41 research outputs found
Pan-cancer analysis of whole genomes
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- Wendl M. C. z
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- Wilkerson M. D. v
- Williams
- Wilmott
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- Wilson R. K. z
- Wintersinger
- Wiznerowicz
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- Wouters
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- ya Al-Ahmadie
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- Yamaguchi T. N. k
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- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
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- Zhemchugov A
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
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- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
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- Fleck I
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
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- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a Zγ pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at s = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fb−1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of Zγ in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
Non-autonomous consequences of cell death and other perks of being metazoan
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Kimura's Disease with Generalized LymphadenopathyDemonstrated by Positron Emission Tomography Scan
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Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions
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- Perepelitsa DV
- Peresedov V
- Peressounko D Yu
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- Pinkenburg C
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- Vazquez-Zambrano E
- Veicht A
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- Zimamyi J
- Zolin L
- Zou L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
International audienceThe PHENIX collaboration presents first measurements of low-momentum (0.41 GeV/c) direct-photon yield dNγdir/dη is a smooth function of dNch/dη and can be well described as proportional to (dNch/dη)α with α≈1.25. This scaling behavior holds for a wide range of beam energies at the Relativistic Heavy Ion Collider and the Large Hadron Collider, for centrality selected samples, as well as for different A+A collision systems. At a given beam energy, the scaling also holds for high pT (>5 GeV/c), but when results from different collision energies are compared, an additional sNN-dependent multiplicative factor is needed to describe the integrated-direct-photon yield
Indian consensus on gastroesophageal reflux disease in adults: A position statement of the Indian Society of Gastroenterology
- Author
- A Becher
- A Fountoulakis
- A Gasiorowska
- A Karyampudi
- A Sharma
- A Woodcock
- A. V. Siva Prasad
- AB Chang
- Abhinav Jain
- AD Amarapurkar
- Ajay K. Jain
- Ajay Kumar
- Ajit Sood
- AK Dutta
- AL Gough
- AM Campagnolo
- Amarender S. Puri
- Amit K. Dutta
- Amol Bapaye
- AP Nagpal
- AP Nagpal
- B Baruah
- B Gopal
- B Kuo
- B Ramu
- B Simon
- B Vaishnav
- B. D. Goswami
- BA Khan
- BB Dean
- BB Pandit
- BC Jacobson
- BF Kessing
- BM Rejeb
- C Donnellan
- C Prakash
- C Stanciu
- CA Fraser-Moodie
- CA Schan
- Cannanore Ganesh Pai
- CJ Kelty
- CL Chu
- CM Bhalaghuru
- CM Saleh
- CN Ford
- CP Gyawali
- CP Gyawali
- D Chourasia
- D Jaspersen
- D Stefanidis
- D. Nageshwar Reddy
- DA Corley
- DA Corley
- DA Corley
- DA Johnson
- DB Skinner
- Devinder Singh
- DL Amarasiri
- DM Hicks
- DO Castell
- E Montgomery
- E Ness-Jensen
- E Ness-Jensen
- E Ness-Jensen
- E Savarino
- E Savarino
- ED Palmer
- EJ Irvine
- EM Mathus-Vliegen
- EM Mathus-Vliegen
- EM Quigley
- ES Lee
- ET Swarbrick
- F Ates
- F Johnsson
- F Pace
- FG Smeets
- G Zaninotto
- G. Venkat Rao
- GL Austin
- Govind K. Makharia
- GS Cooper
- H Pollmann
- H Zhang
- HB El-Serag
- HY Wang
- I Këlliçi
- IM Gralnek
- Inder Mainie
- J Aida
- J Dent
- J Dent
- J Kim
- J Smith
- J Smith
- J Weigt
- J Zacny
- J-H Wang
- J-X Zhang
- J. W. Rey
- Jaswinder Singh Sodhi
- Jayanthi Venkataraman
- JC Delchier
- JE Richter
- JE Richter
- JG Mastronarde
- JH Meier
- JH Peters
- JH Rubenstein
- JM Inadomi
- JM Inadomi
- JM Streitz Jr
- Jose Filipe Alvares
- JP Shoenut
- JP Waring
- JR Giudicessi
- JS Sodhi
- JV Cherian
- JW Chen
- JW Hamilton
- JW van Sandick
- K Epari
- K Goda
- K Kandiah
- K Madan
- K Madan
- K Visrodia
- K. Vashani
- KE Sigterman
- KK Wang
- KL Goh
- KL Wu
