
- Author
- A Yoshida
- AA Bahnassy
- AM Cheung
- AS Adhikari
- C Ginestier
- C Smith
- CE Eyler
- CT Jordan
- D Ucar
- DA Hess
- EH Huang
- F Jiang
- FA Burgener
- GJ Leiros
- H Towbin
- HB El-Serag
- J Douville
- J Hilton
- J Jia
- JF Geschwind
- K Takahashi
- L Armstrong
- M Alamgeer
- M Michishita
- ML Guzman
- P Dalerba
- Paul E. Makidon
- Prashasnika Gehlot
- R Januchowski
- R Lindahl
- S Ma
- S Parpart
- S Tanaka
- S Traussnigg
- Sanjay Gupta
- T Reya
- T Tanei
- Vivek Shukla
- WY Lau
- Y Du
- YT Saw
- ZA Rasheed
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Aamer A
- Aaniana K
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- Abaliksta T
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- Abantanga F
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- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
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- El Halawany M
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- El Magd AA
- El Mesery S
- El Sayed GS
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- El Shoura Y
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- El-Dien KS
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- El-Din RA
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- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
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- El-Sagheer N
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- El-Shahat NS
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- Elashmawy M
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- Elazoul M
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- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
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- EldosoukyMohammed A
- Elebute O
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- Elena G
- Elfarargy A
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- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
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- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
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- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
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- Ellison Q
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- Elrazek AA
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- Elsameea AA
- Elsawahly DME
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- Elsemelawy R
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- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
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- Elwy E
- Elzahed N
- Elzayat I
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- Elzowawi F
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- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
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- Essam M
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- Esteban E
- Estee MM
- Estupinian S
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- Etienne S
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- Evajelista CV
- Evans D
- Evans E
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- Eyssartier E
- Ezzat E
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- Faccincani R
- Fadel A
- Fahiem A
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- Farhangmehr N
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- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
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- Filatau A
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- Frisk B
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- Guevara Torres S
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- Halicioglu I
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- Ibrahim A
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- Jurdell E
- Kaafarani H
- Kabariti R
- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci AA
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah SK
- Kamarulzamil SNA
- Kamil R
- Kamya S
- Kanani A
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- Kang MK
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- Karabacak U
- Karabelias G
- Karabulut K
- Karahan SR
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
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- Karjiker P
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- Karlo R
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- Karousos D
- Karumnas P
- Kaselis N
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- Kasem E
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- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke KR
- Kelany M
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- Kennedy ED
- Kennedy M
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- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
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- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
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- Khatri C
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- Khattab K
- Khedr AE-RH
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khouri Ferreira SA
- Khreishi R
- Khreishi R
- Khulu LB
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim MY-H