- KM Fock
- KM Fock
- KM Fock
- Krishnadas Devadas
- L Bujanda
- L Kia
- L-H Ren
- Lalit Shimpi
- LB Gerson
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- LG Gordon
- LH Eusebi
- LM Mathus-Vliegen
- Lorance Peter
- LR Lundell
- M Alikhan
- M Jain
- M Jain
- M Kerkhof
- M Nilsson
- M Piesman
- M Quante
- M Shapiro
- M Singh
- M. Miyasaka
- MA van Herwaarden
- Mahesh Kumar Goenka
- MD Noar
- ME Numans
- MF Vaezi
- MG Patti
- MJ Peters
- MM Wolfe
- Mohandas K. Mallath
- MR Littner
- MR Stein
- MS McDonagh
- MS Rosaida
- N Chiba
- N Freidin
- N Ishimura
- N Vakil
- Naresh Bhat
- NE Schindlbeck
- NE Schindlbeck
- NT Gunaratnam
- OO Koch
- P Bitnar
- P Bytzer
- P Chang
- P Duroux
- P Moayyedi
- P Sharma
- P Sharma
- P Sharma
- PA Gatenby
- Paul M. Smith
- PC Belafsky
- Periodic health examination: 2. 1984 update
- Philip Abraham
- Philip Mathew
- PJ Boekema
- PJ Kahrilas
- PJ Kahrilas
- PJ Kahrilas
- PJ Kahrilas
- PJ Kahrilas
- PJ Kahrilas
- PK Sharma
- PL Peghini
- PL Peghini
- PO Katz
- Praveen Mathew
- Praveen Mathew
- PS Dhawan
- PW Weijenborg
- R Fass
- R Fass
- R Harrison
- R Hunt
- R Pore
- Rajkumar T. Wadhwa
- Rakesh Kalapala
- Rakesh Kalapala
- Rakesh Kochhar
- Randhir Sud
- RC Fitzgerald
- RD Marks
- RM Khoury
- RM Lovell
- Rohit Dama
- Ronnie Fass
- RR Smith
- RS Irwin
- S Allampati
- S Bhat
- S Bhatia
- S Charles
- S Cohen
- S Futagami
- S Gaddam
- S Hanna
- S Kumar
- S Lanzon-Miller
- S Li
- S Maldhure
- S Mine
- S Peng
- S Rameschandra
- S Rodriguez
- S Roman
- S Sethi
- S Vigneri
- S Xue
- Sanjeev K. Issar
- Saurabh Kedia
- SC Kadakia
- SE Kaufman
- SF Price
- Shivram Prasad Singh
- Shobna J. Bhatia
- SJ Bhatia
- SJ Spechler
- SJ Spechler
- SM Harding
- SS Kao
- Stuart J. Spechler
- Subhashchandra Nandwani
- Sudipta Dhar Chowdhury
- Sunil Dadhich
- SY Nam
- T Kaltenbach
- T Kamiya
- T Lind
- T Surdea-Blaga
- T Tran
- TA Boghossian
- TM Ours
- TO Kiljander
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- UC Ghoshal
- Uday C. Ghoshal
- Usha Dutta
- V Sandur
- V Singhal
- V Stanghellini
- Vandana Midha
- Venkatakrishnan Leelakrishnan
- Vineet Ahuja
- Vinod Kumar Dixit
- W Fan
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- WL Curvers
- WM Wong
- XP Niu
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- Publication venue
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Search for heavy long-lived multi-charged particles in the full LHC Run 2 pp collision data at s = 13 TeV using the ATLAS detector
- Author
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- Zhao H
- Zhao P
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- Zhemchugov A
- Zheng X
- Zheng Z
- Zhong D
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- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/11/2023
- Field of study
A search for heavy long-lived multi-charged particles is performed using the ATLAS detector at the LHC. Data collected in 2015–2018 at √s = 13 TeV from pp collisions corresponding to an integrated luminosity of 139 fb−1 are examined. Particles producing anomalously high ionization, consistent with long-lived spin-½ massive particles with electric charges from |q| = 2e to |q| = 7e are searched for. No statistically significant evidence of such particles is observed, and 95% confidence level cross-section upper limits are calculated and interpreted as the lower mass limits for a Drell–Yan plus photon-fusion production mode. The least stringent limit, 1060 GeV, is obtained for |q| = 2e particles, and the most stringent one, 1600 GeV, is for |q| = 6e particles
Tools for estimating fake/non-prompt lepton backgrounds with the ATLAS detector at the LHC
- Author
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- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- HAL CCSD
- Publication date
- 29/11/2022
- Field of study
International audienceMeasurements and searches performed with the ATLAS detector at the CERN LHC often involve signatures with one or more prompt leptons. Such analysesare subject to `fake/non-prompt' lepton backgrounds, where either a hadron or a lepton from a hadron decay or an electron from a photon conversion satisfies the prompt-leptonselection criteria. These backgrounds often arise within a hadronic jet because of particle decays in the showering process, particle misidentification or particleinteractions with the detector material. As it is challenging to model these processes with high accuracy in simulation, their estimation typically uses data-driven methods.Three methods for carrying out this estimation are described, along with their implementation in ATLAS and their performance