- Kim S-H
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- King R
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- Kojo ATT
- Kojo ATT
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- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong SN
- Kong V
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- Konstantina K
- Kontos M
- Kordorwu HEK
- Korkolis D
- Kosai NR
- Kosai NR
- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Kyrou G
- Kyziridis D
- L'Heveder A
- La Brocca A
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- Labib P
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- Lam FY
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- Lam WH
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- Lauzikas G
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- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
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- Lazzarini Cury AD
- Le VTH
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- Leal M
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- Lecompte J-F
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- Lee F
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- Leusink A
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- Liew I
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- Lilford R
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- Lim G
- Lim H
- Lim J
- Lim PJ
- Lim SJ
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- Lim SY
- Limache S
- Limaye N
- Limoges B
- Linares Delgado MSDFT
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- Machaca M
- Machain Vega GM
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- Maciejec L
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- Madrid Barrientos LA
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- Mangan C
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- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
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- Mitroudi M
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- Mogan YP
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- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed MMH
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- Monteleone M
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- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
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- Moodley Y
- Moore R
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- Mora JJV
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- Morandi E
- Moreira G
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- Mosalum O
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- Mousa M
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- Nwabuoku E
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- Samaraweera DI
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- Sammarco G
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- Semeda N
- Semiz A
- Sena-Ruiz F
- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
- Seyoum N
- Sfougaris D
- Sgroi G
- Shaalan M
- Shabkah A
- Shachykava T
- Shah A
- Shah J
- Shah R
- Shaharuddin S
- Shahbaz AR
- Shaheen A
- Shahine A
- Shahzad N
- Shaikh N
- Shaikh S
- Shaker H
- Shaker R
- Shaker R
- Shakshouk HAG
- Shalabi A
- Shalaby A
- Shalaby M
- Shalaby M
- Shalhoub J
- Shamasneh A
- Shamsedine AW
- Shamsi G
- Shamsi GS
- Shariffuddin AM
- Sharma A
- Sharpin C
- Shatkar V
- Shatkar V
- Shaw CA
- Shaw CA
- Shawki M
- Shawki M
- Shawky MY
- Shawqi M
- Sheehan J
- Shehata S
- Sherif MA
- Sherman T
- Sheshe A
- Sheshe A
- Sheta A
- Sheth S
- Shibao Miyasato H
- Shillito S
- Shimy G
- Shiwani H
- Shiwani HA
- Sholadoye T
- Shrimanker N
- Shu Yip SB
- Shu S
- Shu S
- Shu S
- Shu S
- Shu S
- Shubianok M
- Shukla J
- Shwky A
- Siaw JY
- Sieda B
- Sierra S
- Sierra S
- Sierra S
- Siguantay M
- Sigurdadottir J
- Sii SSY
- Sileri P
- Silvani P
- Silvestre BP
- Silvestri V
- Simioni A
- Simoes RL
- Simutis G
- Singh P
- Singh S
- Sinha S
- Sinha Y
- Sion M
- Sishuba N
- Sivaganesh S
- Skardziukaite A
- Skehan J
- Skelly B
- Skerritt C
- Slade R
- Slapelyte E
- Sleem AS
- Sleem M
- Smart N
- Smart N
- Smart N
- Smart NJ
- Smedley A
- Smith C
- Smith C
- Smith D
- Snaith AC
- Snyder E
- Soares Miguel GP
- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
- Soley R
- Soliman A
- Soliman A
- Soliman AR
- Soliman N
- Soliman NA
- Soliman S
- Soliman Y
- Sollazzo V
- Soltani N
- Som R
- Song J
- Song J
- Soon WC
- Soon WC
- Soreide JA
- Soreide K
- Soreide K
- Soreide K
- Soreide K
- Souaibou YI
- Souaibou YI
- Soulou V
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spina A
- Sproule L
- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
- Sroor F
- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
- Stock S
- Stock S
- Stoddart M
- Stoddart M
- Stoddart M
- Stourton F
- Strazdas A
- Strupas K
- Strupas K
- Strupas K
- Stuva J
- Styles K
- Suarez A
- Suarez AAB
- Subocius A
- Suleiman SI
- Summerour V
- Sund M
- Sund M
- Sunderland G
- Sundstrom SM
- Suresh S
- Sutandi N
- Sutanto EPR
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
- Ting JRS
- To K
- To K
- Todd KO
- Toeema AG
- Tolba H
- Tolg C
- Tolonen M
- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola SK
- Tugnoli G
- Tugnoli G
- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Effects of topical atropine on intraocular pressure and myopia progression: a prospective comparative study
- Author
- A Chia
- A Chia
- A Glasser
- AC Chou
- AJ Lee
- C Angelini
- Chi-Chin Sun
- Chia-Yi Lee
- CW Pan
- DS Fan
- G Duncan
- G Wen
- H Jensen
- H Jensen
- IP Herring
- J Cooper
- J Cooper
- J Gwiazda
- J Wallman
- JE Walsh
- K Stadtbäumer
- Ken-Kuo Lin
- L Zou
- LS Harris
- ME Wilson
- MH Edwards
- NA McBrien
- P Ganesan
- PC Wu
- RA Stone
- RH Bedrossian
- RH Kennedy
- S Balakrishnan
- S Hadjikoutis
- S Tsukahara
- SC Kao
- SH Greenstein
- SM Li
- SM Saw
- SW Leo
- T Wygnanski-Jaffe
- TE Wu
- WH Chua
- Y Lachkar
- YF Shih
- YH Guo
- Yi-Fang Lin
- YT Fang
- YY Song
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
- Author
- Adair LS
- Akiyama M
- Bennett DA
- Bin Wei W
- Cai H
- Chai JF
- Chambers JC
- Chang LC
- Chee ML
- Chen CH
- Chen YT
- Chen Z
- Cheng CY
- Clarke R
- Dorajoo R
- Edwards TL
- Elliott P
- Friedlander Y
- Gordon-Larsen P
- Han S
- He J
- Heng CK
- Hirata M
- Hozawa A
- Huang W
- Huo S
- Hwang MY
- Ichihara S
- Igase M
- Isono M
- Jonas JB
- Kamatani Y
- Kato N
- Katsuya T
- Kelly TN
- Kim BJ
- Kim YJ
- Koh WP
- Kohara K
- Kooner JS
- Kubo M
- Lee J
- Lee NR
- Li H
- Li L
- Lin K
- Lin X
- Liu J
- Long J
- Matoba N
- Matsubara T
- Matsuda K
- Miki T
- Millwood IY
- Mohlke KL
- Momozawa Y
- Moon S
- Nabika T
- Nakashima E
- Nakatochi M
- Narita A
- Nierenberg JL
- Rakugi H
- Reilly DF
- Sabanayagam C
- Sasaki M
- Saw WY
- Shirota M
- Shu XO
- Sim X
- Spracklen CN
- Sun L
- Tabara Y
- Tai ES
- Takahashi A
- Takeuchi F
- Teo YY
- van der Harst P
- Walters RG
- Wang C
- Wang YX
- Wong TY
- Wu JY
- Xiang YB
- Xu L
- Yamamoto K
- Yamamoto M
- Yokota M
- Yuan JM
- Zhang L
- Zhao W
- Zheng W
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/10/2022
- Field of study
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.</p
Primary neuroendocrine neoplasm of the esophagus – Report of 14 cases from a single institute and review of the literature
- Author
- Adachi K
- Akagi I
- Ando T
- Asayama M
- Atsumi K
- Atsumi K
- Babich JP
- Basu S
- Bennouna J
- Bibeau F
- Briggs JC
- Brown Jr RS
- Caldwell CB
- Cary NR
- Casas F
- Chatni SS
- Chen KC
- Chen SB
- Chen WW
- Chin K
- Chino O
- Chong FK
- Chow V
- Chuah SK
- Clark T
- Cook MG
- Cox PM
- Craig SR
- Deepak P
- del Valle Ruiz SR
- Doherty MA
- Eccles DM
- Einspanier GR
- Enzinger PC
- Fattahi Masoum SH
- Feng JF
- Feng W
- Fenlon HM
- Flavio Roberto TAKEDA
- Francisco TUSTUMI
- Fukuchi M
- Funakoshi S
- Gao R
- Gollard R
- González LM
- Goscinski MA
- Goto T
- Guilherme Luiz Stelko PEREIRA
- Gumprich T
- Gupta NM
- Heyes FL
- Hoang MP
- Horai T
- Hosseini S
- Hou X
- Hsu PK
- Huang Q
- Huang YL
- Hudson E
- Huncharek M
- Imai T
- Isoyama Y
- Ivan CECCONELLO
- Johnson FE
- Kadhim MM
- Kanamoto A
- Kanno K
- Kitajima T
- Koide N
- Krishnatreya M
- Ku GY
- Kukar M
- Kuo CH
- Kuriry H
- Lam KY
- Law SY
- Lee CG
- Lee YT
- Li J
- Lichtenstein S
- Lim CS
- Liñán Padilla A
- Lu J
- Lu XJ
- Lv J
- Lü JM
- Macaigne G
- Madroszyk A
- Maheswari GK
- Makino H
- Martin R
- Maru DM
- Matsuda K
- Matsunaga M
- Matsuoka M
- Matsusaka T
- McCullen M
- Medgyesy CD
- Mimori K
- Mitani M
- Mori M
- Muguruma K
- Mulder LD
- Nakajima Y
- Nawroz IM
- Nayal B
- Nemoto K
- Nevarez A
- Nichols GL
- Nishimaki T
- Noguchi T
- Ohmura Y
- Okuma HS
- Okumura T
- Pantvaidya GH
- Partensky C
- Poynton AR
- Purdy S
- Raja S
- Rankin R
- Ready AR
- Reid HA
- Rekhtman N
- Reyes CV
- Rice TW
- Rodrigo Hideki UEMA
- Rosenthal SN
- Rubens Antonio Aissar SALLUM
- Sabanathan S
- Sahai P
- Sahnane N
- Sato T
- Saw EC
- Schuerle T
- Shimoda T
- Shinohara Y
- Shirafuji T
- Siegal A
- Song Y
- Sun KL
- Tanabe G
- Tanaka T
- Terada T
- Tetreault SA
- Tokunaga N
- Travis WD
- Veits L
- Vera-Mémdez FJ
- Vos B
- Wakahama O
- Walker SJ
- Wilson CI
- Wu Z
- Xie MR
- Yachida S
- Yagi M
- Yamamoto J
- Yamamoto S
- Yan H
- Yang L
- Yau KK
- Yazıcı O
- Yekeler E
- Yun JP
- Zhan XK
- Zhang Z
- Zhou Q
- Zhu Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
- Ç
- Ö
- Ž
- Ž
- Ž
- &apos
- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf Am
- Abdelrouf Dm
- Abdelshafy M
- Abdelshakour M
- Abdrabou Ak
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem Em
- Abdullah Ma
- Abdullah N
- Abdullah Nan
- Abdullah Nan
- Abdullahi L
- Abdurrazzaaq A
- Abebe Ns
- Abebe Ns
- Abem Oe
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud Mr
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga Ms
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed Maf
- Abu-Toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adı
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel Be
- Adel I
- Adella Fj
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa Ao
- Ademuyiwa Ao
- Ademuyiwa Ao
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa Ao
- Adisa Ao
- Adnan Ab
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi Am
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguilar Wlm
- Aguilar Wlm
- Aguilar-Jimenez J
- Aguilera M
- Aguilera Ml
- Aguilera Ml
- Aguilera O
- Aguilera-Arevalo Ml
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed Ea
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed Lam
- Ahmed S
- Ahmed S
- Ahmed Sm
- Ahounou Eys
- Aigrain Y
- Ajah J
- Ajai O
- Ajao A
- Ajao Ae
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag Aa
- Al-Azraqi Iaa
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi Jj
- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-Saqqa S
- Al-Saqqa Sw
- Al-Shammari A
- Al-Slaibi I
- Al-Taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi Ma
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi Msa
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali Cdm
- Ali E
- Ali Fm
- Ali H
- Ali S
- Ali Sawew
- Ali Ss
- Ali Tha
- Ali W
- Alihonou T
- Alimi Q
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen Jly
- Allen-Ingabire Jc
- Allott R
- Almallah A
- Almanon Cl
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby Mh
- Alnawam E
- Alnuqaydan Sa
- Alnusairat A
- Alomar In
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzahrani M
- Alzahrani Mna
- Alzayat T
- Aman Nf
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar Ms
- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika Ffa
- Andreotti D
- Andress C
- Andriola V
- Ang Yl
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
- Arafa O
- Arafa S
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
- Arnaud Ap
- Arnaud Ap
- Arnaud Ap
- Arshad Mm
- Arslan E
- Arsyad Hm
- Arthur T
- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
- Ashton A
- Asi F
- Asilah Smd
- Assal A
- Assouto Pa
- Asturias S
- Asumah H
- Ata A
- Ata Aaa
- Ata Ay
- Atiyeh A
- Atkins Et
- Atkinson K
- Atobatele K
- Attallah Na
- Attard M
- Attia A
- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
- Azmitia Jra
- Azodo Ia
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki Ma
- Badicel M
- Badr A
- Badr Mfm
- Badwi Nm
- Badwi Nm
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila Rmh
- Balkan Aza
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis Vj
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal Gs
- Baraka H
- Barakat Sae
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas Gn
- Barnacle J
- Barneo L
- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
- Barrios E
- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
- Basto Caa
- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada Ag
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai Rm
- Benons N
- Bentounsi Z
- Benyaiche C
- Bermú
- Bernardo Cg
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezzina M
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj Is
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal Kf
- Bhopal Kf
- Bianco F
- Bigaran A
- Billy M
- Birindelli A
- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bré
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu Mr
- Bratu Rm
- Braungart S
- Bravo Jac
- Bray Ld
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat Sd
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning Drl
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt Mt
- Cabrera Ccrr
- Cacurri A
- Cadogan Dd
- Cahill R
- Caliman C
- Callan R
- Calua Ac
- Camacho R
- Cameron B
- Camilleri Gm
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan Jf
- Campagnaro T
- Canto Md
- Capito C
- Capleton P
- Carabott K
- Cardozo Jt
- Cardozo Ram
- Careta Mc
- Carlucci M
- Carmona Jm
- Carneros Vj
- Carpio J
- Carrasco N
- Carreira Ja
- Cassar K
- Castillo Vdp
- Castro Mr
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Celis Jmv
- Cengiz Tb
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai Ca
- Chai Fy
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan Tk
- Chan Xw
- Chan Z
- Chandrakumar C
- Chang K
- Chang Ky
- Chapman A
- Chapman Sj
- Charles A
- Cheah Aez
- Chen Cy
- Chen Jhc
- Chen Ky
- Chen Tl
- Chenn R
- Cheong Yj
- Chetta N
- Cheung Yhe
- Chew Ls
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin Px
- Chin Yr
- Chiong Jac
- Chiong Jac
- Chiu S
- Chiu S
- Chiu Smy
- Choi J
- Choi P
- Chong Bfhk
- Chong Cl
- Chong Cl
- Chong Cl
- Chong Cs
- Chong Hy
- Chong Hy
- Choudhry A
- Chow Cyn
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung Kj
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark Dj
- Clark T
- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
- Clements Jm
- Clerico G
- Clifford C
- Cloro Lm
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker Dm
- Cocorullo G
- Cohen Dm
- Cohen F
- Cole S
- Coletta D
- Coletti M
- Collado Mv
- Colombani Jf
- Cona C
- Conci S
- Confalonieri G
- Conlon Kc
- Connor K
- Connor K
- Contreras E
- Contreras-Vergara Al
- Coomber R
- Coompson Cl
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Correa Jc
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz Dh
- Cruz H
- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- Cury Adl
- Dé
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- D&apos
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk Mo
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish Ak
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
- Davies R
- Davor A
- Dawnay G
- Dawood K
- Dawoud H
- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum Dl
- Decker E
- Decoud Hp
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
- Goh Cc
- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone